Table of Contents
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Volume 9 Issue 8, Aug 2024

Review Article
Harnessing the potential of hydrogels for advanced therapeutic applications: current achievements and future directions
Peilin Lu,Dongxue Ruan,Meiqi Huang,Mi Tian,Kangshun Zhu,Ziqi Gan &…Zecong Xiao 
https://doi.org/10.1038/s41392-024-01852-x
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Cancer stem cells: advances in knowledge and implications for cancer therapy
Xianjing Chu,Wentao Tian,Jiaoyang Ning,Gang Xiao,Yunqi Zhou,Ziqi Wang,Zhuofan Zhai,Guilong Tanzhu,Jie Yang &…Rongrong Zhou 
https://doi.org/10.1038/s41392-024-01851-y
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Bacterial persisters: molecular mechanisms and therapeutic development
Hongxia Niu,Jiaying Gu &Ying Zhang 
https://doi.org/10.1038/s41392-024-01866-5
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Exploring treatment options in cancer: tumor treatment strategies
Beilei Liu  ORCID: orcid.org/0000-0002-0623-9093,Hongyu Zhou,Licheng Tan,Kin To Hugo Siu &…Xin-Yuan Guan  ORCID: orcid.org/0000-0002-4485-6017 
https://doi.org/10.1038/s41392-024-01856-7
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Targeting cytokine and chemokine signaling pathways for cancer therapy
Ming Yi,Tianye Li,Mengke Niu,Haoxiang Zhang,Yuze Wu,Kongming Wu &…Zhijun Dai 
https://doi.org/10.1038/s41392-024-01868-3
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Letter
Dietary protein sources, gut microbiome, and puberty timing in children: findings from a cohort study
Yujie Xu,Jingyuan Xiong  ORCID: orcid.org/0000-0001-9354-862X,Xiaoyu Wang,Fang He &…Guo Cheng 
https://doi.org/10.1038/s41392-024-01890-5
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Heterogeneous hybrid immunity against Omicron variant JN.1 at 11 months following breakthrough infection
Xuan He  ORCID: orcid.org/0000-0002-9448-4426,Jingyou Yu  ORCID: orcid.org/0000-0002-0775-6623,Jiajing Jiang,Jinyuan Liu,Qi Qi,Dan Liu &…Weimin Li  ORCID: orcid.org/0000-0003-0985-0311 
https://doi.org/10.1038/s41392-024-01898-x
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Hypoxia-induced nuclear localization of ubiquinol-cytochrome-c reductase complex assembly factor 3 (UQCC3) in hepatocellular carcinoma
Yun Yang,Yinhao Wei,Yiying Sun,Yong Zhou &…Hanshuo Yang 
https://doi.org/10.1038/s41392-024-01909-x
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Article
Semaphorin 3C (Sema3C) reshapes stromal microenvironment to promote hepatocellular carcinoma progression
Hao Peng,Meng Yang,Kun Feng  ORCID: orcid.org/0000-0002-2046-2283,Qingpeng Lv &…Yewei Zhang 
https://doi.org/10.1038/s41392-024-01887-0
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A deep learning-driven discovery of berberine derivatives as novel antibacterial against multidrug-resistant Helicobacter pylori
Xixi Guo,Xiaosa Zhao,Xi Lu,Liping Zhao,Qingxuan Zeng,Fenbei Chen,Zhimeng Zhang,Mengyi Xu,Shijiao Feng,Tianyun Fan,Wei Wei,Xin Zhang,Jing Pang,Xuefu You,Danqing Song,Yanxiang Wang &…Jiandong Jiang  ORCID: orcid.org/0000-0003-1173-685X 
https://doi.org/10.1038/s41392-024-01895-0
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Synergistic induction of mitotic pyroptosis and tumor remission by inhibiting proteasome and WEE family kinases
Zhan-Li Chen,Chen Xie,Wei Zeng,Rui-Qi Huang,Jin-E Yang,Jin-Yu Liu,Ya-Jing Chen &…Shi-Mei Zhuang  ORCID: orcid.org/0000-0002-2512-3942 
https://doi.org/10.1038/s41392-024-01896-z
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SHR-A1811 (antibody-drug conjugate) in advanced HER2-mutant non-small cell lung cancer: a multicenter, open-label, phase 1/2 study
Ziming Li,Zhengbo Song,Wei Hong,Nong Yang,Yongsheng Wang,Hong Jian,Zibin Liang,Sheng Hu,Min Peng,Yan Yu,Yan Wang,Zicong Jiao,Kaijing Zhao,Ke Song,You Li,Wei Shi &…Shun Lu  ORCID: orcid.org/0000-0001-8833-7262 
https://doi.org/10.1038/s41392-024-01897-y
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In vivo evaluation of guide-free Cas9-induced safety risks in a pig model
Weikai Ge,Shixue Gou,Xiaozhu Zhao,Qin Jin,Zhenpeng Zhuang,Yu Zhao,Yanhui Liang,Zhen Ouyang,Xiaoyi Liu,Fangbing Chen,Hui Shi,Haizhao Yan,Han Wu  ORCID: orcid.org/0000-0002-0129-4130,Liangxue Lai  ORCID: orcid.org/0000-0002-5256-6802 &…Kepin Wang 
https://doi.org/10.1038/s41392-024-01905-1
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Intranasal adenovirus-vectored Omicron vaccine induced nasal immunoglobulin A has superior neutralizing potency than serum antibodies
Si Chen,Zhengyuan Zhang,Qian Wang,Qi Yang,Li Yin,Lishan Ning,Zhilong Chen,Jielin Tang,Weiqi Deng,Ping He,Hengchun Li,Linjing Shi,Yijun Deng,Zijian Liu,Hemeng Bu,Yaohui Zhu,Wenming Liu,Linbing Qu  ORCID: orcid.org/0000-0002-3964-1740,Liqiang Feng,Xiaoli Xiong  ORCID: orcid.org/0000-0002-4632-9122,Baoqing Sun,Nanshan Zhong,Feng Li  ORCID: orcid.org/0000-0003-3169-6349,Pingchao Li,Xinwen Chen  ORCID: orcid.org/0000-0002-4052-8155 &…Ling Chen 
https://doi.org/10.1038/s41392-024-01906-0
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CDC7 inhibition impairs neuroendocrine transformation in lung and prostate tumors through MYC degradation
Alvaro Quintanal-Villalonga  ORCID: orcid.org/0000-0002-7234-3446,Kenta Kawasaki,Esther Redin,Fathema Uddin,Swanand Rakhade,Vidushi Durani,Amin Sabet,Moniquetta Shafer,Wouter R. Karthaus,Samir Zaidi,Yingqian A. Zhan  ORCID: orcid.org/0000-0002-3548-9227,Parvathy Manoj,Harsha Sridhar,Dennis Kinyua,Hong Zhong,Barbara P. Mello,Metamia Ciampricotti,Umesh K. Bhanot,Irina Linkov,Juan Qiu,Radhika A. Patel,Colm Morrissey,Sanjoy Mehta,Jesse Barnes,Michael C. Haffner,Nicholas D. Socci,Richard P. Koche,Elisa de Stanchina,Sonia Molina-Pinelo,Sohrab Salehi,Helena A. Yu,Joseph M. Chan &…Charles M. Rudin  ORCID: orcid.org/0000-0001-5204-3465 
https://doi.org/10.1038/s41392-024-01908-y
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Research Highlight
Boosting liver regeneration: kinase inhibitor as a new tool to prevent liver failure
Anna Sichler,Norbert Hüser &Klaus-Peter Janssen  ORCID: orcid.org/0000-0002-4707-7887 
https://doi.org/10.1038/s41392-024-01879-0
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Artificial intelligence meets body sense: task-driven neural networks reveal computational principles of the proprioceptive pathway
Leonard E. van Dyck  ORCID: orcid.org/0000-0002-6006-8539,Frank Bremmer  ORCID: orcid.org/0000-0003-1597-7407 &Katharina Dobs  ORCID: orcid.org/0000-0001-6619-5590 
https://doi.org/10.1038/s41392-024-01870-9
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Prosaposin hyperglycosylation: a novel tumor immune escape mechanism and implications for cancer immunotherapy
Matthias Peipp,Diana Dudziak &Christian Kellner 
https://doi.org/10.1038/s41392-024-01877-2
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The Ca2+-sensing receptor and the pocketome: comparing nature’s complexity with human intervention in receptor modulation
Edda S. F. Matthees  ORCID: orcid.org/0000-0002-7760-5900 &Carsten Hoffmann  ORCID: orcid.org/0000-0003-0884-9300 
https://doi.org/10.1038/s41392-024-01863-8
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G protein-mediated signal transduction: a molecular choreography of G protein activation after GTP binding
Evi Kostenis  ORCID: orcid.org/0000-0001-8284-5514,Lars Jürgenliemke  ORCID: orcid.org/0009-0001-2701-9276 &Judith Alenfelder  ORCID: orcid.org/0009-0009-3733-3443 
https://doi.org/10.1038/s41392-024-01903-3
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Sensory neurons: unveiling the symphony of wound healing
Dongsheng Jiang  ORCID: orcid.org/0000-0003-0961-2671,Hans-Günther Machens &Yuval Rinkevich 
https://doi.org/10.1038/s41392-024-01880-7
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Proximity-dependent protein (de)stabilization: screening the human ORFeome for protein degraders and stabilizers
Thomas Hermanns  ORCID: orcid.org/0000-0001-5350-7479 &Kay Hofmann  ORCID: orcid.org/0000-0002-2289-9083 
https://doi.org/10.1038/s41392-024-01884-3
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Synthetic lethality by PARP inhibitors: new mechanism uncovered based on unresolved transcription-replication conflicts
Marina Kolesnichenko &Claus Scheidereit 
https://doi.org/10.1038/s41392-024-01893-2
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Microglial complex I activity: a crucial factor for smoldering inflammation in the central nervous system
Jana K. Sonner  ORCID: orcid.org/0000-0002-4700-272X,Christina Mayer  ORCID: orcid.org/0000-0002-4148-2822 &Manuel A. Friese  ORCID: orcid.org/0000-0001-6380-2420 
https://doi.org/10.1038/s41392-024-01894-1
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Comment
Adhesion G protein-coupled receptor latrophilin 1 (ADGRL1): a novel regulator of glucose and energy homeostasis
Kavaljit H. Chhabra  ORCID: orcid.org/0000-0001-6378-3645 
https://doi.org/10.1038/s41392-024-01925-x
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