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Volume 5 Issue 3, Sep 2020

Article
CD137 costimulation enhances the antiviral activity of Vγ9Vδ2-T cells against influenza virus
Yujun Pei,Kun Wen,Zheng Xiang,Chunyu Huang,Xiwei Wang,Xiaofeng Mu,Liyan Wen,Yinping Liu &…Wenwei Tu 
https://doi.org/10.1038/s41392-020-0174-2
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Twist1-induced miR-199a-3p promotes liver fibrosis by suppressing caveolin-2 and activating TGF-β pathway
Xiaoxue Yang,Liping Ma,Rong Wei,Tinghong Ye  ORCID: orcid.org/0000-0002-3296-6753,JianKang Zhou,Maoyao Wen,Ruoting Men,Rami I. Aqeilan,Yong Peng  ORCID: orcid.org/0000-0002-1181-3467 &…Li Yang 
https://doi.org/10.1038/s41392-020-0169-z
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miR-410 induces both epithelial–mesenchymal transition and radioresistance through activation of the PI3K/mTOR pathway in non-small cell lung cancer
Yue Yuan,Hu Liao,Qiang Pu,Xixian Ke,Xueting Hu,Yongfang Ma,Xinmei Luo,Qianqian Jiang,Yi Gong,Min Wu  ORCID: orcid.org/0000-0003-1205-982X,Lunxu Liu &…Wen Zhu 
https://doi.org/10.1038/s41392-020-0182-2
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The deubiquitylase UCHL3 maintains cancer stem-like properties by stabilizing the aryl hydrocarbon receptor
Lianlian Ouyang,Bin Yan,Yating Liu,Chao Mao,Min Wang,Na Liu,Zuli Wang,Shouping Liu,Ying Shi,Ling Chen,Xiang Wang,Yan Cheng,Ya Cao,Desheng Xiao,Lingqiang Zhang,Shuang Liu &…Yongguang Tao 
https://doi.org/10.1038/s41392-020-0181-3
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SUMOylation stabilizes hSSB1 and enhances the recruitment of NBS1 to DNA damage sites
Liwen Zhou,Lisi Zheng,Kaishun Hu,Xin Wang,Ruhua Zhang,Yezi Zou,Li Zhong  ORCID: orcid.org/0000-0002-1646-2862,Shang Wang,Yuanzhong Wu &…Tiebang Kang  ORCID: orcid.org/0000-0001-8805-4174 
https://doi.org/10.1038/s41392-020-0172-4
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Thrombin is a therapeutic target for non-small-cell lung cancer to inhibit vasculogenic mimicry formation
Bing Zhao,Mengfang Wu,Zhihuang Hu,Yixin Ma,Wang Qi,Yanling Zhang,Yaran Li,Min Yu,Huijie Wang &…Wei Mo 
https://doi.org/10.1038/s41392-020-0167-1
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Tetrahedral framework nucleic acids promote scarless healing of cutaneous wounds via the AKT-signaling pathway
Junyao Zhu,Mei Zhang,Yang Gao,Xin Qin,Tianxu Zhang,Weitong Cui,Chenchen Mao,Dexuan Xiao &…Yunfeng Lin  ORCID: orcid.org/0000-0003-1224-6561 
https://doi.org/10.1038/s41392-020-0173-3
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ALDH2 contributes to melatonin-induced protection against APP/PS1 mutation-prompted cardiac anomalies through cGAS-STING-TBK1-mediated regulation of mitophagy
Shuyi Wang,Lin Wang,Xing Qin,Subat Turdi,Dongdong Sun,Bruce Culver,Russel J. Reiter,Xiaoming Wang,Hao Zhou &…Jun Ren  ORCID: orcid.org/0000-0002-0275-0783 
https://doi.org/10.1038/s41392-020-0171-5
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Auranofin mitigates systemic iron overload and induces ferroptosis via distinct mechanisms
Lei Yang,Hao Wang  ORCID: orcid.org/0000-0001-7661-3688,Xiang Yang,Qian Wu,Peng An,Xi Jin,Weiwei Liu,Xin Huang,Yuzhu Li,Shiyu Yan,Shuying Shen,Tingbo Liang,Junxia Min  ORCID: orcid.org/0000-0001-8099-6327 &…Fudi Wang  ORCID: orcid.org/0000-0001-8730-0003 
https://doi.org/10.1038/s41392-020-00253-0
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The AKT-independent MET–V-ATPase–MTOR axis suppresses liver cancer vaccination
Xing Huang  ORCID: orcid.org/0000-0002-8886-2777,Xingyuan Xu,Xun Wang,Tianyu Tang,Enliang Li,Xiaozhen Zhang,Jian Xu,Hang Shen,Chengxiang Guo,Tao Xu,Jianhong Ren,Xueli Bai &…Tingbo Liang 
https://doi.org/10.1038/s41392-020-0179-x
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Adaptive immune responses to SARS-CoV-2 infection in severe versus mild individuals
Fan Zhang,Rui Gan,Ziqi Zhen,Xiaoli Hu,Xiang Li,Fengxia Zhou,Ying Liu,Chuangeng Chen,Shuangyu Xie,Bailing Zhang,Xiaoke Wu &…Zhiwei Huang 
https://doi.org/10.1038/s41392-020-00263-y
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Membranous NOX5-derived ROS oxidizes and activates local Src to promote malignancy of tumor cells
Jie Chen,Yan Wang,Weimin Zhang,Di Zhao,Lingyuan Zhang,Jiawen Fan,Jinting Li &…Qimin Zhan 
https://doi.org/10.1038/s41392-020-0193-z
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Comparison of nonhuman primates identified the suitable model for COVID-19
Shuaiyao Lu,Yuan Zhao,Wenhai Yu,Yun Yang,Jiahong Gao,Junbin Wang,Dexuan Kuang,Mengli Yang,Jing Yang,Chunxia Ma,Jingwen Xu,Xingli Qian,Haiyan Li,Siwen Zhao,Jingmei Li,Haixuan Wang,Haiting Long,Jingxian Zhou,Fangyu Luo,Kaiyun Ding,Daoju Wu,Yong Zhang,Yinliang Dong,Yuqin Liu,Yinqiu Zheng,Xiaochen Lin,Li Jiao,Huanying Zheng,Qing Dai,Qiangming Sun,Yunzhang Hu,Changwen Ke,Hongqi Liu &…Xiaozhong Peng 
https://doi.org/10.1038/s41392-020-00269-6
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A CRISPR knockout negative screen reveals synergy between CDKs inhibitor and metformin in the treatment of human cancer in vitro and in vivo
Yarui Ma,Qing Zhu,Junbo Liang,Yifei Li,Mo Li,Ying Zhang,Xiaobing Wang,Yixin Zeng &…Yuchen Jiao 
https://doi.org/10.1038/s41392-020-0203-1
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Addiction to protein kinase Cɩ due to PRKCI gene amplification can be exploited for an aptamer-based targeted therapy in ovarian cancer
Hina Rehmani,Yue Li,Tao Li,Ravi Padia,Ozlem Calbay,Lingtao Jin,Huijun Chen &…Shuang Huang 
https://doi.org/10.1038/s41392-020-0197-8
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IGF-1R inhibition induces MEK phosphorylation to promote survival in colon carcinomas
Qing Wang,Yan Zhang,Jiang Zhu,Honggang Zheng,Shuntai Chen,Li Chen &…Hsin-Sheng Yang 
https://doi.org/10.1038/s41392-020-0204-0
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Human umbilical cord-derived mesenchymal stem cell therapy in patients with COVID-19: a phase 1 clinical trial
Fanping Meng,Ruonan Xu,Siyu Wang,Zhe Xu,Chao Zhang  ORCID: orcid.org/0000-0001-8126-8145,Yuanyuan Li,Tao Yang,Lei Shi,Junliang Fu,Tianjun Jiang,Lei Huang,Peng Zhao,Xin Yuan,Xing Fan,Ji-Yuan Zhang,Jinwen Song  ORCID: orcid.org/0000-0002-8582-8012,Dawei Zhang,Yanmei Jiao,Limin Liu,Chunbao Zhou,Markus Maeurer,Alimuddin Zumla,Ming Shi &…Fu-Sheng Wang  ORCID: orcid.org/0000-0002-8043-6685 
https://doi.org/10.1038/s41392-020-00286-5
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Mitomycin C enhanced the efficacy of PD-L1 blockade in non-small cell lung cancer
Min Luo,Fang Wang,Hong Zhang,Kenneth K. W. To,Shaocong Wu,Zhen Chen,Shaobo Liang &…Liwu Fu 
https://doi.org/10.1038/s41392-020-0200-4
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Research Highlight
Multispecific drugs: the fourth wave of biopharmaceutical innovation
Yifei Wang &Shengyong Yang 
https://doi.org/10.1038/s41392-020-0201-3
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BET family protein degraders poised to join the senolytic arsenal
Zufeng Guo  ORCID: orcid.org/0000-0002-4370-9445,Hanjing Peng &Yongmei Xie  ORCID: orcid.org/0000-0002-7913-0283 
https://doi.org/10.1038/s41392-020-0202-2
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An effective platform for cancer immunotherapy: pooled knockin targeting for genome engineering
Ke Jin  ORCID: orcid.org/0000-0001-5371-3440,Long Zhang  ORCID: orcid.org/0000-0001-8139-0474 &Fangfang Zhou 
https://doi.org/10.1038/s41392-020-0208-9
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Multi-cancer blood testing combined with PET-CT: road for hope to screen for cancer and guide intervention
Tao Jiang,Shengxiang Ren &Caicun Zhou 
https://doi.org/10.1038/s41392-020-0210-2
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Eating self for not be eaten: Pancreatic cancer suppresses self-immunogenicity by autophagy-mediated MHC-I degradation
Xing Huang  ORCID: orcid.org/0000-0002-8886-2777,Xiaozhen Zhang,Xueli Bai &…Tingbo Liang 
https://doi.org/10.1038/s41392-020-0209-8
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Targeting the entry step of SARS-CoV-2: a promising therapeutic approach
Jing Li,Peng Zhan &Xinyong Liu 
https://doi.org/10.1038/s41392-020-0195-x
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Door to the cell for COVID-19 opened, leading way to therapies
Zhiwei Huang &Jijie Chai 
https://doi.org/10.1038/s41392-020-00215-6
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How genome ‘escape’ from mechanical stress-induced damage
Xiaoyun Dai 
https://doi.org/10.1038/s41392-020-00227-2
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Mapping the T cell response to COVID-19
Junwei Li,Junhua Wang,Angray S. Kang  ORCID: orcid.org/0000-0002-4672-4114 &…Pradeep Kumar Sacitharan 
https://doi.org/10.1038/s41392-020-00228-1
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Rewiring local immune milieu by boosting dendritic cell for pancreatic cancer treatment
Yifan Zhang &Qun-Ying Lei  ORCID: orcid.org/0000-0002-8547-8518 
https://doi.org/10.1038/s41392-020-00225-4
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Mitochondria hyperactivity contributes to social behavioral impairments
Yun Zhang,Lin Peng &Weihong Song  ORCID: orcid.org/0000-0001-9928-889X 
https://doi.org/10.1038/s41392-020-00239-y
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Structural basis of signaling of cannabinoids receptors: paving a way for rational drug design in controling mutiple neurological and immune diseases
Shenming Huang,Peng Xiao &Jinpeng Sun 
https://doi.org/10.1038/s41392-020-00240-5
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Microbiome harbored within tumors: a new chance to revisit our understanding of cancer pathogenesis and treatment
Kunming Zhao &Ying Hu 
https://doi.org/10.1038/s41392-020-00244-1
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Targeting chemokines/chemokine receptors: a promising strategy for enhancing the immunotherapy of pancreatic ductal adenocarcinoma
Ruining Gong &He Ren  ORCID: orcid.org/0000-0002-9528-0580 
https://doi.org/10.1038/s41392-020-00267-8
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An extracellular matrix paradox in myocardial scar formation
Sangkyun Cho,David T. Paik  ORCID: orcid.org/0000-0002-7830-312X &Joseph C. Wu  ORCID: orcid.org/0000-0002-6068-8041 
https://doi.org/10.1038/s41392-020-00270-z
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Step further towards targeted senolytic therapy: therapeutic potential of uPAR-CAR T cells for senescence-related diseases
Yujia Huang &Tao Liu  ORCID: orcid.org/0000-0001-5347-5892 
https://doi.org/10.1038/s41392-020-00268-7
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Dietary intervention, a promising adjunct for cancer therapy
Rongchen Shi &Hongming Miao  ORCID: orcid.org/0000-0001-6355-3612 
https://doi.org/10.1038/s41392-020-00271-y
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CCDC25: precise navigator for neutrophil extracellular traps on the prometastatic road
Ruochen Liu,Erhu Zhao,Feng Wang &…Hongjuan Cui 
https://doi.org/10.1038/s41392-020-00285-6
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Rab22a-NeoF1: a promising target for osteosarcoma patients with lung metastasis
Kai Xie,Xinyi Zhang &Yongguang Tao 
https://doi.org/10.1038/s41392-020-00273-w
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Molecular features of IGHV3-53-encoded antibodies elicited by SARS-CoV-2
Francesca Fagiani,Michele Catanzaro &Cristina Lanni  ORCID: orcid.org/0000-0002-3061-4738 
https://doi.org/10.1038/s41392-020-00287-4
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Human-viral chimera: a novel protein affecting viral virulence and driving host T-cell immunity
Zhenling Wang,Li Zhang &Min Wu  ORCID: orcid.org/0000-0003-1205-982X 
https://doi.org/10.1038/s41392-020-00272-x
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The first human trial of CRISPR-based cell therapy clears safety concerns as new treatment for late-stage lung cancer
Shenghui He  ORCID: orcid.org/0000-0001-8842-7137 
https://doi.org/10.1038/s41392-020-00283-8
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Promising inhibitors targeting Mpro: an ideal strategy for anti-SARS-CoV-2 drug discovery
Yi Chen,Guan Wang &Liang Ouyang  ORCID: orcid.org/0000-0001-5537-8834 
https://doi.org/10.1038/s41392-020-00291-8
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H3.3S31 phosphorylation: linking transcription elongation to stimulation responses
Hong Wen &Xiaobing Shi 
https://doi.org/10.1038/s41392-020-00293-6
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Letter
Molecular docking, synthesis and biological evaluation of Vascular Endothelial Growth Factor (VEGF) B based peptide as antiangiogenic agent targeting the second domain of the Vascular Endothelial Growth Factor Receptor 1 (VEGFR1D2) for anticancer application
Afsaneh Sadremomtaz,Ameena M. Ali,Foroozan Jouyandeh,Saeed Balalaie,Razieh Navari,Sylvain Broussy  ORCID: orcid.org/0000-0003-3098-5317,Kamran Mansouri,Matthew R. Groves &…S. Mohsen Asghari 
https://doi.org/10.1038/s41392-020-0177-z
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Identification of exosomal miRNAs as diagnostic biomarkers for cholangiocarcinoma and gallbladder carcinoma
Xin-ying Xue,Yu-xia Liu,Chen Wang,Xin-jin Gu,Zhi-qiang Xue,Xue-lei Zang,Xi-dong Ma,Hui Deng,Rong Liu,Lei Pan &…San-hong Liu 
https://doi.org/10.1038/s41392-020-0162-6
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Amyloid β neurotoxicity is IDO1–Kyn–AhR dependent and blocked by IDO1 inhibitor
Zhenzhen Duan,Shengnan Zhang,Heng Liang,Zikang Xing,Leilei Guo,Lei Shi,Lisha Du,Chunxiang Kuang,Osamu Takikawa &…Qing Yang 
https://doi.org/10.1038/s41392-020-0188-9
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The role of furin cleavage site in SARS-CoV-2 spike protein-mediated membrane fusion in the presence or absence of trypsin
Shuai Xia,Qiaoshuai Lan  ORCID: orcid.org/0000-0001-5524-3542,Shan Su,Xinling Wang,Wei Xu,Zezhong Liu,Yun Zhu,Qian Wang,Lu Lu  ORCID: orcid.org/0000-0002-2255-0391 &…Shibo Jiang  ORCID: orcid.org/0000-0001-8283-7135 
https://doi.org/10.1038/s41392-020-0184-0
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BARMR1-mediated sorafenib resistance is derived through stem-like property acquisition by activating integrin-FAK signaling pathways
Xing Rong Guo,Meng Ye Shan,Yu Huang,Zong Li Zhang,Yue Yuan,Long Jun Dai,Jue Wang,Xue Peng Zhou,Fu Yun Ji,Jun Ming Tang,Zhong Ji Meng &…Xu Zhi Ruan 
https://doi.org/10.1038/s41392-020-0189-8
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HIV-1 exposure triggers autophagic degradation of stathmin and hyperstabilization of microtubules to disrupt epithelial cell junctions
Wei Xie  ORCID: orcid.org/0000-0002-3844-3013,Dengwen Li,Dan Dong,Yuanyuan Li,You Zhang,Liangwei Duan,Xinqi Liu,Wenxiang Meng,Min Liu &…Jun Zhou  ORCID: orcid.org/0000-0003-3131-7804 
https://doi.org/10.1038/s41392-020-0175-1
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Temporal profiling of plasma cytokines, chemokines and growth factors from mild, severe and fatal COVID-19 patients
Zhi-Sheng Xu,Ting Shu,Liang Kang,Di Wu,Xing Zhou,Bo-Wei Liao,Xiu-Lian Sun,Xi Zhou &…Yan-Yi Wang 
https://doi.org/10.1038/s41392-020-0211-1
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The H2BG53D oncohistone directly upregulates ANXA3 transcription and enhances cell migration in pancreatic ductal adenocarcinoma
Yi Ching Esther Wan,Jiaxian Liu,Lina Zhu,Tze Zhen Evangeline Kang,Xiaoxuan Zhu,John Lis  ORCID: orcid.org/0000-0003-1201-9406,Toyotaka Ishibashi,Charles G. Danko  ORCID: orcid.org/0000-0002-1999-7125,Xin Wang  ORCID: orcid.org/0000-0002-5122-2418 &…Kui Ming Chan  ORCID: orcid.org/0000-0001-6430-3340 
https://doi.org/10.1038/s41392-020-00219-2
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A time-resolved proteotranscriptomics atlas of the human placenta reveals pan-cancer immunomodulators
Na Ding,Botao Zhang,Wantao Ying,Jie Song,Lin Feng,Kaitai Zhang,Hongxia Li,Juan Xu,Ting Xiao &…Shujun Cheng 
https://doi.org/10.1038/s41392-020-00224-5
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PI3K activation is enhanced by FOXM1D binding to p110 and p85 subunits
Qi Wang,Pingzhao Zhang,Wei Zhang,Xin Zhang,Jianfeng Chen,Peipei Ding,Luying Li,Xinyue Lv,Ling Li &…Weiguo Hu  ORCID: orcid.org/0000-0002-7397-6800 
https://doi.org/10.1038/s41392-020-00218-3
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YL064 activates proteasomal-dependent degradation of c-Myc and synergistically enhances the anti-tumor activity of ABT-199 in diffuse large B cell lymphoma
Huizhuang Shan,Yang Cao,Xinhua Xiao,Meng Liu,Yunzhao Wu,Qi Zhu,Hanzhang Xu,Hu Lei  ORCID: orcid.org/0000-0003-3288-5205,Zhujun Yao  ORCID: orcid.org/0000-0002-6716-4232 &…Yingli Wu  ORCID: orcid.org/0000-0001-7909-8757 
https://doi.org/10.1038/s41392-020-00236-1
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Reversible acetylation modulates dishevelled-2 puncta formation in canonical Wnt signaling activation
Jinhong Shen,Lin Hu  ORCID: orcid.org/0000-0001-8986-3918,Li Yang,Mengshi Zhang,Weihong Sun  ORCID: orcid.org/0000-0002-6292-903X,Xiaomei Lu,Gufa Lin  ORCID: orcid.org/0000-0001-8097-7222,Chao Huang,Xiaoren Zhang &…Y. Eugene Chin 
https://doi.org/10.1038/s41392-020-00229-0
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HIF-1α and HDAC1 mediated regulation of FAM99A-miR92a signaling contributes to hypoxia induced HCC metastasis
Bixing Zhao  ORCID: orcid.org/0000-0002-0055-3989,Kun Ke,Yingchao Wang,Fei Wang,Yingjun Shi,Xiaoyuan Zheng,Xiaoyu Yang,Xiaolong Liu  ORCID: orcid.org/0000-0002-3096-4981 &…Jingfeng Liu 
https://doi.org/10.1038/s41392-020-00223-6
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Single cell transcriptome revealed SARS-CoV-2 entry genes enriched in colon tissues and associated with coronavirus infection and cytokine production
Haoyan Chen,Tian-Hui Zou,Baoqin Xuan,Yuqing Yan,Tingting Yan,Chaoqin Shen,Gang Zhao,Ying-Xuan Chen,Xiao Xiao,Jie Hong &…Jing-Yuan Fang  ORCID: orcid.org/0000-0003-2282-0248 
https://doi.org/10.1038/s41392-020-00237-0
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NEDD8-conjugating enzyme UBC12 as a novel therapeutic target in esophageal squamous cell carcinoma
Shiwen Wang,Jingrong Xian,Lihui Li,Yanyu Jiang,Yue Liu,Lili Cai,Robert M. Hoffman,Lijun Jia,Hu Zhao &…Yanmei Zhang 
https://doi.org/10.1038/s41392-020-00226-3
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In vivo target protein degradation induced by PROTACs based on E3 ligase DCAF15
Liang Li,Dazhao Mi,Haixiang Pei,Qiuhui Duan,Xinyue Wang,Wenbo Zhou,Jianping Jin,Dali Li  ORCID: orcid.org/0000-0002-0046-8493,Mingyao Liu &…Yihua Chen  ORCID: orcid.org/0000-0003-1733-7980 
https://doi.org/10.1038/s41392-020-00245-0
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FTO interacts with FOXO3a to enhance its transcriptional activity and inhibits aggression in gliomas
Bangbao Tao,Xuehua Huang,Juanhong Shi,Jun Liu,Shu Li,Chunyan Xu,Jun Zhong,Liang Wan,Baohui Feng &…Bin Li 
https://doi.org/10.1038/s41392-020-00234-3
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Construction of paclitaxel-based antibody–drug conjugates with a PEGylated linker to achieve superior therapeutic index
Ting Shao,Tianzhi Chen,Yuning Chen,Xiaoyue Liu,Yi-Li Chen,Qi Wang,Tong Zhu,Maojun Guo,Hui Li,Dianwen Ju &…Chunhe Wang 
https://doi.org/10.1038/s41392-020-00247-y
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Crystal structure of SARS-CoV-2 nsp10/nsp16 2′-O-methylase and its implication on antiviral drug design
Sheng Lin,Hua Chen,Fei Ye,Zimin Chen,Fanli Yang,Yue Zheng,Yu Cao,Jingxin Qiao,Shengyong Yang &…Guangwen Lu 
https://doi.org/10.1038/s41392-020-00241-4
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Resistomycin attenuates triple-negative breast cancer progression by inhibiting E3 ligase Pellino-1 and inducing SNAIL/SLUG degradation
Shan-shan Liu,Jie Qi,Zu-dong Teng,Fu-tao Tian,Xiao-xi Lv,Ke Li,Ya-jie Song,Wei-dong Xie,Zhuo-wei Hu  ORCID: orcid.org/0000-0001-8559-9371 &…Xia Li 
https://doi.org/10.1038/s41392-020-00255-y
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Cryo-EM structure of activated bile acids receptor TGR5 in complex with stimulatory G protein
Geng Chen,Xiankun Wang,Yunjun Ge,Ling Ma,Qiang Chen,Huihui Liu  ORCID: orcid.org/0000-0003-3181-8289,Yang Du  ORCID: orcid.org/0000-0001-8107-6397,Richard D. Ye,Hongli Hu  ORCID: orcid.org/0000-0003-3658-272X &…Ruobing Ren  ORCID: orcid.org/0000-0003-4517-7216 
https://doi.org/10.1038/s41392-020-00262-z
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First-in-human pilot study of an integrin α6-targeted radiotracer for SPECT imaging of breast cancer
Shi Gao,Bing Jia,Guokai Feng,Chengyan Dong,Hui Du,Lin Bai,Qian Zhong,Qingjie Ma,Musheng Zeng &…Fan Wang 
https://doi.org/10.1038/s41392-020-00266-9
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Regulation of BMP2K in AP2M1-mediated EGFR internalization during the development of gallbladder cancer
Xiaoling Song,Maolan Li,Wenguang Wu,Wei Dang,Yuan Gao,Rui Bian,Runfa Bao,Yunping Hu,Defei Hong,Jun Gu &…Yingbin Liu  ORCID: orcid.org/0000-0001-6110-0185 
https://doi.org/10.1038/s41392-020-00250-3
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Identification of a hotspot on PD-L1 for pH-dependent binding by monoclonal antibodies for tumor therapy
Hongchuan Liu,Xiaoshan Bi,Yuehua Zhou,Rui Shi,Sheng Yao,Jianxun Qi,Hui Feng,Meiqing Feng,Jinghua Yan &…Shuguang Tan 
https://doi.org/10.1038/s41392-020-00254-z
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GSDME enhances Cisplatin sensitivity to regress non-small cell lung carcinoma by mediating pyroptosis to trigger antitumor immunocyte infiltration
Zhouyangfan Peng,Pengfei Wang,Wei Song,Qingmei Yao,Yinjia Li,Linglong Liu,Yapei Li &…Sufang Zhou 
https://doi.org/10.1038/s41392-020-00274-9
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TIPE-mediated up-regulation of MMP-9 promotes colorectal cancer invasion and metastasis through MKK-3/p38/NF-κB pro-oncogenic signaling pathway
Huiyu Chen,Yuhan Ye,Yan Yang,Mengya Zhong,Lei Gu,Zhaopu Han,Jinhua Qiu,Zhongchen Liu,Xingfeng Qiu &…Guohong Zhuang 
https://doi.org/10.1038/s41392-020-00276-7
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TCP1 regulates Wnt7b/β-catenin pathway through P53 to influence the proliferation and migration of hepatocellular carcinoma cells
Nanhong Tang,Xiaoling Cai,Lirong Peng,Hekun Liu &…Yuanzhong Chen 
https://doi.org/10.1038/s41392-020-00278-5
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JMJD3 promotes esophageal squamous cell carcinoma pathogenesis through epigenetic regulation of MYC
Shu-Man Li,Li-Ru He,Jie-Wei Chen,Jie Zhou,Run-Cong Nie,Xiao-Han Jin,Xin Wang,Jian-Hua Fu,Feng-Wei Wang &…Dan Xie  ORCID: orcid.org/0000-0003-2242-3138 
https://doi.org/10.1038/s41392-020-00282-9
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miR-24-3p promotes colon cancer progression by targeting ING1
Zhiying Gao,Likun Zhou,Shiyu Hua,Huan Wu,Laizhi Luo,Libo Li,Shuping Wang,Yanqing Liu,Zhen Zhou &…Xi Chen 
https://doi.org/10.1038/s41392-020-0206-y
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PD-1 abrogates the prolonged persistence of CD8+ CAR-T cells with 4-1BB co-stimulation
Feng Li  ORCID: orcid.org/0000-0002-3895-0437,Zhen Zhang,Yujing Xuan,Daiqun Zhang,Jinyan Liu,Aitian Li,Shumin Wang,Ting Li,Xiaojuan Shi &…Yi Zhang  ORCID: orcid.org/0000-0001-9861-4681 
https://doi.org/10.1038/s41392-020-00277-6
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Trifolirhizin induces autophagy-dependent apoptosis in colon cancer via AMPK/mTOR signaling
Dongdong Sun,Weiwei Tao,Feng Zhang,Weixing Shen,Jiani Tan,Liu Li,Qinghai Meng,Yugen Chen,Ye Yang &…Haibo Cheng 
https://doi.org/10.1038/s41392-020-00281-w
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Bexarotene combined with lapatinib for the treatment of Cushing’s disease: evidence based on drug repositioning and experimental confirmation
Haoying Yu,Shuyue Ren,Jingrong Wang,Tingting Lv,Lan Sun  ORCID: orcid.org/0000-0003-2931-5172 &…Guanhua Du 
https://doi.org/10.1038/s41392-020-00284-7
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Achyranthes bidentata polysaccharide can safely prevent NSCLC metastasis via targeting EGFR and EMT
Chunlian Zhong,Jingyi Yang,Yusheng Lu,Huanzhang Xie,Shengyi Zhai,Chen Zhang,Zhiying Luo,Xuanchen Chen,Xuanmo Fang &…Lee Jia  ORCID: orcid.org/0000-0001-6839-5545 
https://doi.org/10.1038/s41392-020-00289-2
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Immune characteristics of severe and critical COVID-19 patients
Li Yang,Jianjun Gou,Jianbo Gao,Lan Huang,Zhiqiang Zhu,Shaofei Ji,Hongchun Liu,Lihua Xing,Mengying Yao &…Yi Zhang  ORCID: orcid.org/0000-0001-9861-4681 
https://doi.org/10.1038/s41392-020-00296-3
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Review Article
The mechanisms of sorafenib resistance in hepatocellular carcinoma: theoretical basis and therapeutic aspects
Weiwei Tang,Ziyi Chen,Wenling Zhang,Ye Cheng,Betty Zhang,Fan Wu,Qian Wang  ORCID: orcid.org/0000-0003-1828-434X,Shouju Wang,Dawei Rong,F. P. Reiter,E. N. De Toni &…Xuehao Wang 
https://doi.org/10.1038/s41392-020-0187-x
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Regulating tumor suppressor genes: post-translational modifications
Ling Chen,Shuang Liu &Yongguang Tao  ORCID: orcid.org/0000-0003-2354-5321 
https://doi.org/10.1038/s41392-020-0196-9
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Overview of lethal human coronaviruses
Bin Chen,Er-Kang Tian,Bin He,Lejin Tian,Ruiying Han,Shuangwen Wang,Qianrong Xiang,Shu Zhang,Toufic El Arnaout &…Wei Cheng 
https://doi.org/10.1038/s41392-020-0190-2
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The interactions between cGAS-STING pathway and pathogens
Zhangliang Cheng,Tong Dai,Xuelin He,Zhengkui Zhang,Feng Xie,Shuai Wang,Long Zhang  ORCID: orcid.org/0000-0001-8139-0474 &…Fangfang Zhou 
https://doi.org/10.1038/s41392-020-0198-7
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Tumor-induced neurogenesis and immune evasion as targets of innovative anti-cancer therapies
Rodolfo Daniel Cervantes-Villagrana  ORCID: orcid.org/0000-0002-6599-7994,Damaris Albores-García,Alberto Rafael Cervantes-Villagrana &…Sara Judit García-Acevez 
https://doi.org/10.1038/s41392-020-0205-z
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Noncoding RNAs: the shot callers in tumor immune escape
Lei Liu,Qin Wang,Zhilin Qiu,Yujuan Kang,Jiena Liu,Shipeng Ning,Yanling Yin,Da Pang  ORCID: orcid.org/0000-0003-2853-4170 &…Shouping Xu 
https://doi.org/10.1038/s41392-020-0194-y
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Therapeutic siRNA: state of the art
Bo Hu,Liping Zhong,Yuhua Weng,Ling Peng,Yuanyu Huang  ORCID: orcid.org/0000-0003-3935-7245,Yongxiang Zhao &…Xing-Jie Liang 
https://doi.org/10.1038/s41392-020-0207-x
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Action mechanisms and research methods of tRNA-derived small RNAs
Yaoyao Xie,Lipeng Yao,Xiuchong Yu,Yao Ruan,Zhe Li &…Junming Guo  ORCID: orcid.org/0000-0003-2026-1075 
https://doi.org/10.1038/s41392-020-00217-4
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Centrosome dysfunction: a link between senescence and tumor immunity
Qi Wu  ORCID: orcid.org/0000-0001-6182-5274,Bei Li,Le Liu,Shengrong Sun &…Si Sun 
https://doi.org/10.1038/s41392-020-00214-7
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The interaction between ferroptosis and lipid metabolism in cancer
Dingshan Li &Yongsheng Li 
https://doi.org/10.1038/s41392-020-00216-5
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Overcoming cancer therapeutic bottleneck by drug repurposing
Zhe Zhang,Li Zhou,Na Xie,Edouard C. Nice,Tao Zhang,Yongping Cui &…Canhua Huang 
https://doi.org/10.1038/s41392-020-00213-8
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Regulation of cancer cell metabolism: oncogenic MYC in the driver’s seat
Yang Dong,Rongfu Tu,Hudan Liu  ORCID: orcid.org/0000-0003-1362-6048 &…Guoliang Qing 
https://doi.org/10.1038/s41392-020-00235-2
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Stress proteins: the biological functions in virus infection, present and challenges for target-based antiviral drug development
Qianya Wan,Dan Song,Huangcan Li &…Ming-liang He 
https://doi.org/10.1038/s41392-020-00233-4
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COVID-19: immunopathogenesis and Immunotherapeutics
Li Yang,Shasha Liu,Jinyan Liu,Zhixin Zhang,Xiaochun Wan,Bo Huang,Youhai Chen &…Yi Zhang  ORCID: orcid.org/0000-0001-9861-4681 
https://doi.org/10.1038/s41392-020-00243-2
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Functional characterization of SOX2 as an anticancer target
Shizhen Zhang,Xiufang Xiong &Yi Sun  ORCID: orcid.org/0000-0002-5841-4287 
https://doi.org/10.1038/s41392-020-00242-3
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Targeted therapies in gynecological cancers: a comprehensive review of clinical evidence
Qiao Wang,Hongling Peng,Xiaorong Qi,Min Wu &…Xia Zhao 
https://doi.org/10.1038/s41392-020-0199-6
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The role of histone methylation in the development of digestive cancers: a potential direction for cancer management
Yuan Chen,Bo Ren,Jinshou Yang  ORCID: orcid.org/0000-0003-1403-305X,Huanyu Wang,Gang Yang,Ruiyuan Xu,Lei You  ORCID: orcid.org/0000-0001-6030-6560 &…Yupei Zhao 
https://doi.org/10.1038/s41392-020-00252-1
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Application of exosomes as liquid biopsy in clinical diagnosis
Biting Zhou  ORCID: orcid.org/0000-0001-5369-0891,Kailun Xu  ORCID: orcid.org/0000-0002-8458-3551,Xi Zheng  ORCID: orcid.org/0000-0001-8505-3061,Ting Chen,Jian Wang,Yongmao Song,Yingkuan Shao  ORCID: orcid.org/0000-0001-9683-5691 &…Shu Zheng  ORCID: orcid.org/0000-0002-2521-190X 
https://doi.org/10.1038/s41392-020-00258-9
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Exosomes: key players in cancer and potential therapeutic strategy
Jie Dai,Yangzhou Su,Suye Zhong,Li Cong,Bang Liu,Junjun Yang,Yongguang Tao  ORCID: orcid.org/0000-0003-2354-5321,Zuping He,Chao Chen &…Yiqun Jiang 
https://doi.org/10.1038/s41392-020-00261-0
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Targeted therapy for hepatocellular carcinoma
Ao Huang,Xin-Rong Yang,Wen-Yuan Chung,Ashley R. Dennison &…Jian Zhou 
https://doi.org/10.1038/s41392-020-00264-x
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CD146, from a melanoma cell adhesion molecule to a signaling receptor
Zhaoqing Wang,Qingji Xu,Nengwei Zhang,Xuemei Du,Guangzhong Xu &…Xiyun Yan 
https://doi.org/10.1038/s41392-020-00259-8
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The potent roles of salt-inducible kinases (SIKs) in metabolic homeostasis and tumorigenesis
Zicheng Sun,Qiwei Jiang,Jie Li &…Jianping Guo 
https://doi.org/10.1038/s41392-020-00265-w
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The updated landscape of tumor microenvironment and drug repurposing
Ming-Zhu Jin &Wei-Lin Jin  ORCID: orcid.org/0000-0001-8011-2405 
https://doi.org/10.1038/s41392-020-00280-x
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Perspective
The model of cytokine release syndrome in CAR T-cell treatment for B-cell non-Hodgkin lymphoma
Jianshu Wei,Yang Liu,Chunmeng Wang,Yajing Zhang,Chuan Tong,Guanghai Dai,Wei Wang  ORCID: orcid.org/0000-0001-7788-1895,John E. J. Rasko  ORCID: orcid.org/0000-0003-3181-7198,J. Joseph Melenhorst,Wenbin Qian  ORCID: orcid.org/0000-0002-9817-6674,Aibin Liang &…Weidong Han  ORCID: orcid.org/0000-0003-3207-3899 
https://doi.org/10.1038/s41392-020-00256-x
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