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Volume 5 Issue 4, Dec 2020

Article
GLUT3 induced by AMPK/CREB1 axis is key for withstanding energy stress and augments the efficacy of current colorectal cancer therapies
Weixing Dai,Ye Xu,Shaobo Mo,Qingguo Li,Jun Yu,Renjie Wang,Yanlei Ma,Yan Ni,Wenqiang Xiang,Lingyu Han,Long Zhang,Sanjun Cai,Jun Qin  ORCID: orcid.org/0000-0002-2263-128X,Wen-Lian Chen,Wei Jia &…Guoxiang Cai 
https://doi.org/10.1038/s41392-020-00220-9
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Disease severity dictates SARS-CoV-2-specific neutralizing antibody responses in COVID-19
Xiangyu Chen,Zhiwei Pan,Shuai Yue,Fei Yu,Junsong Zhang,Yang Yang,Ren Li,Bingfeng Liu,Xiaofan Yang,Leiqiong Gao,Zhirong Li,Yao Lin,Qizhao Huang,Lifan Xu,Jianfang Tang,Li Hu,Jing Zhao,Pinghuang Liu,Guozhong Zhang,Yaokai Chen  ORCID: orcid.org/0000-0002-3229-0108,Kai Deng  ORCID: orcid.org/0000-0002-9973-8130 &…Lilin Ye 
https://doi.org/10.1038/s41392-020-00301-9
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COVID-19-activated SREBP2 disturbs cholesterol biosynthesis and leads to cytokine storm
Wonhwa Lee  ORCID: orcid.org/0000-0003-4336-5221,June Hong Ahn,Hee Ho Park,Hong Nam Kim  ORCID: orcid.org/0000-0002-0329-0029,Hyelim Kim,Youngbum Yoo,Hyosoo Shin,Kyung Soo Hong,Jong Geol Jang,Chun Gwon Park,Eun Young Choi,Jong-Sup Bae &…Young-Kyo Seo 
https://doi.org/10.1038/s41392-020-00292-7
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An individualized immune signature of pretreatment biopsies predicts pathological complete response to neoadjuvant chemoradiotherapy and outcomes in patients with esophageal squamous cell carcinoma
Chaoqi Zhang,Guochao Zhang,Nan Sun,Zhen Zhang,Liyan Xue,Zhihui Zhang,Haijun Yang,Yuejun Luo,Xiaoli Zheng,Yonglei Zhang,Yufen Yuan,Ruixue Lei,Zhaoyang Yang,Bo Zheng,Le Wang,Yun Che,Feng Wang,Sihui Wang,Shugeng Gao,Qi Xue,Yi Zhang  ORCID: orcid.org/0000-0001-9861-4681 &…Jie He  ORCID: orcid.org/0000-0002-0285-5403 
https://doi.org/10.1038/s41392-020-00221-8
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VDR–SOX2 signaling promotes colorectal cancer stemness and malignancy in an acidic microenvironment
Pei-Shan Hu,Ting Li,Jin-Fei Lin,Miao-Zhen Qiu,De-Shen Wang,Ze-Xian Liu,Zhan-Hong Chen,Lu-Ping Yang,Xiao-Long Zhang,Qi Zhao,Yan-Xing Chen,Yun-Xin Lu,Qi-Nian Wu,Heng-Ying Pu,Zhao-Lei Zeng,Dan Xie  ORCID: orcid.org/0000-0003-2242-3138,Huai-Qiang Ju  ORCID: orcid.org/0000-0003-1713-5465,Hui-Yan Luo &…Rui-Hua Xu  ORCID: orcid.org/0000-0001-9771-8534 
https://doi.org/10.1038/s41392-020-00230-7
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CYP2S1 is a synthetic lethal target in BRAFV600E-driven thyroid cancers
Yiqi Li,Xi Su,Chao Feng,Siyu Liu,Haixia Guan,Yue Sun,Nongyue He,Meiju Ji &…Peng Hou 
https://doi.org/10.1038/s41392-020-00231-6
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Carbamylated erythropoietin regulates immune responses and promotes long-term kidney allograft survival through activation of PI3K/AKT signaling
Ning Na,Daqiang Zhao,Jinhua Zhang,Jiaqing Wu,Bin Miao,Heng Li,Yingxun Luo,Zuofu Tang,Wensheng Zhang  ORCID: orcid.org/0000-0002-4712-8656,Joseph A. Bellanti &…Song Guo Zheng 
https://doi.org/10.1038/s41392-020-00232-5
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Novel insights into stress-induced susceptibility to influenza: corticosterone impacts interferon-β responses by Mfn2-mediated ubiquitin degradation of MAVS
Zhuo Luo,Li-Fang Liu,Ying-Nan Jiang,Lu-Ping Tang,Wen Li,Shu-Hua Ouyang,Long-Fang Tu,Yan-Ping Wu,Hai-Biao Gong,Chang-Yu Yan,Shan Jiang,Yu-Hui Lu,Tongzheng Liu,Zhenyou Jiang,Hiroshi Kurihara,Yang Yu,Xin-Sheng Yao,Yi-Fang Li &…Rong-Rong He  ORCID: orcid.org/0000-0001-5505-5672 
https://doi.org/10.1038/s41392-020-00238-z
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Sarcoma stratification by combined pH2AX and MAP17 (PDZK1IP1) levels for a better outcome on doxorubicin plus olaparib treatment
Marco Perez,José Manuel García-Heredia,Blanca Felipe-Abrio,Sandra Muñoz-Galván,Javier Martín-Broto  ORCID: orcid.org/0000-0001-7350-6916 &…Amancio Carnero 
https://doi.org/10.1038/s41392-020-00246-z
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Nanoparticle enhanced combination therapy for stem-like progenitors defined by single-cell transcriptomics in chemotherapy-resistant osteosarcoma
Li Wang,Xiaojia Huang,Xinru You,Tianqi Yi,Bing Lu,Jiali Liu,Guohao Lu,Minglin Ma,Changye Zou,Jun Wu &…Wei Zhao 
https://doi.org/10.1038/s41392-020-00248-x
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The cross-talk between methylation and phosphorylation in lymphoid-specific helicase drives cancer stem-like properties
Na Liu,Rui Yang,Ying Shi,Ling Chen,Yating Liu,Zuli Wang,Shouping Liu,Lianlian Ouyang,Haiyan Wang,Weiwei Lai,Chao Mao,Min Wang,Yan Cheng,Shuang Liu,Xiang Wang,Hu Zhou,Ya Cao,Desheng Xiao &…Yongguang Tao 
https://doi.org/10.1038/s41392-020-00249-w
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The efficacy assessment of convalescent plasma therapy for COVID-19 patients: a multi-center case series
Hao Zeng,Dongfang Wang,Jingmin Nie,Haoyu Liang,Jiang Gu  ORCID: orcid.org/0000-0001-8035-4551,Anne Zhao,Lixin Xu,Chunhui Lang,Xiaoping Cui,Xiaolan Guo,Changlong Zhou,Haibo Li,Bin Guo,Jinyong Zhang,Qiang Wang,Li Fang,Wen Liu,Yishan Huang,Wei Mao,Yaokai Chen  ORCID: orcid.org/0000-0002-3229-0108 &…Quanming Zou 
https://doi.org/10.1038/s41392-020-00329-x
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SARS-CoV-2 triggers inflammatory responses and cell death through caspase-8 activation
Shufen Li,Yulan Zhang,Zhenqiong Guan,Huiling Li,Meidi Ye,Xi Chen,Jun Shen,Yiwu Zhou,Zheng-Li Shi,Peng Zhou &…Ke Peng  ORCID: orcid.org/0000-0003-0172-8725 
https://doi.org/10.1038/s41392-020-00334-0
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Discovery of a novel EGFR ligand DPBA that degrades EGFR and suppresses EGFR-positive NSCLC growth
Nan Yao,Chen-Ran Wang,Ming-Qun Liu,Ying-Jie Li,Wei-Min Chen,Zheng-Qiu Li,Qi Qi  ORCID: orcid.org/0000-0003-4460-0713,Jin-Jian Lu  ORCID: orcid.org/0000-0001-6703-3120,Chun-Lin Fan,Min-Feng Chen,Ming Qi,Xiao-Bo Li,Jian Hong,Dong-Mei Zhang &…Wen-Cai Ye 
https://doi.org/10.1038/s41392-020-00251-2
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Dietary fats suppress the peritoneal seeding of colorectal cancer cells through the TLR4/Cxcl10 axis in adipose tissue macrophages
Wei Xiang,Rongchen Shi,Dapeng Zhang,Xia Kang,Lili Zhang,Jing Yuan,Xuan Zhang &…Hongming Miao  ORCID: orcid.org/0000-0001-6355-3612 
https://doi.org/10.1038/s41392-020-00327-z
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Pathological features of COVID-19-associated lung injury: a preliminary proteomics report based on clinical samples
Ling Leng,Ruiyuan Cao,Jie Ma,Danlei Mou,Yunping Zhu,Wei Li,Luye Lv,Dunqin Gao,Shikun Zhang,Feng Gong,Lei Zhao,Bintao Qiu,Haiping Xiang,Zhongjie Hu,Yingmei Feng,Yan Dai,Jiang Zhao,Zhihong Wu,Hongjun Li &…Wu Zhong  ORCID: orcid.org/0000-0002-0536-620X 
https://doi.org/10.1038/s41392-020-00355-9
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Irreversible electroporation plus allogenic Vγ9Vδ2 T cells enhances antitumor effect for locally advanced pancreatic cancer patients
Mao Lin,Xiaoyan Zhang,Shuzhen Liang,Haihua Luo,Mohammed Alnaggar,Aihua Liu,Zhinan Yin,Jibing Chen,Lizhi Niu &…Yong Jiang 
https://doi.org/10.1038/s41392-020-00260-1
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Poly(I:C) preconditioning protects the heart against myocardial ischemia/reperfusion injury through TLR3/PI3K/Akt-dependent pathway
Erya Chen,Chan Chen,Zhendong Niu,Lu Gan,Qiao Wang,Ming Li,XingWei Cai,Rui Gao,Sruthi Katakam,Hai Chen,Shu Zhang,Ronghua Zhou,Xu Cheng,Yanhua Qiu,Hai Yu,Tao Zhu &…Jin Liu 
https://doi.org/10.1038/s41392-020-00257-w
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Identification of miR-515-3p and its targets, vimentin and MMP3, as a key regulatory mechanism in esophageal cancer metastasis: functional and clinical significance
Hui-Fang Hu,Wen Wen Xu,Wei-Xia Zhang,Xin Yan  ORCID: orcid.org/0000-0001-6248-3931,Yang-Jia Li,Bin Li &…Qing-Yu He  ORCID: orcid.org/0000-0003-0503-9492 
https://doi.org/10.1038/s41392-020-00275-8
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RBD-Fc-based COVID-19 vaccine candidate induces highly potent SARS-CoV-2 neutralizing antibody response
Zezhong Liu,Wei Xu,Shuai Xia,Chenjian Gu,Xinling Wang,Qian Wang,Jie Zhou,Yanling Wu,Xia Cai,Di Qu,Tianlei Ying,Youhua Xie,Lu Lu  ORCID: orcid.org/0000-0002-2255-0391,Zhenghong Yuan &…Shibo Jiang  ORCID: orcid.org/0000-0001-8283-7135 
https://doi.org/10.1038/s41392-020-00402-5
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Review Article
FGF/FGFR signaling in health and disease
Yangli Xie,Nan Su,Jing Yang,Qiaoyan Tan,Shuo Huang  ORCID: orcid.org/0000-0001-9495-4339,Min Jin,Zhenhong Ni,Bin Zhang,Dali Zhang,Fengtao Luo,Hangang Chen,Xianding Sun,Jian Q. Feng,Huabing Qi &…Lin Chen  ORCID: orcid.org/0000-0001-7764-9412 
https://doi.org/10.1038/s41392-020-00222-7
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Epitranscriptomics and epiproteomics in cancer drug resistance: therapeutic implications
Huibin Song,Dongcheng Liu,Shaowei Dong,Leli Zeng,Zhuoxun Wu,Pan Zhao,Litu Zhang  ORCID: orcid.org/0000-0002-3305-3294,Zhe-Sheng Chen  ORCID: orcid.org/0000-0002-8289-097X &…Chang Zou 
https://doi.org/10.1038/s41392-020-00300-w
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Chitinase-3 like-protein-1 function and its role in diseases
Ting Zhao,Zhongping Su,Yingchang Li,Xiaoren Zhang &…Qiang You  ORCID: orcid.org/0000-0003-3308-4127 
https://doi.org/10.1038/s41392-020-00303-7
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Targeting NF-κB pathway for the therapy of diseases: mechanism and clinical study
Hui Yu,Liangbin Lin,Zhiqiang Zhang  ORCID: orcid.org/0000-0003-1796-081X,Huiyuan Zhang &…Hongbo Hu  ORCID: orcid.org/0000-0002-8177-7641 
https://doi.org/10.1038/s41392-020-00312-6
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Receptor-binding domain-specific human neutralizing monoclonal antibodies against SARS-CoV and SARS-CoV-2
Fei Yu,Rong Xiang,Xiaoqian Deng,Lili Wang,Zhengsen Yu,Shijun Tian,Ruiying Liang,Yanbai Li,Tianlei Ying &…Shibo Jiang  ORCID: orcid.org/0000-0001-8283-7135 
https://doi.org/10.1038/s41392-020-00318-0
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Recent advances in the development of protein–protein interactions modulators: mechanisms and clinical trials
Haiying Lu,Qiaodan Zhou,Jun He,Zhongliang Jiang,Cheng Peng,Rongsheng Tong &…Jianyou Shi 
https://doi.org/10.1038/s41392-020-00315-3
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NAD+ metabolism: pathophysiologic mechanisms and therapeutic potential
Na Xie,Lu Zhang,Wei Gao,Canhua Huang  ORCID: orcid.org/0000-0003-2247-7750,Peter Ernst Huber,Xiaobo Zhou,Changlong Li,Guobo Shen &…Bingwen Zou  ORCID: orcid.org/0000-0002-0825-3657 
https://doi.org/10.1038/s41392-020-00311-7
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Advances in targeted therapy for esophageal cancer
Yan-Ming Yang,Pan Hong,Wen Wen Xu,Qing-Yu He  ORCID: orcid.org/0000-0003-0503-9492 &…Bin Li  ORCID: orcid.org/0000-0002-8979-610X 
https://doi.org/10.1038/s41392-020-00323-3
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Emerging role of tumor cell plasticity in modifying therapeutic response
Siyuan Qin,Jingwen Jiang,Yi Lu  ORCID: orcid.org/0000-0002-1060-6925,Edouard C. Nice,Canhua Huang,Jian Zhang &…Weifeng He 
https://doi.org/10.1038/s41392-020-00313-5
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Overview of current targeted therapy in gallbladder cancer
Xiaoling Song,Yunping Hu,Yongsheng Li,Rong Shao,Fatao Liu &…Yingbin Liu 
https://doi.org/10.1038/s41392-020-00324-2
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NADPH homeostasis in cancer: functions, mechanisms and therapeutic implications
Huai-Qiang Ju  ORCID: orcid.org/0000-0003-1713-5465,Jin-Fei Lin,Tian Tian,Dan Xie  ORCID: orcid.org/0000-0003-2242-3138 &…Rui-Hua Xu  ORCID: orcid.org/0000-0001-9771-8534 
https://doi.org/10.1038/s41392-020-00326-0
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A systematic review of SARS-CoV-2 vaccine candidates
Yetian Dong,Tong Dai,Yujun Wei,Long Zhang  ORCID: orcid.org/0000-0001-8139-0474,Min Zheng &…Fangfang Zhou 
https://doi.org/10.1038/s41392-020-00352-y
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Development of synthetic lethality in cancer: molecular and cellular classification
Shijie Li,Win Topatana  ORCID: orcid.org/0000-0001-8580-1920,Sarun Juengpanich,Jiasheng Cao,Jiahao Hu,Bin Zhang,Diana Ma,Xiujun Cai  ORCID: orcid.org/0000-0002-6457-0577 &…Mingyu Chen  ORCID: orcid.org/0000-0001-5113-754X 
https://doi.org/10.1038/s41392-020-00358-6
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Exosome-mediated metabolic reprogramming: the emerging role in tumor microenvironment remodeling and its influence on cancer progression
Enli Yang,Xuan Wang,Zhiyuan Gong,Miao Yu,Haiwei Wu &…Dongsheng Zhang 
https://doi.org/10.1038/s41392-020-00359-5
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Advances in targeted therapy mainly based on signal pathways for nasopharyngeal carcinoma
Yuanbo Kang,Weihan He,Caiping Ren  ORCID: orcid.org/0000-0001-6880-7394,Jincheng Qiao,Qiuyong Guo,Jingyu Hu,Hongjuan Xu,Xingjun Jiang &…Lei Wang 
https://doi.org/10.1038/s41392-020-00340-2
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Progress in the mechanism and targeted drug therapy for COPD
Cuixue Wang,Jiedong Zhou,Jinquan Wang,Shujing Li,Atsushi Fukunaga  ORCID: orcid.org/0000-0003-2026-8154,Junji Yodoi &…Hai Tian 
https://doi.org/10.1038/s41392-020-00345-x
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Immune checkpoint molecules in natural killer cells as potential targets for cancer immunotherapy
Yuqing Cao,Xiaoyu Wang,Tianqiang Jin,Yu Tian,Chaoliu Dai,Crystal Widarma,Rui Song &…Feng Xu 
https://doi.org/10.1038/s41392-020-00348-8
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Beyond just a tight fortress: contribution of stroma to epithelial-mesenchymal transition in pancreatic cancer
Ashenafi Bulle &Kian-Huat Lim  ORCID: orcid.org/0000-0002-2766-200X 
https://doi.org/10.1038/s41392-020-00341-1
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COVID-19-associated gastrointestinal and liver injury: clinical features and potential mechanisms
Peijie Zhong,Jing Xu,Dong Yang,Yue Shen,Lu Wang,Yun Feng,Chunling Du,Yuanlin Song,Chaomin Wu,Xianglin Hu  ORCID: orcid.org/0000-0002-7133-9867 &…Yangbai Sun 
https://doi.org/10.1038/s41392-020-00373-7
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Precise design strategies of nanomedicine for improving cancer therapeutic efficacy using subcellular targeting
Xianglei Fu,Yanbin Shi,Tongtong Qi,Shengnan Qiu,Yi Huang,Xiaogang Zhao,Qifeng Sun &…Guimei Lin 
https://doi.org/10.1038/s41392-020-00342-0
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Targeting nuclear acid-mediated immunity in cancer immune checkpoint inhibitor therapies
Miaoqin Chen,Shiman Hu,Yiling Li,Ting Ting Jiang,Hongchuan Jin &…Lifeng Feng  ORCID: orcid.org/0000-0003-4506-1213 
https://doi.org/10.1038/s41392-020-00347-9
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Letter
RMI2 plays crucial roles in growth and metastasis of lung cancer
Weixiang Zhan,Yina Liu,Ying Gao,Run Gong,Wen Wang,Ruhua Zhang,Yuanzhong Wu,Tiebang Kang &…Denghui Wei 
https://doi.org/10.1038/s41392-020-00295-4
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LKB1-AMPK axis negatively regulates ferroptosis by inhibiting fatty acid synthesis
Changzhi Li,Xuan Dong,Wenjing Du,Xin Shi,Kangjie Chen,Wei Zhang &…Minghui Gao 
https://doi.org/10.1038/s41392-020-00297-2
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Storm of soluble immune checkpoints associated with disease severity of COVID-19
Yaxian Kong,Yu Wang,Xueying Wu,Junyan Han,Guoli Li,Mingxi Hua,Kai Han,Henghui Zhang,Ang Li &…Hui Zeng  ORCID: orcid.org/0000-0002-7456-6061 
https://doi.org/10.1038/s41392-020-00308-2
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Augmented efficacy of exogenous extracellular vesicles targeted to injured kidneys
Xiao-Jun Chen,Kai Jiang,Christopher M. Ferguson,Hui Tang,Xiangyang Zhu,Amir Lerman &…Lilach O. Lerman  ORCID: orcid.org/0000-0002-3271-3887 
https://doi.org/10.1038/s41392-020-00304-6
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Discovery of a highly potent and selective Bruton’s tyrosine kinase inhibitor avoiding impairment of ADCC effects for B-cell non-Hodgkin lymphoma
Juan Liu,Qianmao Liang,Aoli Wang,Fengming Zou,Ziping Qi,Kailin Yu,Qingwang Liu,Cheng Chen,Jing Liu &…Qingsong Liu  ORCID: orcid.org/0000-0002-7829-2547 
https://doi.org/10.1038/s41392-020-00309-1
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L1 drives HSC aging and affects prognosis of chronic myelomonocytic leukemia
Ying Wang,Jin-ping Zheng,Ying Luo,Junyi Wang,Lingjie Xu,Jinyong Wang,John M. Sedivy,Zhangfa Song,Hu Wang &…Zhenyu Ju 
https://doi.org/10.1038/s41392-020-00279-4
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A cell-based large-scale screening of natural compounds for inhibitors of SARS-CoV-2
Zhe-Rui Zhang,Ya-Nan Zhang,Xiao-Dan Li,Hong-Qing Zhang,Shu-Qi Xiao,Fei Deng,Zhi-Ming Yuan,Han-Qing Ye  ORCID: orcid.org/0000-0001-7770-4071 &…Bo Zhang  ORCID: orcid.org/0000-0002-8895-3679 
https://doi.org/10.1038/s41392-020-00343-z
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Identification and validation of predictive factors for progression to severe COVID-19 pneumonia by proteomics
Biao Di,Hongling Jia,Oscar Junhong Luo  ORCID: orcid.org/0000-0002-1266-3069,Fangqin Lin,Kuibiao Li,Yuanliang Zhang,Huadong Wang,Huiying Liang,Jun Fan  ORCID: orcid.org/0000-0001-6637-9891 &…Zhicong Yang 
https://doi.org/10.1038/s41392-020-00333-1
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Main protease of SARS-CoV-2 serves as a bifunctional molecule in restricting type I interferon antiviral signaling
Yaoxing Wu,Ling Ma,Zhen Zhuang,Sihui Cai,Zhiyao Zhao,Lingli Zhou,Jing Zhang,Pei-Hui Wang,Jincun Zhao  ORCID: orcid.org/0000-0003-2515-5589 &…Jun Cui 
https://doi.org/10.1038/s41392-020-00332-2
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Salvianolic acid C potently inhibits SARS-CoV-2 infection by blocking the formation of six-helix bundle core of spike protein
Chan Yang,Xiaoyan Pan,Xinfeng Xu,Chen Cheng,Yuan Huang,Lin Li,Shibo Jiang  ORCID: orcid.org/0000-0001-8283-7135,Wei Xu,Gengfu Xiao &…Shuwen Liu  ORCID: orcid.org/0000-0001-6346-5006 
https://doi.org/10.1038/s41392-020-00325-1
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Randomized, multicenter, open-label trial of autologous cytokine-induced killer cell immunotherapy plus chemotherapy for squamous non-small-cell lung cancer: NCT01631357
Liang Liu,Quanli Gao,Jingting Jiang,Junping Zhang,Xin Song,Jiuwei Cui,Yunbin Ye,Zhiyu Wang,Xinwei Zhang &…Xiubao Ren 
https://doi.org/10.1038/s41392-020-00337-x
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The ubiquitin ligase E6AP facilitates HDAC6-mediated deacetylation and degradation of tumor suppressors
Yanan Zhang  ORCID: orcid.org/0000-0002-5039-0348,Zhida Chen,Jing Lin,Jie Liu,Yahong Lin,Huayue Li,Yongyi Xi,Bo Wei,Lihua Ding &…Qinong Ye  ORCID: orcid.org/0000-0001-8032-8919 
https://doi.org/10.1038/s41392-020-00330-4
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Identification and validation of heterotypic cell-in-cell structure as an adverse prognostic predictor for young patients of resectable pancreatic ductal adenocarcinoma
Hongyan Huang,Meifang He,Yanbin Zhang,Bo Zhang,Zubiao Niu,You Zheng,Wen Li,Peilin Cui,Xiaoning Wang &…Qiang Sun  ORCID: orcid.org/0000-0001-8094-2214 
https://doi.org/10.1038/s41392-020-00346-w
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Omics study reveals abnormal alterations of breastmilk proteins and metabolites in puerperant women with COVID-19
Yin Zhao,You Shang,Yujie Ren,Yuanyuan Bie,Yang Qiu,Yin Yuan,Yun Zhao,Li Zou,Shu-Hai Lin &…Xi Zhou 
https://doi.org/10.1038/s41392-020-00362-w
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Inflammatory cytokines, T lymphocyte subsets, and ritonavir involved in liver injury of COVID-19 patients
Shengtao Liao,Ke Zhan,Li Gan,Yang Bai,Jinfang Li,Guodan Yuan,Ying Cai,An Zhang,Song He &…Zhechuan Mei  ORCID: orcid.org/0000-0001-9766-3684 
https://doi.org/10.1038/s41392-020-00363-9
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Baicalein inhibits SARS-CoV-2/VSV replication with interfering mitochondrial oxidative phosphorylation in a mPTP dependent manner
Shichao Huang,Yu’e Liu,Yanan Zhang,Ru Zhang,ChengJie Zhu,Lihong Fan,Gang Pei,Bo Zhang  ORCID: orcid.org/0000-0002-8895-3679 &…Yufeng Shi 
https://doi.org/10.1038/s41392-020-00353-x
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GSK-LSD1, an LSD1 inhibitor, quashes SARS-CoV-2-triggered cytokine release syndrome in-vitro
Kyung Soo Hong,June Hong Ahn,Jong Geol Jang,Jong Ho Lee,Hong Nam Kim  ORCID: orcid.org/0000-0002-0329-0029,Dongha Kim  ORCID: orcid.org/0000-0002-3454-6605 &…Wonhwa Lee  ORCID: orcid.org/0000-0003-4336-5221 
https://doi.org/10.1038/s41392-020-00391-5
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A systemic and molecular study of subcellular localization of SARS-CoV-2 proteins
Jing Zhang,Ruth Cruz-cosme,Meng-Wei Zhuang,Dongxiao Liu,Yuan Liu,Shaolei Teng  ORCID: orcid.org/0000-0001-8326-9889,Pei-Hui Wang  ORCID: orcid.org/0000-0001-6853-2423 &…Qiyi Tang 
https://doi.org/10.1038/s41392-020-00372-8
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Bimodular effects of D614G mutation on the spike glycoprotein of SARS-CoV-2 enhance protein processing, membrane fusion, and viral infectivity
Xiaoyi Jiang,Zhengrong Zhang,Chenxi Wang,Hongguang Ren,Lihua Gao,Haoran Peng,Zubiao Niu,He Ren,Hongyan Huang &…Qiang Sun  ORCID: orcid.org/0000-0002-5342-0637 
https://doi.org/10.1038/s41392-020-00392-4
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The effect of whey protein on viral infection and replication of SARS-CoV-2 and pangolin coronavirus in vitro
Huahao Fan  ORCID: orcid.org/0000-0001-5007-2158,Bixia Hong,Yuqian Luo,Qi Peng,Liqin Wang,Xiangshu Jin,Yangzhen Chen,Yunjia Hu,Yi Shi  ORCID: orcid.org/0000-0002-3053-2687,Tong Li,Hui Zhuang,Yi-Hua Zhou,Yigang Tong &…Kuanhui Xiang  ORCID: orcid.org/0000-0001-5022-5863 
https://doi.org/10.1038/s41392-020-00408-z
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Low-dose corticosteroid combined with immunoglobulin reverses deterioration in severe cases with COVID-19
Zhi-Guo Zhou,Di-Xuan Jiang,Shu-Min Xie,Jing Zhang,Fang Zheng,Hong Peng,Xuan Chen,Ji-Yang Liu &…Lei Zhang 
https://doi.org/10.1038/s41392-020-00407-0
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Research Highlight
A new player in the beneficial effects of exercise on the aged brain
M. Llorens-Martín 
https://doi.org/10.1038/s41392-020-00305-5
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Profiling and characterization of SARS-CoV-2 mutants’ infectivity and antigenicity
Lin Wang,Ling Wang &Hui Zhuang 
https://doi.org/10.1038/s41392-020-00302-8
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The p(l)ot thickens: cannabinoid receptors on astroglial mitochondria coordinate animal behaviors by regulating lactate availability for neurons
Erik Keimpema,Tibor Harkany &Alán Alpár 
https://doi.org/10.1038/s41392-020-00298-1
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How mammalian piRNAs instruct de novo DNA methylation of transposons
Zhiqing Li,Xiaoyin Tang &En-Zhi Shen 
https://doi.org/10.1038/s41392-020-00294-5
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Type I IFN deficiency: an immunological characteristic of severe COVID-19 patients
Zhenling Wang,Hailong Pan &Boguang Jiang 
https://doi.org/10.1038/s41392-020-00306-4
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A genome-wide screening for DNA repair genes: much more players than hitherto known
Bernd Kaina  ORCID: orcid.org/0000-0002-8217-0809 
https://doi.org/10.1038/s41392-020-00314-4
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TH17 cells…Sorting the good out from the bad
Junwei Li,Le Jiang,Yongxiang Yi &…Pradeep Kumar Sacitharan 
https://doi.org/10.1038/s41392-020-00316-2
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Targeting multiple epitopes on the spike protein: a new hope for COVID-19 antibody therapy
Yeping Sun,Bostjan Kobe  ORCID: orcid.org/0000-0001-9413-9166 &Jianxun Qi 
https://doi.org/10.1038/s41392-020-00320-6
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Semaphorins or Frizzled –it is the receptor that direct the action of clostridial glucosylating toxins
Klaus Aktories  ORCID: orcid.org/0000-0002-5397-0436 
https://doi.org/10.1038/s41392-020-00307-3
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Microbiota-mediated phytate metabolism activates HDAC3 to contribute intestinal homeostasis
Xiaoxing Li,Harry Cheuk Hay Lau  ORCID: orcid.org/0000-0003-3581-2909 &Jun Yu 
https://doi.org/10.1038/s41392-020-00321-5
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Supramolecular attack particle: the way cytotoxic T lymphocytes kill target cells
Jiaqi Liu,Yanqi Ye &Lulu Cai  ORCID: orcid.org/0000-0002-5678-1112 
https://doi.org/10.1038/s41392-020-00319-z
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Targeting metabolic/epigenetic pathways: a potential strategy for cancer therapy in diffuse intrinsic pontine gliomas
Kun Zhao &Hongming Miao  ORCID: orcid.org/0000-0001-6355-3612 
https://doi.org/10.1038/s41392-020-00344-y
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Cysteine-113 covalency inspires the development of Pin1 inhibitor
Wenchen Pu,Jiao Li &Yong Peng  ORCID: orcid.org/0000-0002-1181-3467 
https://doi.org/10.1038/s41392-020-00339-9
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Is smaller better? Vaccine targeting recombinant receptor-binding domain might hold the key for mass production of effective prophylactics to fight the COVID-19 pandemic
Manish Muhuri &Guangping Gao 
https://doi.org/10.1038/s41392-020-00317-1
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SARS-CoV-2-specific T-cells in unexposed humans: presence of cross-reactive memory cells does not equal protective immunity
Rory D. de Vries  ORCID: orcid.org/0000-0003-2817-0127 
https://doi.org/10.1038/s41392-020-00338-w
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SARS-CoV-2: the many pros of targeting PLpro
Christopher B. McClain  ORCID: orcid.org/0000-0002-8246-4639 &Nicolas Vabret 
https://doi.org/10.1038/s41392-020-00335-z
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TREM2 marks tumor-associated macrophages
Kyohei Nakamura  ORCID: orcid.org/0000-0002-6631-9028 &Mark J. Smyth 
https://doi.org/10.1038/s41392-020-00356-8
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Gut microbiome alters functions of mutant p53 to promote tumorigenesis
Harry Cheuk Hay Lau  ORCID: orcid.org/0000-0003-3581-2909 &Jun Yu  ORCID: orcid.org/0000-0001-5008-2153 
https://doi.org/10.1038/s41392-020-00336-y
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Inhibition of translation and immune responses by the virulence factor Nsp1 of SARS-CoV-2
Kendra R. Vann,Adam H. Tencer &Tatiana G. Kutateladze  ORCID: orcid.org/0000-0001-7375-6990 
https://doi.org/10.1038/s41392-020-00350-0
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Azvudine (FNC): a promising clinical candidate for COVID-19 treatment
Bin Yu  ORCID: orcid.org/0000-0002-0531-2236 &Junbiao Chang 
https://doi.org/10.1038/s41392-020-00351-z
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SARS-CoV-2 spike behavior in situ: a Cryo-EM images for a better understanding of the COVID-19 pandemic
Alaa M. Ismail &Abdo A. Elfiky 
https://doi.org/10.1038/s41392-020-00365-7
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Cancer vaccines: shared tumor antigens return to the spotlight
Lijin Li,S. Peter Goedegebuure &William Gillanders 
https://doi.org/10.1038/s41392-020-00364-8
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SARS-CoV-2 spike protein: flexibility as a new target for fighting infection
Ciro Leonardo Pierri  ORCID: orcid.org/0000-0003-1816-548X 
https://doi.org/10.1038/s41392-020-00369-3
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Thrombin-mediated vasculogenic mimicry: important lessons to improve anticoagulant therapy of selected cancer patients
C. Arnold Spek  ORCID: orcid.org/0000-0002-2149-4068 
https://doi.org/10.1038/s41392-020-00366-6
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Outsmarting SARS-CoV-2 by empowering a decoy ACE2
Milena Sokolowska  ORCID: orcid.org/0000-0001-9710-6685 
https://doi.org/10.1038/s41392-020-00370-w
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Human recombinant soluble ACE2 (hrsACE2) shows promise for treating severe COVID­19
Tarek Mohamed Abd El-Aziz,Ahmed Al-Sabi &James D. Stockand 
https://doi.org/10.1038/s41392-020-00374-6
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A high-fat diet: an unexpected role in preventing the metastatic seeding of colorectal cancer
Min Long,Wenjing Wang &Qiu Sun  ORCID: orcid.org/0000-0001-5122-2226 
https://doi.org/10.1038/s41392-020-00386-2
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Small is beautiful–a glycolytic metabolite signals mTORC1 activation in cancer cell metabolism
Angela M. Otto 
https://doi.org/10.1038/s41392-020-00371-9
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A cozy niche in an iron world
Marcus Conrad  ORCID: orcid.org/0000-0003-1140-5612 &Mariia Novikova 
https://doi.org/10.1038/s41392-020-00368-4
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Extracellular vesicle fingerprinting: the next generation for cancer diagnosis?
Vanessa Sandim &Robson Q. Monteiro  ORCID: orcid.org/0000-0002-5260-2332 
https://doi.org/10.1038/s41392-020-00385-3
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Therapeutic utility of immunosuppressive TREM2+ macrophages: an important step forward in potentiating the immune checkpoint inhibitors
Fulya Koksalar Alkan &Hasan Korkaya 
https://doi.org/10.1038/s41392-020-00383-5
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Above the dose threshold: a simple way to improve the delivery efficiency of nanomedicine
Lei Yang,Yanqi Ye &Lulu Cai  ORCID: orcid.org/0000-0002-5678-1112 
https://doi.org/10.1038/s41392-020-00400-7
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ecDNA within tumors: a new mechanism that drives tumor heterogeneity and drug resistance
Xixi Zeng,Maoping Wan &Jianmin Wu  ORCID: orcid.org/0000-0002-8223-1667 
https://doi.org/10.1038/s41392-020-00403-4
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Battle at the entrance gate: CIITA as a weapon to prevent the internalization of SARS-CoV-2 and Ebola viruses
Rafal Butowt,Krzysztof Pyrc &Christopher S. von Bartheld 
https://doi.org/10.1038/s41392-020-00405-2
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Peroxisome: the new player in ferroptosis
Daolin Tang &Guido Kroemer  ORCID: orcid.org/0000-0002-9334-4405 
https://doi.org/10.1038/s41392-020-00404-3
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SERIneALanine Killer: SPT promiscuity inhibits tumour growth via intra-tumoral deoxysphingolipid production
Mattia Falcone  ORCID: orcid.org/0000-0003-0906-5735 &Oliver D. K. Maddocks  ORCID: orcid.org/0000-0002-5551-9091 
https://doi.org/10.1038/s41392-020-00401-6
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Fossicking for microbial defense system: novel antiviral immunity
Ping Lin,Qun Wu &Min Wu  ORCID: orcid.org/0000-0003-1205-982X 
https://doi.org/10.1038/s41392-020-00423-0
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Perspective
Convalescent plasma therapy for COVID-19: a tried-and-true old strategy?
Yongzhi Xi  ORCID: orcid.org/0000-0001-9980-9245 
https://doi.org/10.1038/s41392-020-00310-8
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