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Volume 4 Issue 3, Sep 2019

Research Highlight
PD-L1 in the palm of your hand: palmitoylation as a target for immuno-oncology
Andreas von Knethen  ORCID: orcid.org/0000-0002-5831-0365 &Bernhard Brüne 
https://doi.org/10.1038/s41392-019-0053-x
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Article
Therapeutic effects of a novel BAFF blocker on arthritis
Bailing Zhou,Hailong Zhang,Xiaoqing Su,Yi Luo,Xiaopeng Li,Chaoheng Yu,Qibing Xie,Xuyang Xia,Gu He &…Li Yang 
https://doi.org/10.1038/s41392-019-0051-z
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Effects of insulin and pathway inhibitors on the PI3K-Akt-mTOR phosphorylation profile in acute myeloid leukemia cells
Ina Nepstad,Kimberley Joanne Hatfield,Ida Sofie Grønningsæter,Elise Aasebø,Maria Hernandez-Valladares,Karen Marie Hagen,Kristin Paulsen Rye,Frode S. Berven,Frode Selheim,Håkon Reikvam &…Øystein Bruserud 
https://doi.org/10.1038/s41392-019-0050-0
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ReishiMax inhibits mTORC1/2 by activating AMPK and inhibiting IGFR/PI3K/Rheb in tumor cells
Didem Sohretoglu,Chao Zhang,Jun Luo &…Shile Huang  ORCID: orcid.org/0000-0002-3239-1072 
https://doi.org/10.1038/s41392-019-0056-7
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EGFR TKIs impair lysosome-dependent degradation of SQSTM1 to compromise the effectiveness in lung cancer
Lixian Yang,Shilong Ying,Shiman Hu,Xiangtong Zhao,Muchun Li,Miaoqin Chen,Yiran Zhu,Ping Song,Liyuan Zhu,Tingting Jiang,Huimin An,Neelum Aziz Yousafzai,Wenxia Xu,Zhiguo Zhang,Xian Wang,Lifeng Feng &…Hongchuan Jin 
https://doi.org/10.1038/s41392-019-0059-4
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The proatherosclerotic function of indoleamine 2, 3-dioxygenase 1 in the developmental stage of atherosclerosis
Heng Liang,Mantian Chen,Fangfei Qi,Lei Shi,Zhenzhen Duan,Ruoyu Yang,Jinchao He,Bin Lou,Yigang Li &…Qing Yang
https://doi.org/10.1038/s41392-019-0058-5
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Jumonji domain-containing 6 (JMJD6) identified as a potential therapeutic target in ovarian cancer
Heng Zheng,Yan Tie,Zhen Fang  ORCID: orcid.org/0000-0003-4310-7898,Xiaoai Wu,Tao Yi,Shuang Huang,Xiao Liang,Yanping Qian,Xi Wang,Ruyu Pi,Siyuan Chen,Yong Peng  ORCID: orcid.org/0000-0002-1181-3467,Shengyong Yang,Xia Zhao &…Xiawei Wei 
https://doi.org/10.1038/s41392-019-0055-8
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Potent delivery of an MMP inhibitor to the tumor microenvironment with thermosensitive liposomes for the suppression of metastasis and angiogenesis
Yaqi Lyu,Qingqing Xiao,Lifang Yin,Lei Yang &…Wei He  ORCID: orcid.org/0000-0003-3075-3831 
https://doi.org/10.1038/s41392-019-0054-9
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miR-124/VAMP3 is a novel therapeutic target for mitigation of surgical trauma-induced microglial activation
Yan Chen,Jing-xian Sun,Wan-kun Chen  ORCID: orcid.org/0000-0001-7394-9266,Gen-cheng Wu,Yan-qing Wang,Ke-ying Zhu  ORCID: orcid.org/0000-0001-7500-1532 &…Jun Wang 
https://doi.org/10.1038/s41392-019-0061-x
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Local delivery of arsenic trioxide nanoparticles for hepatocellular carcinoma treatment
Jian Hu,Yi Dong,Li Ding,Yang Dong,Zhihua Wu,Wenping Wang,Ming Shen &…Yourong Duan 
https://doi.org/10.1038/s41392-019-0062-9
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E6-induced selective translation of WNT4 and JIP2 promotes the progression of cervical cancer via a noncanonical WNT signaling pathway
Lin Zhao,Longlong Wang,Chenglan Zhang,Ze Liu,Yongjun Piao  ORCID: orcid.org/0000-0002-2769-6437,Jie Yan,Rong Xiang,Yuanqing Yao &…Yi Shi  ORCID: orcid.org/0000-0003-2530-410X 
https://doi.org/10.1038/s41392-019-0060-y
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Letter
Genome-wide identification of DNA-PKcs-associated RNAs by RIP-Seq
Zhiquan Song,Ying Xie,Zongpei Guo,Yang Han,Hua Guan,Xiaodan Liu,Teng Ma &…Ping-kun Zhou 
https://doi.org/10.1038/s41392-019-0057-6
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The effect of selective serotonin reuptake inhibitors on cognitive function in patients with Alzheimer’s disease and vascular dementia: focusing on fluoxetine with long follow-up periods
Yi Xie,Pei-Pei Liu,Ya-Jun Lian,Hong-Bo Liu &…Jian-Sheng Kang  ORCID: orcid.org/0000-0002-2603-9718 
https://doi.org/10.1038/s41392-019-0064-7
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BE-PIGS: a base-editing tool with deaminases inlaid into Cas9 PI domain significantly expanded the editing scope
Yanhong Wang,Lifang Zhou,Nan Liu &…Shaohua Yao 
https://doi.org/10.1038/s41392-019-0072-7
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Review Article
History and progress of hypotheses and clinical trials for Alzheimer’s disease
Pei-Pei Liu,Yi Xie,Xiao-Yan Meng &…Jian-Sheng Kang  ORCID: orcid.org/0000-0002-2603-9718 
https://doi.org/10.1038/s41392-019-0063-8
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Targeted therapy in chronic diseases using nanomaterial-based drug delivery vehicles
Akhand Pratap Singh,Arpan Biswas  ORCID: orcid.org/0000-0002-7028-6388,Aparna Shukla &…Pralay Maiti 
https://doi.org/10.1038/s41392-019-0068-3
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Targeted therapeutic options and future perspectives for HER2-positive breast cancer
Jiani Wang &Binghe Xu 
https://doi.org/10.1038/s41392-019-0069-2
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Genetically engineered T cells for cancer immunotherapy
Dan Li,Xue Li,Wei-Lin Zhou,Yong Huang,Xiao Liang,Lin Jiang,Xiao Yang,Jie Sun,Zonghai Li,Wei-Dong Han &…Wei Wang  ORCID: orcid.org/0000-0001-7788-1895 
https://doi.org/10.1038/s41392-019-0070-9
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