Table of Contents
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Volume 9 Issue 9, Sep 2024

Review Article
Mechanism insights and therapeutic intervention of tumor metastasis: latest developments and perspectives
Xiaoli Shi,Xinyi Wang  ORCID: orcid.org/0009-0003-3055-7547,Wentao Yao,Dongmin Shi,Xihuan Shao,Zhengqing Lu,Yue Chai,Jinhua Song,Weiwei Tang  ORCID: orcid.org/0000-0002-8516-819X &…Xuehao Wang  ORCID: orcid.org/0000-0001-5849-0098 
https://doi.org/10.1038/s41392-024-01885-2
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Glycosylation: mechanisms, biological functions and clinical implications
Mengyuan He,Xiangxiang Zhou &Xin Wang  ORCID: orcid.org/0000-0001-8051-1481 
https://doi.org/10.1038/s41392-024-01886-1
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Cell–cell communication: new insights and clinical implications
Jimeng Su,Ying Song,Zhipeng Zhu,Xinyue Huang,Jibiao Fan,Jie Qiao &…Fengbiao Mao 
https://doi.org/10.1038/s41392-024-01888-z
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Current advance of nanotechnology in diagnosis and treatment for malignant tumors
Bilan Wang,Shiqi Hu,Yan Teng,Junli Chen,Haoyuan Wang,Yezhen Xu,Kaiyu Wang,Jianguo Xu,Yongzhong Cheng &…Xiang Gao  ORCID: orcid.org/0000-0001-7478-5072 
https://doi.org/10.1038/s41392-024-01889-y
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Therapeutic advances of targeting receptor tyrosine kinases in cancer
Ciprian Tomuleasa,Adrian-Bogdan Tigu,Raluca Munteanu,Cristian-Silviu Moldovan,David Kegyes,Anca Onaciu,Diana Gulei,Gabriel Ghiaur,Hermann Einsele &…Carlo M. Croce 
https://doi.org/10.1038/s41392-024-01899-w
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Drug tolerant persister cell plasticity in cancer: a revolutionary strategy for more effective anticancer therapies
Jun He,Zejing Qiu,Jingjing Fan,Xiaohong Xie,Qinsong Sheng &…Xinbing Sui  ORCID: orcid.org/0000-0001-7330-0467 
https://doi.org/10.1038/s41392-024-01891-4
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MYC and KRAS cooperation: from historical challenges to therapeutic opportunities in cancer
Sílvia Casacuberta-Serra  ORCID: orcid.org/0000-0002-2595-1115,Íñigo González-Larreategui,Daniel Capitán-Leo &…Laura Soucek  ORCID: orcid.org/0000-0002-4750-7971 
https://doi.org/10.1038/s41392-024-01907-z
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The JAK-STAT pathway: from structural biology to cytokine engineering
You Lv,Jianxun Qi  ORCID: orcid.org/0000-0002-9358-4732,Jeffrey J. Babon,Longxing Cao,Guohuang Fan,Jiajia Lang,Jin Zhang,Pengbing Mi,Bostjan Kobe  ORCID: orcid.org/0000-0001-9413-9166 &…Faming Wang 
https://doi.org/10.1038/s41392-024-01934-w
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Recent advances in Alzheimer’s disease: mechanisms, clinical trials and new drug development strategies
Jifa Zhang,Yinglu Zhang,Jiaxing Wang  ORCID: orcid.org/0000-0002-3202-2402,Yilin Xia,Jiaxian Zhang &…Lei Chen 
https://doi.org/10.1038/s41392-024-01911-3
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Tertiary lymphoid structures in diseases: immune mechanisms and therapeutic advances
Lianyu Zhao,Song Jin,Shengyao Wang,Zhe Zhang,Xuan Wang,Zhanwei Chen,Xiaohui Wang,Shengyun Huang,Dongsheng Zhang &…Haiwei Wu  ORCID: orcid.org/0000-0003-1813-3760 
https://doi.org/10.1038/s41392-024-01947-5
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Hyperuricemia and its related diseases: mechanisms and advances in therapy
Lin Du,Yao Zong,Haorui Li,Qiyue Wang,Lei Xie,Bo Yang,Yidan Pang  ORCID: orcid.org/0000-0002-2286-1069,Changqing Zhang,Zhigang Zhong &…Junjie Gao  ORCID: orcid.org/0000-0003-4820-8524 
https://doi.org/10.1038/s41392-024-01916-y
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Article
Revealing the crucial roles of suppressive immune microenvironment in cardiac myxoma progression
Zedong Jiang,Qianlong Kang,Hong Qian,Zhijie Xu  ORCID: orcid.org/0000-0003-2047-883X,Huan Tong,Jiaqing Yang,Li Li,Renwei Li,Guangqi Li,Fei Chen,Nan Lin,Yunuo Zhao,Huashan Shi  ORCID: orcid.org/0000-0002-9958-9892,Juan Huang &…Xuelei Ma  ORCID: orcid.org/0000-0002-9148-5001 
https://doi.org/10.1038/s41392-024-01912-2
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Targeting Lactobacillus johnsonii to reverse chronic kidney disease
Hua Miao,Fei Liu,Yan-Ni Wang,Xiao-Yong Yu,Shougang Zhuang,Yan Guo,Nosratola D. Vaziri,Shi-Xing Ma,Wei Su,You-Quan Shang,Ming Gao,Jin-Hua Zhang,Li Zhang,Ying-Yong Zhao  ORCID: orcid.org/0000-0002-0239-7342 &…Gang Cao  ORCID: orcid.org/0000-0002-0819-0430 
https://doi.org/10.1038/s41392-024-01913-1
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Ribosomal modification protein rimK-like family member A activates betaine-homocysteine S-methyltransferase 1 to ameliorate hepatic steatosis
Han Yan,Wenjun Liu  ORCID: orcid.org/0009-0005-8050-6355,Rui Xiang,Xin Li,Song Hou,Luzheng Xu,Lin Wang  ORCID: orcid.org/0000-0001-5586-3012,Dong Zhao,Xingkai Liu,Guoqing Wang  ORCID: orcid.org/0000-0001-9326-3755,Yujing Chi  ORCID: orcid.org/0000-0002-4069-9093 &…Jichun Yang 
https://doi.org/10.1038/s41392-024-01914-0
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LIM-domain-only 4 (LMO4) enhances CD8+ T-cell stemness and tumor rejection by boosting IL-21-STAT3 signaling
Roland C. Schelker,Jessica Fioravanti  ORCID: orcid.org/0000-0001-6263-4306,Fabio Mastrogiovanni,Jeremy G. Baldwin,Nisha Rana,Peng Li,Ping Chen,Timea Vadász,Rosanne Spolski,Christoph Heuser-Loy  ORCID: orcid.org/0000-0003-1410-7573,Dragana Slavkovic-Lukic  ORCID: orcid.org/0000-0002-3107-7727,Pedro Noronha,Giuseppe Damiano,Laura Raccosta,Daniela Maggioni,Sree Pullugula,Jian-Xin Lin  ORCID: orcid.org/0000-0001-5849-9412,Jangsuk Oh,Patrick Grandinetti,Mario Lecce,Leo Hesse,Emilia Kocks,Azucena Martín-Santos,Claudia Gebhard,William G. Telford,Yun Ji,Nicholas P. Restifo,Vincenzo Russo,Michael Rehli,Wolfgang Herr,Warren J. Leonard  ORCID: orcid.org/0000-0002-5740-7448 &…Luca Gattinoni  ORCID: orcid.org/0000-0003-2239-3282 
https://doi.org/10.1038/s41392-024-01915-z
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Potassium voltage-gated channel subfamily H member 2 (KCNH2) is a promising target for incretin secretagogue therapies
Ying-Chao Yuan,Hao Wang,Ze-Ju Jiang,Chang Liu,Qi Li,Si-Rui Zhou &…Jin-Kui Yang  ORCID: orcid.org/0000-0002-5430-2149 
https://doi.org/10.1038/s41392-024-01923-z
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Gefitinib (an EGFR tyrosine kinase inhibitor) plus anlotinib (an multikinase inhibitor) for untreated, EGFR-mutated, advanced non-small cell lung cancer (FL-ALTER): a multicenter phase III trial
Hua-Qiang Zhou  ORCID: orcid.org/0000-0003-3538-4481,Ya-Xiong Zhang  ORCID: orcid.org/0000-0002-3632-0300,Gang Chen,Qi-Tao Yu,Hua Zhang,Guo-Wu Wu,Di Wu,Ying-Cheng Lin,Jun-Fei Zhu,Jian-Hua Chen,Xiao-Hua Hu,Bin Lan,Ze-Qiang Zhou,Hai-Feng Lin,Zi-Bing Wang,Xiao-Lin Lei,Suo-Ming Pan,Li-Ming Chen,Jian Zhang,Tian-Dong Kong,Ji-Cheng Yao,Xin Zheng,Feng Li,Li Zhang &…Wen-Feng Fang 
https://doi.org/10.1038/s41392-024-01927-9
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Branched-chain amino acid transaminase 1 confers EGFR-TKI resistance through epigenetic glycolytic activation
Tao Zhang,Zilu Pan,Jing Gao,Qingqing Wu,Gang Bai,Yan Li,Linjiang Tong,Fang Feng,Mengzhen Lai,Yingqiang Liu,Peiran Song,Yi Ning,Haotian Tang,Wen Luo,Yi Chen  ORCID: orcid.org/0000-0002-2181-0403,Yan Fang,Hui Zhang,Qiupei Liu,Yudi Zhang,Hua Wang,Zhiwei Chen,Yi Chen,Meiyu Geng  ORCID: orcid.org/0000-0002-7362-0847,Hongbin Ji  ORCID: orcid.org/0000-0003-0891-6390,Guilong Zhao,Hu Zhou  ORCID: orcid.org/0000-0001-7006-4737,Jian Ding  ORCID: orcid.org/0000-0002-5815-4956 &…Hua Xie 
https://doi.org/10.1038/s41392-024-01928-8
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Annexin A1 binds PDZ and LIM domain 7 to inhibit adipogenesis and prevent obesity
Lu Fang,Changjie Liu,Zong-zhe Jiang,Mengxiao Wang,Kang Geng,Yangkai Xu,Yujie Zhu,Yiwen Fu,Jing Xue,Wenxin Shan,Qi Zhang,Jie Chen,Jiahong Chen,Mingming Zhao,Yuxuan Guo  ORCID: orcid.org/0000-0002-6009-4403,K. W. Michael Siu,Y. Eugene Chen  ORCID: orcid.org/0000-0003-2357-7825,Yong Xu,Donghui Liu &…Lemin Zheng  ORCID: orcid.org/0000-0003-4473-6936 
https://doi.org/10.1038/s41392-024-01930-0
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Predicting gastric cancer response to anti-HER2 therapy or anti-HER2 combined immunotherapy based on multi-modal data
Zifan Chen,Yang Chen,Yu Sun,Lei Tang,Li Zhang,Yajie Hu,Meng He,Zhiwei Li,Siyuan Cheng,Jiajia Yuan,Zhenghang Wang,Yakun Wang,Jie Zhao,Jifang Gong,Liying Zhao,Baoshan Cao,Guoxin Li,Xiaotian Zhang,Bin Dong &…Lin Shen  ORCID: orcid.org/0000-0003-1134-2922 
https://doi.org/10.1038/s41392-024-01932-y
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Research Highlight
Breaking barriers: noncanonical inflammasome executes blood–brain barrier disruption
Martin Dichgans  ORCID: orcid.org/0000-0002-0654-387X,Jonas J. Neher &Yaw Asare  ORCID: orcid.org/0000-0002-8946-5650 
https://doi.org/10.1038/s41392-024-01921-1
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Single cell whole-genome sequencing of brain cells: age- and cell-type specific mutational profiles
Melania Capasso  ORCID: orcid.org/0000-0001-8659-9867 &N. Ahmad Aziz  ORCID: orcid.org/0000-0001-6184-458X 
https://doi.org/10.1038/s41392-024-01892-3
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Nascent mRNA damage: depot and disposal
Mark Helm &Marie-Luise Winz 
https://doi.org/10.1038/s41392-024-01900-6
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Novel pathomechanistic insights into lysosomal storage disorders: how neuron-intrinsic cGAS-STING signaling drives disease progression
Maximilian Frosch  ORCID: orcid.org/0000-0002-5418-0962 &Marco Prinz  ORCID: orcid.org/0000-0002-0349-1955 
https://doi.org/10.1038/s41392-024-01901-5
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Biofilms and exopolysaccharides in Pseudomonas aeruginosa: pathogenesis, immune evasion, and lung–brain signaling during pneumonia
Shuaibing Zhang  ORCID: orcid.org/0000-0003-4455-0971 &Pierre Stallforth  ORCID: orcid.org/0000-0001-7260-9921 
https://doi.org/10.1038/s41392-024-01902-4
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An emerging artificial nanomachine: a nanoengine with a reversible clutch
Ziqi Fang,Jianxin Jiang &Min Wu  ORCID: orcid.org/0000-0003-1205-982X 
https://doi.org/10.1038/s41392-024-01919-9
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Opioid receptors: single molecule studies shed light on mechanisms of efficacy
Cornelius Krasel  ORCID: orcid.org/0000-0001-8309-8696 &Moritz Bünemann  ORCID: orcid.org/0000-0002-2259-4378 
https://doi.org/10.1038/s41392-024-01920-2
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Mind-body control: a new perspective on motor neuron function
Maria-Luise Petrovic-Erfurth &Albena Jordanova 
https://doi.org/10.1038/s41392-024-01922-0
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Letter
Robust neutralizing antibody response to the XBB.1.5 trivalent recombinant protein vaccine booster
Bing-Dong Zhan  ORCID: orcid.org/0000-0003-3916-1306,Xue-Dong Song,Xin Yu,Guo-Jian Yang,Sheng Wan &…Mai-Juan Ma  ORCID: orcid.org/0000-0002-8105-462X 
https://doi.org/10.1038/s41392-024-01924-y
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Immune recall enhances cross-reactive antibody longevity after a large wave of SARS-CoV-2 breakthrough infection
Dan Li,Qingfei Chu,Kang Li,Lanjuan Li &…Yiming Shao 
https://doi.org/10.1038/s41392-024-01926-w
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Enhancing RBD exposure and S1 shedding by an extremely conserved SARS-CoV-2 NTD epitope
Qianhui Zhu,Pan Liu,Shuo Liu,Can Yue &…Xiangxi Wang  ORCID: orcid.org/0000-0003-0635-278X 
https://doi.org/10.1038/s41392-024-01940-y
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