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Volume 5 Issue 2, Jun 2020

Article
A novel silicone derivative of natural osalmid (DCZ0858) induces apoptosis and cell cycle arrest in diffuse large B-cell lymphoma via the JAK2/STAT3 pathway
Kang Lu,Bo Li,Hui Zhang,Zhijian Xu,Dongliang Song,Lu Gao,Haiguo Sun,Liping Li,Yingcong Wang,Qilin Feng,Gege Chen,Liangning Hu,Rong Wei,Yongsheng Xie,Dandan Yu,Xiaosong Wu,Weiliang Zhu &…Jumei Shi 
https://doi.org/10.1038/s41392-020-0123-0
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C3G contributes to platelet activation and aggregation by regulating major signaling pathways
Sara Gutiérrez-Herrero,Cristina Fernández-Infante,Luis Hernández-Cano,Sara Ortiz-Rivero,Carlos Guijas,Víctor Martín-Granado,José Ramón González-Porras,Jesús Balsinde,Almudena Porras &…Carmen Guerrero 
https://doi.org/10.1038/s41392-020-0119-9
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High salt diet accelerates the progression of murine lupus through dendritic cells via the p38 MAPK and STAT1 signaling pathways
Ze Xiu Xiao,Xiaojiang Hu,Ximei Zhang,Zhigang Chen,Julie Wang,Ke Jin,Feng Lin Cao,Baoqing Sun,Joseph A. Bellanti,Nancy Olsen &…Song Guo Zheng 
https://doi.org/10.1038/s41392-020-0139-5
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The Ap-2α/Elk-1 axis regulates Sirpα-dependent tumor phagocytosis by tumor-associated macrophages in colorectal cancer
Xiaojiao Wang,Xi Luo,Chuan Chen,Ye Tang,Lian Li,Banghui Mo,Houjie Liang &…Songtao Yu 
https://doi.org/10.1038/s41392-020-0124-z
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WIP1 promotes cancer stem cell properties by inhibiting p38 MAPK in NSCLC
Kaiyuan Deng,Liang Liu,Xiaoming Tan,Zhen Zhang,Jianjun Li,Yang Ou,Xin Wang,Shuang Yang,Rong Xiang &…Peiqing Sun 
https://doi.org/10.1038/s41392-020-0126-x
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PD-L1 is a direct target of cancer-FOXP3 in pancreatic ductal adenocarcinoma (PDAC), and combined immunotherapy with antibodies against PD-L1 and CCL5 is effective in the treatment of PDAC
Xiuchao Wang,Xin Li,Xunbin Wei,Haiping Jiang,Chungen Lan,Shengyu Yang,Han Wang,Yanhui Yang,Caijuan Tian,Zanmei Xu,Jiangyan Zhang,Jihui Hao &…He Ren 
https://doi.org/10.1038/s41392-020-0144-8
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Pleiotropic tumor suppressor functions of WWOX antagonize metastasis
Saleh Khawaled,Giovanni Nigita  ORCID: orcid.org/0000-0001-8880-4334,Rosario Distefano  ORCID: orcid.org/0000-0001-7241-7751,Sara Oster,Sung-Suk Suh,Yoav Smith,Abed Khalaileh,Yong Peng  ORCID: orcid.org/0000-0002-1181-3467,Carlo M. Croce,Tamar Geiger,Victoria L. Seewaldt &…Rami I. Aqeilan  ORCID: orcid.org/0000-0002-6034-023X 
https://doi.org/10.1038/s41392-020-0136-8
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NUSAP1 potentiates chemoresistance in glioblastoma through its SAP domain to stabilize ATR
Yuzu Zhao,Jiang He,Yongsen Li,Shengqing Lv &…Hongjuan Cui 
https://doi.org/10.1038/s41392-020-0137-7
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Exosomes with low miR-34c-3p expression promote invasion and migration of non-small cell lung cancer by upregulating integrin α2β1
Wenjing Huang,Yanyan Yan,Yun Liu,Minting Lin,Jinxiang Ma,Wei Zhang,Jianwei Dai,Jiajun Li,Qiaoru Guo,Hubiao Chen,Bolat Makabel,Hong Liu,Chaoyue Su,Hong Bi &…Jianye Zhang  ORCID: orcid.org/0000-0001-5242-3687 
https://doi.org/10.1038/s41392-020-0133-y
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Enhancing the antitumor activity of an engineered TRAIL-coated oncolytic adenovirus for treating acute myeloid leukemia
Zixuan Wang,Wenmo Liu,Lizheng Wang,Peng Gao,Zhe Li,Jiaxin Wu,Haihong Zhang,Hui Wu,Wei Kong,Bin Yu &…Xianghui Yu 
https://doi.org/10.1038/s41392-020-0135-9
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The CRL3BTBD9 E3 ubiquitin ligase complex targets TNFAIP1 for degradation to suppress cancer cell migration
Lihui Li,Wenjuan Zhang,Yue Liu,Xiaojun Liu,Lili Cai,Jihui Kang,Yunjing Zhang,Wenlian Chen,Changsheng Dong,Yanmei Zhang,Mingsong Wang,Wenyi Wei  ORCID: orcid.org/0000-0003-0512-3811 &…Lijun Jia 
https://doi.org/10.1038/s41392-020-0140-z
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A novel role of LRP5 in tubulointerstitial fibrosis through activating TGF-β/Smad signaling
Xuemin He,Rui Cheng,Chao Huang,Yusuke Takahashi,Yanhui Yang,Siribhinya Benyajati,Yanming Chen,Xin A. Zhang &…Jian-xing Ma 
https://doi.org/10.1038/s41392-020-0142-x
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Breast cancer-derived exosomes transmit lncRNA SNHG16 to induce CD73+γδ1 Treg cells
Chao Ni,Qing-Qing Fang,Wu-Zhen Chen,Jin-Xing Jiang,Zhou Jiang,Jun Ye,Ting Zhang,Liu Yang,Fan-Bo Meng,Wen-Jie Xia,Miaochun Zhong &…Jian Huang 
https://doi.org/10.1038/s41392-020-0129-7
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Bcl-3 promotes Wnt signaling by maintaining the acetylation of β-catenin at lysine 49 in colorectal cancer
Xi Chen,Chen Wang,Yuhang Jiang,Qi Wang,Yu Tao,Haohao Zhang,Yongxu Zhao,Yiming Hu,Cuifeng Li,Deji Ye,Dandan Liu,Wenxia Jiang,Eugene Y. Chin,Sheng Chen,Yongzhong Liu,Mingliang Wang,Sanhong Liu &…Xiaoren Zhang 
https://doi.org/10.1038/s41392-020-0138-6
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MCU-induced mitochondrial calcium uptake promotes mitochondrial biogenesis and colorectal cancer growth
Yang Liu,Mingpeng Jin,Yaya Wang,Jianjun Zhu,Rui Tan,Jing Zhao,Xiaoying Ji,Chao Jin,Yongfeng Jia,Tingting Ren &…Jinliang Xing 
https://doi.org/10.1038/s41392-020-0155-5
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Erianin, a novel dibenzyl compound in Dendrobium extract, inhibits lung cancer cell growth and migration via calcium/calmodulin-dependent ferroptosis
Peng Chen,Qibiao Wu,Jiao Feng,Lili Yan,Yitian Sun,Shuiping Liu,Yu Xiang,Mingming Zhang,Ting Pan,Xiaying Chen,Ting Duan,Lijuan Zhai,Bingtao Zhai,Wengang Wang,Ruonan Zhang,Bi Chen,Xuemeng Han,Yicong Li,Liuxi Chen,Ying Liu,Xingxing Huang,Ting Jin,Wenzheng Zhang,Hong Luo,Xiaohui Chen,Yongqiang Li,Qiujie Li,Guohua Li,Qin Zhang,Lvjia Zhuo,Zuyi Yang,Huifen Tang,Tian Xie,Xiaoping Ouyang &…Xinbing Sui 
https://doi.org/10.1038/s41392-020-0149-3
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Insulin-like growth factor 1-induced enolase 2 deacetylation by HDAC3 promotes metastasis of pancreatic cancer
Yan Zheng,Chao Wu,Jimeng Yang,Yue Zhao,Huliang Jia,Min Xue,Da Xu,Feng Yang,Deliang Fu,Chaoqun Wang,Beiyuan Hu,Ze Zhang,Tianen Li,Shican Yan,Xuan Wang,Peter J. Nelson,Christiane Bruns,Lunxiu Qin &…Qiongzhu Dong  ORCID: orcid.org/0000-0002-2433-7199 
https://doi.org/10.1038/s41392-020-0146-6
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Drp1-dependent remodeling of mitochondrial morphology triggered by EBV-LMP1 increases cisplatin resistance
Longlong Xie,Feng Shi,Yueshuo Li,We Li,Xinfang Yu,Lin Zhao,Min Zhou,Jianmin Hu,Xiangjian Luo,Min Tang,Jia Fan,Jian Zhou,Qiang Gao,Weizhong Wu,Xin Zhang,Weihua Liao,Ann M. Bode &…Ya Cao 
https://doi.org/10.1038/s41392-020-0151-9
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Hypoxia-induced GBE1 expression promotes tumor progression through metabolic reprogramming in lung adenocarcinoma
Lifeng Li,Li Yang,Zhirui Fan,Wenhua Xue,Zhibo Shen,Yongliang Yuan,Xiangdong Sun,Dan Wang,Jingyao Lian,Liping Wang,Jie Zhao &…Yi Zhang 
https://doi.org/10.1038/s41392-020-0152-8
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p190A inactivating mutations cause aberrant RhoA activation and promote malignant transformation via the Hippo-YAP pathway in endometrial cancer
Xiaoli Wen,Jing Wan,Qizhi He,Mengfei Wang,Shuangdi Li,Mei Jiang,Zhen Qian,Binya Liu,Wen Lu,Kai Wang,Kun Gao &…Xiaoping Wan 
https://doi.org/10.1038/s41392-020-0170-6
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Identification and characterization of mammaglobin-A epitope in heterogenous breast cancers for enhancing tumor-targeting therapy
Zhiqiang Liu,Xiqin Yang,Cuimi Duan,Jiangxue Li,Rongsheng Tong,Yuting Fan,Jiannan Feng,Ruiyuan Cao,Wu Zhong,Xiaoyan Feng,Heqiu Zhang &…Lulu Cai 
https://doi.org/10.1038/s41392-020-0183-1
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Acetylation promotes BCAT2 degradation to suppress BCAA catabolism and pancreatic cancer growth
Ming-Zhu Lei,Xu-Xu Li,Ye Zhang,Jin-Tao Li,Fan Zhang,Yi-Ping Wang,Miao Yin,Jia Qu &…Qun-Ying Lei  ORCID: orcid.org/0000-0002-8547-8518 
https://doi.org/10.1038/s41392-020-0168-0
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Letter
Inhibition of USP14 and UCH37 deubiquitinating activity by b-AP15 as a potential therapy for tumors with p53 deficiency
Yu-Shui Ma,Xiao-Feng Wang,Fei Yu,Ting-Miao Wu,Ji-Bin Liu,Yun-Jie Zhang,Qing Xia,Zong-Yuan Jiang,Qin-Lu Lin &…Da Fu 
https://doi.org/10.1038/s41392-020-0143-9
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Adiponectin exacerbates influenza infection in elderly individuals via IL-18
Youzhu Jiang,Changhua Yi,Yongxiang Yi,Qingwen Jin,Angray S. Kang  ORCID: orcid.org/0000-0002-4672-4114,Junwei Li &…Pradeep Kumar Sacitharan 
https://doi.org/10.1038/s41392-020-0141-y
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The HIF-1A/miR-17-5p/PDCD4 axis contributes to the tumor growth and metastasis of gastric cancer
Jiayu Zhao,Anqi Xiao,Chunyu Liu,Chao Ye,Kai Yin,Minghon Lu,Ruihua Jiao,Xi Chen,Chenyu Zhang &…Minghui Liu 
https://doi.org/10.1038/s41392-020-0132-z
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Overexpression of PSAT1 regulated by G9A sustains cell proliferation in colorectal cancer
Huijuan Wang  ORCID: orcid.org/0000-0002-8113-3774,Longzhen Cui,Dandan Li,Ming Fan,Zhangnan Liu,Chunqi Liu,Sijing Pan,Lei Zhang,Hailong Zhang &…Yinglan Zhao 
https://doi.org/10.1038/s41392-020-0147-5
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A retrospective cohort study of methylprednisolone therapy in severe patients with COVID-19 pneumonia
Yin Wang,Weiwei Jiang,Qi He,Cheng Wang,Baoju Wang,Pan Zhou,Nianguo Dong &…Qiaoxia Tong 
https://doi.org/10.1038/s41392-020-0158-2
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Immune dysfunction leads to mortality and organ injury in patients with COVID-19 in China: insights from ERS-COVID-19 study
Dongze Li  ORCID: orcid.org/0000-0002-7548-7007,You Chen,Hong Liu,Yu Jia,Fanghui Li,Wei Wang,Jiang Wu,Zhi Wan,Yu Cao &…Rui Zeng 
https://doi.org/10.1038/s41392-020-0163-5
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Therapeutic efficacy of Pudilan Xiaoyan Oral Liquid (PDL) for COVID-19 in vitro and in vivo
Wei Deng,Yanfeng Xu,Qi Kong,Jing Xue,Pin Yu,Jiangning Liu,Qi Lv,Fengdi Li,Qiang Wei &…Linlin Bao 
https://doi.org/10.1038/s41392-020-0176-0
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Use of copper-cysteamine nanoparticles to simultaneously enable radiotherapy, oxidative therapy and immunotherapy for melanoma treatment
Qi Zhang,Xiangdong Guo,Yingnan Cheng,Lalit Chudal,Nil Kanatha Pandey,Jieyou Zhang,Lun Ma,Qing Xi,Guangze Yang,Ying Chen,Xin Ran,Chengzhi Wang,Jingyi Zhao,Yan Li,Li Liu,Zhi Yao,Wei Chen,Yuping Ran &…Rongxin Zhang 
https://doi.org/10.1038/s41392-020-0156-4
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Na+/K+-ATPase-dependent autophagy protects brain against ischemic injury
Mengyuan Zhu  ORCID: orcid.org/0000-0001-6047-8557,Lei Cao,Siping Xiong,Haijian Sun,Zhiyuan Wu &…Jin-Song Bian  ORCID: orcid.org/0000-0002-7741-598X 
https://doi.org/10.1038/s41392-020-0153-7
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Biomolecular network-based synergistic drug combination discovery: a combination of paeoniflorin and liquiritin alleviates neuropathic pain by inhibiting neuroinflammation via suppressing the chemokine signaling pathway
Qiuyan Guo,Weijie Li,Chao Wang,Xia Mao,Xiaoyue Wang,Wenjia Chen,Haiyu Xu,Qian Wang,Yanqiong Zhang  ORCID: orcid.org/0000-0002-9358-111X &…Na Lin 
https://doi.org/10.1038/s41392-020-0160-8
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Progression of malignant pleural effusion during the early stage of gefitinib treatment in advanced EGFR-mutant lung adenocarcinoma involving complex driver gene mutations
Ning Liu,Min Yu,Tao Yin,Yong Jiang,Xuelian Liao,Jie Tang,Yanying Li,Diyuan Qin,Dan Li &…Yongsheng Wang 
https://doi.org/10.1038/s41392-020-0161-7
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Loss of tyrosine phosphatase SHP2 activity promotes growth of colorectal carcinoma HCT-116 cells
Xin Chen,Xueqi Fu,Wanke Zhao,Wan-Ting Tina Ho,Shu Xing  ORCID: orcid.org/0000-0001-5449-4497 &…Zhizhuang Joe Zhao  ORCID: orcid.org/0000-0003-4323-4301 
https://doi.org/10.1038/s41392-020-0192-0
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Research Highlight
NLRP3 inflammasome as a novel therapeutic target for Alzheimer’s disease
Yun Zhang,Zhifang Dong &Weihong Song  ORCID: orcid.org/0000-0001-9928-889X 
https://doi.org/10.1038/s41392-020-0145-7
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Human herpesvirus 4 and adaptive immunity in Alzheimer’s disease
Jian-Sheng Kang  ORCID: orcid.org/0000-0002-2603-9718 &Pei-Pei Liu 
https://doi.org/10.1038/s41392-020-0125-y
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Protecting against different subtypes of influenza viruses: a nanoparticle approach
Changhua Yi,Yongxiang Yi,Junwei Li &…Pradeep Kumar Sacitharan 
https://doi.org/10.1038/s41392-020-0157-3
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Igniting autophagy through the regulation of phase separation
Shouheng Jin  ORCID: orcid.org/0000-0002-2728-2859 &Jun Cui 
https://doi.org/10.1038/s41392-020-0154-6
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Liquid phase condensation directs nucleosome epigenetic modifications
Yi Yang &Chuanhe Yu 
https://doi.org/10.1038/s41392-020-0166-2
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Designing of improved drugs for COVID-19: Crystal structure of SARS-CoV-2 main protease Mpro
Hylemariam Mihiretie Mengist  ORCID: orcid.org/0000-0002-8467-6985,Xiaojiao Fan &Tengchuan Jin  ORCID: orcid.org/0000-0002-1395-188X 
https://doi.org/10.1038/s41392-020-0178-y
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Targeting the premetastatic niche: epigenetic therapies in the spotlight
Vivien Low,John Blenis &Ana P. Gomes 
https://doi.org/10.1038/s41392-020-0165-3
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Gasdermin: a novel therapeutic target for tumour treatment by activating anti-tumour immunity
Caiyun Fu 
https://doi.org/10.1038/s41392-020-0180-4
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A suspicious role of interferon in the pathogenesis of SARS-CoV-2 by enhancing expression of ACE2
Shan Su  ORCID: orcid.org/0000-0003-0593-9968 &Shibo Jiang  ORCID: orcid.org/0000-0001-8283-7135 
https://doi.org/10.1038/s41392-020-0185-z
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Review Article
DNA damage response signaling pathways and targets for radiotherapy sensitization in cancer
Rui-Xue Huang &Ping-Kun Zhou  ORCID: orcid.org/0000-0001-7666-1209 
https://doi.org/10.1038/s41392-020-0150-x
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Target identification of natural medicine with chemical proteomics approach: probe synthesis, target fishing and protein identification
Xiao Chen,Yutong Wang,Nan Ma,Jing Tian,Yurou Shao,Bo Zhu,Yin Kwan Wong,Zhen Liang,Chang Zou &…Jigang Wang 
https://doi.org/10.1038/s41392-020-0186-y
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Immune response in COVID-19: addressing a pharmacological challenge by targeting pathways triggered by SARS-CoV-2
Michele Catanzaro,Francesca Fagiani,Marco Racchi,Emanuela Corsini,Stefano Govoni  ORCID: orcid.org/0000-0002-7243-6837 &…Cristina Lanni  ORCID: orcid.org/0000-0002-3061-4738 
https://doi.org/10.1038/s41392-020-0191-1
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Editorial
Novel targeted drugs approved by the NMPA and FDA in 2019
Wenjing Wang &Qiu Sun 
https://doi.org/10.1038/s41392-020-0164-4
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