Sihui Luo ORCID: orcid.org/0000-0001-8503-0310,Xueying Zheng,Wei Bao,Sheng Nie,Yu Ding,Tong Yue,Yilun Zhou,Ying Hu,Hua Li,Qiongqiong Yang,Qijun Wan,Bicheng Liu ORCID: orcid.org/0000-0002-4584-1853,Hong Xu,Guisen Li,Gang Xu,Chunbo Chen,Huafeng Liu,Yongjun Shi,Yan Zha,Yaozhong Kong,Guobin Su,Ying Tang ORCID: orcid.org/0000-0003-0777-5565,Mengchun Gong,Linong Ji,Fan Fan Hou ORCID: orcid.org/0000-0003-3117-7418 &…Jianping Weng ORCID: orcid.org/0000-0002-5488-5217

https://doi.org/10.1038/s41392-024-01854-9

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First-line penpulimab (an anti-PD1 antibody) and anlotinib (an angiogenesis inhibitor) with nab-paclitaxel/gemcitabine (PAAG) in metastatic pancreatic cancer: a prospective, multicentre, biomolecular exploratory, phase II trial

Huizi Sha,Fan Tong,Jiayao Ni,Yi Sun ORCID: orcid.org/0000-0002-3818-1260,Yahui Zhu,Liang Qi,Xiaoqin Li,Wei Li,Yan Yang,Qing Gu,Xing Zhang,Xiaoxuan Wang,Chan Zhu,Dongsheng Chen,Baorui Liu &…Juan Du

https://doi.org/10.1038/s41392-024-01857-6

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Farnesyltransferase inhibitor lonafarnib suppresses respiratory syncytial virus infection by blocking conformational change of fusion glycoprotein

Qi Yang,Bao Xue,Fengjiang Liu ORCID: orcid.org/0000-0002-9400-308X,Yongzhi Lu,Jielin Tang,Mengrong Yan,Qiong Wu,Ruyi Chen,Anqi Zhou,Lijie Liu,Junjun Liu,Changbin Qu,Qingxin Wu,Muqing Fu,Jiayi Zhong,Jianwei Dong,Sijie Chen,Fan Wang,Yuan Zhou,Jie Zheng,Wei Peng,Jinsai Shang ORCID: orcid.org/0000-0001-8164-1544 &…Xinwen Chen ORCID: orcid.org/0000-0002-4052-8155

https://doi.org/10.1038/s41392-024-01858-5

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Nonconserved epitopes dominate reverse preexisting T cell immunity in COVID-19 convalescents

Xin Wang,Jie Zhang,Maoshun Liu,Yuanyuan Guo,Peipei Guo,Xiaonan Yang,Bingli Shang,Min Li,Jinmin Tian,Ting Zhang,Xi Wang ORCID: orcid.org/0000-0001-6753-3053,Ronghua Jin,Jikun Zhou,George F. Gao ORCID: orcid.org/0000-0002-3869-615X &…Jun Liu ORCID: orcid.org/0000-0003-3605-4070

https://doi.org/10.1038/s41392-024-01876-3

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Genetically programmable cell membrane-camouflaged nanoparticles for targeted combination therapy of colorectal cancer

Yun Yang,Qingya Liu,Meng Wang,Lang Li,Yan Yu,Meng Pan,Danrong Hu ORCID: orcid.org/0000-0001-9998-4393,Bingyang Chu,Ying Qu &…Zhiyong Qian

https://doi.org/10.1038/s41392-024-01859-4

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Neoadjuvant camrelizumab (an anti-PD-1 antibody) plus chemotherapy or apatinib (a VEGFR-2 inhibitor) for initially unresectable stage II–III non-small-cell lung cancer: a multicentre, two-arm, phase 2 exploratory study

Haoran Xia,Han Zhang,Zheng Ruan,Huibiao Zhang,Liangdong Sun,Hezhong Chen,Yongxin Zhou,Lele Zhang ORCID: orcid.org/0000-0002-5595-3103,Dongliang Bian,Xinsheng Zhu,Jing Zhang,Fenghuan Sun,Huansha Yu,Nan Song,Xiaogang Liu,Yuming Zhu,Haiping Zhang,Wenxin He,Jian Chen,Jie Yang,Guohan Chen,Shiliang Xie,Dongfang Tang,Xiaomiao Zhang,Liang Duan,Deping Zhao,Qinchuan Li,Peng Zhang &…Gening Jiang

https://doi.org/10.1038/s41392-024-01861-w

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Targeted therapy for capillary-venous malformations

Lola Zerbib,Sophia Ladraa,Antoine Fraissenon,Charles Bayard,Marina Firpion,Quitterie Venot,Sanela Protic,Clément Hoguin,Amandine Thomas,Sylvie Fraitag,Jean-Paul Duong,Sophie Kaltenbach,Estelle Balducci,Coline Lefevre,Patrick Villarese,Vahid Asnafi,Christine Broissand,Nicolas Goudin,Ivan Nemazanyy ORCID: orcid.org/0000-0001-8080-839X,Gwennhael Autret,Bertrand Tavitian ORCID: orcid.org/0000-0002-5349-8194,Christophe Legendre,Nadia Arzouk,Veronique Minard-Colin,Caroline Chopinet,Michael Dussiot,Denise M. Adams,Tristan Mirault,Laurent Guibaud,Paul Isenring &…Guillaume Canaud

https://doi.org/10.1038/s41392-024-01862-9

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DNA of neutrophil extracellular traps promote NF-κB-dependent autoimmunity via cGAS/TLR9 in chronic obstructive pulmonary disease

Jun Chen,Tao Wang,Xiaoou Li,Lijuan Gao,Ke Wang,Mengxin Cheng,Zijian Zeng,Lei Chen,Yongchun Shen &…Fuqiang Wen ORCID: orcid.org/0000-0001-6205-4758

https://doi.org/10.1038/s41392-024-01881-6

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Penpulimab, an anti-PD-1 antibody, for heavily pretreated metastatic nasopharyngeal carcinoma: a single-arm phase II study

Xiaozhong Chen,Wei Wang,Qingfeng Zou,Xiaodong Zhu,Qin Lin,Yi Jiang,Yan Sun,Liangfang Shen,Lin Wang,Guorong Zou,Xiaoyan Lin,Shaojun Lin,Minying Li,Ying Wang,Ruilian Xu,Rui Ao,Rensheng Wang,Haifeng Lin,Shuang Huang,Tingting Xu,Wenting Li,Mengying Xia,Yu Xia,Zhongmin Wang ORCID: orcid.org/0000-0002-1683-5147,Baiyong Li,Jingao Li &…Chaosu Hu ORCID: orcid.org/0000-0001-6407-3311

https://doi.org/10.1038/s41392-024-01865-6

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Optimized RNA interference therapeutics combined with interleukin-2 mRNA for treating hepatitis B virus infection

Wenjing Zai,Min Yang,Kuan Jiang,Juan Guan,Huijing Wang,Kongying Hu,Chao Huang,Jieliang Chen,Wei Fu ORCID: orcid.org/0000-0003-2321-1057,Changyou Zhan ORCID: orcid.org/0000-0002-5215-2829 &…Zhenghong Yuan

https://doi.org/10.1038/s41392-024-01871-8

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Engineered extracellular vesicles for targeted reprogramming of cancer-associated fibroblasts to potentiate therapy of pancreatic cancer

Pengcheng Zhou,Xuanlong Du,Weilu Jia,Kun Feng ORCID: orcid.org/0000-0002-2046-2283 &…Yewei Zhang

https://doi.org/10.1038/s41392-024-01872-7

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Targeting a disintegrin and metalloprotease (ADAM) 17-CD122 axis enhances CD8+ T cell effector differentiation and anti-tumor immunity

Lina Sun,Anjun Jiao,Haiyan Liu,Renyi Ding,Ning Yuan,Biao Yang,Cangang Zhang,Xiaoxuan Jia,Gang Wang ORCID: orcid.org/0000-0001-6020-7263,Yanhong Su,Dan Zhang,Lin Shi,Chenming Sun,Aijun Zhang,Lianjun Zhang ORCID: orcid.org/0000-0001-9448-7718 &…Baojun Zhang ORCID: orcid.org/0000-0002-7786-4304

https://doi.org/10.1038/s41392-024-01873-6

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A Cullin 5-based complex serves as an essential modulator of ORF9b stability in SARS-CoV-2 replication

Yuzheng Zhou,Zongpeng Chen,Sijie Liu,Sixu Liu,Yujie Liao,Ashuai Du,Zijun Dong,Yongxing Zhang,Xuan Chen,Siyi Tao,Xin Wu,Aroona Razzaq,Gang Xu,De-an Tan,Shanni Li,Youwen Deng,Jian Peng,Shuyan Dai,Xu Deng,Xianwen Zhang,Taijiao Jiang,Zheng Zhang ORCID: orcid.org/0000-0002-3544-1389,Gong Cheng ORCID: orcid.org/0000-0001-7447-5488,Jincun Zhao ORCID: orcid.org/0000-0003-2515-5589 &…Zanxian Xia ORCID: orcid.org/0000-0002-5810-1678

https://doi.org/10.1038/s41392-024-01874-5

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Clinical efficacy and identification of factors confer resistance to afatinib (tyrosine kinase inhibitor) in EGFR-overexpressing esophageal squamous cell carcinoma

Yanni Wang,Chang Liu,Huan Chen,Xi Jiao,Yujiao Wang,Yanshuo Cao,Jian Li ORCID: orcid.org/0000-0002-9333-3255,Xiaotian Zhang,Yu Sun,Na Zhuo,Fengxiao Dong,Mengting Gao,Fengyuan Wang,Liyuan Dong,Jifang Gong,Tianqi Sun ORCID: orcid.org/0000-0003-2994-4526,Wei Zhu,Henghui Zhang ORCID: orcid.org/0000-0002-2820-7447,Lin Shen ORCID: orcid.org/0000-0003-1134-2922 &…Zhihao Lu ORCID: orcid.org/0000-0002-5588-5657

https://doi.org/10.1038/s41392-024-01875-4

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Review Article

Pathology of pain and its implications for therapeutic interventions

Bo Cao,Qixuan Xu,Yajiao Shi,Ruiyang Zhao,Hanghang Li,Jie Zheng,Fengyu Liu,You Wan &…Bo Wei

https://doi.org/10.1038/s41392-024-01845-w

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Tumor initiation and early tumorigenesis: molecular mechanisms and interventional targets

Shaosen Zhang ORCID: orcid.org/0000-0003-0010-1445,Xinyi Xiao,Yonglin Yi,Xinyu Wang,Lingxuan Zhu,Yanrong Shen,Dongxin Lin ORCID: orcid.org/0000-0002-8723-8868 &…Chen Wu

https://doi.org/10.1038/s41392-024-01848-7

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Research Highlight

Linking IL-10 signaling with lipid metabolic programs in macrophages: dysregulated ceramide homeostasis drives colitis

Imke Atreya &Markus F. Neurath

https://doi.org/10.1038/s41392-024-01864-7

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Beyond the code: the role of histone methylation in cancer resistance and therapy

Daniel Noerenberg &Frederik Damm ORCID: orcid.org/0000-0001-5553-1173

https://doi.org/10.1038/s41392-024-01878-1

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Decoding the genetic program of micronucleus formation: linking chromosomal instability to human disease