Table of Contents
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Volume 9 Issue 3, Mar 2024

Review Article
Alternative splicing and related RNA binding proteins in human health and disease
Yining Tao,Qi Zhang,Haoyu Wang,Xiyu Yang &…Haoran Mu 
https://doi.org/10.1038/s41392-024-01734-2
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Extracellular vesicles as tools and targets in therapy for diseases
Mudasir A. Kumar,Sadaf K. Baba,Hana Q. Sadida,Sara Al. Marzooqi,Jayakumar Jerobin,Faisal H. Altemani,Naseh Algehainy,Mohammad A. Alanazi,Abdul-Badi Abou-Samra,Rakesh Kumar,Ammira S. Al-Shabeeb Akil,Muzafar A. Macha  ORCID: orcid.org/0000-0003-4468-4435,Rashid Mir &…Ajaz A. Bhat  ORCID: orcid.org/0000-0003-3640-6275 
https://doi.org/10.1038/s41392-024-01735-1
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Major depressive disorder: hypothesis, mechanism, prevention and treatment
Lulu Cui,Shu Li,Siman Wang,Xiafang Wu,Yingyu Liu,Weiyang Yu,Yijun Wang,Yong Tang  ORCID: orcid.org/0000-0002-2543-066X,Maosheng Xia  ORCID: orcid.org/0000-0003-4829-0812 &…Baoman Li  ORCID: orcid.org/0000-0002-3959-9570 
https://doi.org/10.1038/s41392-024-01738-y
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Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases
Jian Sheng Loh,Wen Qi Mak,Li Kar Stella Tan,Chu Xin Ng,Hong Hao Chan,Shiau Hueh Yeow,Jhi Biau Foo,Yong Sze Ong,Chee Wun How &…Kooi Yeong Khaw 
https://doi.org/10.1038/s41392-024-01743-1
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Nanotechnology’s frontier in combatting infectious and inflammatory diseases: prevention and treatment
Yujing Huang,Xiaohan Guo,Yi Wu,Xingyu Chen,Lixiang Feng,Na Xie  ORCID: orcid.org/0000-0003-3775-6277 &…Guobo Shen 
https://doi.org/10.1038/s41392-024-01745-z
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Protein translation: biological processes and therapeutic strategies for human diseases
Xuechao Jia,Xinyu He,Chuntian Huang,Jian Li,Zigang Dong  ORCID: orcid.org/0000-0002-4174-4028 &…Kangdong Liu 
https://doi.org/10.1038/s41392-024-01749-9
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Precise genome-editing in human diseases: mechanisms, strategies and applications
Yanjiang Zheng,Yifei Li  ORCID: orcid.org/0000-0002-3096-4287,Kaiyu Zhou,Tiange Li,Nathan J. VanDusen &…Yimin Hua 
https://doi.org/10.1038/s41392-024-01750-2
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Metabolic memory: mechanisms and diseases
Hao Dong,Yuezhang Sun,Lulingxiao Nie,Aimin Cui,Pengfei Zhao,Wai Keung Leung &…Qi Wang 
https://doi.org/10.1038/s41392-024-01755-x
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Article
DNA framework signal amplification platform-based high-throughput systemic immune monitoring
Ye Chen  ORCID: orcid.org/0000-0002-7217-366X,Xingyu Chen,Bowen Zhang,Yuxin Zhang,Songhang Li,Zhiqiang Liu,Yang Gao,Yuxuan Zhao,Lin Yan,Yi Li,Taoran Tian &…Yunfeng Lin  ORCID: orcid.org/0000-0003-1224-6561 
https://doi.org/10.1038/s41392-024-01736-0
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Nutrient restriction-activated Fra-2 promotes tumor progression via IGF1R in miR-15a downmodulated pancreatic ductal adenocarcinoma
Gian Luca Rampioni Vinciguerra  ORCID: orcid.org/0000-0003-0739-1668,Marina Capece  ORCID: orcid.org/0000-0002-7624-8059,Luca Reggiani Bonetti,Giovanni Nigita,Federica Calore,Sydney Rentsch,Paolo Magistri,Roberto Ballarin,Fabrizio Di Benedetto,Rosario Distefano  ORCID: orcid.org/0000-0001-7241-7751,Roberto Cirombella,Andrea Vecchione  ORCID: orcid.org/0000-0002-5497-6856,Barbara Belletti,Gustavo Baldassarre,Francesca Lovat &…Carlo M. Croce 
https://doi.org/10.1038/s41392-024-01740-4
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Docking protein 6 (DOK6) selectively docks the neurotrophic signaling transduction to restrain peripheral neuropathy
Yan Guo,Pan Xiang,Xiaojiao Sun,Wei Liu,Jiafeng Zhou,Bin Yin,Lin Hou,Boqin Qiang,Huiliang Li,Pengcheng Shu  ORCID: orcid.org/0000-0002-3091-2559 &…Xiaozhong Peng  ORCID: orcid.org/0000-0002-8564-0247 
https://doi.org/10.1038/s41392-024-01742-2
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Safety, immunogenicity and protective effectiveness of heterologous boost with a recombinant COVID-19 vaccine (Sf9 cells) in adult recipients of inactivated vaccines
Wenxin Luo,Jiadi Gan,Zhu Luo,Shuangqing Li,Zhoufeng Wang,Jiaxuan Wu,Huohuo Zhang,Jinghong Xian,Ruixin Cheng,Xiumei Tang,Yi Liu,Ling Yang,Qianqian Mou,Xue Zhang,Yi Chen,Weiwen Wang,Yantong Wang,Lin Bai,Xuan Wei,Rui Zhang,Lan Yang,Yaxin Chen,Li Yang,Yalun Li,Dan Liu,Weimin Li  ORCID: orcid.org/0000-0003-0985-0311 &…Lei Chen 
https://doi.org/10.1038/s41392-024-01751-1
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SARS-CoV-2 spike protein-ACE2 interaction increases carbohydrate sulfotransferases and reduces N-acetylgalactosamine-4-sulfatase by p38 MAPK
Sumit Bhattacharyya &Joanne K. Tobacman 
https://doi.org/10.1038/s41392-024-01741-3
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Aptamers targeting SARS-CoV-2 nucleocapsid protein exhibit potential anti pan-coronavirus activity
Minghui Yang,Chunhui Li,Guoguo Ye,Chenguang Shen,Huiping Shi,Liping Zhong,Yuxin Tian,Mengyuan Zhao,Pengfei Wu,Abid Hussain,Tian Zhang,Haiyin Yang,Jun Yang,Yuhua Weng,Xinyue Liu,Zhimin Wang,Lu Gan,Qianyu Zhang,Yingxia Liu  ORCID: orcid.org/0000-0001-6335-3346,Ge Yang,Yuanyu Huang  ORCID: orcid.org/0000-0003-3935-7245 &…Yongxiang Zhao  ORCID: orcid.org/0000-0003-2214-5887 
https://doi.org/10.1038/s41392-024-01748-w
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Asialoglycoprotein receptor 1 promotes SARS-CoV-2 infection of human normal hepatocytes
Xinyi Yang,Xu Zheng,Yuqi Zhu,Xiaying Zhao,Jun Liu,Jiangna Xun,Songhua Yuan,Jun Chen,Hanyu Pan,Jinlong Yang,Jing Wang,Zhimin Liang,Xiaoting Shen,Yue Liang,Qinru Lin,Huitong Liang,Min Li,Fei Peng,Daru Lu,Jianqing Xu,Hongzhou Lu,Shibo Jiang,Ping Zhao &…Huanzhang Zhu  ORCID: orcid.org/0000-0001-5797-0292 
https://doi.org/10.1038/s41392-024-01754-y
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TEA domain transcription factor 1 (TEAD1) induces cardiac fibroblasts cells remodeling through BRD4/Wnt4 pathway
Shuai Song,Xiaokai Zhang,Zihang Huang,Yongchao Zhao,Shuyang Lu,Linqi Zeng,Fengze Cai,Tongyao Wang,Zhiqiang Pei,Xinyu Weng,Wei Luo  ORCID: orcid.org/0000-0001-9416-9592,Hao Lu,Zilun Wei,Jian Wu,Peng Yu,Li Shen,Xiaochun Zhang,Aijun Sun &…Junbo Ge  ORCID: orcid.org/0000-0002-9360-7332 
https://doi.org/10.1038/s41392-023-01732-w
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A novel alternative for pyrogen detection based on a transgenic cell line
Qing He,Chuan-Fei Yu,Gang Wu,Kai-Qin Wang,Yong-Bo Ni,Xiao Guo,Zhi-Hao Fu,Lan Wang,De-Jiang Tan,Hua Gao,Can Wang,Gang Chen,Xu-Hong Chen,Bo Chen &…Jun-Zhi Wang 
https://doi.org/10.1038/s41392-024-01744-0
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Eosinophils promote CD8+ T cell memory generation to potentiate anti-bacterial immunity
Jun Zhou,Jiaqi Liu,Bingjing Wang,Nan Li,Juan Liu  ORCID: orcid.org/0000-0001-6666-705X,Yanmei Han &…Xuetao Cao  ORCID: orcid.org/0000-0001-9677-7647 
https://doi.org/10.1038/s41392-024-01752-0
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Research Highlight
Discovering deaminases using AlphaFold2: a strategy to search for tool proteins for gene editing
Yongye Huang  ORCID: orcid.org/0000-0002-9083-250X,Jianxin Jiang &Min Wu  ORCID: orcid.org/0000-0003-1205-982X 
https://doi.org/10.1038/s41392-024-01737-z
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Gut microbiome regulates inflammation and insulin resistance: a novel therapeutic target to improve insulin sensitivity
Dilvin Semo  ORCID: orcid.org/0009-0005-4386-8533,Holger Reinecke &Rinesh Godfrey 
https://doi.org/10.1038/s41392-024-01746-y
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Feeding the vasculature with cruciferous vegetables: a secret for organ protection
Priya Veluswamy,Jens Wippermann &Max Wacker  ORCID: orcid.org/0000-0003-0664-2613 
https://doi.org/10.1038/s41392-024-01747-x
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Resilience conferred by APOE-R136S: a defense bestowed by nature to combat Alzheimer’s disease
Bin Xiao  ORCID: orcid.org/0000-0003-2986-4980,Joshua Kuruvilla &Eng-King Tan  ORCID: orcid.org/0000-0003-2977-9743 
https://doi.org/10.1038/s41392-024-01775-7
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Navigating Epstein–Barr virus autoimmunity: role of NK cells and T cells in multiple sclerosis
Chu Xie  ORCID: orcid.org/0000-0003-1206-3124,Cong Sun  ORCID: orcid.org/0000-0003-1786-7420 &Mu-Sheng Zeng  ORCID: orcid.org/0000-0003-3509-5591 
https://doi.org/10.1038/s41392-024-01774-8
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Eliciting CD4-mimicking broadly neutralizing antibodies: new avenues towards the rational design of an HIV vaccine
Frauke Muecksch &Oliver T. Fackler  ORCID: orcid.org/0000-0003-2982-4209 
https://doi.org/10.1038/s41392-024-01776-6
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Editorial
Targeted drug approvals in 2023: breakthroughs by the FDA and NMPA
Lang Zheng,Wenjing Wang &Qiu Sun  ORCID: orcid.org/0000-0001-5122-2226 
https://doi.org/10.1038/s41392-024-01770-y
Full Text | PDF | Abstract