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Volume 9 Issue 6, Jun 2024

Article
Combination therapy with oncolytic virus and T cells or mRNA vaccine amplifies antitumor effects
Rao Fu,Ruoyao Qi,Hualong Xiong,Xing Lei,Yao Jiang,Jinhang He,Feng Chen,Liang Zhang,Dekui Qiu,Yiyi Chen,Meifeng Nie,Xueran Guo,Yuhe Zhu,Jinlei Zhang,Mingxi Yue,Jiali Cao,Guosong Wang,Yuqiong Que,Mujing Fang,Yingbin Wang,Yixin Chen  ORCID: orcid.org/0000-0002-9591-634X,Tong Cheng  ORCID: orcid.org/0000-0002-1638-6214,Shengxiang Ge  ORCID: orcid.org/0000-0002-7165-3004,Jun Zhang  ORCID: orcid.org/0000-0002-6601-9180,Quan Yuan  ORCID: orcid.org/0000-0001-5487-561X,Tianying Zhang  ORCID: orcid.org/0000-0002-2477-329X &…Ningshao Xia  ORCID: orcid.org/0000-0003-0179-5266 
https://doi.org/10.1038/s41392-024-01824-1
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Cholangiocarcinoma combined with biliary obstruction: an exosomal circRNA signature for diagnosis and early recurrence monitoring
Ningyuan Wen,Dingzhong Peng,Xianze Xiong,Geng Liu,Guilin Nie,Yaoqun Wang,Jianrong Xu,Shaofeng Wang,Sishu Yang,Yuan Tian,Bei Li,Jiong Lu &…Nansheng Cheng 
https://doi.org/10.1038/s41392-024-01814-3
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Haploidentical hematopoietic cell transplantation with or without an unrelated cord blood unit for adult acute myeloid leukemia: a multicenter, randomized, open-label, phase 3 trial
Biqi Zhou,Jia Chen,Tianhui Liu,Yishan Ye,Yanming Zhang,Yiyang Ding,Hong Liu,MingQing Zhu,Xiao Ma,Xiaoli Li,Longfei Zhao,Zhihong Lin,He Huang  ORCID: orcid.org/0000-0002-2723-1621,Yang Xu  ORCID: orcid.org/0000-0003-4643-2098 &…Depei Wu  ORCID: orcid.org/0000-0002-6312-3863 
https://doi.org/10.1038/s41392-024-01820-5
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A pathological joint–liver axis mediated by matrikine-activated CD4+ T cells
Junzhi Yi,Hui Zhang,Fangyuan Bao,Zhichu Chen,Yuliang Zhong,Tianning Ye,Xuri Chen,Jingyi Qian,Mengya Tian,Min Zhu,Zhi Peng,Zongyou Pan,Jianyou Li,Zihao Hu,Weiliang Shen,Jiaqi Xu,Xianzhu Zhang,Youzhi Cai,Mengjie Wu,Hua Liu,Jing Zhou &…Hongwei Ouyang 
https://doi.org/10.1038/s41392-024-01819-y
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Effect of plateletcrit and methylenetetrahydrofolate reductase (MTHFR) C677T genotypes on folic acid efficacy in stroke prevention
Yuncong Shi,Zhengzhipeng Zhang,Binyan Wang,Yu Wang,Xiangyi Kong,Yong Sun,Aimin Li,Yimin Cui,Yan Zhang,Jianping Li,Yong Huo &…Hui Huang  ORCID: orcid.org/0000-0001-5716-4012 
https://doi.org/10.1038/s41392-024-01817-0
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SARS-CoV-2 aberrantly elevates mitochondrial bioenergetics to induce robust virus propagation
Hye Jin Shin,Wooseong Lee,Keun Bon Ku,Gun Young Yoon  ORCID: orcid.org/0000-0003-2659-9819,Hyun-Woo Moon  ORCID: orcid.org/0000-0002-4191-7590,Chonsaeng Kim,Mi-Hwa Kim,Yoon-Sun Yi,Sangmi Jun,Bum-Tae Kim,Jong-Won Oh,Aleem Siddiqui &…Seong-Jun Kim  ORCID: orcid.org/0000-0001-8504-2872 
https://doi.org/10.1038/s41392-024-01836-x
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Structural basis of negative regulation of CRISPR-Cas7-11 by TPR-CHAT
Tian Hong,Qinghua Luo,Haiyun Ma,Xin Wang,Xinqiong Li,Chongrong Shen,Jie Pang,Yan Wang,Yuejia Chen,Changbin Zhang,Zhaoming Su  ORCID: orcid.org/0000-0002-9279-1721,Haohao Dong  ORCID: orcid.org/0000-0002-5022-3494 &…Xiaodi Tang  ORCID: orcid.org/0000-0001-7452-5211 
https://doi.org/10.1038/s41392-024-01821-4
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Enhanced potency of an IgM-like nanobody targeting conserved epitope in SARS-CoV-2 spike N-terminal domain
Bo Liu,Honghui Liu,Pu Han,Xiaoyun Wang,Chunmei Wang,Xinxin Yan,Wenwen Lei,Ke Xu,Jianjie Zhou,Jianxun Qi,Ruiwen Fan,Guizhen Wu,Wen-xia Tian,George F. Gao  ORCID: orcid.org/0000-0002-3869-615X &…Qihui Wang 
https://doi.org/10.1038/s41392-024-01847-8
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Safety, immunogenicity and protective effect of sequential vaccination with inactivated and recombinant protein COVID-19 vaccine in the elderly: a prospective longitudinal study
Hong-Hong Liu,Yunbo Xie,Bao-Peng Yang,Huan-Yue Wen,Peng-Hui Yang,Jin-E Lu,Yan Liu,Xi Chen,Meng-Meng Qu,Yang Zhang,Wei-Guo Hong,Yong-Gang Li,Junliang Fu  ORCID: orcid.org/0009-0001-8318-6888 &…Fu-Sheng Wang  ORCID: orcid.org/0000-0002-8043-6685 
https://doi.org/10.1038/s41392-024-01846-9
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2-APQC, a small-molecule activator of Sirtuin-3 (SIRT3), alleviates myocardial hypertrophy and fibrosis by regulating mitochondrial homeostasis
Fu Peng,Minru Liao,Wenke Jin,Wei Liu,Zixiang Li,Zhichao Fan,Ling Zou,Siwei Chen,Lingjuan Zhu,Qian Zhao,Gu Zhan,Liang Ouyang  ORCID: orcid.org/0000-0001-5537-8834,Cheng Peng,Bo Han  ORCID: orcid.org/0000-0003-3200-4682,Jin Zhang &…Leilei Fu  ORCID: orcid.org/0000-0002-0857-2682 
https://doi.org/10.1038/s41392-024-01816-1
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Sintilimab (anti-PD-1 antibody) plus chidamide (histone deacetylase inhibitor) in relapsed or refractory extranodal natural killer T-cell lymphoma (SCENT): a phase Ib/II study
Yan Gao,Haixia He,Xueping Li,Liling Zhang,Wei Xu  ORCID: orcid.org/0000-0003-4208-7477,Ru Feng,Wenyu Li,Yin Xiao,Xinxiu Liu,Yu Chen,Xiaoxiao Wang,Bing Bai,Huijing Wu,Qingqing Cai  ORCID: orcid.org/0000-0001-5447-3282,Zhiming Li  ORCID: orcid.org/0000-0001-9730-9917,Jibin Li  ORCID: orcid.org/0000-0001-7632-3648,Suxia Lin,Yanxia He,Liqin Ping,Cheng Huang,Jiaying Mao,Xiujin Chen,Baitian Zhao &…Huiqiang Huang 
https://doi.org/10.1038/s41392-024-01825-0
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DEAD-box helicase 17 (DDX17) protects cardiac function by promoting mitochondrial homeostasis in heart failure
Mingjing Yan,Junpeng Gao  ORCID: orcid.org/0000-0003-2938-2359,Ming Lan,Que Wang,Yuan Cao,Yuxuan Zheng,Yao Yang,Wenlin Li,Xiaoxue Yu,Xiuqing Huang,Lin Dou,Bing Liu,Junmeng Liu,Hongqiang Cheng  ORCID: orcid.org/0000-0001-9662-1570,Kunfu Ouyang,Kun Xu,Shenghui Sun,Jin Liu,Weiqing Tang,Xiyue Zhang,Yong Man,Liang Sun,Jianping Cai,Qing He,Fuchou Tang,Jian Li  ORCID: orcid.org/0000-0003-3320-7924 &…Tao Shen  ORCID: orcid.org/0000-0001-5856-0818 
https://doi.org/10.1038/s41392-024-01831-2
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Initial COVID-19 severity influenced by SARS-CoV-2-specific T cells imprints T-cell memory and inversely affects reinfection
Gang Yang,Jinpeng Cao,Jian Qin,Xinyue Mei  ORCID: orcid.org/0000-0001-9562-0488,Shidong Deng,Yingjiao Xia,Jun Zhao,Junxiang Wang,Tao Luan,Daxiang Chen,Peiyu Huang,Cheng Chen,Xi Sun,Qi Luo,Jie Su,Yunhui Zhang,Nanshan Zhong &…Zhongfang Wang 
https://doi.org/10.1038/s41392-024-01867-4
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Targeting BCL9/BCL9L enhances antigen presentation by promoting conventional type 1 dendritic cell (cDC1) activation and tumor infiltration
Fenglian He,Zhongen Wu,Chenglong Liu,Yuanyuan Zhu,Yan Zhou,Enming Tian,Rina Rosin-Arbesfeld,Dehua Yang  ORCID: orcid.org/0000-0003-3028-3243,Ming-Wei Wang  ORCID: orcid.org/0000-0001-6550-9017 &…Di Zhu  ORCID: orcid.org/0000-0003-4622-4600 
https://doi.org/10.1038/s41392-024-01838-9
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Natural evidence of coronaviral 2′-O-methyltransferase activity affecting viral pathogenesis via improved substrate RNA binding
Jikai Deng,Shimin Yang,Yingjian Li,Xue Tan,Jiejie Liu,Yanying Yu,Qiang Ding  ORCID: orcid.org/0000-0002-6226-869X,Chengpeng Fan,Hongyun Wang,Xianyin Chen,Qianyun Liu,Xiao Guo,Feiyu Gong,Li Zhou &…Yu Chen  ORCID: orcid.org/0000-0003-1300-4652 
https://doi.org/10.1038/s41392-024-01860-x
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Research Highlight
Dietary selection of commensal protists: expanding host immunity by impacting trans-kindom competition with bacteria
Bo Li  ORCID: orcid.org/0009-0004-0852-1000,Min Wu  ORCID: orcid.org/0000-0003-1205-982X &Huaqiong Li 
https://doi.org/10.1038/s41392-024-01834-z
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CAR-T overdrive: harnessing inosine for metabolic rewiring and stemness induction
Martí Farrera-Sal  ORCID: orcid.org/0000-0002-8170-1276 &Michael Schmueck-Henneresse  ORCID: orcid.org/0000-0001-5964-9179 
https://doi.org/10.1038/s41392-024-01818-z
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Unveiling the culprit: the fusobacterium lineage that populates colorectal cancer
Johannes Betge  ORCID: orcid.org/0000-0001-9549-1866 &Matthias P. Ebert 
https://doi.org/10.1038/s41392-024-01844-x
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PARP1-DNA co-condensation: the driver of broken DNA repair
Xiang Wei,Fangfang Zhou  ORCID: orcid.org/0000-0003-1870-7584 &Long Zhang  ORCID: orcid.org/0000-0001-8139-0474 
https://doi.org/10.1038/s41392-024-01832-1
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High-resolution spatiotemporal mapping: a comprehensive view of eukaryotic cell cycle proteome dynamics
Jing Zou,Ziran Qin &Long Zhang  ORCID: orcid.org/0000-0001-8139-0474 
https://doi.org/10.1038/s41392-024-01850-z
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Peripheral immune cell-derived matrix metalloprotease 8 (MMP8): brain trafficking promotes depression-like behavior
Dietmar Spengler &Theo Rein  ORCID: orcid.org/0000-0003-2850-4289 
https://doi.org/10.1038/s41392-024-01833-0
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Letter
Robust neutralization of SARS-CoV-2 variants including JN.1 and BA.2.87.1 by trivalent XBB vaccine-induced antibodies
Xun Wang,Shujun Jiang,Wentai Ma,Yanliang Zhang &…Pengfei Wang  ORCID: orcid.org/0000-0003-2454-7652 
https://doi.org/10.1038/s41392-024-01849-6
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Review Article
Mitochondrial dysfunction: mechanisms and advances in therapy
Yao Zong,Hao Li,Peng Liao  ORCID: orcid.org/0000-0002-4583-5285,Long Chen,Yao Pan,Yongqiang Zheng,Changqing Zhang,Delin Liu,Minghao Zheng  ORCID: orcid.org/0000-0003-1185-4768 &…Junjie Gao  ORCID: orcid.org/0000-0003-4820-8524 
https://doi.org/10.1038/s41392-024-01839-8
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Tumor biomarkers for diagnosis, prognosis and targeted therapy
Yue Zhou,Lei Tao  ORCID: orcid.org/0000-0002-8344-4656,Jiahao Qiu,Jing Xu,Xinyu Yang,Yu Zhang,Xinyu Tian,Xinqi Guan,Xiaobo Cen  ORCID: orcid.org/0000-0002-9760-5238 &…Yinglan Zhao  ORCID: orcid.org/0000-0002-5168-5842 
https://doi.org/10.1038/s41392-024-01823-2
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Development of pharmacological immunoregulatory anti-cancer therapeutics: current mechanistic studies and clinical opportunities
Nanhao Yin  ORCID: orcid.org/0009-0004-5995-595X,Xintong Li,Xuanwei Zhang,Shaolong Xue,Yu Cao,Gabriele Niedermann,You Lu &…Jianxin Xue 
https://doi.org/10.1038/s41392-024-01826-z
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Notch signaling pathway in cancer: from mechanistic insights to targeted therapies
Qingmiao Shi,Chen Xue,Yifan Zeng,Xin Yuan,Qingfei Chu,Shuwen Jiang,Jinzhi Wang,Yaqi Zhang,Danhua Zhu &…Lanjuan Li 
https://doi.org/10.1038/s41392-024-01828-x
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Molecular insights of exercise therapy in disease prevention and treatment
David Walzik  ORCID: orcid.org/0000-0002-9577-1435,Tiffany Y. Wences Chirino  ORCID: orcid.org/0000-0002-6153-0705,Philipp Zimmer  ORCID: orcid.org/0000-0001-9631-4503 &…Niklas Joisten  ORCID: orcid.org/0000-0002-9947-8746 
https://doi.org/10.1038/s41392-024-01841-0
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Macrophages in cardiovascular diseases: molecular mechanisms and therapeutic targets
Runkai Chen,Hongrui Zhang,Botao Tang,Yukun Luo,Yufei Yang,Xin Zhong,Sifei Chen,Xinjie Xu,Shengkang Huang &…Canzhao Liu  ORCID: orcid.org/0000-0002-9035-5723 
https://doi.org/10.1038/s41392-024-01840-1
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Comment
Recent advances in treatment of follicular lymphoma: efficacy of PI3Kα/δ inhibitor (TQ-B3525)
Takuya Watanabe  ORCID: orcid.org/0000-0003-3820-0262 
https://doi.org/10.1038/s41392-024-01842-z
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