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Volume 8 Issue 10, Oct 2023

Article
Intestinal microbiota links to allograft stability after lung transplantation: a prospective cohort study
Junqi Wu,Chongwu Li,Peigen Gao,Chenhong Zhang,Pei Zhang,Lei Zhang,Chenyang Dai,Kunpeng Zhang,Bowen Shi,Mengyang Liu,Junmeng Zheng,Bo Pan,Zhan Chen,Chao Zhang,Wanqing Liao,Weihua Pan,Wenjie Fang &…Chang Chen  ORCID: orcid.org/0000-0002-9981-3110 
https://doi.org/10.1038/s41392-023-01515-3
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Generation of inactivated IL2RG and RAG1 monkeys with severe combined immunodeficiency using base editing
Zheng Xiao,Huang Chunhui,Lin Yingqi,Bofeng Han,Chen Yizhi,Li Caijuan,Li Jiawei,Ding Yongyan,Song Xichen,Wang Wei,Liang Weien,Wu Jianhao,Wu Jiaxi,Gao Jiale,Wei Chengxi,Zhang Xudong,Zhuchi Tu &…Sen Yan  ORCID: orcid.org/0000-0003-4889-1570 
https://doi.org/10.1038/s41392-023-01544-y
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A metabolome atlas of mouse brain on the global metabolic signature dynamics following short-term fasting
Yaping Shao,Zhenfa Fu,Yanfeng Wang,Zhaofei Yang,Yushan Lin,Song Li,Cheng Cheng,Min Wei,Zheyi Liu,Guowang Xu  ORCID: orcid.org/0000-0003-4298-3554 &…Weidong Le  ORCID: orcid.org/0000-0001-7459-2705 
https://doi.org/10.1038/s41392-023-01552-y
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Temporospatial inhibition of Erk signaling is required for lymphatic valve formation
Yaping Meng,Tong Lv,Junfeng Zhang,Weimin Shen,Lifang Li,Yaqi Li,Xin Liu,Xing Lei,Xuguang Lin,Hanfang Xu,Anming Meng  ORCID: orcid.org/0000-0001-7228-3431 &…Shunji Jia  ORCID: orcid.org/0000-0001-8678-1714 
https://doi.org/10.1038/s41392-023-01571-9
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Oit3, a promising hallmark gene for targeting liver sinusoidal endothelial cells
Zhi-Wen Li,Bai Ruan,Pei-Jun Yang,Jing-Jing Liu,Ping Song,Juan-Li Duan &…Lin Wang  ORCID: orcid.org/0000-0001-5586-3012 
https://doi.org/10.1038/s41392-023-01621-2
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CBX4 deletion promotes tumorigenesis under KrasG12D background by inducing genomic instability
Fangzhen Chen,Wulei Hou,Xiangtian Yu,Jing Wu,Zhengda Li,Jietian Xu,Zimu Deng,Gaobin Chen  ORCID: orcid.org/0000-0001-9988-1773,Bo Liu  ORCID: orcid.org/0000-0002-5008-296X,Xiaoxing Yin,Wei Yu,Lei Zhang,Guoliang Xu,Hongbin Ji  ORCID: orcid.org/0000-0003-0891-6390,Chunmin Liang  ORCID: orcid.org/0000-0002-6129-9902 &…Zuoyun Wang 
https://doi.org/10.1038/s41392-023-01623-0
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RNA binding protein TIAR modulates HBV replication by tipping the balance of pgRNA translation
Ting Zhang,Huiling Zheng,Danjuan Lu,Guiwen Guan,Deyao Li,Jing Zhang,Shuhong Liu,Jingmin Zhao,Ju-Tao Guo,Fengmin Lu &…Xiangmei Chen 
https://doi.org/10.1038/s41392-023-01573-7
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Impact of genetic patterns on sorafenib efficacy in patients with FLT3-ITD acute myeloid leukemia undergoing allogeneic hematopoietic stem cell transplantation: a multi-center, cohort study
Ruoyang Shao,Yu Zhang,Jinping He,Fen Huang,Zhiping Fan,Kaibo Yang,Yajing Xu,Na Xu,Yi Luo,Lan Deng,Xi Zhang  ORCID: orcid.org/0000-0002-8548-2832,Jia Chen,Mingzhe Han,Xudong Li,Sijian Yu,Hui Liu,Xinquan Liang,Xiaodan Luo,Pengcheng Shi,Zhixiang Wang,Ling Jiang,Xuan Zhou,Ren Lin,Yan Chen,Sanfang Tu,Jing Sun,Yu Wang,Qifa Liu &…Li Xuan 
https://doi.org/10.1038/s41392-023-01614-1
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Broadly neutralizing antibodies derived from the earliest COVID-19 convalescents protect mice from SARS-CoV-2 variants challenge
Qianyun Liu,Haiyan Zhao,Zhiqiang Li,Zhen Zhang,Rui Huang,Mengxue Gu,Ke Zhuang,Qing Xiong,Xianying Chen,Weiyi Yu,Shengnan Qian,Yuzhen Zhang,Xue Tan,Muyi Zhang,Feiyang Yu,Ming Guo,Zhixiang Huang,Xin Wang,Wenjie Xiang,Bihao Wu,Fanghua Mei,Kun Cai  ORCID: orcid.org/0000-0002-4321-133X,Limin Zhou,Li Zhou,Ying Wu,Huan Yan,Sheng Cao,Ke Lan  ORCID: orcid.org/0000-0002-0384-8598 &…Yu Chen  ORCID: orcid.org/0000-0003-1300-4652 
https://doi.org/10.1038/s41392-023-01615-0
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MDIG-mediated H3K9me3 demethylation upregulates Myc by activating OTX2 and facilitates liver regeneration
Jinpeng Du,Wenwei Liao,Haichuan Wang  ORCID: orcid.org/0000-0002-6886-5698,Guimin Hou,Min Liao,Lin Xu,Jiwei Huang,Kefei Yuan  ORCID: orcid.org/0000-0003-4308-7743,Xiangzheng Chen &…Yong Zeng  ORCID: orcid.org/0000-0002-3347-9690 
https://doi.org/10.1038/s41392-023-01575-5
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Duration of humoral immunity from smallpox vaccination and its cross-reaction with Mpox virus
Entao Li,Xiaoping Guo,Dongxiang Hong,Qizan Gong,Wenyu Xie,Tingting Li,Jian Wang,Xia Chuai &…Sandra Chiu  ORCID: orcid.org/0000-0001-9034-5755 
https://doi.org/10.1038/s41392-023-01574-6
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Hypoxia-inducible factor upregulation by roxadustat attenuates drug reward by altering brain iron homoeostasis
Pengju Yan,Ningning Li,Ming Ma,Zhaoli Liu,Huicui Yang,Jinnan Li,Chunlei Wan,Shuliu Gao,Shuai Li,Longtai Zheng,John L. Waddington,Lin Xu &…Xuechu Zhen 
https://doi.org/10.1038/s41392-023-01578-2
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NAD+ exhaustion by CD38 upregulation contributes to blood pressure elevation and vascular damage in hypertension
Yumin Qiu,Shiyue Xu,Xi Chen,Xing Wu,Zhe Zhou,Jianning Zhang,Qiang Tu,Bing Dong,Zhefu Liu,Jiang He,Xiaoyu Zhang,Shuangshuang Liu,Chen Su,Hui Huang  ORCID: orcid.org/0000-0001-5716-4012,Wenhao Xia &…Jun Tao 
https://doi.org/10.1038/s41392-023-01577-3
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Long-term survival benefit of anti-PD-1 therapy in patients with relapsed or refractory classical Hodgkin lymphoma
Weiping Liu,Ningjing Lin,Xinqin Feng,Yan Xie,Chong You,Xiaohua Zhou  ORCID: orcid.org/0000-0001-7935-1222,Yuqin Song &…Jun Zhu  ORCID: orcid.org/0000-0003-3479-2547 
https://doi.org/10.1038/s41392-023-01600-7
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Dynamic single-cell mapping unveils Epstein‒Barr virus-imprinted T-cell exhaustion and on-treatment response
Miao-Zhen Qiu  ORCID: orcid.org/0000-0002-4774-6235,Chaoye Wang,Zhiying Wu,Qi Zhao  ORCID: orcid.org/0000-0002-8683-6145,Zhibin Zhao,Chun-Yu Huang,Wenwei Wu,Li-Qiong Yang,Zhi-Wei Zhou,Yu Zheng,Hong-Ming Pan,Zexian Liu  ORCID: orcid.org/0000-0001-9698-0610,Zhao-Lei Zeng  ORCID: orcid.org/0000-0003-4420-5625,Hui-Yan Luo  ORCID: orcid.org/0000-0001-6312-9299,Feng Wang,Feng-Hua Wang,Si-Yu Yang,Meng-Xing Huang,Zhexiong Lian  ORCID: orcid.org/0000-0002-9525-1421,Haiyan Zhang &…Rui-Hua Xu  ORCID: orcid.org/0000-0001-9771-8534 
https://doi.org/10.1038/s41392-023-01622-1
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The cGAS-STING pathway-dependent sensing of mitochondrial DNA mediates ocular surface inflammation
Weijie Ouyang,Shoubi Wang,Dan Yan,Jieli Wu,Yunuo Zhang,Wei Li,Jiaoyue Hu &…Zuguo Liu 
https://doi.org/10.1038/s41392-023-01624-z
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CXXC finger protein 1 (CFP1) bridges the reshaping of genomic H3K4me3 signature to the advancement of lung adenocarcinoma
Tao Fan,Chu Xiao,Hengchang Liu,Yu Liu,Liyu Wang,He Tian,Chunxiang Li  ORCID: orcid.org/0000-0003-3477-1535 &…Jie He  ORCID: orcid.org/0000-0003-0327-8852 
https://doi.org/10.1038/s41392-023-01612-3
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Tauopathy promotes spinal cord-dependent production of toxic amyloid-beta in transgenic monkeys
Zhuchi Tu,Sen Yan  ORCID: orcid.org/0000-0003-4889-1570,Bofeng Han,Caijuan Li,Weien Liang,Yingqi Lin,Yongyan Ding,Huiyi Wei,Lu Wang,Hao Xu,Jianmeng Ye,Bang Li,Shihua Li  ORCID: orcid.org/0000-0003-1775-6536 &…Xiao-Jiang Li 
https://doi.org/10.1038/s41392-023-01601-6
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A viral RNA-dependent RNA polymerase inhibitor VV116 broadly inhibits human coronaviruses and has synergistic potency with 3CLpro inhibitor nirmatrelvir
Yumin Zhang  ORCID: orcid.org/0000-0003-0767-1221,Yuan Sun  ORCID: orcid.org/0000-0001-8244-7436,Yuanchao Xie,Weijuan Shang,Zhen Wang,Hualiang Jiang  ORCID: orcid.org/0000-0003-0656-6315,Jingshan Shen  ORCID: orcid.org/0000-0001-9679-9934,Gengfu Xiao  ORCID: orcid.org/0000-0001-9401-235X &…Leike Zhang  ORCID: orcid.org/0000-0002-2593-2571 
https://doi.org/10.1038/s41392-023-01587-1
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Secreted LRPAP1 binds and triggers IFNAR1 degradation to facilitate virus evasion from cellular innate immunity
Huangcan Li  ORCID: orcid.org/0000-0003-1409-9219,Xiong Wang,Yiran Wang,Yichen Li,Ying Chen,Yin-Ting Wong,Jufang He &…Ming-Liang He 
https://doi.org/10.1038/s41392-023-01630-1
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Orthosteric ligand selectivity and allosteric probe dependence at Hydroxycarboxylic acid receptor HCAR2
Lin Cheng,Suyue Sun,Heli Wang,Chang Zhao,Xiaowen Tian,Ying Liu,Ping Fu  ORCID: orcid.org/0000-0002-3061-5925,Zhenhua Shao  ORCID: orcid.org/0000-0001-7204-801X,Renjie Chai  ORCID: orcid.org/0000-0002-3885-543X &…Wei Yan 
https://doi.org/10.1038/s41392-023-01625-y
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Non-small cell lung cancers (NSCLCs) oncolysis using coxsackievirus B5 and synergistic DNA-damage response inhibitors
Bopei Cui,Lifang Song,Qian Wang,Kelei Li,Qian He,Xing Wu,Fan Gao,Mingchen Liu,Chaoqiang An,Qiushuang Gao,Chaoying Hu,Xiaotian Hao,Fangyu Dong,Jiuyue Zhou,Dong Liu,Ziyang Song,Xujia Yan,Jialu Zhang,Yu Bai,Qunying Mao,Xiaoming Yang  ORCID: orcid.org/0000-0002-2598-4355 &…Zhenglun Liang 
https://doi.org/10.1038/s41392-023-01603-4
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Baseline gut microbiota and metabolome predict durable immunogenicity to SARS-CoV-2 vaccines
Ye Peng  ORCID: orcid.org/0000-0003-3791-2305,Lin Zhang,Chris K. P. Mok,Jessica Y. L. Ching,Shilin Zhao,Matthew K. L. Wong,Jie Zhu,Chunke Chen,Shilan Wang,Shuai Yan,Biyan Qin,Yingzhi Liu,Xi Zhang  ORCID: orcid.org/0000-0003-1340-7128,Chun Pun Cheung,Pui Kuan Cheong,Ka Long Ip,Adrian C. H. Fung,Kenneth K. Y. Wong,David S. C. Hui,Francis K. L. Chan,Siew C. Ng &…Hein M. Tun  ORCID: orcid.org/0000-0001-7597-5062 
https://doi.org/10.1038/s41392-023-01629-8
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Combined FOLFOX4 with all-trans retinoic acid versus FOLFOX4 with placebo in treatment of advanced hepatocellular carcinoma with extrahepatic metastasis: a randomized, double-blind comparative study
Juxian Sun,Feifei Mao,Chang Liu,Fan Zhang,Dafeng Jiang,Weixing Guo,Lei Huo,Liping Zhou,Wan Yee Lau,Jie Shi &…Shuqun Cheng 
https://doi.org/10.1038/s41392-023-01604-3
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STAT5 promotes PD-L1 expression by facilitating histone lactylation to drive immunosuppression in acute myeloid leukemia
Ze-Wei Huang,Xue-Ning Zhang,Ling Zhang,Ling-Ling Liu,Jing-Wen Zhang,Yu-Xiang Sun  ORCID: orcid.org/0009-0002-0915-6557,Jue-Qiong Xu,Quentin Liu &…Zi-Jie Long  ORCID: orcid.org/0000-0002-1616-6019 
https://doi.org/10.1038/s41392-023-01605-2
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Research Highlight
Boosting T cell immunity against cytomegalovirus: a potential strategy combating human aging and age-related diseases
Matthias Wirth  ORCID: orcid.org/0000-0002-8340-0872,Walburgis Brenner &Oliver H. Krämer  ORCID: orcid.org/0000-0003-3973-045X 
https://doi.org/10.1038/s41392-023-01590-6
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From Tpex to Tex: a journey through CD8+ T cell responses in cancer immunotherapy
Julia M. Messmer  ORCID: orcid.org/0000-0001-7858-1501,Maike Effern &Michael Hölzel  ORCID: orcid.org/0000-0003-4048-8824 
https://doi.org/10.1038/s41392-023-01595-1
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Fumarate hydratase: a new checkpoint of metabolic regulation in inflammatory macrophages
Aicha Jeridi,Theodore S. Kapellos &Ali Önder Yildirim 
https://doi.org/10.1038/s41392-023-01594-2
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Cancer cells evade ferroptosis: sex hormone-driven membrane-bound O-acyltransferase domain-containing 1 and 2 (MBOAT1/2) expression
Alexia Belavgeni,Wulf Tonnus &Andreas Linkermann 
https://doi.org/10.1038/s41392-023-01593-3
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Targeting copper to combat macrophage-driven inflammation: a potential advanced therapeutic strategy
Ralf Weiskirchen  ORCID: orcid.org/0000-0003-3888-0931 
https://doi.org/10.1038/s41392-023-01592-4
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Skeletal muscle-directed gene therapy: hijacking the fusogenic properties of muscle cells
Hildegard Büning,Michael Morgan &Axel Schambach 
https://doi.org/10.1038/s41392-023-01584-4
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RBFOX2: a key factor in suppressing PDAC metastasis through regulation of alternative splicing events
Laura Urbach &Shiv K. Singh  ORCID: orcid.org/0000-0002-5725-4058 
https://doi.org/10.1038/s41392-023-01585-3
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Base editing: a novel cure for severe combined immunodeficiency
Teng-Cheong Ha  ORCID: orcid.org/0000-0001-6945-0462,Michael Morgan &Axel Schambach 
https://doi.org/10.1038/s41392-023-01586-2
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Base editing: a promising tool to rescue spinal muscular atrophy
Priyanka Bhatia &Jared Sterneckert 
https://doi.org/10.1038/s41392-023-01583-5
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Transcriptional-translational conflict: a novel exploitable tumor suppressive mechanism
Maria Mudryj &Paramita M. Ghosh  ORCID: orcid.org/0000-0002-7304-2936 
https://doi.org/10.1038/s41392-023-01591-5
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Genetic differences between primary and metastatic cancer: a pan-cancer whole-genome comparison study
Lei Zhong,Zhipeng Zhao &Xiaonan Zhang 
https://doi.org/10.1038/s41392-023-01596-0
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Letter
Nanobody-based bispecific T-cell engager (Nb-BiTE): a new platform for enhanced T-cell immunotherapy
Xiao-mei Yang,Xuan-dong Lin,Wei Shi  ORCID: orcid.org/0000-0003-0368-1887,Shen-xia Xie,Xia-ning Huang,Shi-hua Yin,Xiao-bing Jiang,Bruce D. Hammock  ORCID: orcid.org/0000-0003-1408-8317,Zhi Ping Xu &…Xiao-ling Lu  ORCID: orcid.org/0000-0001-9049-2077 
https://doi.org/10.1038/s41392-023-01523-3
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I prostanoid receptor activation attenuates pressure overload-induced cardiac hypertrophy by enhancing glucose oxidation
Qian Liu,Guizhu Liu,Yujuan Zhuo,Shihong Chen,Yinghong Zheng,Kai Zhang  ORCID: orcid.org/0000-0003-2800-0531,Song Xiang,Jiangping Song,Liming Yang &…Ying Yu  ORCID: orcid.org/0000-0002-6476-1752 
https://doi.org/10.1038/s41392-023-01541-1
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Review Article
Mitochondrial dynamics in health and disease: mechanisms and potential targets
Wen Chen,Huakan Zhao &Yongsheng Li 
https://doi.org/10.1038/s41392-023-01547-9
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Recent advances in targeting the “undruggable” proteins: from drug discovery to clinical trials
Xin Xie,Tingting Yu,Xiang Li,Nan Zhang,Leonard J. Foster,Cheng Peng,Wei Huang  ORCID: orcid.org/0000-0003-0832-1864 &…Gu He  ORCID: orcid.org/0000-0002-1536-8882 
https://doi.org/10.1038/s41392-023-01589-z
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A new wave of innovations within the DNA damage response
Qi Li,Wenyuan Qian,Yang Zhang,Lihong Hu,Shuhui Chen &…Yuanfeng Xia 
https://doi.org/10.1038/s41392-023-01548-8
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Circular RNA vaccine in disease prevention and treatment
Dun Niu  ORCID: orcid.org/0000-0003-4303-668X,Yaran Wu  ORCID: orcid.org/0000-0003-2059-3504 &Jiqin Lian 
https://doi.org/10.1038/s41392-023-01561-x
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Amino acid metabolism in health and disease
Zhe-Nan Ling,Yi-Fan Jiang,Jun-Nan Ru,Jia-Hua Lu,Bo Ding &…Jian Wu  ORCID: orcid.org/0000-0002-6325-0766 
https://doi.org/10.1038/s41392-023-01569-3
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Endoplasmic reticulum stress: molecular mechanism and therapeutic targets
Xingyi Chen,Chaoran Shi,Meihui He,Siqi Xiong &…Xiaobo Xia  ORCID: orcid.org/0000-0003-1720-7860 
https://doi.org/10.1038/s41392-023-01570-w
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mRNA vaccines in disease prevention and treatment
Gang Zhang,Tianyu Tang,Yinfeng Chen,Xing Huang  ORCID: orcid.org/0000-0002-8886-2777 &…Tingbo Liang  ORCID: orcid.org/0000-0003-0143-3353 
https://doi.org/10.1038/s41392-023-01579-1
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The role of cell death in SARS-CoV-2 infection
Cui Yuan,Zhenling Ma,Jiufeng Xie,Wenqing Li,Lijuan Su,Guozhi Zhang,Jun Xu,Yaru Wu,Min Zhang &…Wei Liu  ORCID: orcid.org/0000-0003-0004-2713 
https://doi.org/10.1038/s41392-023-01580-8
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Targeting ferroptosis opens new avenues for the development of novel therapeutics
Shumin Sun,Jie Shen,Jianwei Jiang,Fudi Wang  ORCID: orcid.org/0000-0001-8730-0003 &…Junxia Min  ORCID: orcid.org/0000-0001-8099-6327 
https://doi.org/10.1038/s41392-023-01606-1
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Microglia in neurodegenerative diseases: mechanism and potential therapeutic targets
Chao Gao,Jingwen Jiang,Yuyan Tan &…Shengdi Chen  ORCID: orcid.org/0000-0002-6242-1025 
https://doi.org/10.1038/s41392-023-01588-0
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Lymph node metastasis in cancer progression: molecular mechanisms, clinical significance and therapeutic interventions
Haoran Ji,Chuang Hu,Xuhui Yang,Yuanhao Liu,Guangyu Ji,Shengfang Ge,Xiansong Wang &…Mingsong Wang 
https://doi.org/10.1038/s41392-023-01576-4
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