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Volume 9 Issue 1, Jan 2024

Research Highlight
Going only half the way: cell cycle exit after the G1 restriction point
Lisa Müller,Tony Gutschner  ORCID: orcid.org/0000-0002-1722-3134 &Mechthild Hatzfeld 
https://doi.org/10.1038/s41392-023-01692-1
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Managing type 2 diabetes: targeting a microbial enzyme as a novel treatment option
Anikó Keller-Pintér,Tamás Korcsmáros &Tibor Vellai 
https://doi.org/10.1038/s41392-023-01694-z
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Tau in the pancreas: understanding the link between type 2 diabetes mellitus and Alzheimer’s disease
Wenlu Li,Steffen Tiedt &Eng H. Lo  ORCID: orcid.org/0000-0002-9327-2915 
https://doi.org/10.1038/s41392-023-01701-3
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IgE-Mast cell mediated allergy: a sensor of food quality
Christopher C. Udoye &Rudolf A. Manz 
https://doi.org/10.1038/s41392-023-01695-y
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Methyltransferase-like 3 (METTL3) inhibition potentiates anti-tumor immunity: a novel strategy for improving anti-PD1 therapy
Anna Brichkina,Roman Suezov &Magdalena Huber  ORCID: orcid.org/0000-0002-2963-0693 
https://doi.org/10.1038/s41392-023-01696-x
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Long-COVID-19: the persisting imprint of SARS-CoV-2 infections on the innate immune system
Marianne Boes &Pascal Falter-Braun 
https://doi.org/10.1038/s41392-023-01717-9
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UniBind: a novel artificial intelligence-based prediction model for SARS-CoV-2 infectivity and variant evolution
Qihong Yan &Jincun Zhao  ORCID: orcid.org/0000-0003-2515-5589 
https://doi.org/10.1038/s41392-023-01691-2
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An unexpected cellular fountain of youth: platelets provide factors rejuvenating brain functions
Harald F. Langer 
https://doi.org/10.1038/s41392-023-01716-w
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Review Article
Non-coding RNAs expression in SARS-CoV-2 infection: Pathogenesis, clinical significance and therapeutic targets
Xiaoxing Liu,Wandi Xiong,Maosen Ye,Tangsheng Lu,Kai Yuan,Suhua Chang,Ying Han  ORCID: orcid.org/0000-0002-8381-4071,Yongxiang Wang,Lin Lu &…Yanping Bao 
https://doi.org/10.1038/s41392-023-01669-0
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Gut liver brain axis in diseases: the implications for therapeutic interventions
Mengyao Yan,Shuli Man  ORCID: orcid.org/0000-0003-4632-3078,Benyue Sun,Long Ma,Lanping Guo,Luqi Huang &…Wenyuan Gao 
https://doi.org/10.1038/s41392-023-01673-4
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Targeting epigenetic and posttranslational modifications regulating ferroptosis for the treatment of diseases
Yumin Wang,Jing Hu,Shuang Wu,Joshua S. Fleishman,Yulin Li,Yinshi Xu,Wailong Zou,Jinhua Wang,Yukuan Feng,Jichao Chen &…Hongquan Wang  ORCID: orcid.org/0000-0002-5447-2017 
https://doi.org/10.1038/s41392-023-01720-0
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Therapeutic cancer vaccines: advancements, challenges and prospects
Ting Fan  ORCID: orcid.org/0000-0003-4557-8888,Mingna Zhang,Jingxian Yang,Zhounan Zhu,Wanlu Cao &…Chunyan Dong 
https://doi.org/10.1038/s41392-023-01674-3
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Targeting the RAS/RAF/MAPK pathway for cancer therapy: from mechanism to clinical studies
Md Entaz Bahar  ORCID: orcid.org/0000-0002-5369-3889,Hyun Joon Kim &Deok Ryong Kim 
https://doi.org/10.1038/s41392-023-01705-z
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New insights into the correlations between circulating tumor cells and target organ metastasis
Qinru Zhan,Bixia Liu,Xiaohua Situ,Yuting Luo,Tongze Fu,Yanxia Wang,Zhongpeng Xie,Lijuan Ren,Ying Zhu,Weiling He &…Zunfu Ke 
https://doi.org/10.1038/s41392-023-01725-9
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Mpox (formerly monkeypox): pathogenesis, prevention and treatment
Junjie Lu,Hui Xing,Chunhua Wang,Mengjun Tang,Changcheng Wu,Fan Ye,Lijuan Yin,Yang Yang,Wenjie Tan  ORCID: orcid.org/0000-0002-5963-1136 &…Liang Shen 
https://doi.org/10.1038/s41392-023-01675-2
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Article
Neoadjuvant nivolumab with or without platinum-doublet chemotherapy based on PD-L1 expression in resectable NSCLC (CTONG1804): a multicenter open-label phase II study
Si-Yang Liu,Song Dong,Xue-Ning Yang  ORCID: orcid.org/0000-0002-8346-2117,Ri-Qiang Liao,Ben-Yuan Jiang,Qun Wang,Xiao-Song Ben,Gui-Bin Qiao,Jun-Tao Lin,Hong-Hong Yan  ORCID: orcid.org/0000-0002-6228-2096,Li-Xu Yan,Qiang Nie,Hai-Yan Tu,Bin-Chao Wang,Jin-Ji Yang,Qing Zhou,Hong-Rui Li,Ke Liu,Wendy Wu,Si-Yang Maggie Liu,Wen-Zhao Zhong  ORCID: orcid.org/0000-0002-8917-8635 &…Yi-Long Wu  ORCID: orcid.org/0000-0002-3611-0258 
https://doi.org/10.1038/s41392-023-01700-4
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Antigen-induced chimeric antigen receptor multimerization amplifies on-tumor cytotoxicity
Yan Sun,Xiu-Na Yang  ORCID: orcid.org/0000-0003-3443-9815,Shuang-Shuang Yang  ORCID: orcid.org/0000-0002-8268-5343,Yi-Zhu Lyu,Bing Zhang,Kai-Wen Liu  ORCID: orcid.org/0000-0002-2186-8031,Na Li,Jia-Chen Cui,Guang-Xiang Huang,Cheng-Lin Liu  ORCID: orcid.org/0009-0000-5322-8621,Jie Xu,Jian-Qing Mi,Zhu Chen,Xiao-Hu Fan,Sai-Juan Chen  ORCID: orcid.org/0000-0003-3789-1284 &…Shuo Chen 
https://doi.org/10.1038/s41392-023-01686-z
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Elevated peripheral levels of receptor-interacting protein kinase 1 (RIPK1) and IL-8 as biomarkers of human amyotrophic lateral sclerosis
Jun Wei,Min Li,Zhi Ye  ORCID: orcid.org/0000-0003-0706-2522,Xinqian Hu,Xiaoyan He,Jia Wang,Gaofeng Chen,Chengyu Zou,Daichao Xu,Hongbing Zhang  ORCID: orcid.org/0000-0001-6291-1027,Junying Yuan &…Yunhong Zha 
https://doi.org/10.1038/s41392-023-01713-z
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Aberrant epithelial cell interaction promotes esophageal squamous-cell carcinoma development and progression
Liping Chen,Shihao Zhu  ORCID: orcid.org/0000-0002-3972-4781,Tianyuan Liu,Xuan Zhao,Tao Xiang,Xiao Hu,Chen Wu &…Dongxin Lin  ORCID: orcid.org/0000-0002-8723-8868 
https://doi.org/10.1038/s41392-023-01710-2
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Pyrotinib and chrysin synergistically potentiate autophagy in HER2-positive breast cancer
Xiaoxiao Liu,Xing Zhang,Zhiying Shao,Xiaorong Zhong,Xin Ding,Liang Wu,Jie Chen,Ping He,Yan Cheng,Kunrui Zhu,Dan Zheng,Jing Jing &…Ting Luo 
https://doi.org/10.1038/s41392-023-01689-w
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Simultaneously targeting extracellular vesicle trafficking and TGF-β receptor kinase activity blocks signaling hyperactivation and metastasis
Adilson Fonseca Teixeira  ORCID: orcid.org/0000-0001-7770-1778,Yanhong Wang,Josephine Iaria,Peter ten Dijke &…Hong-Jian Zhu 
https://doi.org/10.1038/s41392-023-01711-1
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Trogocytosis of CAR molecule regulates CAR-T cell dysfunction and tumor antigen escape
You Zhai,Yicong Du,Guanzhang Li,Mingchen Yu,Huimin Hu,Changqing Pan,Di Wang,Zhongfang Shi,Xu Yan,Xuesong Li,Tao Jiang  ORCID: orcid.org/0000-0002-7008-6351 &…Wei Zhang  ORCID: orcid.org/0000-0001-7800-3189 
https://doi.org/10.1038/s41392-023-01708-w
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Letter
Host cyclophilin A facilitates SARS-CoV-2 infection by binding and stabilizing spike on virions
Xiangpeng Sheng,Fang Zhu,Hong Peng,Fan Yang,Yi Yang,Cong Yang,Zhen Wang  ORCID: orcid.org/0000-0003-0920-3173,Wei Chen,Deyin Guo  ORCID: orcid.org/0000-0002-8297-0814 &…Ronggui Hu 
https://doi.org/10.1038/s41392-023-01719-7
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Microglial glutaminase 1 mediates chronic restraint stress-induced depression-like behaviors and synaptic damages
Huili Chen,Shengyang Fu,Xiangyu Li,Meng Shi,Jiazhen Qian,Shu Zhao,Ping Yuan,Lu Ding,Xiaohuan Xia &…Jialin C. Zheng  ORCID: orcid.org/0000-0003-2286-0151 
https://doi.org/10.1038/s41392-023-01699-8
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Development of a potent benzonitrile-based inhibitor of glutaminyl-peptide cyclotransferase-like protein (QPCTL) with antitumor efficacy
Lei Yu,Pengcheng Zhao,Yaoliang Sun,Zening Zheng,Wenhao Du,Lishan Zhang,Yaxu Li,Longyan Xie,Shilin Xu &…Ping Wang  ORCID: orcid.org/0000-0002-9922-5407 
https://doi.org/10.1038/s41392-023-01715-x
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Durable and enhanced immunity against SARS-CoV-2 elicited by manganese nanoadjuvant formulated subunit vaccine
Mengyu Guo,Mingjing Cao  ORCID: orcid.org/0000-0003-1741-3808,Jiufeng Sun,Ziwei Chen,Xin Wang,Lianpan Dai  ORCID: orcid.org/0000-0001-8352-1327,George F. Gao  ORCID: orcid.org/0000-0002-3869-615X,Yuliang Zhao,Yaling Wang &…Chunying Chen  ORCID: orcid.org/0000-0002-6027-0315 
https://doi.org/10.1038/s41392-023-01718-8
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Targeting complement hyperactivation: a novel therapeutic approach for severe pneumonia induced by influenza virus/staphylococcus aureus coinfection
Leili Jia,Haihua Luo,Lizhong Li,Mingyao Wang  ORCID: orcid.org/0000-0003-4731-3488,Jiangfeng Liu,Yuan Liang,Shan Li,Yong Jiang  ORCID: orcid.org/0000-0002-8087-5717,Juntao Yang  ORCID: orcid.org/0000-0003-1180-391X &…Hongbin Song 
https://doi.org/10.1038/s41392-023-01714-y
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Perspective
Strategies for the development and approval of COVID-19 vaccines and therapeutics in the post-pandemic period
Danyi Ao,Xuemei He,Jian Liu &…Li Xu 
https://doi.org/10.1038/s41392-023-01724-w
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