Table of Contents
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Volume 5 Issue 1, Mar 2020

Review Article
Applications of genome editing technology in the targeted therapy of human diseases: mechanisms, advances and prospects
Hongyi Li,Yang Yang,Weiqi Hong,Mengyuan Huang,Min Wu &…Xia Zhao 
https://doi.org/10.1038/s41392-019-0089-y
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PIM kinase inhibition: co-targeted therapeutic approaches in prostate cancer
Sabina Luszczak,Christopher Kumar,Vignesh Krishna Sathyadevan,Benjamin S. Simpson  ORCID: orcid.org/0000-0003-3685-6110,Kathy A. Gately,Hayley C. Whitaker &…Susan Heavey  ORCID: orcid.org/0000-0002-2974-4578 
https://doi.org/10.1038/s41392-020-0109-y
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Targeting cancer stem cell pathways for cancer therapy
Liqun Yang,Pengfei Shi,Gaichao Zhao,Jie Xu,Wen Peng,Jiayi Zhang,Guanghui Zhang,Xiaowen Wang,Zhen Dong,Fei Chen &…Hongjuan Cui 
https://doi.org/10.1038/s41392-020-0110-5
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Potential targeted therapy and diagnosis based on novel insight into growth factors, receptors, and downstream effectors in acute kidney injury and acute kidney injury-chronic kidney disease progression
Li Gao,Xiang Zhong,Juan Jin,Jun Li &…Xiao-ming Meng  ORCID: orcid.org/0000-0002-1166-561X 
https://doi.org/10.1038/s41392-020-0106-1
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The role of ubiquitination in tumorigenesis and targeted drug discovery
Lu Deng,Tong Meng,Lei Chen,Wenyi Wei  ORCID: orcid.org/0000-0003-0512-3811 &…Ping Wang 
https://doi.org/10.1038/s41392-020-0107-0
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Advances in targeted therapy for malignant lymphoma
Li Wang,Wei Qin,Yu-Jia Huo,Xiao Li,Qing Shi  ORCID: orcid.org/0000-0003-1934-0833,John E. J. Rasko  ORCID: orcid.org/0000-0003-3181-7198,Anne Janin &…Wei-Li Zhao 
https://doi.org/10.1038/s41392-020-0113-2
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Molecular principles of metastasis: a hallmark of cancer revisited
Jawad Fares  ORCID: orcid.org/0000-0002-5368-8764,Mohamad Y. Fares,Hussein H. Khachfe,Hamza A. Salhab &…Youssef Fares 
https://doi.org/10.1038/s41392-020-0134-x
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Comprehensive review of targeted therapy for colorectal cancer
Yuan-Hong Xie,Ying-Xuan Chen &Jing-Yuan Fang 
https://doi.org/10.1038/s41392-020-0116-z
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Letter
Use of a 6-miRNA panel to distinguish lymphoma from reactive lymphoid hyperplasia
Juanjuan Kang,Sisi Yu,Song Lu,Guohui Xu,Jiang Zhu,Na Yan,Delun Luo,Kai Xu,Zhihui Zhang &…Jian Huang  ORCID: orcid.org/0000-0003-3282-8892 
https://doi.org/10.1038/s41392-019-0097-y
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Role of the PPAR pathway in atrial fibrillation associated with heart valve disease: transcriptomics and proteomics in human atrial tissue
Huan-Xin Chen,Ming-Yang Li,Yi-Yao Jiang,Hai-Tao Hou,Jun Wang,Xiao-Cheng Liu,Qin Yang &…Guo-Wei He 
https://doi.org/10.1038/s41392-019-0093-2
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Potential benefits of precise corticosteroids therapy for severe 2019-nCoV pneumonia
Wei Zhou,Yisi Liu,Dongdong Tian,Cheng Wang,Sa Wang,Jing Cheng,Ming Hu,Minghao Fang &…Yue Gao 
https://doi.org/10.1038/s41392-020-0127-9
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Cancer-associated histone mutation H2BG53D disrupts DNA–histone octamer interaction and promotes oncogenic phenotypes
Yi Ching Esther Wan,Tsz Chui Sophia Leung,Dongbo Ding,Xulun Sun,Jiaxian Liu,Lina Zhu,Tze Zhen Evangeline Kang,Du Yang,Yuchen Zhang,Jitian Zhang,Chengmin Qian,Michael Shing Yan Huen,Qing Li  ORCID: orcid.org/0000-0003-0251-9159,Maggie Zi Ying Chow,Zongli Zheng,Junhong Han,Ajay Goel  ORCID: orcid.org/0000-0003-1396-6341,Xin Wang  ORCID: orcid.org/0000-0002-5122-2418,Toyotaka Ishibashi &…Kui Ming Chan  ORCID: orcid.org/0000-0001-6430-3340 
https://doi.org/10.1038/s41392-020-0131-0
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The identification of a CD47-blocking “hotspot” and design of a CD47/PD-L1 dual-specific antibody with limited hemagglutination
Rui Shi  ORCID: orcid.org/0000-0001-8469-8730,Yan Chai,Xiaomin Duan,Xiaoshan Bi,Qingrui Huang,Qihui Wang,Shuguang Tan,George F. Gao,Jianhua Zhu &…Jinghua Yan 
https://doi.org/10.1038/s41392-020-0121-2
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Lymphopenia predicts disease severity of COVID-19: a descriptive and predictive study
Li Tan,Qi Wang,Duanyang Zhang,Jinya Ding,Qianchuan Huang,Yi-Quan Tang,Qiongshu Wang &…Hongming Miao 
https://doi.org/10.1038/s41392-020-0148-4
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Article
DNA methylation markers in the diagnosis and prognosis of common leukemias
Hua Jiang,Zhiying Ou,Yingyi He,Meixing Yu,Shaoqing Wu,Gen Li,Jie Zhu,Ru Zhang,Jiayi Wang,Lianghong Zheng,Xiaohong Zhang,Wenge Hao,Liya He,Xiaoqiong Gu,Qingli Quan,Edward Zhang,Huiyan Luo,Wei Wei,Zhihuan Li,Guangxi Zang,Charlotte Zhang,Tina Poon,Daniel Zhang,Ian Ziyar,Run-ze Zhang,Oulan Li,Linhai Cheng,Taylor Shimizu,Xinping Cui,Jian-kang Zhu,Xin Sun &…Kang Zhang 
https://doi.org/10.1038/s41392-019-0090-5
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Targeting folate receptor β positive tumor-associated macrophages in lung cancer with a folate-modified liposomal complex
Yan Tie  ORCID: orcid.org/0000-0002-1271-5375,Heng Zheng,Zhiyao He,Jingyun Yang,Bin Shao,Li Liu,Min Luo,Xia Yuan,Yu Liu,Xiangxian Zhang,Hongyi Li,Min Wu &…Xiawei Wei 
https://doi.org/10.1038/s41392-020-0115-0
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NT157 has antineoplastic effects and inhibits IRS1/2 and STAT3/5 in JAK2V617F-positive myeloproliferative neoplasm cells
Bruna Alves Fenerich,Jaqueline Cristina Fernandes,Ana Paula Nunes Rodrigues Alves,Juan Luiz Coelho-Silva,Renata Scopim-Ribeiro,Priscila Santos Scheucher,Christopher A. Eide,Cristina E. Tognon,Brian J. Druker  ORCID: orcid.org/0000-0001-8331-8206,Eduardo Magalhães Rego,João Agostinho Machado-Neto &…Fabiola Traina  ORCID: orcid.org/0000-0003-4258-289X 
https://doi.org/10.1038/s41392-019-0102-5
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Fibronectin-targeted dual-acting micelles for combination therapy of metastatic breast cancer
Zhuoran Gong  ORCID: orcid.org/0000-0002-7195-0527,Min Chen,Qiushi Ren,Xiuli Yue &…Zhifei Dai 
https://doi.org/10.1038/s41392-019-0104-3
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Silencing MYH9 blocks HBx-induced GSK3β ubiquitination and degradation to inhibit tumor stemness in hepatocellular carcinoma
Xian Lin,Ai-min Li,Yong-Hao Li,Rong-Cheng Luo,Yu-Jiao Zou,Yi-Yi Liu,Chen Liu,Ying-Ying Xie,Shi Zuo,Zhan Liu,Zhen Liu &…Wei-Yi Fang  ORCID: orcid.org/0000-0002-1480-3707 
https://doi.org/10.1038/s41392-020-0111-4
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Both IDO1 and TDO contribute to the malignancy of gliomas via the Kyn–AhR–AQP4 signaling pathway
Lisha Du,Zikang Xing,Bangbao Tao,Tianqi Li,Dan Yang,Weirui Li,Yuanting Zheng,Chunxiang Kuang &…Qing Yang 
https://doi.org/10.1038/s41392-019-0103-4
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Inhibition of CDK9 by voruciclib synergistically enhances cell death induced by the Bcl-2 selective inhibitor venetoclax in preclinical models of acute myeloid leukemia
Daniel A. Luedtke,Yongwei Su,Jun Ma,Xinyu Li,Steven A. Buck,Holly Edwards,Lisa Polin,Juiwanna Kushner,Sijana H. Dzinic,Kathryn White,Hai Lin,Jeffrey W. Taub &…Yubin Ge  ORCID: orcid.org/0000-0002-8748-716X 
https://doi.org/10.1038/s41392-020-0112-3
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SIRT3-mediated inhibition of FOS through histone H3 deacetylation prevents cardiac fibrosis and inflammation
Xavier Palomer,M. Silvia Román-Azcona,Javier Pizarro-Delgado,Ana Planavila,Francesc Villarroya,Brenda Valenzuela-Alcaraz,Fátima Crispi,Álvaro Sepúlveda-Martínez,Irene Miguel-Escalada,Jorge Ferrer,J. Francisco Nistal,Raquel García,Mercy M. Davidson,Emma Barroso &…Manuel Vázquez-Carrera  ORCID: orcid.org/0000-0001-7138-8207 
https://doi.org/10.1038/s41392-020-0114-1
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D609 protects retinal pigmented epithelium as a potential therapy for age-related macular degeneration
Bowen Wang,Li Wang,Sijie Gu,Yankun Yu,Huaxing Huang,Kunlun Mo,He Xu,Fanzhu Zeng,Yichen Xiao,Lulu Peng,Chunqiao Liu,Nan Cao,Yizhi Liu,Jin Yuan &…Hong Ouyang 
https://doi.org/10.1038/s41392-020-0122-1
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CDK4/6 inhibition blocks cancer metastasis through a USP51-ZEB1-dependent deubiquitination mechanism
Zhen Zhang,Jianjun Li,Yang Ou,Guang Yang,Kaiyuan Deng,Qiong Wang,Zhaoyang Wang,Wenhao Wang,Quansheng Zhang,Hang Wang,Wei Sun,Peiqing Sun &…Shuang Yang 
https://doi.org/10.1038/s41392-020-0118-x
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Combined inhibition of Notch and FLT3 produces synergistic cytotoxic effects in FLT3/ITD+ acute myeloid leukemia
Dan Li,Tongjuan Li,Zhen Shang,Lei Zhao,Qian Xu,Jiaqi Tan,Yun Qin,Yuanyuan Zhang,Yang Cao,Na Wang,Liang Huang  ORCID: orcid.org/0000-0002-8370-3232,Xiaojian Zhu,Kuangguo Zhou,Liting Chen,Chunrui Li,Ting Xie,Yi Yang,Jue Wang &…Jianfeng Zhou 
https://doi.org/10.1038/s41392-020-0108-z
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The Agpat4/LPA axis in colorectal cancer cells regulates antitumor responses via p38/p65 signaling in macrophages
Dapeng Zhang,Rongchen Shi,Wei Xiang,Xia Kang,Bo Tang,Chuan Li,Linfeng Gao,Xuan Zhang,Lili Zhang,Rongyang Dai &…Hongming Miao 
https://doi.org/10.1038/s41392-020-0117-y
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The circFASN/miR-33a pathway participates in tacrolimus-induced dysregulation of hepatic triglyceride homeostasis
Chenzhi Zhang,Kangchen Chen,Rongli Wei,Guanghan Fan,Xuechun Cai,Li Xu,Beini Cen,Jianguo Wang,Haiyang Xie,Shusen Zheng &…Xiao Xu 
https://doi.org/10.1038/s41392-020-0105-2
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Research Highlight
Switching off DNA repair—how colorectal cancer evades targeted therapies through adaptive mutability
Jörg Fahrer  ORCID: orcid.org/0000-0001-5225-2718 
https://doi.org/10.1038/s41392-020-0120-3
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Mitochondrial dysfunction and alcohol-associated liver disease: a novel pathway and therapeutic target
Mohamed A. Abdallah &Ashwani K. Singal 
https://doi.org/10.1038/s41392-020-0128-8
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