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Volume 8 Issue 12, Dec 2023

Article
Immunity-and-matrix-regulatory cells enhance cartilage regeneration for meniscus injuries: a phase I dose-escalation trial
Liangjiang Huang,Song Zhang,Jun Wu,Baojie Guo,Tingting Gao,Sayed Zulfiqar Ali Shah  ORCID: orcid.org/0000-0002-9555-1539,Bo Huang,Yajie Li,Bo Zhu,Jiaqi Fan,Liu Wang,Yani Xiao,Wenjing Liu,Yao Tian,Zhengyu Fang,Yingying Lv,Lingfeng Xie,Sheng Yao,Gaotan Ke,Xiaolin Huang,Ying Huang,Yujuan Li,Yi Jia,Zhongwen Li,Guihai Feng,Yan Huo,Wei Li  ORCID: orcid.org/0000-0001-7864-404X,Qi Zhou  ORCID: orcid.org/0000-0002-6549-9362,Jie Hao,Baoyang Hu  ORCID: orcid.org/0000-0003-3993-4014 &…Hong Chen 
https://doi.org/10.1038/s41392-023-01670-7
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SUMOylation-triggered ALIX activation modulates extracellular vesicles circTLCD4-RWDD3 to promote lymphatic metastasis of non-small cell lung cancer
Xiayao Diao,Chao Guo  ORCID: orcid.org/0000-0003-2170-5096,Hanhao Zheng,Ke Zhao,Yuming Luo,Mingjie An,Yan Lin,Jiancheng Chen,Yuanlong Li,Yuting Li,Xuehan Gao,Jiaqi Zhang,Mengxin Zhou,Wenliang Bai,Lei Liu,Guige Wang,Lanjun Zhang,Xiaotian He,Rusi Zhang,Zhihua Li,Changhao Chen &…Shanqing Li  ORCID: orcid.org/0000-0002-5602-9393 
https://doi.org/10.1038/s41392-023-01685-0
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The tumor-enriched small molecule gambogic amide suppresses glioma by targeting WDR1-dependent cytoskeleton remodeling
Jiaorong Qu,Bojun Qiu,Yuxin Zhang,Yan Hu,Zhixing Wang,Zhiang Guan,Yiming Qin,Tongtong Sui,Fan Wu,Boyang Li,Wei Han &…Xiaozhong Peng  ORCID: orcid.org/0000-0002-8564-0247 
https://doi.org/10.1038/s41392-023-01666-3
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Metatranscriptome of human lung microbial communities in a cohort of mechanically ventilated COVID-19 Omicron patients
Lin Wang,Jia-Bao Cao,Bin-Bin Xia  ORCID: orcid.org/0000-0002-1174-5273,Yue-Juan Li,Xuan Zhang,Guo-Xin Mo,Rui-Juan Wang,Si-Qi Guo,Yu-Qing Zhang,Kun Xiao,Guang-Fa Zhu,Peng-Fei Liu,Li-Cheng Song,Xi-Hui Ma,Ping-Chao Xiang,Jiang Wang,Yu-Hong Liu,Fei Xie,Xu-Dong Zhang,Xiang-Xin Li,Wan-Lu Sun,Yan Cao,Kai-Fei Wang,Wen-Hui Zhang,Wei-Chao Zhao,Peng Yan,Ji-Chao Chen,Yu-Wei Yang,Zhong-Kuo Yu,Jing-Si Tang,Li Xiao,Jie-Min Zhou,Li-Xin Xie &…Jun Wang  ORCID: orcid.org/0000-0002-8859-7707 
https://doi.org/10.1038/s41392-023-01684-1
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Microcolin H, a novel autophagy inducer, exerts potent antitumour activity by targeting PITPα/β
Hange Yang,Xiaowei Zhang,Cong Wang,Hailong Zhang  ORCID: orcid.org/0000-0002-0030-3234,Juan Yi,Kun Wang,Yanzhe Hou,Peihong Ji,Xiaojie Jin,Chenghao Li,Min Zhang,Shan Huang,Haoyuan Jia,Kuan Hu  ORCID: orcid.org/0000-0003-2448-2254,Lingyun Mou &…Rui Wang 
https://doi.org/10.1038/s41392-023-01667-2
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Predictive biomarkers of response and survival following immunotherapy with a PD-L1 inhibitor benmelstobart (TQB2450) and antiangiogenic therapy with a VEGFR inhibitor anlotinib for pretreated advanced triple negative breast cancer
Yiqun Han  ORCID: orcid.org/0000-0001-5338-3058,Jiayu Wang,Tao Sun,Quchang Ouyang,Jianwen Li,Jie Yuan &…Binghe Xu 
https://doi.org/10.1038/s41392-023-01672-5
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Oncolytic adenoviruses expressing checkpoint inhibitors for cancer therapy
Daoyuan Xie  ORCID: orcid.org/0009-0009-5375-2664,Yaomei Tian,Die Hu,Yuanda Wang,Yuling Yang,Bailing Zhou,Rui Zhang,Zhixiang Ren,Mohan Liu,Jie Xu,Chunyan Dong,Binyan Zhao &…Li Yang  ORCID: orcid.org/0000-0002-9989-0394 
https://doi.org/10.1038/s41392-023-01683-2
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Review Article
The long-term health outcomes, pathophysiological mechanisms and multidisciplinary management of long COVID
Jingwei Li,Yun Zhou,Jiechao Ma,Qin Zhang,Jun Shao,Shufan Liang,Yizhou Yu  ORCID: orcid.org/0000-0002-0470-5548,Weimin Li  ORCID: orcid.org/0000-0003-0985-0311 &…Chengdi Wang  ORCID: orcid.org/0000-0002-5284-2889 
https://doi.org/10.1038/s41392-023-01640-z
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Smart nanoparticles for cancer therapy
Leming Sun  ORCID: orcid.org/0000-0002-3188-9557,Hongmei Liu,Yanqi Ye,Yang Lei,Rehmat Islam,Sumin Tan,Rongsheng Tong,Yang-Bao Miao &…Lulu Cai  ORCID: orcid.org/0000-0002-5678-1112 
https://doi.org/10.1038/s41392-023-01642-x
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Bromodomain and extraterminal (BET) proteins: biological functions, diseases and targeted therapy
Zhi-Qiang Wang,Zhao-Cong Zhang,Yu-Yang Wu,Ya-Nan Pi,Sheng-Han Lou,Tian-Bo Liu,Ge Lou &…Chang Yang 
https://doi.org/10.1038/s41392-023-01647-6
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Nuclear transport proteins: structure, function and disease relevance
Yang Yang,Lu Guo,Lin Chen,Bo Gong,Da Jia  ORCID: orcid.org/0000-0002-2205-1998 &…Qingxiang Sun 
https://doi.org/10.1038/s41392-023-01649-4
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Transcriptional co-activators: emerging roles in signaling pathways and potential therapeutic targets for diseases
Priyanka Dey Talukdar &Urmi Chatterji  ORCID: orcid.org/0000-0002-9317-5672 
https://doi.org/10.1038/s41392-023-01651-w
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Hypoxia-induced signaling in the cardiovascular system: pathogenesis and therapeutic targets
Yongchao Zhao  ORCID: orcid.org/0000-0002-2145-7187,Weidong Xiong  ORCID: orcid.org/0009-0000-4244-3713,Chaofu Li  ORCID: orcid.org/0000-0002-7100-5787,Ranzun Zhao,Hao Lu  ORCID: orcid.org/0000-0002-0322-4400,Shuai Song,You Zhou,Yiqing Hu  ORCID: orcid.org/0000-0002-1813-9778,Bei Shi  ORCID: orcid.org/0000-0001-5316-2351 &…Junbo Ge  ORCID: orcid.org/0000-0002-9360-7332 
https://doi.org/10.1038/s41392-023-01652-9
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γδ T cells: origin and fate, subsets, diseases and immunotherapy
Yi Hu,Qinglin Hu,Yongsheng Li  ORCID: orcid.org/0000-0003-2175-9449,Ligong Lu  ORCID: orcid.org/0000-0003-1405-0052,Zheng Xiang,Zhinan Yin  ORCID: orcid.org/0000-0001-6524-8777,Dieter Kabelitz  ORCID: orcid.org/0000-0002-4160-7103 &…Yangzhe Wu 
https://doi.org/10.1038/s41392-023-01653-8
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Multifunctional mesoporous silica nanoparticles for biomedical applications
Bolong Xu  ORCID: orcid.org/0000-0003-2564-5473,Shanshan Li,Rui Shi &…Huiyu Liu  ORCID: orcid.org/0000-0003-4465-8501 
https://doi.org/10.1038/s41392-023-01654-7
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Signaling pathways and targeted therapies for psoriasis
Jia Guo,Hanyi Zhang  ORCID: orcid.org/0000-0003-0476-8490,Wenrui Lin,Lixia Lu,Juan Su &…Xiang Chen  ORCID: orcid.org/0000-0001-8187-636X 
https://doi.org/10.1038/s41392-023-01655-6
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Research Highlight
Human embryo models: unveiling sophisticated self-organization of stem cells during post-implantation stages
Manqiang Lin &Michael Sigal 
https://doi.org/10.1038/s41392-023-01677-0
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Sellhi neutrophils: a key to triumph in cancer therapy
Ekaterina Pylaeva &Jadwiga Jablonska  ORCID: orcid.org/0000-0003-1490-2542 
https://doi.org/10.1038/s41392-023-01671-6
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Single-cell genomics: the human biomolecular and cell atlases
Yuqing Mei,Jingjing Wang &Guoji Guo  ORCID: orcid.org/0000-0002-1716-4621 
https://doi.org/10.1038/s41392-023-01676-1
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Decoding γδ T cell anticancer therapies: integrating CRISPR screens with tumor organoids
Jian Zhou,Min Wu  ORCID: orcid.org/0000-0003-1205-982X &Gen Yang 
https://doi.org/10.1038/s41392-023-01678-z
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The Vγ4/butyrophilin conspiracy: novel role of intraepithelial γδ T cells in chronic inflammatory bowel disease
Dieter Kabelitz  ORCID: orcid.org/0000-0002-4160-7103 
https://doi.org/10.1038/s41392-023-01697-w
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Versatile guardians: regenerative regulatory T cells in Parkinson’s disease rodent models
Chi Wang Ip &Jörg Wischhusen  ORCID: orcid.org/0000-0002-0390-4297 
https://doi.org/10.1038/s41392-023-01681-4
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SARS-CoV-2 Omicron subvariant BA.2.86: limited potential for global spread
Xinling Wang,Lu Lu  ORCID: orcid.org/0000-0002-2255-0391 &Shibo Jiang  ORCID: orcid.org/0000-0001-8283-7135 
https://doi.org/10.1038/s41392-023-01712-0
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