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Volume 8 Issue 9, Sep 2023

Article
Gold nanoparticles combat enveloped RNA virus by affecting organelle dynamics
Fangzhou Li,Qianqian Huang,Ziran Zhou,Qiongge Guan,Fei Ye,Baoying Huang,Weisheng Guo  ORCID: orcid.org/0000-0002-8064-357X &…Xing-Jie Liang 
https://doi.org/10.1038/s41392-023-01562-w
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Extracellular RNAs-TLR3 signaling contributes to cognitive impairment after chronic neuropathic pain in mice
Xueying Zhang,Rui Gao,Changteng Zhang,Yi Teng,Hai Chen,Qi Li,Changliang Liu,Jiahui Wu,Liuxing Wei,Liyun Deng,Lining Wu,Shixin Ye-Lehmann,Xiaobo Mao  ORCID: orcid.org/0000-0001-6587-556X,Jin Liu,Tao Zhu &…Chan Chen  ORCID: orcid.org/0000-0001-5823-8247 
https://doi.org/10.1038/s41392-023-01543-z
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Reduced smooth muscle-fibroblasts transformation potentially decreases intestinal wound healing and colitis-associated cancer in ageing mice
Yi Liu,Yanhong Ji,Ruiyi Jiang,Chao Fang,Gang Shi,Lin Cheng,Yinan Zuo,Yixin Ye,Xiaolan Su,Junshu Li,Huiling Wang,Yuan Wang,Yi Lin,Lei Dai,Shuang Zhang &…Hongxin Deng 
https://doi.org/10.1038/s41392-023-01554-w
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NPRC deletion mitigated atherosclerosis by inhibiting oxidative stress, inflammation and apoptosis in ApoE knockout mice
Cheng Cheng,Jie Zhang,Xiaodong Li,Fei Xue,Lei Cao,Linlin Meng,Wenhai Sui  ORCID: orcid.org/0000-0001-6114-0443,Meng Zhang,Yuxia Zhao,Bo Xi,Xiao Yu,Feng Xu,Jianmin Yang,Yun Zhang  ORCID: orcid.org/0000-0003-4432-6144 &…Cheng Zhang  ORCID: orcid.org/0000-0003-3672-6543 
https://doi.org/10.1038/s41392-023-01560-y
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Chronic pulmonary bacterial infection facilitates breast cancer lung metastasis by recruiting tumor-promoting MHCIIhi neutrophils
Teng Ma,Yu Tang,Taolin Wang,Yang Yang,Yige Zhang,Ruihuan Wang,Yongxin Zhang,Yi Li,Mingbo Wu,Miao Tang,Xueli Hu,Chaoyu Zou,Yuan Ren,Huan Liu,Qianhua Zhang,Heyue Li,Min Wu  ORCID: orcid.org/0000-0003-1205-982X,Jing Li  ORCID: orcid.org/0000-0001-5173-0781 &…Xikun Zhou  ORCID: orcid.org/0000-0001-6768-2382 
https://doi.org/10.1038/s41392-023-01542-0
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High-density lipoprotein regulates angiogenesis by long non-coding RNA HDRACA
Zhi-Wei Mo,Yue-Ming Peng,Yi-Xin Zhang,Yan Li,Bi-Ang Kang,Ya-Ting Chen,Le Li,Mary G. Sorci-Thomas  ORCID: orcid.org/0000-0002-6464-5006,Yi-Jun Lin,Yang Cao,Si Chen,Ze-Long Liu,Jian-Jun Gao,Zhan-Peng Huang  ORCID: orcid.org/0000-0001-7054-655X,Jia-Guo Zhou,Mian Wang,Guang-Qi Chang,Meng-Jie Deng,Yu-Jia Liu,Zhen-Sheng Ma,Zuo-Jun Hu,Yu-Gang Dong,Zhi-Jun Ou &…Jing-Song Ou 
https://doi.org/10.1038/s41392-023-01558-6
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Envonalkib versus crizotinib for treatment-naive ALK-positive non-small cell lung cancer: a randomized, multicenter, open-label, phase III trial
Yunpeng Yang,Jie Min,Nong Yang,Qitao Yu,Ying Cheng,Yanqiu Zhao,Manxiang Li,Hong Chen,Shou’an Ren,Jianying Zhou,Wu Zhuang,Xintian Qin,Lejie Cao,Yan Yu,Jian Zhang,Jianxing He,Jifeng Feng,Hao Yu,Li Zhang &…Wenfeng Fang 
https://doi.org/10.1038/s41392-023-01538-w
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CDK7-YAP-LDHD axis promotes D-lactate elimination and ferroptosis defense to support cancer stem cell-like properties
Mengzhu Lv,Ying Gong,Xuesong Liu,Yan Wang,Qingnan Wu,Jie Chen,Qingjie Min  ORCID: orcid.org/0000-0002-4330-7411,Dongyu Zhao,Xianfeng Li,Dongshao Chen,Di Yang,Danna Yeerken,Rui Liu,Jinting Li,Weimin Zhang &…Qimin Zhan  ORCID: orcid.org/0000-0002-1731-938X 
https://doi.org/10.1038/s41392-023-01555-9
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Metformin escape in prostate cancer by activating the PTGR1 transcriptional program through a novel super-enhancer
Jianheng Ye,Shanghua Cai,Yuanfa Feng,Jinchuang Li,Zhiduan Cai,Yulin Deng,Ren Liu,Xuejin Zhu,Jianming Lu  ORCID: orcid.org/0000-0002-3794-641X,Yangjia Zhuo,Yingke Liang,Jianjiang Xie,Yanqiong Zhang  ORCID: orcid.org/0000-0002-9358-111X,Huichan He,Zhaodong Han,Zhenyu Jia  ORCID: orcid.org/0000-0002-1428-904X &…Weide Zhong 
https://doi.org/10.1038/s41392-023-01516-2
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VEGF-B prevents excessive angiogenesis by inhibiting FGF2/FGFR1 pathway
Chunsik Lee  ORCID: orcid.org/0000-0002-8151-7196,Rongyuan Chen,Guangli Sun,Xialin Liu,Xianchai Lin,Chang He,Liying Xing,Lixian Liu,Lasse D. Jensen,Anil Kumar,Harald F. Langer,Xiangrong Ren,Jianing Zhang,Lijuan Huang,Xiangke Yin,JongKyong Kim  ORCID: orcid.org/0000-0001-7930-723X,Juanhua Zhu,Guanqun Huang,Jiani Li,Weiwei Lu,Wei Chen,Juanxi Liu,Jiaxin Hu,Qihang Sun,Weisi Lu,Lekun Fang  ORCID: orcid.org/0000-0002-0296-292X,Shasha Wang,Haiqing Kuang,Yihan Zhang,Geng Tian,Jia Mi,Bi-Ang Kang,Masashi Narazaki,Aaron Prodeus,Luc Schoonjans,David M. Ornitz  ORCID: orcid.org/0000-0003-1592-7629,Jean Gariepy,Guy Eelen  ORCID: orcid.org/0000-0003-3354-5819,Mieke Dewerchin,Yunlong Yang  ORCID: orcid.org/0000-0003-1551-9828,Jing-Song Ou,Antonio Mora  ORCID: orcid.org/0000-0003-1344-1131,Jin Yao,Chen Zhao,Yizhi Liu,Peter Carmeliet  ORCID: orcid.org/0000-0001-7961-1821,Yihai Cao  ORCID: orcid.org/0000-0003-1308-0065 &…Xuri Li 
https://doi.org/10.1038/s41392-023-01539-9
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Cryo-EM structure of the nucleocapsid-like assembly of respiratory syncytial virus
Yan Wang,Chong Zhang,Yongbo Luo  ORCID: orcid.org/0000-0003-2806-3161,Xiaobin Ling,Bingnan Luo  ORCID: orcid.org/0000-0002-9367-4359,Guowen Jia  ORCID: orcid.org/0000-0002-6507-6204,Dan Su,Haohao Dong  ORCID: orcid.org/0000-0002-5022-3494 &…Zhaoming Su  ORCID: orcid.org/0000-0002-9279-1721 
https://doi.org/10.1038/s41392-023-01602-5
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A20 promotes colorectal cancer immune evasion by upregulating STC1 expression to block “eat-me” signal
Min Luo,Xueping Wang,Shaocong Wu,Chuan Yang,Qiao Su,Lamei Huang,Kai Fu,Sainan An,Fachao Xie,Kenneth Kin Wah To,Fang Wang &…Liwu Fu 
https://doi.org/10.1038/s41392-023-01545-x
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Letter
Nanoparticle-based multivalent human antibodies offer potent and broad neutralization against Omicron sublineages
Yizhen Wang,Feibo Song  ORCID: orcid.org/0000-0003-1116-1902,Siling Wang,Miaolin Lan,Tingdong Li,Huilin Guo,Yali Zhang,Shengxiang Ge  ORCID: orcid.org/0000-0002-7165-3004,Zizheng Zheng &…Ningshao Xia  ORCID: orcid.org/0000-0003-0179-5266 
https://doi.org/10.1038/s41392-023-01512-6
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Sebaceous gland reprogramming with a single gene, PPARG, and small molecules
Yiqiong Liu,Shuaifei Ji,Huanhuan Gao,Huating Chen,Jiangbing Xiang,Shaoyuan Cui,Christos C. Zouboulis,Aizhen Cai,Xiaobing Fu &…Xiaoyan Sun 
https://doi.org/10.1038/s41392-023-01531-3
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RUNX1 promotes mitophagy and alleviates pulmonary inflammation during acute lung injury
Xiaoju Tang  ORCID: orcid.org/0000-0002-9795-6409,Lichun Zhong,Xin Tian,Ying Zou,Silu Hu  ORCID: orcid.org/0000-0001-9974-7910,Jia Liu  ORCID: orcid.org/0000-0001-9474-4139,Ping Li,Min Zhu,Fengming Luo &…Huajing Wan 
https://doi.org/10.1038/s41392-023-01520-6
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Comprehensive landscape of resistance mechanisms for neoadjuvant therapy in esophageal squamous cell carcinoma by single-cell transcriptomics
Yushang Yang,Yanguo Li  ORCID: orcid.org/0000-0001-9064-0033,Haopeng Yu,Zhenyu Ding,Longqi Chen,Xiaoxi Zeng,Shunmin He  ORCID: orcid.org/0000-0002-7294-0865,Qi Liao,Yi Zhao  ORCID: orcid.org/0000-0001-6046-8420 &…Yong Yuan 
https://doi.org/10.1038/s41392-023-01518-0
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Chemogenetic activation of G12 signaling enhances adipose tissue browning
Yuki Ono,Ryo Ito,Kaito Arai,Gurdeep Singh,Tsuyoshi Saitoh,Robert B. Russell,Francesco Raimondi,Junken Aoki,Juro Sakai  ORCID: orcid.org/0000-0003-4043-1035 &…Asuka Inoue  ORCID: orcid.org/0000-0003-0805-4049 
https://doi.org/10.1038/s41392-023-01524-2
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IRF7 and CTSS are pivotal for cutaneous wound healing and may serve as therapeutic targets
Jiali Yin  ORCID: orcid.org/0000-0002-5245-4851,Dongxin Shi,Yan Sun,Peiyao Zhu,Yiping Zhao,Xuegang Xu,Hongduo Chen,Yan Wu,Zhengwei Yuan  ORCID: orcid.org/0000-0003-0967-9462 &…Xing-Hua Gao 
https://doi.org/10.1038/s41392-023-01517-1
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Research Highlight
Tracing the failing heart: dual genetic fate mapping for target identification
Yaw Asare  ORCID: orcid.org/0000-0002-8946-5650,Christian Stoppe &Jürgen Bernhagen  ORCID: orcid.org/0000-0003-2996-2652 
https://doi.org/10.1038/s41392-023-01564-8
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Commanding the Commander: structure of a key protein machinery in endosomal trafficking
Xin Yong,Chunzhuang Zhou,Daniel D. Billadeau &…Da Jia  ORCID: orcid.org/0000-0002-2205-1998 
https://doi.org/10.1038/s41392-023-01568-4
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Calreticulin surface presentation: a signal for natural killer cells to attack
Jasmine P. Castellanos &Joseph C. Genereux 
https://doi.org/10.1038/s41392-023-01551-z
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Predicting the next move: tracking the complexity of lung cancer evolution and metastasis
Carina Lorenz,Axel M. Hillmer  ORCID: orcid.org/0000-0002-3381-7266 &Johannes Brägelmann  ORCID: orcid.org/0000-0002-1306-2169 
https://doi.org/10.1038/s41392-023-01567-5
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A promising small molecule binding pocket in class B GPCRs: expanding potential for drug development
Huan Xiao,Qian Sun &Qiu Sun  ORCID: orcid.org/0000-0001-5122-2226 
https://doi.org/10.1038/s41392-023-01598-y
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Lactic control of tumor growth: a new role for an old metabolite
Carolina E. Hagberg 
https://doi.org/10.1038/s41392-023-01565-7
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Rough operators: sphingomyelinase inhibitors spike NK cells to kill cancer
Mattias Carlsten  ORCID: orcid.org/0000-0001-9815-0012 &Yenan T. Bryceson 
https://doi.org/10.1038/s41392-023-01550-0
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Interaction of microglia and T cells: a deadly duo behind Tau-mediated neurodegeneration
Bilge Askin  ORCID: orcid.org/0000-0002-6582-3249 &Susanne Wegmann  ORCID: orcid.org/0000-0002-5388-2479 
https://doi.org/10.1038/s41392-023-01563-9
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Decode protein-metabolite regulatory network: one MIDAS at a time
Tian Liu &Chen Gao 
https://doi.org/10.1038/s41392-023-01566-6
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Unexpected bonds: ubiquitin-like conjugation of cGAS/CD-NTases supports their enzymatic activity and antiphage defense
Katarzyna Andryka-Cegielski  ORCID: orcid.org/0000-0002-4554-3557,Sofía Soler  ORCID: orcid.org/0000-0003-2939-6267 &Eva Bartok  ORCID: orcid.org/0000-0003-0556-1950 
https://doi.org/10.1038/s41392-023-01549-7
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Somatic mutant clone screening: scan for novel NASH target genes in mouse liver
Tian Lan,Adrien Guillot  ORCID: orcid.org/0000-0002-6002-9986 &Frank Tacke  ORCID: orcid.org/0000-0001-6206-0226 
https://doi.org/10.1038/s41392-023-01572-8
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Intestinal eosinophils: characterization of elusive granulocytes as anti-bacterial and immunomodulatory effector cells in colitis
Tim Holland &Jochen Mattner 
https://doi.org/10.1038/s41392-023-01581-7
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Cardiac optogenetics: regulating brain states via the heart
Silvia Rodriguez-Rozada  ORCID: orcid.org/0000-0001-6068-844X,Stefan Frantz &Philip Tovote 
https://doi.org/10.1038/s41392-023-01582-6
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Review Article
Nanomedicine in cancer therapy
Dahua Fan,Yongkai Cao,Meiqun Cao,Yajun Wang,Yongliang Cao &…Tao Gong 
https://doi.org/10.1038/s41392-023-01536-y
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TET (Ten-eleven translocation) family proteins: structure, biological functions and applications
Xinchao Zhang,Yue Zhang,Chaofu Wang &…Xu Wang 
https://doi.org/10.1038/s41392-023-01537-x
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Mechanisms and regulation of defensins in host defense
Jie Fu,Xin Zong,Mingliang Jin,Junxia Min  ORCID: orcid.org/0000-0001-8099-6327,Fudi Wang  ORCID: orcid.org/0000-0001-8730-0003 &…Yizhen Wang 
https://doi.org/10.1038/s41392-023-01553-x
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The mitophagy pathway and its implications in human diseases
Shouliang Wang,Haijiao Long,Lianjie Hou,Baorong Feng,Zihong Ma,Ying Wu,Yu Zeng,Jiahao Cai,Da-wei Zhang &…Guojun Zhao 
https://doi.org/10.1038/s41392-023-01503-7
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Immunotherapy in hematologic malignancies: achievements, challenges and future prospects
Lu Tang,Zhongpei Huang,Heng Mei &…Yu Hu  ORCID: orcid.org/0000-0002-2815-4568 
https://doi.org/10.1038/s41392-023-01521-5
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Hedgehog signaling in tissue homeostasis, cancers and targeted therapies
Junjun Jing,Zhuoxuan Wu,Jiahe Wang,Guowen Luo,Hengyi Lin,Yi Fan &…Chenchen Zhou 
https://doi.org/10.1038/s41392-023-01559-5
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Mitochondrial heterogeneity in diseases
Long Chen,Mengnan Zhou,Hao Li,Delin Liu,Peng Liao,Yao Zong,Changqing Zhang,Weiguo Zou &…Junjie Gao  ORCID: orcid.org/0000-0003-4820-8524 
https://doi.org/10.1038/s41392-023-01546-w
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Methylation across the central dogma in health and diseases: new therapeutic strategies
Ruochen Liu,Erhu Zhao,Huijuan Yu,Chaoyu Yuan,Muhammad Nadeem Abbas &…Hongjuan Cui 
https://doi.org/10.1038/s41392-023-01528-y
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Immune checkpoint therapy for solid tumours: clinical dilemmas and future trends
Qian Sun  ORCID: orcid.org/0000-0002-9313-8986,Zhenya Hong,Cong Zhang,Liangliang Wang,Zhiqiang Han &…Ding Ma 
https://doi.org/10.1038/s41392-023-01522-4
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Epigenetic regulation in major depression and other stress-related disorders: molecular mechanisms, clinical relevance and therapeutic potential
Minlan Yuan,Biao Yang,Gerson Rothschild,J. John Mann  ORCID: orcid.org/0000-0002-0265-6586,Larry D. Sanford,Xiangdong Tang,Canhua Huang,Chuang Wang &…Wei Zhang 
https://doi.org/10.1038/s41392-023-01519-z
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