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Volume 9 Issue 11, Nov 2024

Perioperative sintilimab and neoadjuvant anlotinib plus chemotherapy for resectable non-small-cell lung cancer: a multicentre, open-label, single-arm, phase 2 trial (TD-NeoFOUR trial)
Hongtao Duan,Changjian Shao  ORCID: orcid.org/0000-0002-2487-9692,Zhilin Luo,Tianhu Wang,Liping Tong,Honggang Liu,Xin Yao,Jie Lei,Jinbo Zhao,Yuan Gao,Tao Jiang &…Xiaolong Yan  ORCID: orcid.org/0000-0003-2419-9707 
2024-10-28
Article
Human adipose and umbilical cord mesenchymal stem cell-derived extracellular vesicles mitigate photoaging via TIMP1/Notch1
Huan Zhang,Xian Xiao,Liping Wang,Xianhao Shi,Nan Fu,Shihua Wang &…Robert Chunhua Zhao
https://doi.org/10.1038/s41392-024-01993-z
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Mechanism exploration and model construction for small cell transformation in EGFR-mutant lung adenocarcinomas
Yan Li,Tongji Xie,Shouzheng Wang,Lin Yang,Xuezhi Hao,Yan Wang,Xingsheng Hu,Lin Wang,Junling Li,Jianming Ying  ORCID: orcid.org/0000-0002-7301-4118 &…Puyuan Xing 
https://doi.org/10.1038/s41392-024-01981-3
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Neoadjuvant toripalimab plus axitinib for clear cell renal cell carcinoma with inferior vena cava tumor thrombus: NEOTAX, a phase 2 study
Liangyou Gu,Cheng Peng,Qiyang Liang,Qingbo Huang,Deqiang Lv,Houming Zhao,Qi Zhang,Yu Zhang,Peng Zhang,Shichao Li,Junnan Xu,Luyao Chen,Yongpeng Xie,Jinhang Li,Gang Guo,Xu Zhang,Baojun Wang &…Xin Ma 
https://doi.org/10.1038/s41392-024-01990-2
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AXIN1 boosts antiviral response through IRF3 stabilization and induced phase separation
Dan-Ling Dai,Chu Xie  ORCID: orcid.org/0000-0003-1206-3124,Lan-Yi Zhong,Shang-Xin Liu,Le-Le Zhang,Hua Zhang,Xing-Ping Wu,Zhou-Ming Wu,Kexin Kang,Yan Li,Ya-Meng Sun,Tian-Liang Xia  ORCID: orcid.org/0009-0002-3369-8612,Chen-Song Zhang,Ao Zhang,Ming Shi,Cong Sun  ORCID: orcid.org/0000-0003-1786-7420,Mei-Ling Chen,Ge-Xin Zhao,Guo-Long Bu,Yuan-Tao Liu  ORCID: orcid.org/0000-0002-5071-9780,Kui-Yuan Huang,Zheng Zhao,Shu-Xin Li,Xiao-Yong Zhang  ORCID: orcid.org/0000-0002-6930-9423,Yun-Fei Yuan,Shi-Jun Wen  ORCID: orcid.org/0000-0002-9347-8243,Lingqiang Zhang  ORCID: orcid.org/0000-0002-9795-2141,Bin-Kui Li,Qian Zhong &…Mu-Sheng Zeng  ORCID: orcid.org/0000-0003-3509-5591 
https://doi.org/10.1038/s41392-024-01978-y
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Envafolimab plus lenvatinib and transcatheter arterial chemoembolization for unresectable hepatocellular carcinoma: a prospective, single-arm, phase II study
Yiwen Chen,Junlei Zhang,Wendi Hu,Xiang Li  ORCID: orcid.org/0000-0002-5942-7282,Ke Sun,Yan Shen,Min Zhang,Jian Wu  ORCID: orcid.org/0000-0002-6325-0766,Shunliang Gao,Jun Yu,Risheng Que,Yun Zhang,Fuchun Yang,Weiliang Xia,Aibin Zhang,Xiaofeng Tang,Xueli Bai  ORCID: orcid.org/0000-0002-2934-0880 &…Tingbo Liang  ORCID: orcid.org/0000-0003-0143-3353 
https://doi.org/10.1038/s41392-024-01991-1
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Benmelstobart plus anlotinib in patients with EGFR-positive advanced NSCLC after failure of EGFR TKIs therapy: a phase I/II study
Meiqi Shi,Ping Chen,Bin Cui,Yuanhu Yao,Juanyi Wang,Tong Zhou &…Li Wang 
https://doi.org/10.1038/s41392-024-01982-2
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Aptamer-drug conjugates-loaded bacteria for pancreatic cancer synergistic therapy
Yu Xiao  ORCID: orcid.org/0009-0009-2203-0917,Tao Pan  ORCID: orcid.org/0000-0003-1586-1463,Wuren Da,Yuanding Liu,Shuangya Chen,Daiquan Chen,Keying Liu,Yihan Zheng,Daolong Xie,Yuan Gao,Haiyan Xu,Yang Sun &…Weihong Tan  ORCID: orcid.org/0000-0002-8066-1524 
https://doi.org/10.1038/s41392-024-01973-3
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Cardiomyocyte-specific knockout of ADAM17 alleviates doxorubicin-induced cardiomyopathy via inhibiting TNFα–TRAF3–TAK1–MAPK axis
Lin Xie,Fei Xue,Cheng Cheng,Wenhai Sui  ORCID: orcid.org/0000-0001-6114-0443,Jie Zhang  ORCID: orcid.org/0000-0002-2782-1592,Linlin Meng,Yue Lu,Wenjing Xiong,Peili Bu,Feng Xu,Xiao Yu,Bo Xi,Lin Zhong,Jianmin Yang,Cheng Zhang  ORCID: orcid.org/0000-0003-3672-6543 &…Yun Zhang  ORCID: orcid.org/0000-0003-4432-6144 
https://doi.org/10.1038/s41392-024-01977-z
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Sequential responsive nano-PROTACs for precise intracellular delivery and enhanced degradation efficacy in colorectal cancer therapy
Liuqing Yang,Ye Yang,Jing Zhang,Minghui Li,Long Yang  ORCID: orcid.org/0000-0003-3388-9929,Xing Wang,Meifang Chen,Hua Zhang,Bing He,Xueqing Wang,Wenbing Dai  ORCID: orcid.org/0000-0002-4114-4022,Yiguang Wang &…Qiang Zhang 
https://doi.org/10.1038/s41392-024-01983-1
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Corynebacterium parakroppenstedtii secretes a novel glycolipid to promote the development of granulomatous lobular mastitis
Ran Liu,Zixuan Luo,Chong Dai,Yuchen Wei,Shuqing Yan,Xinwen Kuang  ORCID: orcid.org/0000-0002-6876-7844,Kuan Qi,Aisi Fu,Yinxin Li,Shuai Fu,Zhengning Ma,Wen Dai,Xiao Xiao,Qing Wu,Haokui Zhou,Yan Rao,Jingping Yuan,Ting Shi,Zixin Deng,Chuang Chen &…Tiangang Liu  ORCID: orcid.org/0000-0001-8087-0345 
https://doi.org/10.1038/s41392-024-01984-0
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MEK inhibition prevents CAR-T cell exhaustion and differentiation via downregulation of c-Fos and JunB
Xiujian Wang,Xiao Tao,Pengjie Chen,Penglei Jiang,Wenxiao Li,Hefeng Chang,Cong Wei,Xinyi Lai,Hao Zhang,Yihan Pan,Lijuan Ding,Zuyu Liang,Jiazhen Cui,Mi Shao,Xinyi Teng,Tianning Gu  ORCID: orcid.org/0000-0003-1550-1011,Jieping Wei,Delin Kong,Xiaohui Si,Yingli Han,Huarui Fu,Yu Lin,Jian Yu,Xia Li  ORCID: orcid.org/0000-0002-1443-3996,Dongrui Wang,Yongxian Hu,Pengxu Qian  ORCID: orcid.org/0000-0001-5636-6704 &…He Huang  ORCID: orcid.org/0000-0002-2723-1621 
https://doi.org/10.1038/s41392-024-01986-y
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Ruxolitinib plus steroids for acute graft versus host disease: a multicenter, randomized, phase 3 trial
Liping Dou  ORCID: orcid.org/0000-0001-7352-9560,Yanli Zhao,Jingjing Yang,Lei Deng,Nan Wang,Xiawei Zhang,Qingyang Liu,Yan Yang,Zhijie Wei,Fuxu Wang,Yifan Jiao,Fei Li,Songhua Luan,Liangding Hu,Sujun Gao,Chuanfang Liu,Xiangjun Liu,Jinsong Yan  ORCID: orcid.org/0000-0003-4109-2602,Xuejun Zhang,Fang Zhou,Peihua Lu  ORCID: orcid.org/0000-0002-6331-7369 &…Daihong Liu 
https://doi.org/10.1038/s41392-024-01987-x
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Systemic longitudinal immune profiling identifies proliferating Treg cells as predictors of immunotherapy benefit: biomarker analysis from the phase 3 CONTINUUM and DIPPER trials
Sai-Wei Huang,Wei Jiang,Sha Xu  ORCID: orcid.org/0000-0003-4685-6296,Yuan Zhang,Juan Du,Ya-Qin Wang,Kun-Yu Yang,Ning Zhang,Fang Liu,Guo-Rong Zou,Feng Jin,Hai-Jun Wu,Yang-Ying Zhou,Xiao-Dong Zhu,Nian-Yong Chen,Cheng Xu,Han Qiao  ORCID: orcid.org/0000-0002-0341-2620,Na Liu  ORCID: orcid.org/0000-0001-8654-3636,Ying Sun,Jun Ma  ORCID: orcid.org/0000-0002-1137-9349,Ye-Lin Liang &…Xu Liu  ORCID: orcid.org/0000-0003-4827-5524 
https://doi.org/10.1038/s41392-024-01988-w
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Perioperative sintilimab and neoadjuvant anlotinib plus chemotherapy for resectable non-small-cell lung cancer: a multicentre, open-label, single-arm, phase 2 trial (TD-NeoFOUR trial)
Hongtao Duan,Changjian Shao  ORCID: orcid.org/0000-0002-2487-9692,Zhilin Luo,Tianhu Wang,Liping Tong,Honggang Liu,Xin Yao,Jie Lei,Jinbo Zhao,Yuan Gao,Tao Jiang &…Xiaolong Yan  ORCID: orcid.org/0000-0003-2419-9707 
https://doi.org/10.1038/s41392-024-01992-0
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Review Article
Type 2 diabetes mellitus in adults: pathogenesis, prevention and therapy
Xi Lu,Qingxing Xie,Xiaohui Pan,Ruining Zhang,Xinyi Zhang,Ge Peng,Yuwei Zhang,Sumin Shen &…Nanwei Tong  ORCID: orcid.org/0000-0002-6051-245X 
https://doi.org/10.1038/s41392-024-01951-9
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Evolving understanding of autoimmune mechanisms and new therapeutic strategies of autoimmune disorders
Yi Song,Jian Li  ORCID: orcid.org/0000-0003-0212-4464 &Yuzhang Wu 
https://doi.org/10.1038/s41392-024-01952-8
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Signaling pathways involved in colorectal cancer: pathogenesis and targeted therapy
Qing Li  ORCID: orcid.org/0000-0003-2652-6070,Shan Geng,Hao Luo,Wei Wang,Ya-Qi Mo,Qing Luo,Lu Wang,Guan-Bin Song,Jian-Peng Sheng &…Bo Xu 
https://doi.org/10.1038/s41392-024-01953-7
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Metabolic regulation of the immune system in health and diseases: mechanisms and interventions
Tengyue Hu,Chang-Hai Liu,Min Lei,Qingmin Zeng,Li Li,Hong Tang &…Nannan Zhang 
https://doi.org/10.1038/s41392-024-01954-6
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The multiple roles of interferon regulatory factor family in health and disease
Lian Wang,Yanghui Zhu,Nan Zhang,Yali Xian,Yu Tang,Jing Ye,Fekrazad Reza,Gu He  ORCID: orcid.org/0000-0002-1536-8882,Xiang Wen &…Xian Jiang  ORCID: orcid.org/0000-0001-5109-6055 
https://doi.org/10.1038/s41392-024-01980-4
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Multi-stage mechanisms of tumor metastasis and therapeutic strategies
Zaoqu Liu  ORCID: orcid.org/0000-0002-0452-742X,Jingqi Chen,Yuqing Ren,Shutong Liu,Yuhao Ba,Anning Zuo,Peng Luo,Quan Cheng  ORCID: orcid.org/0000-0003-2401-5349,Hui Xu &…Xinwei Han  ORCID: orcid.org/0000-0003-4407-4864 
https://doi.org/10.1038/s41392-024-01955-5
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Iron homeostasis and ferroptosis in human diseases: mechanisms and therapeutic prospects
Qin Ru,Yusheng Li,Lin Chen,Yuxiang Wu,Junxia Min  ORCID: orcid.org/0000-0001-8099-6327 &…Fudi Wang  ORCID: orcid.org/0000-0001-8730-0003 
https://doi.org/10.1038/s41392-024-01969-z
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Cold and hot tumors: from molecular mechanisms to targeted therapy
Bo Wu,Bo Zhang,Bowen Li,Haoqi Wu &…Meixi Jiang 
https://doi.org/10.1038/s41392-024-01979-x
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Research Highlight
The phage anti-restriction induced system: new insights into bacterial immunity and bacteriophage escape strategies
Yi Zhong  ORCID: orcid.org/0000-0002-0929-8224 &Volker M. Lauschke  ORCID: orcid.org/0000-0002-1140-6204 
https://doi.org/10.1038/s41392-024-01995-x
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A microglial compliment: controlling neuronal function from within
Dilara Hasavci &Thomas Blank 
https://doi.org/10.1038/s41392-024-01989-9
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Allogeneic CAR T cells for autoimmune diseases: a glimpse into the future
Dimitrios Mougiakakos  ORCID: orcid.org/0000-0002-2817-6660 
https://doi.org/10.1038/s41392-024-01998-8
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Discovery of biosynthetic enzymes for β-D-manno-heptoses across kingdoms: novel agonists for ALPK1/NF-κB-dependent immune response
Gunter Maubach  ORCID: orcid.org/0000-0002-9059-496X,Michelle C. C. Lim &Michael Naumann 
https://doi.org/10.1038/s41392-024-02003-y
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Beyond borders: the choroid plexus-immune communication during neuroinflammation
Anaelle Aurelie Dumas,Adrià Dalmau Gasull  ORCID: orcid.org/0000-0002-8410-8048 &Marco Prinz  ORCID: orcid.org/0000-0002-0349-1955 
https://doi.org/10.1038/s41392-024-01997-9
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The upper airway microbiota: how host and environment shape this ecological niche
Ann-Kathrin Lederer &Kristina Endres 
https://doi.org/10.1038/s41392-024-01996-w
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Late onset Alzheimer’s disease: modeling disease hallmarks via in vitro 3D iNeuron cultures
Giacomo Masserdotti  ORCID: orcid.org/0000-0003-3621-3481 
https://doi.org/10.1038/s41392-024-01999-7
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A breath of fresh air: targeted non-viral in vivo gene correction in the mammalian lung
Jixin Liu &Dirk Grimm  ORCID: orcid.org/0000-0001-6227-5665 
https://doi.org/10.1038/s41392-024-01994-y
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Therapeutic interfering particles against HIV: molecular parasites reducing viremia
Henning Gruell  ORCID: orcid.org/0000-0002-0725-7138,Stanley Odidika &Philipp Schommers  ORCID: orcid.org/0000-0003-3375-6800 
https://doi.org/10.1038/s41392-024-02001-0
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Integrate and conquer: pan-cancer proteogenomics uncovers cancer vulnerabilities and therapeutic opportunities
Debomita Chakraborty  ORCID: orcid.org/0000-0002-8590-7001,Rossana Romero  ORCID: orcid.org/0000-0002-4319-236X &Krishnaraj Rajalingam  ORCID: orcid.org/0000-0002-4175-9633 
https://doi.org/10.1038/s41392-024-02009-6
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PD-1 and LAG-3: synergistic fostering of T cell exhaustion
Maike Hofmann,Robert Thimme &Wolfgang W. Schamel 
https://doi.org/10.1038/s41392-024-02000-1
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5-Formylcytosine: a new epigenetic player
Dharmendra Kumar,Iqbal Hyder &Wilfried A. Kues  ORCID: orcid.org/0000-0002-0850-8103 
https://doi.org/10.1038/s41392-024-02016-7
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Gut microbial carcinogen metabolism: another avenue to cancer
Florian R. Greten  ORCID: orcid.org/0000-0002-3928-6080 &Melek C. Arkan 
https://doi.org/10.1038/s41392-024-02015-8
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Miniproteins may have a big impact: new therapeutics for autoimmune diseases and beyond
Nariaki Asada  ORCID: orcid.org/0000-0002-5659-2944,Christian F. Krebs &Ulf Panzer 
https://doi.org/10.1038/s41392-024-02010-z
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Mapping Alzheimer’s disease: exploring cellular vulnerability and resilience
Natalia Ortí-Casañ  ORCID: orcid.org/0000-0002-8103-7037,John R. Bethea &Ulrich L. M. Eisel 
https://doi.org/10.1038/s41392-024-02014-9
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