Table of Contents
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Volume 8 Issue 11, Nov 2023

Review Article
Multifaceted role of mTOR (mammalian target of rapamycin) signaling pathway in human health and disease
Vivek Panwar,Aishwarya Singh,Manini Bhatt,Rajiv K. Tonk,Shavkatjon Azizov,Agha Saquib Raza,Shinjinee Sengupta,Deepak Kumar &…Manoj Garg  ORCID: orcid.org/0000-0002-3492-2957 
https://doi.org/10.1038/s41392-023-01608-z
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Drug-microbiota interactions: an emerging priority for precision medicine
Qing Zhao,Yao Chen,Weihua Huang,Honghao Zhou &…Wei Zhang  ORCID: orcid.org/0000-0002-6190-3129 
https://doi.org/10.1038/s41392-023-01619-w
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The IL-17 family in diseases: from bench to bedside
Longjie Huangfu,Ruiying Li,Yamei Huang &…Shan Wang 
https://doi.org/10.1038/s41392-023-01620-3
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Astrocytes in human central nervous system diseases: a frontier for new therapies
Alexei Verkhratsky  ORCID: orcid.org/0000-0003-2592-9898,Arthur Butt,Baoman Li,Peter Illes,Robert Zorec,Alexey Semyanov,Yong Tang  ORCID: orcid.org/0000-0002-2543-066X &…Michael V. Sofroniew  ORCID: orcid.org/0000-0001-6075-0178 
https://doi.org/10.1038/s41392-023-01628-9
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From signalling pathways to targeted therapies: unravelling glioblastoma’s secrets and harnessing two decades of progress
Brittany Dewdney  ORCID: orcid.org/0000-0002-6362-369X,Misty R. Jenkins  ORCID: orcid.org/0000-0001-6564-2715,Sarah A. Best,Saskia Freytag,Krishneel Prasad,Jeff Holst  ORCID: orcid.org/0000-0002-0377-9318,Raelene Endersby  ORCID: orcid.org/0000-0003-3554-2769 &…Terrance G. Johns 
https://doi.org/10.1038/s41392-023-01637-8
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RNA modification in cardiovascular disease: implications for therapeutic interventions
Cong Wang,Xuyang Hou,Qing Guan,Huiling Zhou,Li Zhou,Lijun Liu,Jijia Liu,Feng Li,Wei Li  ORCID: orcid.org/0000-0002-7267-6494 &…Haidan Liu  ORCID: orcid.org/0000-0002-6062-0813 
https://doi.org/10.1038/s41392-023-01638-7
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Research Highlight
Artificial sweetener sucralose: a possible modulator of autoimmune diseases
Nicolle Kränkel &Ursula Rauch-Kroehnert 
https://doi.org/10.1038/s41392-023-01607-0
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Ras homolog family member J (RHOJ): a key regulator of chemoresistance associated with epithelial-mesenchymal transition
Sijia Liu  ORCID: orcid.org/0000-0002-1326-4932,Jiang Ren &Long Zhang  ORCID: orcid.org/0000-0001-8139-0474 
https://doi.org/10.1038/s41392-023-01597-z
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Germ-free, carefree: injured skin uses IL-24 to kick-start repair independent of pathogen-recognition
Ruben A. Ferrer,Marta Torregrossa &Sandra Franz  ORCID: orcid.org/0000-0002-3449-2723 
https://doi.org/10.1038/s41392-023-01609-y
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Safeguarding transcriptional memory: a mitotic bookmarking role for chromatin remodelers
Godwin Sokpor  ORCID: orcid.org/0000-0002-7120-0793,Huu Phuc Nguyen &Tran Tuoc  ORCID: orcid.org/0000-0003-2079-7259 
https://doi.org/10.1038/s41392-023-01610-5
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Bispecific immune molecule PD1-IL2v: a new therapeutic strategy for pancreatic ductal adenocarcinoma
Yuan Gao,Liqing Yu &Hongming Miao  ORCID: orcid.org/0000-0001-6355-3612 
https://doi.org/10.1038/s41392-023-01611-4
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Starving out brain tumors: a reprogrammed lysine catabolism serves as a novel target for glioblastoma treatment
Désirée Gül,Oliver H. Krämer  ORCID: orcid.org/0000-0003-3973-045X &Christoph Reinhardt 
https://doi.org/10.1038/s41392-023-01616-z
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Ectodysplasin A2 receptor-NF-κB-inducing kinase axis: a new player in muscle wasting to cancer cachexia
Janusz von Renesse  ORCID: orcid.org/0000-0002-5103-5137 &Peter Mirtschink 
https://doi.org/10.1038/s41392-023-01617-y
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Targeting menin: a promising therapeutic strategy for susceptible acute leukemia subtypes
Pietro Di Fazio  ORCID: orcid.org/0000-0003-0091-8498 
https://doi.org/10.1038/s41392-023-01627-w
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Activated STING: an ion channel to trigger non-interferon-related functions
Zhengyu Gao  ORCID: orcid.org/0000-0002-6777-8840,Bin Wang &Long Zhang  ORCID: orcid.org/0000-0001-8139-0474 
https://doi.org/10.1038/s41392-023-01633-y
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Cephalopod RNA recoding: linking protein plasticity to thermal adaptation and catalyzing beyond-species protein characterization
Junyi Wang  ORCID: orcid.org/0000-0003-0464-4543,Guoping Li &Min Wu  ORCID: orcid.org/0000-0003-1205-982X 
https://doi.org/10.1038/s41392-023-01632-z
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B-cell immune checkpoint TIM-1: a potential target for tumour immunotherapy
Xinyu Tian,Xiangyun Zheng &Dong Tian 
https://doi.org/10.1038/s41392-023-01643-w
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Unmasking metabolic dependencies in pancreatic cancer: aberrant polyamine synthesis as a promising new therapeutic target
Gerrit Wolters-Eisfeld  ORCID: orcid.org/0000-0002-2984-6515,Thilo Hackert &Cenap Güngör  ORCID: orcid.org/0000-0002-5173-9492 
https://doi.org/10.1038/s41392-023-01662-7
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Dietary reprogram of macrophages for cell competition: a promising strategy for malignant cancer control
Jian Chen,Zhaoliang Su  ORCID: orcid.org/0000-0002-5998-5575 &Guangchuan Wang  ORCID: orcid.org/0000-0001-5315-1599 
https://doi.org/10.1038/s41392-023-01664-5
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Letter
Gut microbe-derived metabolite indole-3-carboxaldehyde alleviates atherosclerosis
Yijing Lu,Wenlong Yang,Zhiyong Qi,Rifeng Gao,Jing Tong,Tingwen Gao,Yin Zhang,Aijun Sun,Shuning Zhang &…Junbo Ge  ORCID: orcid.org/0000-0002-9360-7332 
https://doi.org/10.1038/s41392-023-01613-2
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Article
Human endogenous retroviruses as epigenetic therapeutic targets in TP53-mutated diffuse large B-cell lymphoma
Ying Fang,Mu-Chen Zhang,Yang He,Chen Li,Hai Fang,Peng-Peng Xu,Shu Cheng,Yan Zhao,Yan Feng,Qian Liu,Li Wang &…Wei-Li Zhao  ORCID: orcid.org/0000-0002-6834-1616 
https://doi.org/10.1038/s41392-023-01626-x
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SARS-CoV-2 spike-specific TFH cells exhibit unique responses in infected and vaccinated individuals
Rongzhang He,Xingyu Zheng,Jian Zhang,Bo Liu,Qijie Wang,Qian Wu,Ziyan Liu,Fangfang Chang,Yabin Hu,Ting Xie,Yongchen Liu,Jun Chen,Jing Yang,Shishan Teng,Rui Lu,Dong Pan,You Wang,Liting Peng,Weijin Huang  ORCID: orcid.org/0000-0002-4246-8889,Velislava Terzieva  ORCID: orcid.org/0000-0002-3782-5917,Wenpei Liu,Youchun Wang  ORCID: orcid.org/0000-0001-9769-5141,Yi-Ping Li  ORCID: orcid.org/0000-0001-6011-3101 &…Xiaowang Qu  ORCID: orcid.org/0000-0002-8135-7292 
https://doi.org/10.1038/s41392-023-01650-x
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P21-activated kinase 1 (PAK1)-mediated cytoskeleton rearrangement promotes SARS-CoV-2 entry and ACE2 autophagic degradation
Ming Liu,Bingtai Lu,Yue Li,Shuofeng Yuan  ORCID: orcid.org/0000-0001-7996-1119,Zhen Zhuang,Guangyu Li,Dong Wang,Liuheyi Ma,Jianheng Zhu,Jinglu Zhao,Chris Chung-Sing Chan  ORCID: orcid.org/0000-0001-7089-4829,Vincent Kwok-Man Poon  ORCID: orcid.org/0000-0002-7737-8912,Kenn Ka-Heng Chik,Zhiyao Zhao,Huifang Xian,Jingxian Zhao,Jincun Zhao  ORCID: orcid.org/0000-0003-2515-5589,Jasper Fuk-Woo Chan  ORCID: orcid.org/0000-0001-6336-6657 &…Yuxia Zhang 
https://doi.org/10.1038/s41392-023-01631-0
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Eosinophils promote pulmonary matrix destruction and emphysema via Cathepsin L
Xia Xu,Tao Yu,Lingling Dong,Rainer Glauben,Siyuan Wu,Ronghua Huang,Shiwei Qumu,Chenli Chang,Jing Guo,Lin Pan,Ting Yang,Xin Lin  ORCID: orcid.org/0000-0003-0956-3654,Ke Huang,Zhihua Chen &…Chen Wang 
https://doi.org/10.1038/s41392-023-01634-x
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Macrophage CARD9 mediates cardiac injury following myocardial infarction through regulation of lipocalin 2 expression
Yan Liu,Yi-hui Shao,Jun-meng Zhang,Ying Wang,Mei Zhou,Hui-qin Li,Cong-cong Zhang,Pei-jie Yu,Shi-juan Gao,Xue-rui Wang,Li-xin Jia,Chun-mei Piao,Jie Du &…Yu-lin Li 
https://doi.org/10.1038/s41392-023-01635-w
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Safety and clinical efficacy of sintilimab (anti-PD-1) in pediatric patients with advanced or recurrent malignancies in a phase I study
Yi Que,Juan Wang,Feifei Sun,Shan Wang,Jia Zhu,Junting Huang,Zhenzhen Zhao,Li Zhang,Juan Liu,Jiaqian Xu,Zijun Zhen,Xiaofei Sun,Suying Lu &…Yizhuo Zhang 
https://doi.org/10.1038/s41392-023-01636-9
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Epigenetic regulation of TP53 is involved in prostate cancer radioresistance and DNA damage response signaling
Catarina Macedo-Silva,Vera Miranda-Gonçalves,Nuno Tiago Tavares,Daniela Barros-Silva,Joana Lencart,João Lobo,Ângelo Oliveira,Margareta P. Correia,Lucia Altucci  ORCID: orcid.org/0000-0002-7312-5387 &…Carmen Jerónimo  ORCID: orcid.org/0000-0003-4186-5345 
https://doi.org/10.1038/s41392-023-01639-6
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Neo-intline: integrated pipeline enables neoantigen design through the in-silico presentation of T-cell epitope
Bingyu Li,Ping Jing,Genhui Zheng  ORCID: orcid.org/0000-0001-5380-2435,Chenyu Pi,Lu Zhang,Zuojing Yin,Lijun Xu,Jingxuan Qiu,Hua Gu,Tianyi Qiu &…Jianmin Fang 
https://doi.org/10.1038/s41392-023-01644-9
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Single-cell transcriptomic analysis reveals a systemic immune dysregulation in COVID-19-associated pediatric encephalopathy
Yi Wang  ORCID: orcid.org/0000-0002-2031-087X,Laurence Don Wai Luu,Shuang Liu,Xiong Zhu,Siyuan Huang,Fang Li,Xiaolan Huang,Linying Guo,Jin Zhang,Haiyan Ge,Yuanyuan Sun,Yi Hui,Yanning Qu,Huicong Wang,Xiaoxia Wang,Weilan Na,Juan Zhou,Dong Qu &…Jun Tai 
https://doi.org/10.1038/s41392-023-01641-y
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Cyst fluid glycoproteins accurately distinguishing malignancies of pancreatic cystic neoplasm
Ming Cui  ORCID: orcid.org/0000-0001-8770-4585,Ya Hu,Zejian Zhang,Tianqi Chen,Menghua Dai,Qiang Xu,Junchao Guo,Taiping Zhang,Quan Liao,Jun Yu &…Yupei Zhao  ORCID: orcid.org/0000-0001-7081-2299 
https://doi.org/10.1038/s41392-023-01645-8
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Astragaloside IV derivative HHQ16 ameliorates infarction-induced hypertrophy and heart failure through degradation of lncRNA4012/9456
Jingjing Wan,Zhen Zhang,Chennan Wu,Saisai Tian,Yibei Zang,Ge Jin,Qingyan Sun,Pin Wang,Xin Luan,Yili Yang,Xuelin Zhan,Lingyu Linda Ye,Dayue Darrel Duan,Xia Liu &…Weidong Zhang 
https://doi.org/10.1038/s41392-023-01660-9
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Anti-PD-1 antibody armored γδ T cells enhance anti-tumor efficacy in ovarian cancer
Yue Wang,Jingyi Han,Dongdong Wang,Menghua Cai,Yi Xu,Yu Hu,Hui Chen,Wei He &…Jianmin Zhang  ORCID: orcid.org/0000-0003-4765-0812 
https://doi.org/10.1038/s41392-023-01646-7
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Fe65-engineered neuronal exosomes encapsulating corynoxine-B ameliorate cognition and pathology of Alzheimer’s disease
Ashok Iyaswamy  ORCID: orcid.org/0000-0003-0186-3863,Abhimanyu Thakur  ORCID: orcid.org/0000-0002-0846-0998,Xin-Jie Guan,Senthilkumar Krishnamoorthi,Tsz Yan Fung,Kejia Lu,Isha Gaurav,Zhijun Yang,Cheng-Fu Su,Kwok-Fai Lau,Kui Zhang,Roy Chun-Laam Ng,Qizhou Lian,King-Ho Cheung,Keqiang Ye  ORCID: orcid.org/0000-0002-7657-8154,Huanhuan Joyce Chen &…Min Li  ORCID: orcid.org/0000-0002-7113-2700 
https://doi.org/10.1038/s41392-023-01657-4
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Real-world effectiveness of an intranasal spray A8G6 antibody cocktail in the post-exposure prophylaxis of COVID-19
Xiaosong Li,Pai Peng,Haijun Deng  ORCID: orcid.org/0000-0002-4890-192X,Qian Yang,Shi Chen,Benhua Li,Miao He,Aishun Jin,Zhu Yang,Ni Tang  ORCID: orcid.org/0000-0001-5830-8786 &…Ailong Huang  ORCID: orcid.org/0000-0003-0148-7423 
https://doi.org/10.1038/s41392-023-01656-5
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Control of CD4+ T cells to restrain inflammatory diseases via eukaryotic elongation factor 2 kinase
Hao-Yun Peng,Liqing Wang,Jugal Kishore Das,Anil Kumar  ORCID: orcid.org/0000-0002-7611-5918,Darby J. Ballard,Yijie Ren,Xiaofang Xiong,Paul de Figueiredo,Jin-Ming Yang &…Jianxun Song  ORCID: orcid.org/0000-0002-9734-6176 
https://doi.org/10.1038/s41392-023-01648-5
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Phase II trial of CDK4/6 inhibitor palbociclib in advanced sarcoma based on mRNA expression of CDK4/CDKN2A
Javier Martin-Broto,Jeronimo Martinez-Garcia,David S. Moura,Andres Redondo,Antonio Gutierrez,Antonio Lopez-Pousa,Javier Martinez-Trufero  ORCID: orcid.org/0000-0002-0997-2573,Isabel Sevilla,Roberto Diaz-Beveridge,Maria Pilar Solis-Hernandez,Amancio Carnero  ORCID: orcid.org/0000-0003-4357-3979,Marco Perez,David Marcilla,Jesus Garcia-Foncillas,Pablo Romero,Javier Fernandez-Jara,Daniel Lopez-Lopez  ORCID: orcid.org/0000-0001-7672-7335,Ivan Arribas &…Nadia Hindi  ORCID: orcid.org/0000-0002-5864-762X 
https://doi.org/10.1038/s41392-023-01661-8
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Characteristics of premanufacture CD8+ T cells determine CAR-T efficacy in patients with diffuse large B-cell lymphoma
Yao Wang  ORCID: orcid.org/0000-0002-9352-422X,Chuan Tong,Yuting Lu,Zhiqiang Wu,Yelei Guo,Yang Liu,Jianshu Wei,Chunmeng Wang,Qingming Yang &…Weidong Han  ORCID: orcid.org/0000-0003-3207-3899 
https://doi.org/10.1038/s41392-023-01659-2
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Tumor-repopulating cell-derived microparticles elicit cascade amplification of chemotherapy-induced antitumor immunity to boost anti-PD-1 therapy
Nana Bie,Tuying Yong  ORCID: orcid.org/0000-0002-1255-9798,Zhaohan Wei,Qingle Liang,Xiaoqiong Zhang,Shiyu Li,Xin Li,Jianye Li,Lu Gan  ORCID: orcid.org/0000-0002-8785-867X &…Xiangliang Yang  ORCID: orcid.org/0000-0003-0683-8763 
https://doi.org/10.1038/s41392-023-01658-3
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Camrelizumab (a PD-1 inhibitor) plus apatinib (an VEGFR-2 inhibitor) and hepatic artery infusion chemotherapy for hepatocellular carcinoma in Barcelona Clinic Liver Cancer stage C (TRIPLET): a phase II study
Tian-Qi Zhang,Zhi-Jun Geng,Meng-Xuan Zuo,Ji-Bin Li  ORCID: orcid.org/0000-0001-7632-3648,Jin-Hua Huang,Zi-Lin Huang,Pei-Hong Wu &…Yang-Kui Gu 
https://doi.org/10.1038/s41392-023-01663-6
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