Volume 5 Issue 4, Dec 2020:
Article
An individualized immune signature of pretreatment biopsies predicts pathological complete response to neoadjuvant chemoradiotherapy and outcomes in patients with esophageal squamous cell carcinoma
Chaoqi Zhang,Guochao Zhang,Nan Sun,Zhen Zhang,Liyan Xue,Zhihui Zhang,Haijun Yang,Yuejun Luo,Xiaoli Zheng,Yonglei Zhang,Yufen Yuan,Ruixue Lei,Zhaoyang Yang,Bo Zheng,Le Wang,Yun Che,Feng Wang,Sihui Wang,Shugeng Gao,Qi Xue,Yi Zhang
ORCID: orcid.org/0000-0001-9861-4681 &…Jie He
ORCID: orcid.org/0000-0002-0285-5403
No clinically available biomarkers can predict pathological complete response (pCR) for esophageal squamous cell carcinomas (ESCCs) with neoadjuvant chemoradiotherapy (nCRT). Considering that antitumor immunity status is an important determinant for nCRT, we performed an integrative analysis of immune-related gene profiles from pretreatment biopsies and constructed the first individualized immune signature for pCR and outcome prediction of ESCCs through a multicenter analysis. During the discovery phase, 14 differentially expressed immune-related genes (DEIGs) with greater than a twofold change between pCRs and less than pCRs (
