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Volume 9 Issue 5, May 2024

Research Highlight
Messing with cancer therapy: how the melanoma phenotype predicts checkpoint inhibitor response
Svenja Meierjohann &Corine Bertolotto 
https://doi.org/10.1038/s41392-024-01785-5
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Optimizing oncolytic virus design: a “Swiss army knife” approach to create a systemically delivered therapeutic
Carolina S. Ilkow &John Cameron Bell 
https://doi.org/10.1038/s41392-024-01815-2
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Neutrophils are shaped by the tumor microenvironment: novel possibilities for targeting neutrophils in cancer
Carlos Silvestre-Roig,Lydia Kalafati &Triantafyllos Chavakis 
https://doi.org/10.1038/s41392-024-01786-4
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Macrocyclic peptides: up-and-coming weapons to combat antimicrobial resistance
Wen-Jing Wang,Xiang-Min Dong &Guo-Bo Li  ORCID: orcid.org/0000-0002-4915-6677 
https://doi.org/10.1038/s41392-024-01813-4
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Modularization of adhesion G protein-coupled receptor (aGPCR) structure: how alternative splicing regulates synaptogenesis
Tobias Langenhan  ORCID: orcid.org/0000-0002-9061-3809 
https://doi.org/10.1038/s41392-024-01829-w
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Cas13d-mediated gene knockdown in CAR T cells: towards off-the-shelf cancer treatment
Midori Johnston,Nadine Urban &Can Dincer  ORCID: orcid.org/0000-0003-3301-1198 
https://doi.org/10.1038/s41392-024-01830-3
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Two hits are better than one: rational dual strategy efficiently fights neuroblastoma
Jacques Zimmer  ORCID: orcid.org/0000-0002-7118-6944,Camille Rolin  ORCID: orcid.org/0000-0002-1373-0278 &Markus Ollert  ORCID: orcid.org/0000-0002-8055-0103 
https://doi.org/10.1038/s41392-024-01827-y
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Harnessing naturally occurring mutations for T-cell therapy: a potential new avenue to enhance treatment efficacy
Michael Hiltensperger  ORCID: orcid.org/0000-0003-4600-1394,Jürgen Ruland  ORCID: orcid.org/0000-0002-8381-3597 &Kilian Schober  ORCID: orcid.org/0000-0001-9323-9472 
https://doi.org/10.1038/s41392-024-01835-y
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Article
Mex-3 RNA binding family member A (MEX3A)/circMPP6 complex promotes colorectal cancer progression by inhibiting autophagy
Ri-Xin Chen,Shui-Dan Xu,Min-Hua Deng,Shi-Hui Hao,Jie-Wei Chen,Xiao-Dan Ma,Wei-Tao Zhuang,Jing-Hua Cao,Yong-Rui Lv,Jin-Long Lin,Si-Yu Li,Gui-Bin Qiao,Dan Xie  ORCID: orcid.org/0000-0003-2242-3138 &…Feng-Wei Wang  ORCID: orcid.org/0000-0003-3886-7331 
https://doi.org/10.1038/s41392-024-01787-3
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XELOX (capecitabine plus oxaliplatin) plus bevacizumab (anti-VEGF-A antibody) with or without adoptive cell immunotherapy in the treatment of patients with previously untreated metastatic colorectal cancer: a multicenter, open-label, randomized, controlled, phase 3 trial
Qiu-Zhong Pan,Jing-Jing Zhao,Liang Liu,Dong-Sheng Zhang,Li-Ping Wang,Wen-Wei Hu,De-Sheng Weng,Xiang Xu  ORCID: orcid.org/0000-0002-1026-2210,Yi-Zhuo Li,Yan Tang,Wei-Hong Zhang,Jie-Yao Li,Xiao Zheng  ORCID: orcid.org/0000-0002-6163-7414,Qi-Jing Wang,Yong-Qiang Li,Tong Xiang,Li Zhou,Shuang-Ning Yang,Chen Wu,Rong-Xing Huang,Jia He,Wei-Jiao Du,Lu-Jun Chen,Yue-Na Wu,Bin Xu,Qiong Shen,Yi Zhang  ORCID: orcid.org/0000-0001-9861-4681,Jing-Ting Jiang,Xiu-Bao Ren  ORCID: orcid.org/0000-0003-4137-2049 &…Jian-Chuan Xia  ORCID: orcid.org/0000-0002-1268-3967 
https://doi.org/10.1038/s41392-024-01788-2
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Circulating tumor cells shielded with extracellular vesicle-derived CD45 evade T cell attack to enable metastasis
Chuan Yang,Xueping Wang,Kenneth K. W. To,Caimei Cui,Min Luo,Shaocong Wu,Lamei Huang,Kai Fu,Can Pan,Zeyu Liu,Teng Fan,Caibo Yang,Fang Wang &…Liwu Fu 
https://doi.org/10.1038/s41392-024-01789-1
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Thiamine-modified metabolic reprogramming of human pluripotent stem cell-derived cardiomyocyte under space microgravity
Xinglong Han,Lina Qu,Miao Yu,Lingqun Ye,Liujia Shi,Guangfu Ye,Jingsi Yang,Yaning Wang,Hao Fan,Yong Wang,Yingjun Tan,Chunyan Wang,Qi Li,Wei Lei,Jianghai Chen,Zhaoxia Liu,Zhenya Shen,Yinghui Li  ORCID: orcid.org/0000-0002-9294-4652 &…Shijun Hu  ORCID: orcid.org/0000-0002-0068-8429 
https://doi.org/10.1038/s41392-024-01791-7
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Infection with SARS-CoV-2 can cause pancreatic impairment
Wei Deng,Linlin Bao,Zhiqi Song,Ling Zhang,Pin Yu,Yanfeng Xu,Jue Wang,Wenjie Zhao,Xiuqin Zhang,Yunlin Han,Yanhong Li,Jiangning Liu,Qi Lv,Xujian Liang,Fengdi Li,Feifei Qi,Ran Deng,Siyuan Wang,Yibai Xiong,Ruiping Xiao  ORCID: orcid.org/0000-0003-2448-409X,Hongyang Wang  ORCID: orcid.org/0000-0002-4709-3334 &…Chuan Qin  ORCID: orcid.org/0000-0002-6261-1232 
https://doi.org/10.1038/s41392-024-01796-2
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Anti-lymphangiogenesis for boosting drug accumulation in tumors
Chunling Wang,Junchao Xu  ORCID: orcid.org/0000-0003-0725-8111,Xiaoyu Cheng,Ge Sun,Fenfen Li,Guangjun Nie  ORCID: orcid.org/0000-0001-5040-9793 &…Yinlong Zhang 
https://doi.org/10.1038/s41392-024-01794-4
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Phase II study of novel orally PI3Kα/δ inhibitor TQ-B3525 in relapsed and/or refractory follicular lymphoma
Huaqing Wang,Jifeng Feng,Yanyan Liu,Zhengzi Qian,Da Gao,Xuehong Ran,Hui Zhou,Lihong Liu,Binghua Wang,Meiyun Fang,Hebing Zhou,Zhenqian Huang,Shi Tao,Zhuowen Chen,Liping Su,Hang Su,Yu Yang,Xiaobao Xie,Huijing Wu,Ping Sun,Guoyu Hu,Aibin Liang  ORCID: orcid.org/0000-0002-8978-1987 &…Zhiming Li  ORCID: orcid.org/0000-0001-9730-9917 
https://doi.org/10.1038/s41392-024-01798-0
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METTL14 downregulation drives S100A4+ monocyte-derived macrophages via MyD88/NF-κB pathway to promote MAFLD progression
Yue-fan Wang,Wen-li Zhang,Zhi-xuan Li,Yue Liu,Jian Tan,Hao-zan Yin,Zhi-chao Zhang,Xian-jie Piao,Min-hao Ruan,Zhi-hui Dai,Si-jie Wang,Chen-yang Mu,Ji-hang Yuan  ORCID: orcid.org/0000-0003-1297-7743,Shu-han Sun  ORCID: orcid.org/0000-0001-6641-6197,Hui Liu  ORCID: orcid.org/0000-0003-4599-5702 &…Fu Yang  ORCID: orcid.org/0000-0003-2459-3923 
https://doi.org/10.1038/s41392-024-01797-1
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The activity and immune dynamics of PD-1 inhibition on high-risk pulmonary ground glass opacity lesions: insights from a single-arm, phase II trial
Bo Cheng,Caichen Li,Jianfu Li,Longlong Gong  ORCID: orcid.org/0000-0002-5844-6078,Peng Liang,Ying Chen,Shuting Zhan,Shan Xiong,Ran Zhong,Hengrui Liang,Yi Feng,Runchen Wang,Haixuan Wang,Hongbo Zheng,Jun Liu  ORCID: orcid.org/0000-0002-9001-9498,Chengzhi Zhou,Wenlong Shao,Yuan Qiu,Jiancong Sun,Zhanhong Xie,Zhu Liang,Chenglin Yang,Xiuyu Cai,Chunxia Su,Wei Wang,Jianxing He &…Wenhua Liang 
https://doi.org/10.1038/s41392-024-01799-z
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A novel engineered IL-21 receptor arms T-cell receptor-engineered T cells (TCR-T cells) against hepatocellular carcinoma
Wei Zhu,Zhiming Zhang,Jinzhang Chen  ORCID: orcid.org/0000-0003-4964-2218,Xiaolan Chen,Lei Huang,Xiaoyong Zhang  ORCID: orcid.org/0000-0002-6930-9423,Xuan Huang,Na Ma,Weikang Xu,Xuan Yi,Xinyu Lu,Xin Fu,Siwei Li,Guoheng Mo,Yiyue Wang,Guosheng Yuan,Mengya Zang,Qi Li,Xiaotao Jiang,Yajing He,Sha Wu,Yukai He,Yongyin Li &…Jinlin Hou  ORCID: orcid.org/0000-0001-8230-8583 
https://doi.org/10.1038/s41392-024-01792-6
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PBX/Knotted 1 homeobox-2 (PKNOX2) is a novel regulator of myocardial fibrosis
Liang Chen,Haotong Li,Xiaorui Liu,Ningning Zhang,Kui Wang,Anteng Shi,Hang Gao,Deniz Akdis,Ardan M. Saguner,Xinjie Xu,Elena Osto,Willem Van de Veen,Guangyu Li,Antoni Bayés-Genís,Firat Duru,Jiangping Song,Xiangjie Li &…Shengshou Hu 
https://doi.org/10.1038/s41392-024-01804-5
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Efficacy and safety of human umbilical cord-derived mesenchymal stem cells in the treatment of refractory immune thrombocytopenia: a prospective, single arm, phase I trial
Yunfei Chen  ORCID: orcid.org/0000-0001-7309-8545,Yanmei Xu  ORCID: orcid.org/0000-0003-4607-9781,Ying Chi,Ting Sun,Yuchen Gao  ORCID: orcid.org/0000-0002-0619-1595,Xueqing Dou,Zhibo Han,Feng Xue,Huiyuan Li,Wei Liu,Xiaofan Liu,Huan Dong,Rongfeng Fu,Mankai Ju,Xinyue Dai,Wentian Wang,Yueshen Ma,Zhen Song,Jundong Gu,Wei Gong,Renchi Yang &…Lei Zhang  ORCID: orcid.org/0000-0001-7769-7377 
https://doi.org/10.1038/s41392-024-01793-5
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FGF7 enhances the expression of ACE2 in human islet organoids aggravating SARS-CoV-2 infection
Hao Meng,Zhiying Liao,Yanting Ji,Dong Wang,Yang Han,Chaolin Huang,Xujuan Hu,Jingyi Chen,Hengrui Zhang,Zonghong Li  ORCID: orcid.org/0000-0002-5153-0007,Changliang Wang  ORCID: orcid.org/0000-0001-9561-3499,Hui Sun,Jiaqi Sun,Lihua Chen  ORCID: orcid.org/0000-0003-3369-1875,Jiaxiang Yin,Jincun Zhao  ORCID: orcid.org/0000-0003-2515-5589,Tao Xu &…Huisheng Liu  ORCID: orcid.org/0000-0001-5371-7943 
https://doi.org/10.1038/s41392-024-01790-8
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SRY-Box transcription factor 9 triggers YAP nuclear entry via direct interaction in tumors
Hui Qian,Chen-Hong Ding,Fang Liu,Shi-Jie Chen,Chen-Kai Huang,Meng-Chao Xiao,Xia-Lu Hong,Ming-Chen Wang,Fang-Zhi Yan,Kai Ding,Ya-Lu Cui,Bai-Nan Zheng,Jin Ding,Cheng Luo  ORCID: orcid.org/0000-0003-3864-8382,Xin Zhang &…Wei-Fen Xie 
https://doi.org/10.1038/s41392-024-01805-4
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Gene replacement therapy in Bietti crystalline corneoretinal dystrophy: an open-label, single-arm, exploratory trial
Jinyuan Wang  ORCID: orcid.org/0000-0002-8378-1249,Jinlu Zhang,Shicheng Yu,Hongyan Li,Shaohong Chen,Jingting Luo,Haibo Wang,Yuxia Guan,Haihan Zhang,Shiyi Yin  ORCID: orcid.org/0000-0001-9119-0302,Huili Wang,Heping Li,Junle Liu,Jingyuan Zhu,Qiong Yang,Ying Sha,Chuan Zhang,Yuhang Yang,Xuan Yang,Xifang Zhang,Xiuli Zhao,Likun Wang  ORCID: orcid.org/0000-0002-0933-2808,Liping Yang &…Wenbin Wei  ORCID: orcid.org/0000-0003-2386-0989 
https://doi.org/10.1038/s41392-024-01806-3
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Dysfunction of the adhesion G protein-coupled receptor latrophilin 1 (ADGRL1/LPHN1) increases the risk of obesity
André Nguyen Dietzsch,Hadi Al-Hasani,Joachim Altschmied,Katharina Bottermann,Jana Brendler,Judith Haendeler  ORCID: orcid.org/0000-0001-8507-4540,Susanne Horn,Isabell Kaczmarek,Antje Körner,Kerstin Krause  ORCID: orcid.org/0000-0003-1766-3698,Kathrin Landgraf  ORCID: orcid.org/0000-0002-6878-6033,Diana Le Duc,Laura Lehmann,Stefan Lehr,Stephanie Pick  ORCID: orcid.org/0009-0005-1325-0812,Albert Ricken,Rene Schnorr,Angela Schulz,Martina Strnadová,Akhil Velluva,Heba Zabri,Torsten Schöneberg,Doreen Thor  ORCID: orcid.org/0000-0002-9522-5098 &…Simone Prömel  ORCID: orcid.org/0000-0001-7800-7323 
https://doi.org/10.1038/s41392-024-01810-7
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Nasal vaccination of triple-RBD scaffold protein with flagellin elicits long-term protection against SARS-CoV-2 variants including JN.1
Xian Li,Mengxin Xu,Jingyi Yang,Li Zhou,Lin Liu,Min Li,Shasha Wang,Mei-Qin Liu,Zhixiang Huang,Zhen Zhang,Shuning Liu,Yunqi Hu,Haofeng Lin,Bowen Liu,Ying Sun,Qingguo Wu,Zheng-Li Shi  ORCID: orcid.org/0000-0001-8089-163X,Ke Lan  ORCID: orcid.org/0000-0002-0384-8598,Yu Chen  ORCID: orcid.org/0000-0003-1300-4652,Huimin Yan  ORCID: orcid.org/0000-0002-7243-8429 &…Yao-Qing Chen  ORCID: orcid.org/0000-0002-4659-1550 
https://doi.org/10.1038/s41392-024-01822-3
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A positive feedback inhibition of isocitrate dehydrogenase 3β on paired-box gene 6 promotes Alzheimer-like pathology
Xin Wang,Qian Liu,Hai-tao Yu,Jia-zhao Xie,Jun-ning Zhao,Zhi-ting Fang,Min Qu,Yao Zhang,Ying Yang &…Jian-Zhi Wang 
https://doi.org/10.1038/s41392-024-01812-5
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Review Article
Progression from ductal carcinoma in situ to invasive breast cancer: molecular features and clinical significance
Jing Wang,Baizhou Li,Meng Luo,Jia Huang,Kun Zhang,Shu Zheng,Suzhan Zhang &…Jiaojiao Zhou  ORCID: orcid.org/0000-0003-0442-6183 
https://doi.org/10.1038/s41392-024-01779-3
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Adeno-associated virus as a delivery vector for gene therapy of human diseases
Jiang-Hui Wang  ORCID: orcid.org/0000-0002-1551-9660,Dominic J. Gessler  ORCID: orcid.org/0000-0003-0067-7444,Wei Zhan,Thomas L. Gallagher &…Guangping Gao 
https://doi.org/10.1038/s41392-024-01780-w
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Protein neddylation and its role in health and diseases
Shizhen Zhang,Qing Yu,Zhijian Li,Yongchao Zhao  ORCID: orcid.org/0000-0003-4610-4182 &…Yi Sun  ORCID: orcid.org/0000-0002-5841-4287 
https://doi.org/10.1038/s41392-024-01800-9
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The gasdermin family: emerging therapeutic targets in diseases
Chenglong Zhu,Sheng Xu  ORCID: orcid.org/0000-0002-9547-8052,Ruoyu Jiang,Yizhi Yu,Jinjun Bian &…Zui Zou 
https://doi.org/10.1038/s41392-024-01801-8
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G protein-coupled receptors (GPCRs): advances in structures, mechanisms and drug discovery
Mingyang Zhang,Ting Chen,Xun Lu,Xiaobing Lan,Ziqiang Chen &…Shaoyong Lu 
https://doi.org/10.1038/s41392-024-01803-6
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Drug repurposing for cancer therapy
Ying Xia,Ming Sun,Hai Huang &…Wei-Lin Jin  ORCID: orcid.org/0000-0001-8011-2405 
https://doi.org/10.1038/s41392-024-01808-1
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Bile acid metabolism and signaling in health and disease: molecular mechanisms and therapeutic targets
Joshua S. Fleishman  ORCID: orcid.org/0000-0003-1092-6272 &Sunil Kumar 
https://doi.org/10.1038/s41392-024-01811-6
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Induced pluripotent stem cells (iPSCs): molecular mechanisms of induction and applications
Jonas Cerneckis,Hongxia Cai &Yanhong Shi  ORCID: orcid.org/0000-0002-3938-5839 
https://doi.org/10.1038/s41392-024-01809-0
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Letter
Poly(A)-specific RNase (PARN) generates and regulates miR-125a-5p 3’-isoforms, displaying an altered expression in breast cancer
Luisa Tomasello,Shoshanah M. Holub,Giovanni Nigita,Rosario Distefano  ORCID: orcid.org/0000-0001-7241-7751 &…Carlo M. Croce 
https://doi.org/10.1038/s41392-024-01795-3
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Comment
Pandemic punch: SARS-CoV-2 hits pancreas
Ninel Azoitei,Sandra Heller &Alexander Kleger  ORCID: orcid.org/0000-0003-0592-5232 
https://doi.org/10.1038/s41392-024-01807-2
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Unraveling the role of METTL14 in metabolic dysfunction-associated fatty liver disease: insights and therapeutic implications
So Jung Kim &Jeongeun Hyun  ORCID: orcid.org/0000-0003-1144-2552 
https://doi.org/10.1038/s41392-024-01837-w
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