Ying Jin ORCID: orcid.org/0000-0001-7105-3052,Run-Jie Huang,Wen-Long Guan,Zhi-Qiang Wang,Zong-Jiong Mai,Yu-Hong Li,Jian Xiao,Xing Zhang,Qi Zhao ORCID: orcid.org/0000-0002-8683-6145,Shi-Fu Chen,Ming Liu,Yan-Xia Shi,Feng Wang ORCID: orcid.org/0000-0001-7668-9674 &…Rui-Hua Xu ORCID: orcid.org/0000-0001-9771-8534

https://doi.org/10.1038/s41392-024-01939-5

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Sintilimab (anti-PD-1 antibody) combined with high-dose methotrexate, temozolomide, and rituximab (anti-CD20 antibody) in primary central nervous system lymphoma: a phase 2 study

Zhiyong Zeng,Apeng Yang,Jingke Yang,Sheng Zhang,Zhen Xing,Xingfu Wang,Wenzhong Mei,Changzhen Jiang,Junfang Lin,Xiyue Wu,Yihui Xue,Zanyi Wu,Lianghong Yu,Dengliang Wang,Jianwu Chen,Shufa Zheng,Qiaoxian Lin,Qingjiao Chen,Jinfeng Dong,Xiaoqiang Zheng,Jizhen Wang,Jinlong Huang,Zhenying Chen,Ping Chen,Meihong Zheng,Xiaofang Zhou,Youwen He ORCID: orcid.org/0000-0002-8983-2684,Yuanxiang Lin &…Junmin Chen

https://doi.org/10.1038/s41392-024-01941-x

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A new paradigm for generating high-quality cardiac pacemaker cells from mouse pluripotent stem cells

Zheyi Lin,Bowen Lin,Chengwen Hang,Renhong Lu,Hui Xiong,Junyang Liu,Siyu Wang,Zheng Gong,Mingshuai Zhang,Desheng Li,Guojian Fang,Jie Ding,Xuling Su,Huixin Guo,Dan Shi,Duanyang Xie,Yi Liu,Dandan Liang,Jian Yang &…Yi-Han Chen ORCID: orcid.org/0000-0003-1000-1835

https://doi.org/10.1038/s41392-024-01942-w

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Anti-PD-L1 antibody ASC22 in combination with a histone deacetylase inhibitor chidamide as a “shock and kill” strategy for ART-free virological control: a phase II single-arm study

Luling Wu ORCID: orcid.org/0000-0002-9918-9047,Zhihang Zheng,Jingna Xun,Li Liu,Jiangrong Wang,Xinyu Zhang,Yueming Shao,Yinzhong Shen,Renfang Zhang,Min Zhang,Meiyan Sun,Tangkai Qi,Zhenyan Wang,Shuibao Xu,Wei Song,Yang Tang,Bihe Zhao,Zichen Song,Jean-Pierre Routy,Hongzhou Lu &…Jun Chen

https://doi.org/10.1038/s41392-024-01943-9

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Sintilimab combined with anlotinib and chemotherapy as second-line or later therapy in extensive-stage small cell lung cancer: a phase II clinical trial

Xiao Han,Jun Guo,Lingyu Li,Yong Huang,Xue Meng ORCID: orcid.org/0000-0001-6311-2649,Linlin Wang,Hui Zhu,Xiangjiao Meng,Qian Shao,Xing Li,Yan Zhang,Jin Wang,Yanhua Chen,Yingjie Zhang,Yiru Chen,Changbin Zhu &…Zhehai Wang

https://doi.org/10.1038/s41392-024-01957-3

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Characterization of ACTN4 as a novel antiviral target against SARS-CoV-2

Miao Zhu,Fang Huang,Huize Sun,Kunpeng Liu,Zhen Chen,Baocheng Yu,Haojie Hao,Haizhou Liu,Shuang Ding ORCID: orcid.org/0000-0002-9810-8428,Xueyan Zhang,Lishi Liu,Kui Zhang,Jierao Ren,Yi Liu,Haibin Liu ORCID: orcid.org/0000-0003-3601-6066,Chao Shan &…Wuxiang Guan ORCID: orcid.org/0000-0002-2415-4659

https://doi.org/10.1038/s41392-024-01956-4

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The p-MYH9/USP22/HIF-1α axis promotes lenvatinib resistance and cancer stemness in hepatocellular carcinoma

Qiaonan Shan,Lu Yin,Qifan Zhan,Jiongjie Yu,Sheng Pan,Jianyong Zhuo,Wei Zhou,Jiaqi Bao,Lincheng Zhang,Jiachen Hong,Jianan Xiang,Qingyang Que,Kangchen Chen,Shengjun Xu,Jingrui Wang,Yangbo Zhu,Bin He,Jingbang Wu,Haiyang Xie,Shusen Zheng,Tingting Feng,Sunbin Ling ORCID: orcid.org/0000-0003-0846-5489 &…Xiao Xu ORCID: orcid.org/0000-0002-2761-2811

https://doi.org/10.1038/s41392-024-01963-5

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Irinotecan hydrochloride liposome HR070803 in combination with 5-fluorouracil and leucovorin in locally advanced or metastatic pancreatic ductal adenocarcinoma following prior gemcitabine-based therapy (PAN-HEROIC-1): a phase 3 trial

Jiujie Cui,Shukui Qin,Yuhong Zhou,Shuang Zhang,Xiaofeng Sun,Mingjun Zhang,Jiuwei Cui ORCID: orcid.org/0000-0001-6496-7550,Weijia Fang,Kangsheng Gu,Zhihua Li,Jufeng Wang,Xiaobing Chen,Jun Yao,Jun Zhou,Gang Wang,Yuxian Bai,Juxiang Xiao,Wensheng Qiu,Bangmao Wang,Tao Xia,Chunyue Wang,Li Kong,Jiajun Yin,Tao Zhang ORCID: orcid.org/0000-0003-4018-3393,Xionghu Shen,Deliang Fu,Chuntao Gao,Huan Wang,Quanren Wang &…Liwei Wang ORCID: orcid.org/0000-0002-8304-3115

https://doi.org/10.1038/s41392-024-01948-4

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Single-cell exome sequencing reveals polyclonal seeding and TRPS1 mutations in colon cancer metastasis

Jianqiang Cai,Weilong Zhang,Yalan Lu,Wenjie Liu,Haitao Zhou,Mei Liu,Xinyu Bi,Jianmei Liu,Jinghua Chen,Yanjiang Yin,Yiqiao Deng,Zhiwen Luo,Yi Yang,Qichen Chen,Xiao Chen,Zheng Xu,Yueyang Zhang,Chaoling Wu,Qizhao Long,Chunyuan Huang,Changjian Yan,Yan Liu,Lei Guo,Weihua Li,Pei Yuan,Yucheng Jiao ORCID: orcid.org/0000-0001-7917-8810,Wei Song,Xiaobing Wang ORCID: orcid.org/0000-0002-0907-364X,Zhen Huang,Jianming Ying ORCID: orcid.org/0000-0002-7301-4118 &…Hong Zhao

https://doi.org/10.1038/s41392-024-01960-8

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Characterization of ferroptosis-triggered pyroptotic signaling in heart failure

https://doi.org/10.1038/s41392-024-01962-6

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GRP75 triggers white adipose tissue browning to promote cancer-associated cachexia

Xu Chen,Qingnan Wu,Wei Gong,Shaolong Ju,Jiawen Fan,Xiaohan Gao,Xingyang Liu,Xiao Lei,Siqi Liu,Xiangdong Ming,Qianyu Wang,Ming Fu,Yongmei Song ORCID: orcid.org/0000-0002-7789-0158,Yan Wang &…Qimin Zhan ORCID: orcid.org/0000-0002-1731-938X

https://doi.org/10.1038/s41392-024-01950-w

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Palmitoylation regulates myelination by modulating the ZDHHC3-Cadm4 axis in the central nervous system

Yanli Chang,Jiangli Zhu,Xiaopeng Li,Yi Deng,Birou Lai,Yidan Ma,Jia Tong,Huicong Liu,Juanjuan Li,Chenyu Yang,Qiao Chen,Chengbiao Lu,Yinming Liang ORCID: orcid.org/0000-0001-9174-4037,Shiqian Qi,Xiaoning Wang &…Eryan Kong ORCID: orcid.org/0000-0002-4086-1441

https://doi.org/10.1038/s41392-024-01971-5

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Surufatinib plus toripalimab combined with etoposide and cisplatin as first-line treatment in advanced small-cell lung cancer patients: a phase Ib/II trial

Yaxiong Zhang ORCID: orcid.org/0000-0002-3632-0300,Yan Huang,Yunpeng Yang,Yuanyuan Zhao,Ting Zhou,Gang Chen,Shen Zhao ORCID: orcid.org/0000-0003-1289-5609,Huaqiang Zhou ORCID: orcid.org/0000-0003-3538-4481,Yuxiang Ma,Shaodong Hong,Hongyun Zhao ORCID: orcid.org/0000-0002-1251-3888,Li Zhang &…Wenfeng Fang

https://doi.org/10.1038/s41392-024-01974-2

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Review Article

Circulating tumor cells: from new biological insights to clinical practice

Xuyu Gu,Shiyou Wei ORCID: orcid.org/0000-0002-1783-0372 &Xin Lv

https://doi.org/10.1038/s41392-024-01938-6

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Sex difference in human diseases: mechanistic insights and clinical implications

Yuncong Shi,Jianshuai Ma,Sijin Li,Chao Liu,Yuning Liu,Jie Chen,Ningning Liu ORCID: orcid.org/0000-0002-9587-2332,Shiming Liu &…Hui Huang ORCID: orcid.org/0000-0001-5716-4012

https://doi.org/10.1038/s41392-024-01929-7

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Emerging and reemerging infectious diseases: global trends and new strategies for their prevention and control

Shen Wang,Wujian Li,Zhenshan Wang,Wanying Yang,Entao Li,Xianzhu Xia,Feihu Yan &…Sandra Chiu ORCID: orcid.org/0000-0001-9034-5755

https://doi.org/10.1038/s41392-024-01917-x

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Pharmacokinetic characteristics of mesenchymal stem cells in translational challenges

Yunlong Shan ORCID: orcid.org/0000-0002-6954-364X,Mengying Zhang,Enxiang Tao,Jing Wang,Ning Wei,Yi Lu,Qing Liu,Kun Hao,Fang Zhou &…Guangji Wang

https://doi.org/10.1038/s41392-024-01936-8

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Crossing epigenetic frontiers: the intersection of novel histone modifications and diseases

Weiyi Yao,Xinting Hu &Xin Wang ORCID: orcid.org/0000-0001-8051-1481

https://doi.org/10.1038/s41392-024-01918-w

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Glucagon-like peptide-1 receptor: mechanisms and advances in therapy

Zhikai Zheng,Yao Zong,Yiyang Ma,Yucheng Tian ORCID: orcid.org/0000-0002-5632-9118,Yidan Pang ORCID: orcid.org/0000-0002-2286-1069,Changqing Zhang &…Junjie Gao

https://doi.org/10.1038/s41392-024-01931-z

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Pyroptosis in health and disease: mechanisms, regulation and clinical perspective

Yifan Liu,Renjie Pan,Yuzhen Ouyang,Wangning Gu,Tengfei Xiao,Hongmin Yang,Ling Tang,Hui Wang,Bo Xiang &…Pan Chen

https://doi.org/10.1038/s41392-024-01958-2

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Neutrophil extracellular traps in homeostasis and disease

Han Wang,Susan J. Kim,Yu Lei,Shuhui Wang,Hui Wang,Hai Huang,Hongji Zhang &…Allan Tsung

https://doi.org/10.1038/s41392-024-01933-x

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A systematic framework for understanding the microbiome in human health and disease: from basic principles to clinical translation

Ziqi Ma,Tao Zuo ORCID: orcid.org/0000-0001-8450-5281,Norbert Frey &…Ashraf Yusuf Rangrez

https://doi.org/10.1038/s41392-024-01946-6

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Pre-metastatic niche: formation, characteristics and therapeutic implication

Yuhang Wang,Jiachi Jia,Fuqi Wang,Yingshuai Fang,Yabing Yang,Quanbo Zhou,Weitang Yuan,Xiaoming Gu,Junhong Hu &…Shuaixi Yang ORCID: orcid.org/0009-0007-7378-7931

https://doi.org/10.1038/s41392-024-01937-7

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Research Highlight

“Clone-specific” antibody-drug conjugates: an innovative strategy in the treatment of T-cell cancers

Dennis Jungherz,Philipp Lückemeier &Marco Herling

https://doi.org/10.1038/s41392-024-01945-7

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Elimination of mutant SWI/SNF complexes by protein quality control: new opportunities targeting aggressive rhabdoid tumours

Andreas Krämer &Stefan Knapp ORCID: orcid.org/0000-0001-5995-6494

https://doi.org/10.1038/s41392-024-01935-9

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Metabolic inflexibility of mitochondria: beneficial for the fitness of regenerating liver cells

Josef Ecker ORCID: orcid.org/0000-0003-4799-0788,Sarah Brunner &Klaus-Peter Janssen ORCID: orcid.org/0000-0002-4707-7887

https://doi.org/10.1038/s41392-024-01959-1

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Type 2 diabetes across populations of different ancestry: deconstructing the genomic landscape

Georgia Xourafa ORCID: orcid.org/0009-0008-1540-0310,Christian Herder ORCID: orcid.org/0000-0002-2050-093X &Michael Roden

https://doi.org/10.1038/s41392-024-01944-8

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One step at a time: new insights into double-stranded ribonucleic acid virus assembly

Virgile Rat,Alexander Borodavka &Don C. Lamb

https://doi.org/10.1038/s41392-024-01949-3

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Spliceosomal repression: unleashing human cell totipotency

Felipe F. Lüttmann ORCID: orcid.org/0000-0003-1864-3525,Kee-Pyo Kim ORCID: orcid.org/0000-0002-8666-8444 &Johnny Kim ORCID: orcid.org/0000-0002-5226-5460

https://doi.org/10.1038/s41392-024-01966-2

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Checkpoint blockade therapy in Hodgkin lymphoma: improved response through combination with JAK inhibition

Marc A. Weniger &Ralf Küppers ORCID: orcid.org/0000-0002-6691-7191

https://doi.org/10.1038/s41392-024-01968-0

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Understanding genetics, sex and signaling: Implications of sex-dependent APOE4-neutrophil-microglia interactions for Alzheimer’s and tauopathies

Natja Haag,Juliane Bremer ORCID: orcid.org/0000-0002-0268-9425 &Hans Zempel ORCID: orcid.org/0000-0002-7510-3077

https://doi.org/10.1038/s41392-024-01967-1

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Advancing clinical-basic-clinical research: exploring novel immunotargets for ovarian cancer

Yuanzhuo Gu,Long Zhang ORCID: orcid.org/0000-0001-8139-0474 &Weiguo Lv

https://doi.org/10.1038/s41392-024-01970-6

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Innate immune sensing of danger signals: novel mechanism of heme complex-mediated lytic cell death

Chintan Chhatbar ORCID: orcid.org/0000-0002-5824-5209,Michael Schulz &Roman Sankowski ORCID: orcid.org/0000-0001-9215-8021

https://doi.org/10.1038/s41392-024-01985-z

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