Table of Contents
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Volume 4 Issue 4, Dec 2019

Letter
The antimicrobial peptide PFR induces necroptosis mediated by ER stress and elevated cytoplasmic calcium and mitochondrial ROS levels: cooperation with Ara-C to act against acute myeloid leukemia
Yudie Lv,Gang Shao  ORCID: orcid.org/0000-0003-1068-6790,Qiyu Zhang,Xi Wang,Yueming Meng,Lingfei Wang,Feiyan Huang,Tianxin Yang,Yuanting Jin &…Caiyun Fu 
https://doi.org/10.1038/s41392-019-0073-6
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Allelic frequency differences of DAOA variants between Caucasians and Asians and their association with major mood disorders
Zhihua Yang,Shuang Zhang,Fuquan Zhang,Yao Yao,Kwangwoo Kim,David Meyre,Hongmei Zhang,Hai Liao,Shuquan Rao &…Xinhe Huang 
https://doi.org/10.1038/s41392-019-0066-5
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Simultaneous cotargeting of ATR and RNA Polymerase I transcription demonstrates synergistic antileukemic effects on acute myeloid leukemia
Tingting Wang,Margaret Shatara,Fangbing Liu,Tristan Knight,Holly Edwards,Guan Wang,Hai Lin,Yue Wang,Jeffrey W. Taub &…Yubin Ge 
https://doi.org/10.1038/s41392-019-0076-3
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Unbiased screening reveals that blocking exportin 1 overcomes resistance to PI3Kα inhibition in breast cancer
Xue-Ling Liu,Bo-Bo Wang,Yi Wang,Yu-Xiang Wang,Chun-hao Yang,Cun Tan,Xi Zhang,Qiao-jun He,Jian Ding &…Ling-Hua Meng 
https://doi.org/10.1038/s41392-019-0085-2
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Dual inhibition of CDK4 and FYN leads to selective cell death in KRAS-mutant colorectal cancer
Yan Wang,Rongjie Lin,Huan Ling,Yuan Ke,Yangyang Zeng,Yudi Xiong,Qian Zhou,Fuxiang Zhou &…Yunfeng Zhou 
https://doi.org/10.1038/s41392-019-0088-z
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Article
Global profiling of O-GlcNAcylated and/or phosphorylated proteins in hepatoblastoma
Hang Song,Ji Ma,Zhixuan Bian,Shuhua Chen,Jiabei Zhu,Jing Wang,Nan Huang,Minzhi Yin,Fenyong Sun,Min Xu &…Qiuhui Pan 
https://doi.org/10.1038/s41392-019-0067-4
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Chemical compound cinobufotalin potently induces FOXO1-stimulated cisplatin sensitivity by antagonizing its binding partner MYH9
YongHao Li,Xiong Liu,Xian Lin,Menyang Zhao,Yanyi Xiao,Chen Liu,Zixi Liang,Zelong Lin,Renhui Yi,Zibo Tang,Jiahao Liu,Xin Li,Qingping Jiang,Libo Li,Yinyin Xie,Zhen Liu &…Weiyi Fang  ORCID: orcid.org/0000-0002-1480-3707 
https://doi.org/10.1038/s41392-019-0084-3
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Tumor-suppressive function and mechanism of HOXB13 in right-sided colon cancer
Binbin Xie,Bingjun Bai,Yuzi Xu  ORCID: orcid.org/0000-0003-2097-0293,Yunlong Liu,Yiming Lv  ORCID: orcid.org/0000-0003-4835-0336,Xing Gao,Fei Wu,Zhipeng Fang,Ying Lou,Hongming Pan &…Weidong Han 
https://doi.org/10.1038/s41392-019-0086-1
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Seryl tRNA synthetase cooperates with POT1 to regulate telomere length and cellular senescence
Yingxi Li,Xiyang Li,Mei Cao,Yuke Jiang,Jie Yan,Ze Liu,Rongcun Yang,Xu Chen,Peiqing Sun,Rong Xiang,Longlong Wang &…Yi Shi  ORCID: orcid.org/0000-0003-2530-410X 
https://doi.org/10.1038/s41392-019-0078-1
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PCDH17 increases the sensitivity of colorectal cancer to 5-fluorouracil treatment by inducing apoptosis and autophagic cell death
Shuiping Liu,Haoming Lin,Da Wang,Qiang Li,Hong Luo,Guoxiong Li,Xiaohui Chen,Yongqiang Li,Peng Chen,Bingtao Zhai,Wengang Wang,Ruonan Zhang,Bi Chen,Mingming Zhang,Xuemeng Han,Qiujie Li,Liuxi Chen,Ying Liu,Xiaying Chen,Guohua Li,Yu Xiang,Ting Duan,Jiao Feng,Jianshu Lou,Xingxing Huang,Qin Zhang,Ting Pan,Lili Yan,Ting Jin,Wenzheng Zhang,Lvjia Zhuo,Yitian Sun,Tian Xie &…Xinbing Sui 
https://doi.org/10.1038/s41392-019-0087-0
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DNA-PKcs promotes alcohol-related liver disease by activating Drp1-related mitochondrial fission and repressing FUNDC1-required mitophagy
Hao Zhou  ORCID: orcid.org/0000-0001-8138-7275,Pingjun Zhu,Jin Wang,Sam Toan &…Jun Ren 
https://doi.org/10.1038/s41392-019-0094-1
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MKP-1 reduces Aβ generation and alleviates cognitive impairments in Alzheimer’s disease models
Yehong Du,Yexiang Du,Yun Zhang,Zhilin Huang,Min Fu,Junjie Li,Yayan Pang,Peng Lei,Yu Tian Wang,Weihong Song,Guiqiong He &…Zhifang Dong 
https://doi.org/10.1038/s41392-019-0091-4
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RETRACTED ARTICLE: Dickkopf-1 contributes to hepatocellular carcinoma tumorigenesis by activating the Wnt/β-catenin signaling pathway
Rui Zhang,Hao-Ming Lin,Ruth Broering,Xiang-de Shi,Xian-huan Yu,Lei-bo Xu,Wen-rui Wu &…Chao Liu 
https://doi.org/10.1038/s41392-019-0082-5
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Integrative analysis of DNA methylation and gene expression identified cervical cancer-specific diagnostic biomarkers
Wanxue Xu,Mengyao Xu,Longlong Wang,Wei Zhou,Rong Xiang,Yi Shi  ORCID: orcid.org/0000-0003-2530-410X,Yunshan Zhang &…Yongjun Piao  ORCID: orcid.org/0000-0002-2769-6437 
https://doi.org/10.1038/s41392-019-0081-6
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TGIF2 promotes the progression of lung adenocarcinoma by bridging EGFR/RAS/ERK signaling to cancer cell stemness
Renle Du,Wenzhi Shen  ORCID: orcid.org/0000-0002-4251-6035,Yi Liu,Wenjuan Gao,Wei Zhou,Jun Li,Shuangtao Zhao,Chong Chen,Yanan Chen,Yanhua Liu,Peiqing Sun,Rong Xiang,Yi Shi  ORCID: orcid.org/0000-0003-2530-410X &…Yunping Luo 
https://doi.org/10.1038/s41392-019-0098-x
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The β-catenin/YAP signaling axis is a key regulator of melanoma-associated fibroblasts
Tianyi Liu,Linli Zhou,Kun Yang,Kentaro Iwasawa,Ana Luisa Kadekaro  ORCID: orcid.org/0000-0003-4832-5958,Takanori Takebe,Thomas Andl &…Yuhang Zhang  ORCID: orcid.org/0000-0002-9738-5343 
https://doi.org/10.1038/s41392-019-0100-7
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Review Article
The interrelationship between cerebral ischemic stroke and glioma: a comprehensive study of recent reports
Mrinal K. Ghosh,Dipankar Chakraborty,Sibani Sarkar,Arijit Bhowmik &…Malini Basu 
https://doi.org/10.1038/s41392-019-0075-4
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Demystifying the manipulation of host immunity, metabolism, and extraintestinal tumors by the gut microbiome
Ziying Zhang,Haosheng Tang,Peng Chen,Hui Xie &…Yongguang Tao 
https://doi.org/10.1038/s41392-019-0074-5
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Targeting cell signaling in allergic asthma
Seyyed Shamsadin Athari  ORCID: orcid.org/0000-0002-6355-6378 
https://doi.org/10.1038/s41392-019-0079-0
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The roles of exosomal miRNAs and lncRNAs in lung diseases
Yang Li,Zhengrong Yin,Jinshuo Fan,Siyu Zhang &…Weibing Yang 
https://doi.org/10.1038/s41392-019-0080-7
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Peptides encoded by noncoding genes: challenges and perspectives
Shuo Wang  ORCID: orcid.org/0000-0002-6893-3072,Chuanbin Mao  ORCID: orcid.org/0000-0002-8142-3659 &Shanrong Liu 
https://doi.org/10.1038/s41392-019-0092-3
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Targeting epigenetic regulators for cancer therapy: mechanisms and advances in clinical trials
Yuan Cheng,Cai He,Manni Wang,Xuelei Ma,Fei Mo,Shengyong Yang,Junhong Han &…Xiawei Wei 
https://doi.org/10.1038/s41392-019-0095-0
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The emerging treatment landscape of targeted therapy in non-small-cell lung cancer
Min Yuan,Li-Li Huang,Jian-Hua Chen,Jie Wu &…Qing Xu 
https://doi.org/10.1038/s41392-019-0099-9
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PROTACs: great opportunities for academia and industry
Xiuyun Sun,Hongying Gao,Yiqing Yang,Ming He,Yue Wu,Yugang Song,Yan Tong &…Yu Rao 
https://doi.org/10.1038/s41392-019-0101-6
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Research Highlight
Clonal replacement of novel T cells: a new phenomenon in the tumor microenvironment following PD-1 blockade
Xue Li,Manni Wang &Rong Xiang 
https://doi.org/10.1038/s41392-019-0077-2
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Coagulation factors: a novel class of endogenous host antimicrobial proteins against drug-resistant gram-negative bacteria
Congran Li &Xuefu You 
https://doi.org/10.1038/s41392-019-0083-4
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Structures of BRAF–MEK1–14-3-3 sheds light on drug discovery
Qiu Sun &Wenjing Wang 
https://doi.org/10.1038/s41392-019-0096-z
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