Table of Contents
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Volume 9 Issue 2, Feb 2024

Review Article
Multifunctional nanoparticle-mediated combining therapy for human diseases
Xiaotong Li,Xiuju Peng,Makhloufi Zoulikha,George Frimpong Boafo,Kosheli Thapa Magar,Yanmin Ju &…Wei He  ORCID: orcid.org/0000-0003-3075-3831 
https://doi.org/10.1038/s41392-023-01668-1
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Programmable synthetic receptors: the next-generation of cell and gene therapies
Fei Teng,Tongtong Cui,Li Zhou,Qingqin Gao,Qi Zhou  ORCID: orcid.org/0000-0002-6549-9362 &…Wei Li  ORCID: orcid.org/0000-0001-7864-404X 
https://doi.org/10.1038/s41392-023-01680-5
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Cellular zinc metabolism and zinc signaling: from biological functions to diseases and therapeutic targets
Bonan Chen  ORCID: orcid.org/0000-0002-2430-7934,Peiyao Yu,Wai Nok Chan,Fuda Xie,Yigan Zhang,Li Liang,Kam Tong Leung  ORCID: orcid.org/0000-0002-7695-2513,Kwok Wai Lo  ORCID: orcid.org/0000-0002-3488-6124,Jun Yu  ORCID: orcid.org/0000-0001-5008-2153,Gary M. K. Tse,Wei Kang  ORCID: orcid.org/0000-0002-4651-677X &…Ka Fai To  ORCID: orcid.org/0000-0003-4919-3707 
https://doi.org/10.1038/s41392-023-01679-y
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Lymphatic vessel: Origin, heterogeneity, biological functions and therapeutic targets
Zhaoliang Hu  ORCID: orcid.org/0000-0002-3222-9235,Xushi Zhao,Zhonghua Wu,Bicheng Qu,Minxian Yuan,Yanan Xing,Yongxi Song &…Zhenning Wang 
https://doi.org/10.1038/s41392-023-01723-x
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The role of inflammasomes in human diseases and their potential as therapeutic targets
Jing Yao,Keenan Sterling,Zhe Wang  ORCID: orcid.org/0000-0003-4255-6763,Yun Zhang &…Weihong Song  ORCID: orcid.org/0000-0001-9928-889X 
https://doi.org/10.1038/s41392-023-01687-y
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Targeting proprotein convertase subtilisin/kexin type 9 (PCSK9): from bench to bedside
Xuhui Bao,Yongjun Liang,Hanman Chang,Tianji Cai,Baijie Feng,Konstantin Gordon,Yuekun Zhu,Hailian Shi,Yundong He  ORCID: orcid.org/0000-0001-9051-1661 &…Liyi Xie 
https://doi.org/10.1038/s41392-023-01690-3
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Ischemia-reperfusion injury: molecular mechanisms and therapeutic targets
Meng Zhang,Qian Liu,Hui Meng,Hongxia Duan,Xin Liu,Jian Wu,Fei Gao  ORCID: orcid.org/0000-0002-4029-6411,Shijun Wang,Rubin Tan  ORCID: orcid.org/0000-0002-1513-5616 &…Jinxiang Yuan 
https://doi.org/10.1038/s41392-023-01688-x
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Intratumoural microbiota: a new frontier in cancer development and therapy
Yaqi Cao,Hui Xia,Xueyun Tan,Chunwei Shi,Yanling Ma,Daquan Meng,Mengmeng Zhou,Zhilei Lv,Sufei Wang &…Yang Jin  ORCID: orcid.org/0000-0003-2409-7073 
https://doi.org/10.1038/s41392-023-01693-0
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Clinical applications of stem cell-derived exosomes
Fei Tan  ORCID: orcid.org/0000-0003-1010-0163,Xuran Li,Zhao Wang,Jiaojiao Li,Khawar Shahzad &…Jialin Zheng  ORCID: orcid.org/0000-0003-2286-0151 
https://doi.org/10.1038/s41392-023-01704-0
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Lung microbiome: new insights into the pathogenesis of respiratory diseases
Ruomeng Li,Jing Li  ORCID: orcid.org/0000-0001-5173-0781 &Xikun Zhou  ORCID: orcid.org/0000-0001-6768-2382 
https://doi.org/10.1038/s41392-023-01722-y
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Article
EZH2 inhibitors promote β-like cell regeneration in young and adult type 1 diabetes donors
Keith Al-Hasani,Safiya Naina Marikar,Harikrishnan Kaipananickal,Scott Maxwell,Jun Okabe,Ishant Khurana,Thomas Karagiannis,Julia J. Liang,Lina Mariana,Thomas Loudovaris,Thomas Kay &…Assam El-Osta 
https://doi.org/10.1038/s41392-023-01707-x
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Josephin domain containing 2 (JOSD2) promotes lung cancer by inhibiting LKB1 (Liver kinase B1) activity
Tao Yuan,Chenming Zeng,Jiawei Liu,Chenxi Zhao,Fujing Ge,Yuekang Li,Meijia Qian,Jiamin Du,Weihua Wang,Yonghao Li,Yue Liu,Xiaoyang Dai,Jianya Zhou,Xueqin Chen,Shenglin Ma,Hong Zhu,Qiaojun He &…Bo Yang 
https://doi.org/10.1038/s41392-023-01706-y
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Camouflaging attenuated Salmonella by cryo-shocked macrophages for tumor-targeted therapy
Leyang Wu,Zengzheng Du,Lin Li,Liyuan Qiao,Shuhui Zhang,Xingpeng Yin,Xiaoyao Chang,Chenyang Li &…Zichun Hua 
https://doi.org/10.1038/s41392-023-01703-1
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Fc receptor-like 5 (FCRL5)-directed CAR-T cells exhibit antitumor activity against multiple myeloma
Zhengyu Yu,Hexian Li,Qizhong Lu,Zongliang Zhang,Aiping Tong  ORCID: orcid.org/0000-0002-3392-5443 &…Ting Niu 
https://doi.org/10.1038/s41392-023-01702-2
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Neddylation is a novel therapeutic target for lupus by regulating double negative T cell homeostasis
Yun Zhang,Lijun Du,Chenxi Wang,Zhangsheng Jiang,Qingchi Duan,Yiping Li,Zhijun Xie,Zhixing He,Yi Sun  ORCID: orcid.org/0000-0002-5841-4287,Lin Huang,Liwei Lu &…Chengping Wen 
https://doi.org/10.1038/s41392-023-01709-9
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Bone-targeting engineered small extracellular vesicles carrying anti-miR-6359-CGGGAGC prevent valproic acid-induced bone loss
Xudong Xie,Peng Cheng,Liangcong Hu,Wu Zhou,Detai Zhang,Samuel Knoedler,Guodong Liu,Yuan Xiong,Hang Xue,Yiqiang Hu,Barbara Kern  ORCID: orcid.org/0000-0001-8062-8444,Doha Obed,Adriana C. Panayi,Lang Chen,Chenchen Yan,Ze Lin,Guandong Dai,Bobin Mi,Yingze Zhang &…Guohui Liu  ORCID: orcid.org/0000-0002-2013-1396 
https://doi.org/10.1038/s41392-023-01726-8
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Hepatic Zbtb18 (Zinc Finger and BTB Domain Containing 18) alleviates hepatic steatohepatitis via FXR (Farnesoid X Receptor)
Lei Zhang,Jiabing Chen,Xiaoying Yang,Chuangpeng Shen,Jiawen Huang,Dong Zhang,Naihua Liu,Chaonan Liu,Yadi Zhong,Yingjian Chen,Kaijia Tang,Jingyi Guo,Tianqi Cui,Siwei Duan,Jiayu Li,Shangyi Huang,Huafeng Pan,Huabing Zhang,Xiaoqiang Tang  ORCID: orcid.org/0000-0003-1314-3417,Yongsheng Chang &…Yong Gao 
https://doi.org/10.1038/s41392-023-01727-7
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AKT2S128/CCTαS315/319/323-positive cancer-associated fibroblasts (CAFs) mediate focal adhesion kinase (FAK) inhibitors resistance via secreting phosphatidylcholines (PCs)
Jie Chen,Lingyuan Zhang,Yuheng Zhu,Di Zhao,Jing Zhang,Yanmeng Zhu,Jingyuan Pang,Yuanfan Xiao,Qingnan Wu,Yan Wang &…Qimin Zhan  ORCID: orcid.org/0000-0002-1731-938X 
https://doi.org/10.1038/s41392-023-01728-6
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QL1706 (anti-PD-1 IgG4/CTLA-4 antibody) plus chemotherapy with or without bevacizumab in advanced non-small cell lung cancer: a multi-cohort, phase II study
Yan Huang,Yunpeng Yang,Yuanyuan Zhao,Hongyun Zhao,Ningning Zhou,Yaxiong Zhang,Likun Chen  ORCID: orcid.org/0000-0003-3201-045X,Ting Zhou,Gang Chen,Ting Wu,Lu Lu,Shilin Xue,Xiaoyan Kang,Li Zhang &…Wenfeng Fang 
https://doi.org/10.1038/s41392-023-01731-x
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Research Highlight
Tripartite motif-containing protein 11 (TRIM11): a novel weapon against Alzheimer’s disease
Yichu Fu,Bi Zhang &Jianfeng Liu 
https://doi.org/10.1038/s41392-023-01729-5
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Janus-faced Mitofusin 2 (MFN2): mitochondria-endoplasmic reticulum shaping and tethering functions unveiled
Camilla Aurora Franchino  ORCID: orcid.org/0009-0002-4502-6514,Elisa Motori &Matteo Bergami 
https://doi.org/10.1038/s41392-023-01730-y
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