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Volume 9 Issue 4, Apr 2024

Article
Contactin-associated protein-like 2 (CNTNAP2) mutations impair the essential α-secretase cleavages, leading to autism-like phenotypes
Qing Zhang,Mengen Xing,Zhengkai Bao,Lu Xu  ORCID: orcid.org/0000-0003-3231-041X,Yang Bai,Wanqi Chen,Wenhao Pan,Fang Cai,Qunxian Wang,Shipeng Guo,Jing Zhang,Zhe Wang  ORCID: orcid.org/0000-0003-4255-6763,Yili Wu,Yun Zhang,Jia-Da Li &…Weihong Song  ORCID: orcid.org/0000-0001-9928-889X 
https://doi.org/10.1038/s41392-024-01768-6
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Suppression of ITPKB degradation by Trim25 confers TMZ resistance in glioblastoma through ROS homeostasis
Yuanliang Yan,Shangjun Zhou,Xi Chen,Qiaoli Yi,Songshan Feng,Zijin Zhao,Yuanhong Liu,Qiuju Liang,Zhijie Xu  ORCID: orcid.org/0000-0003-2047-883X,Zhi Li &…Lunquan Sun  ORCID: orcid.org/0000-0002-0558-5250 
https://doi.org/10.1038/s41392-024-01763-x
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Structure-based design of pan-coronavirus inhibitors targeting host cathepsin L and calpain-1
Xiong Xie,Qiaoshuai Lan  ORCID: orcid.org/0000-0001-5524-3542,Jinyi Zhao  ORCID: orcid.org/0000-0002-5119-359X,Sulin Zhang  ORCID: orcid.org/0000-0002-9167-4689,Lu Liu,Yumin Zhang  ORCID: orcid.org/0000-0003-0767-1221,Wei Xu,Maolin Shao,Jingjing Peng,Shuai Xia,Yan Zhu,Keke Zhang,Xianglei Zhang  ORCID: orcid.org/0000-0001-5175-8311,Ruxue Zhang,Jian Li,Wenhao Dai,Zhen Ge,Shulei Hu,Changyue Yu,Jiang Wang  ORCID: orcid.org/0000-0003-1705-4905,Dakota Ma,Mingyue Zheng  ORCID: orcid.org/0000-0002-3323-3092,Haitao Yang  ORCID: orcid.org/0000-0002-1875-3268,Gengfu Xiao  ORCID: orcid.org/0000-0001-9401-235X,Zihe Rao,Lu Lu  ORCID: orcid.org/0000-0002-2255-0391,Leike Zhang  ORCID: orcid.org/0000-0002-2593-2571,Fang Bai  ORCID: orcid.org/0000-0003-1468-5568,Yao Zhao  ORCID: orcid.org/0000-0002-2932-2164,Shibo Jiang  ORCID: orcid.org/0000-0001-8283-7135 &…Hong Liu  ORCID: orcid.org/0000-0003-3685-6268 
https://doi.org/10.1038/s41392-024-01758-8
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Anti-metabolic agent pegaspargase plus PD-1 antibody sintilimab for first-line treatment in advanced natural killer T cell lymphoma
Jie Xiong  ORCID: orcid.org/0000-0002-7547-5049,Shu Cheng,Xiao Gao,Shan-He Yu,Yu-Ting Dai  ORCID: orcid.org/0000-0001-8275-2115,Xin-Yun Huang,Hui-Juan Zhong,Chao-Fu Wang,Hong-Mei Yi,Hao Zhang,Wei-Guo Cao,Rong Li,Wei Tang,Yan Zhao,Peng-Peng Xu,Li Wang &…Wei-Li Zhao  ORCID: orcid.org/0000-0002-6834-1616 
https://doi.org/10.1038/s41392-024-01782-8
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Targeting carnitine palmitoyl transferase 1A (CPT1A) induces ferroptosis and synergizes with immunotherapy in lung cancer
Lei Ma,Chong Chen  ORCID: orcid.org/0000-0001-7191-3761,Chunxing Zhao,Tong Li,Lingyu Ma,Jiayu Jiang,Zhaojun Duan,Qin Si,Tsung-Hsien Chuang,Rong Xiang  ORCID: orcid.org/0000-0003-3487-7348 &…Yunping Luo 
https://doi.org/10.1038/s41392-024-01772-w
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Alpha5 nicotine acetylcholine receptor subunit promotes intrahepatic cholangiocarcinoma metastasis
Yan Fu,Keyu Shen,Hao Wang,Shun Wang,Xufeng Wang,Le Zhu,Yan Zheng,Tiantian Zou,Hongfei Ci,Qiongzhu Dong  ORCID: orcid.org/0000-0002-2433-7199 &…Lun-Xiu Qin 
https://doi.org/10.1038/s41392-024-01761-z
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Tet methylcytosine dioxygenase 2 (TET2) deficiency elicits EGFR-TKI (tyrosine kinase inhibitors) resistance in non-small cell lung cancer
Jian Zhang  ORCID: orcid.org/0000-0001-9877-1601,Kejia Zhao,Wenjing Zhou,Ran Kang,Shiyou Wei,Yueli Shu,Cheng Yu,Yin Ku,Yonghong Mao,Hao Luo,Juqin Yang,Jiandong Mei  ORCID: orcid.org/0000-0003-0842-5540,Qiang Pu,Senyi Deng,Zhengyu Zha,Gang Yuan,Shensi Shen  ORCID: orcid.org/0000-0002-5087-8220,Yaohui Chen &…Lunxu Liu  ORCID: orcid.org/0000-0003-3964-5378 
https://doi.org/10.1038/s41392-024-01778-4
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Efficacy and safety of PD-1 blockade plus long-course chemoradiotherapy in locally advanced rectal cancer (NECTAR): a multi-center phase 2 study
Zhengyang Yang,Jiale Gao,Jianyong Zheng,Jiagang Han,Ang Li,Gang Liu,Yi Sun,Jie Zhang,Guangyong Chen,Rui Xu,Xiao Zhang,Yishan Liu,Zhigang Bai,Wei Deng,Wei He,Hongwei Yao &…Zhongtao Zhang 
https://doi.org/10.1038/s41392-024-01762-y
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Elevated Kallistatin promotes the occurrence and progression of non-alcoholic fatty liver disease
Zhenzhen Fang,Gang Shen,Yina Wang,Fuyan Hong,Xiumei Tang,Yongcheng Zeng,Ting Zhang,Huanyi Liu,Yanmei Li,Jinhong Wang,Jing Zhang,Anton Gao,Weiwei Qi,Xia Yang,Ti Zhou &…Guoquan Gao 
https://doi.org/10.1038/s41392-024-01781-9
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SARS-CoV-2 envelope protein impairs airway epithelial barrier function and exacerbates airway inflammation via increased intracellular Cl− concentration
Jian-Bang Xu,Wei-Jie Guan  ORCID: orcid.org/0000-0001-5463-391X,Yi-Lin Zhang  ORCID: orcid.org/0000-0001-5350-8279,Zhuo-Er Qiu,Lei Chen  ORCID: orcid.org/0000-0002-9488-1173,Xiao-Chun Hou,Junqing Yue,Yu-Yun Zhou,Jie Sheng,Lei Zhao,Yun-Xin Zhu,Jing Sun,Jincun Zhao  ORCID: orcid.org/0000-0003-2515-5589,Wen-Liang Zhou &…Nan-Shan Zhong 
https://doi.org/10.1038/s41392-024-01753-z
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First-line camrelizumab (a PD-1 inhibitor) plus apatinib (an VEGFR-2 inhibitor) and chemotherapy for advanced gastric cancer (SPACE): a phase 1 study
Xiaofeng Chen,Hao Xu,Xiaobing Chen,Tongpeng Xu,Yitong Tian,Deqiang Wang,Fen Guo,Kangxin Wang,Guangfu Jin,Xiao Li,Rong Wang,Fengyuan Li,Yongbin Ding,Jie Tang,Yueyu Fang,Jing Zhao,Liang Liu,Ling Ma,Lijuan Meng,Zhiguo Hou,Rongrong Zheng,Yang Liu,Ni Guan,Bei Zhang,Shuang Tong,Shiqing Chen,Xing Li &…Yongqian Shu 
https://doi.org/10.1038/s41392-024-01773-9
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Rapid development of double-hit mRNA antibody cocktail against orthopoxviruses
Hang Chi,Suo-Qun Zhao,Ru-Yi Chen,Xing-Xing Suo,Rong-Rong Zhang,Wen-Hui Yang,Dong-Sheng Zhou  ORCID: orcid.org/0000-0003-3827-5969,Min Fang  ORCID: orcid.org/0000-0002-5278-1430,Bo Ying,Yong-Qiang Deng  ORCID: orcid.org/0000-0002-2306-1039 &…Cheng-Feng Qin  ORCID: orcid.org/0000-0002-0632-2807 
https://doi.org/10.1038/s41392-024-01766-8
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Review Article
Peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1) family in physiological and pathophysiological process and diseases
Lu Qian,Yanli Zhu,Chao Deng,Zhenxing Liang,Junmin Chen,Ying Chen,Xue Wang,Yanqing Liu,Ye Tian &…Yang Yang  ORCID: orcid.org/0000-0002-1163-2359 
https://doi.org/10.1038/s41392-024-01756-w
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New clinical trial design in precision medicine: discovery, development and direction
Xiao-Peng Duan  ORCID: orcid.org/0000-0002-2421-1756,Bao-Dong Qin,Xiao-Dong Jiao,Ke Liu,Zhan Wang &…Yuan-Sheng Zang 
https://doi.org/10.1038/s41392-024-01760-0
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NF-κB in biology and targeted therapy: new insights and translational implications
Qing Guo,Yizi Jin,Xinyu Chen,Xiaomin Ye,Xin Shen,Mingxi Lin,Cheng Zeng,Teng Zhou &…Jian Zhang 
https://doi.org/10.1038/s41392-024-01757-9
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Ferroptosis in cancer: from molecular mechanisms to therapeutic strategies
Qian Zhou,Yu Meng,Daishi Li,Lei Yao,Jiayuan Le,Yihuang Liu,Yuming Sun,Furong Zeng  ORCID: orcid.org/0000-0001-6621-8131,Xiang Chen  ORCID: orcid.org/0000-0001-8187-636X &…Guangtong Deng  ORCID: orcid.org/0000-0002-4424-9727 
https://doi.org/10.1038/s41392-024-01769-5
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Effects of dietary intervention on human diseases: molecular mechanisms and therapeutic potential
Yu-Ling Xiao  ORCID: orcid.org/0000-0002-3684-0816,Yue Gong,Ying-Jia Qi  ORCID: orcid.org/0009-0006-9878-4019,Zhi-Ming Shao &…Yi-Zhou Jiang 
https://doi.org/10.1038/s41392-024-01771-x
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Protein lipidation in health and disease: molecular basis, physiological function and pathological implication
Yuan Yuan,Peiyuan Li,Jianghui Li,Qiu Zhao  ORCID: orcid.org/0000-0002-1596-5505,Ying Chang  ORCID: orcid.org/0000-0001-8972-4109 &…Xingxing He  ORCID: orcid.org/0000-0003-0001-8473 
https://doi.org/10.1038/s41392-024-01759-7
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TGF-β signaling in health, disease and therapeutics
Ziqin Deng,Tao Fan,Chu Xiao,He Tian,Yujia Zheng,Chunxiang Li  ORCID: orcid.org/0000-0003-3477-1535 &…Jie He  ORCID: orcid.org/0000-0003-0327-8852 
https://doi.org/10.1038/s41392-024-01764-w
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Harnessing innate immune pathways for therapeutic advancement in cancer
Ankang Hu,Li Sun,Hao Lin,Yuheng Liao,Hui Yang  ORCID: orcid.org/0000-0002-2865-5311 &…Ying Mao  ORCID: orcid.org/0000-0001-8055-115X 
https://doi.org/10.1038/s41392-024-01765-9
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RNA modifications in cellular metabolism: implications for metabolism-targeted therapy and immunotherapy
Wei-Wei Liu,Si-Qing Zheng,Tian Li,Yun-Fei Fei,Chen Wang,Shuang Zhang,Fei Wang,Guan-Min Jiang &…Hao Wang 
https://doi.org/10.1038/s41392-024-01777-5
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The two sides of chromosomal instability: drivers and brakes in cancer
Rendy Hosea,Sharon Hillary,Sumera Naqvi,Shourong Wu &…Vivi Kasim  ORCID: orcid.org/0000-0001-9182-8230 
https://doi.org/10.1038/s41392-024-01767-7
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Research Highlight
Diabetes and pulmonary infection: how hyperglycaemia shapes the immune system
Christian Herder  ORCID: orcid.org/0000-0002-2050-093X,Michael Roden  ORCID: orcid.org/0000-0001-8200-6382 &Nicolas Venteclef 
https://doi.org/10.1038/s41392-024-01784-6
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Cholesterol business: life or death by rust
Shubhangi Gavali,Francesca Maremonti &Andreas Linkermann  ORCID: orcid.org/0000-0001-6287-9725 
https://doi.org/10.1038/s41392-024-01802-7
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