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Volume 9 Issue 12, Dec 2024

Article
Macrophages promote pre-metastatic niche formation of breast cancer through aryl hydrocarbon receptor activity
Xu Jiang, Jiaqi Wang, Liangyu Lin, Liming Du, Yayun Ding, Fanjun Zheng, Hongzhen Xie, Yu Wang, Mingyuan Hu, Benming Liu, Muhan Xu, Jingjie Zhai, Xuefeng Wang, Jiayin Ye, Wei Cao, Chao Feng, Jingyi Feng, Zongliu Hou, Mingyao Meng, Ju Qiu, Qing Li, Yufang Shi & Ying Wang
https://doi.org/10.1038/s41392-024-02042-5
Full Text | PDF | Abstract | Open Access
Anlotinib plus chemotherapy as a first-line treatment for gastrointestinal cancer patients with unresectable liver metastases: a multicohort, multicenter, exploratory trial
Jun-Wei Wu, Chen-Fei Zhou, Zheng-Xiang Han, Huan Zhang, Jun Yan, Jun Chen, Chun-Bin Wang, Zhi-Quan Qin, Yong Mao, Xin-Yu Tang, Liang-Jun Zhu, Xiao-Wei Wei, Dong-Hai Cui, Xiu-Li Yang, Min Shi, Li-Qin Zhao, Jin-Ling Jiang, Wei-You Zhu, Hong-Mei Wang, Chun Wang, Ling-Jun Zhu & Jun Zhang
https://doi.org/10.1038/s41392-024-02051-4
Full Text | PDF | Abstract | Open Access
Genomic landscape of circulating tumor DNA in HER2-low metastatic breast cancer
Zongbi Yi, Kaixiang Feng, Dan Lv, Yanfang Guan, Youcheng Shao, Fei Ma & Binghe Xu
https://doi.org/10.1038/s41392-024-02047-0
Full Text | PDF | Abstract | Open Access
CXCR1+ neutrophil infiltration orchestrates response to third-generation EGFR-TKI in EGFR mutant non-small-cell lung cancer
Haowei Wang, Anwen Xiong, Xiaoxia Chen, Junhong Guo, Zhuoran Tang, Chunyan Wu, Shengxiang Ren, Caicun Zhou, Jian Chen, Likun Hou & Tao Jiang
https://doi.org/10.1038/s41392-024-02045-2
Full Text | PDF | Abstract | Open Access
First-line benmelstobart plus anlotinib and chemotherapy in advanced or metastatic/recurrent esophageal squamous cell carcinoma: a multi-center phase 2 study
Ning Li,Jin Xia,Xiaohui Gao,Jianwei Zhou,Yonggui Hong,Donghai Cui,Xuesong Zhao,Tao Wu,Yanzhen Guo,Junsheng Wang &…Suxia Luo
https://doi.org/10.1038/s41392-024-02008-7
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Overexpression of STX11 alleviates pulmonary fibrosis by inhibiting fibroblast activation via the PI3K/AKT/mTOR pathway
Guichuan Huang,Xiangsheng Yang,Qingyang Yu,Qun Luo,Chunrong Ju,Bangyan Zhang,Yijing Chen,Zihan Liang,Shu Xia,Xiaohua Wang,Dong Xiang,Nanshan Zhong &…Xiao Xiao Tang ORCID: orcid.org/0000-0002-3383-0989
https://doi.org/10.1038/s41392-024-02011-y
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Comparison of drug-eluting bead transarterial chemoembolization combined with apatinib versus drug-eluting bead transarterial chemoembolization for the treatment of unresectable hepatocellular carcinoma: a randomized, prospective, multicenter phase III trial
Xuhua Duan,Hao Li,Donglin Kuang,Pengfei Chen,Mengfan Zhang,Tengfei Li,Dechao Jiao,Yanliang Li,Xiang He,Cheng Xing,Haibo Wang,Yaoxian Liu,Limin Xie,Shixi Zhang,Qiang Zhang,Peixin Zhu,Yongchuang Chang,Jichen Xie,Jianzhuang Ren &…Xinwei Han
https://doi.org/10.1038/s41392-024-02012-x
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2D4, a humanized monoclonal antibody targeting CD132, is a promising treatment for systemic lupus erythematosus
Huiqi Yin,Liming Li,Xiwei Feng,Zijun Wang,Meiling Zheng,Junpeng Zhao,Xinyu Fan,Wei Wu,Lingyu Gao,Yijing Zhan,Ming Zhao &…Qianjin Lu
https://doi.org/10.1038/s41392-024-02017-6
Full Text | PDF | Abstract
Identifying genetic targets in clinical subtypes of Parkinson’s disease for optimizing pharmacological treatment strategies
Dewen Kong,Cao Li,LingYan Ma,Lida Du,Nan Jiang,Xiaoyue Zhao,Sen Zhang,Zhigang Zhao,Lianhua Fang &…Guanhua Du
https://doi.org/10.1038/s41392-024-02020-x
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Renal remodeling by CXCL10-CXCR3 axis-recruited mesenchymal stem cells and subsequent IL4I1 secretion in lupus nephritis
Qixiang Zhang,Yunlong Shan ORCID: orcid.org/0000-0002-6954-364X,Luping Shen,Qi Ni,Dandan Wang,Xin Wen,Huanke Xu,Xiaoyan Liu,Zhu Zeng,Jingwen Yang,Yukai Wang,Jiali Liu,Yueyan Su,Ning Wei,Jing Wang,Lingyun Sun,Guangji Wang &…Fang Zhou ORCID: orcid.org/0000-0002-8271-4116
https://doi.org/10.1038/s41392-024-02018-5
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EphrinB2-mediated CDK5/ISL1 pathway enhances cardiac lymphangiogenesis and alleviates ischemic injury by resolving post-MI inflammation
Yingnan Bai,Liming Chen,Fanghao Guo,Jinghong Zhang,Jinlin Hu,Xuefei Tao,Qing Lu,Wenyi Li,Xueying Chen,Ting Gong,Nan Qiu,Yawei Jin,Lifan Yang,Yu Lei,Chengchao Ruan ORCID: orcid.org/0000-0001-5229-9428,Qing Jing,John P. Cooke,Shijun Wang,Yunzeng Zou ORCID: orcid.org/0000-0003-1871-5496 &…Junbo Ge ORCID: orcid.org/0000-0002-9360-7332
https://doi.org/10.1038/s41392-024-02019-4
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Intranasal delivery of a subunit protein vaccine provides protective immunity against JN.1 and XBB-lineage variants
Hong Lei,Weiqi Hong ORCID: orcid.org/0000-0003-1668-2301,Jingyun Yang,Cai He,Yanan Zhou,Yu Zhang,Aqu Alu ORCID: orcid.org/0000-0002-9981-0120,Jie Shi,Jian Liu,Furong qin,Danyi Ao,Xiya Huang,Zimin Chen ORCID: orcid.org/0000-0002-2862-9674,Hao Yang,Yun Yang,Wenhai Yu,Cong Tang,Junbin Wang,Bai Li,Qing Huang,Hongbo Hu ORCID: orcid.org/0000-0002-8177-7641,Wei Cheng,Haohao Dong ORCID: orcid.org/0000-0002-5022-3494,Jian Lei ORCID: orcid.org/0000-0001-9326-0554,Lu Chen ORCID: orcid.org/0000-0002-1083-9729,Xikun Zhou ORCID: orcid.org/0000-0001-6768-2382,Jiong Li ORCID: orcid.org/0000-0002-3742-630X,Li Yang,Zhenling Wang,Wei Wang ORCID: orcid.org/0000-0001-7788-1895,Guobo Shen ORCID: orcid.org/0000-0002-8917-196X,Jinliang Yang,Zhiwei Zhao,Xiangrong Song ORCID: orcid.org/0000-0002-2853-2696,Guangwen Lu ORCID: orcid.org/0000-0001-7568-592X,Qiangming Sun,Youchun Wang,Shuaiyao Lu ORCID: orcid.org/0000-0003-1675-9735 &…Xiawei Wei ORCID: orcid.org/0000-0002-6513-6422
https://doi.org/10.1038/s41392-024-02025-6
Full Text | PDF | Abstract
First-in-human, phase 1 dose-escalation and dose-expansion study of a RET inhibitor SY-5007 in patients with advanced RET-altered solid tumors
Wei Li,Yongsheng Wang,Anwen Xiong,Ge Gao,Zhengbo Song,Yiping Zhang,Dingzhi Huang,Feng Ye,Qiming Wang,Zhihui Li,Jiaye Liu,Chunwei Xu,Yinghui Sun,Xijie Liu,Fei Zhou ORCID: orcid.org/0000-0002-5865-0052 &…Caicun Zhou ORCID: orcid.org/0000-0002-6958-0766
https://doi.org/10.1038/s41392-024-02006-9
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A protein vaccine of RBD integrated with immune evasion mutation shows broad protection against SARS-CoV-2
Ran An,Hao Yang,Cong Tang,Qianqian Li,Qing Huang,Haixuan Wang,Junbin Wang,Yanan Zhou,Yun Yang,Hongyu Chen,Wenhai Yu,Bai Li,Daoju Wu,Yong Zhang,Fangyu Luo,Wenqi Quan,Jingwen Xu,Dongdong Lin,Xiaoming Liang  ORCID: orcid.org/0009-0001-3438-0027,Yuhuan Yan,Longhai Yuan,Xuena Du,Yuxia Yuan,Yanwen Li,Qiangming Sun,Youchun Wang  ORCID: orcid.org/0000-0001-9769-5141 &…Shuaiyao Lu  ORCID: orcid.org/0000-0003-1675-9735 
https://doi.org/10.1038/s41392-024-02007-8
Full Text | PDF | Abstract
Research Highlight
Mef2d: a novel transcription factor in type 2 allergic lung inflammation
Laura Surace ORCID: orcid.org/0000-0001-8152-0611,Christoph Wilhelm ORCID: orcid.org/0000-0002-9839-0291 &Christian Bode ORCID: orcid.org/0000-0002-0830-870X
https://doi.org/10.1038/s41392-024-02022-9
Full Text | PDF | Abstract
Intermittent high-fat diet: atherosclerosis progression by neutrophil reprogramming
Andrea Herrero-Cervera,Raphael Chevre &Oliver Soehnlein ORCID: orcid.org/0000-0002-7854-0694
https://doi.org/10.1038/s41392-024-02027-4
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Multiplexed RNAs in lipid nanoparticles: potential therapeutic vaccine for chronic hepatitis B
Hari Krishnareddy Rachamala &Srujan Marepally ORCID: orcid.org/0000-0002-2451-3359
https://doi.org/10.1038/s41392-024-02026-5
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Moving towards precision psychiatry: the hard nut of depression
Juergen Dukart ORCID: orcid.org/0000-0003-0492-5644,Leon D. Lotter &Simon B. Eickhoff
https://doi.org/10.1038/s41392-024-02023-8
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Post-fast refeeding: rise of intestinal stemness and mutagen-induced cancer risk through polyamine metabolism
Sarah Brunner ORCID: orcid.org/0000-0002-3293-1657,Klaus-Peter Janssen ORCID: orcid.org/0000-0002-4707-7887 &Josef Ecker ORCID: orcid.org/0000-0003-4799-0788
https://doi.org/10.1038/s41392-024-02038-1
Full Text | PDF | Abstract
Metformin: decelerates biomarkers of aging clocks
Ram Abou Zaki &Assam El-Osta ORCID: orcid.org/0000-0001-7968-7375
https://doi.org/10.1038/s41392-024-02046-1
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Beyond the classic GPCR: unraveling the role of GPR155 role in cholesterol sensing and signaling
Torsten Schöneberg ORCID: orcid.org/0000-0001-5313-0237
https://doi.org/10.1038/s41392-024-02059-w
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Next-generation mpox vaccines: efficacy of mRNA-1769 compared to modified vaccinia virus Ankara in non-human primates
Leonie Mayer,Leonie M. Weskamm &Marylyn M. Addo
https://doi.org/10.1038/s41392-024-02058-x
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Early intermittent cholesterol exposure accelerates atherosclerosis: an oscillating amplifier calling for preemptive control
Maria Kral,Yvonne Döring &Christian Weber 
https://doi.org/10.1038/s41392-024-02032-7
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Review Article
Comprehensive snapshots of natural killer cells functions, signaling, molecular mechanisms and clinical utilization
Sumei Chen,Haitao Zhu &Youssef Jounaidi
https://doi.org/10.1038/s41392-024-02005-w
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Progress and prospects of mRNA-based drugs in pre-clinical and clinical applications
Yingying Shi,Meixing Shi,Yi Wang ORCID: orcid.org/0000-0002-3676-9183 &…Jian You ORCID: orcid.org/0000-0002-7114-6299
https://doi.org/10.1038/s41392-024-02002-z
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Membraneless organelles in health and disease: exploring the molecular basis, physiological roles and pathological implications
Yangxin Li ORCID: orcid.org/0000-0002-2364-3207,Yuzhe Liu,Xi-Yong Yu,Yan Xu,Xiangbin Pan,Yi Sun,Yanli Wang,Yao-Hua Song &…Zhenya Shen
https://doi.org/10.1038/s41392-024-02013-w
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Targeted protein degradation: advances in drug discovery and clinical practice
Guangcai Zhong,Xiaoyu Chang ORCID: orcid.org/0009-0006-9597-1599,Weilin Xie &…Xiangxiang Zhou
https://doi.org/10.1038/s41392-024-02004-x
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Letter
A comprehensive proteomic analysis of umbilical cord blood supports COVID-19 vaccination before pregnancy
Jianbin Guo,Xiaoyue Tang,Roujie Huang,Jiangfeng Liu &…Lan Zhu ORCID: orcid.org/0000-0001-5753-5426
https://doi.org/10.1038/s41392-024-02024-7
Full Text | PDF | Abstract