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Volume 8 Issue 8, Aug 2023

Article
SIRT6 is an epigenetic repressor of thoracic aortic aneurysms via inhibiting inflammation and senescence
Yang-Nan Ding,Ting-Ting Wang,Shuang-Jie Lv,Xiaoqiang Tang  ORCID: orcid.org/0000-0003-1314-3417,Zi-Yu Wei,Fang Yao,Han-Shi Xu,Yi-Nan Chen,Xiao-Man Wang,Hui-Yu Wang,He-Ping Wang,Zhu-Qin Zhang,Xiang Zhao,De-Long Hao,Li-Hong Sun,Zhou Zhou,Li Wang  ORCID: orcid.org/0000-0002-5570-1336,Hou-Zao Chen  ORCID: orcid.org/0000-0001-6805-3182 &…De-Pei Liu 
https://doi.org/10.1038/s41392-023-01456-x
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Traumatic brain injury stimulates sympathetic tone-mediated bone marrow myelopoiesis to favor fracture healing
Weijian Liu,Wei Chen,Mao Xie,Chao Chen,Zengwu Shao,Yiran Zhang,Haiyue Zhao,Qingcheng Song,Hongzhi Hu,Xin Xing,Xianyi Cai,Xiangtian Deng,Xinyan Li,Peng Wang,Guohui Liu  ORCID: orcid.org/0000-0002-2013-1396,Liming Xiong,Xiao Lv &…Yingze Zhang 
https://doi.org/10.1038/s41392-023-01457-w
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E3 ligase MG53 suppresses tumor growth by degrading cyclin D1
Meng Fang,Hong-Kun Wu,Yumeng Pei,Yan Zhang,Xiangyu Gao,Yanyun He,Gengjia Chen,Fengxiang Lv,Peng Jiang,Yumei Li,Wenwen Li,Peng Jiang,Lin Wang,Jiafu Ji,Xinli Hu  ORCID: orcid.org/0000-0003-4911-5354 &…Rui-Ping Xiao 
https://doi.org/10.1038/s41392-023-01458-9
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SARS-CoV-2 spike protein receptor-binding domain perturbates intracellular calcium homeostasis and impairs pulmonary vascular endothelial cells
Kai Yang  ORCID: orcid.org/0000-0003-3044-2240,Shiyun Liu,Han Yan,Wenju Lu,Xiaoqian Shan,Haixia Chen,Changlei Bao,Huazhuo Feng,Jing Liao,Shuxin Liang,Lei Xu,Haiyang Tang,Jason X.-J. Yuan,Nanshan Zhong &…Jian Wang 
https://doi.org/10.1038/s41392-023-01556-8
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BICC1 drives pancreatic cancer progression by inducing VEGF-independent angiogenesis
Chongbiao Huang,Hui Li,Yang Xu,Chao Xu,Huizhi Sun,Zengxun Li,Yi Ge,Hongwei Wang,Tiansuo Zhao,Song Gao,Xiuchao Wang,Shengyu Yang,Peiqing Sun  ORCID: orcid.org/0000-0003-2255-6504,Zhe Liu,Jing Liu,Antao Chang &…Jihui Hao 
https://doi.org/10.1038/s41392-023-01478-5
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Incorporation of a Toll-like receptor 2/6 agonist potentiates mRNA vaccines against cancer and infectious diseases
Yangzhuo Gu,Jingyun Yang,Cai He,Tingmei Zhao  ORCID: orcid.org/0000-0003-0979-1374,Ran Lu,Jian Liu,Xianming Mo  ORCID: orcid.org/0000-0003-3897-3126,Fuqiang Wen &…Huashan Shi 
https://doi.org/10.1038/s41392-023-01479-4
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Cancer cell employs a microenvironmental neural signal trans-activating nucleus-mitochondria coordination to acquire stemness
Bin He  ORCID: orcid.org/0000-0002-7690-4730,Rui Gao,Shasha Lv,Ailin Chen,Junxiu Huang,Luoxuan Wang,Yunxiu Feng,Jiesi Feng,Bing Liu,Jie Lei,Bing Deng,Bin He,Bai Cui,Fei Peng,Min Yan,Zifeng Wang,Eric W-F Lam  ORCID: orcid.org/0000-0003-1274-3576,Bilian Jin,Zhiming Shao,Yulong Li  ORCID: orcid.org/0000-0002-9166-9919,Jianwei Jiao  ORCID: orcid.org/0000-0002-7893-0721,Xi Wang &…Quentin Liu 
https://doi.org/10.1038/s41392-023-01487-4
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Destroying pathogen-tumor symbionts synergizing with catalytic therapy of colorectal cancer by biomimetic protein-supported single-atom nanozyme
Xinyue Wang,Qian Chen,Yefei Zhu,Kairuo Wang,Yongliang Chang,Xiawei Wu,Weichao Bao,Tongcheng Cao,Hangrong Chen,Yang Zhang &…Huanlong Qin 
https://doi.org/10.1038/s41392-023-01491-8
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Interaction between neutrophil extracellular traps and cardiomyocytes contributes to atrial fibrillation progression
Li He,Ruiqi Liu,Honghua Yue,Xiaoxin Zhang,Xiaohui Pan,Yutao Sun,Jun Shi,Guonian Zhu,Chaoyi Qin  ORCID: orcid.org/0000-0001-7340-0628 &…Yingqiang Guo 
https://doi.org/10.1038/s41392-023-01497-2
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Metabolic reprogramming of proinflammatory macrophages by target delivered roburic acid effectively ameliorates rheumatoid arthritis symptoms
Na Jia,Yunzhen Gao,Min Li,Yi Liang,Yuwen Li,Yunzhu Lin,Shiqi Huang,Qing Lin,Xun Sun  ORCID: orcid.org/0000-0002-0218-1664,Qin He,Yuqin Yao  ORCID: orcid.org/0000-0003-2097-6978,Ben Zhang,Zhirong Zhang &…Ling Zhang 
https://doi.org/10.1038/s41392-023-01499-0
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Letter
Chemotherapy induces cell plasticity; controlling plasticity increases therapeutic response
Francisco J. Iborra  ORCID: orcid.org/0000-0002-0692-3696,Cristina Martí,Virtu Calabuig-Navarro,Petros Papadopoulos,Salvador Meseguer,Pedro M. Iborra,Francisco García,Antonio Martínez-Lorente,Fernando Almazán &…Juana Calabuig 
https://doi.org/10.1038/s41392-023-01500-w
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Defining a highly conserved cryptic epitope for antibody recognition of SARS-CoV-2 variants
Aihua Hao,Wenping Song,Cheng Li,Xiang Zhang,Chao Tu,Xun Wang,Pengfei Wang  ORCID: orcid.org/0000-0003-2454-7652,Yanling Wu,Tianlei Ying  ORCID: orcid.org/0000-0002-9597-2843 &…Lei Sun  ORCID: orcid.org/0000-0001-8741-0202 
https://doi.org/10.1038/s41392-023-01534-0
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Bone marrow adipoq+ cell population controls bone mass via sclerostin in mice
Huanqing Gao,Yiming Zhong,Sixiong Lin  ORCID: orcid.org/0000-0001-7155-5044,Qinnan Yan,Xuenong Zou &…Guozhi Xiao  ORCID: orcid.org/0000-0002-4269-2450 
https://doi.org/10.1038/s41392-023-01461-0
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Targeting tumor microenvironment with antibody-guided IL-2 pro-cytokine promotes and rejuvenates dysfunctional CD8+ T cells
Xue Wang,Longchao Liu,Tao Yue,Zhichen Sun,Joonbeom Bae,Kuo-Fu Tseng,Anli Zhang,Jian Qiao  ORCID: orcid.org/0000-0002-5228-2906 &…Yang-Xin Fu  ORCID: orcid.org/0000-0001-8441-6617 
https://doi.org/10.1038/s41392-023-01463-y
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Monkeypox virus 2022, gene heterogeneity and protein polymorphism
Yanjiao Li,Jingjing Hou,Zhong Sun  ORCID: orcid.org/0000-0002-3100-5053,Jingjing Hu,Karuppiah Thilakavathy,Yuxi Wang,Zhongjun Shao,Yihan Lu,Weibing Wang  ORCID: orcid.org/0000-0002-4824-5088 &…Chenglong Xiong 
https://doi.org/10.1038/s41392-023-01540-2
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Function and Cryo-EM structures of broadly potent bispecific antibodies against multiple SARS-CoV-2 Omicron sublineages
Ping Ren,Yingxia Hu,Lei Peng,Luojia Yang,Kazushi Suzuki,Zhenhao Fang  ORCID: orcid.org/0000-0002-1246-3665,Meizhu Bai,Liqun Zhou,Yanzhi Feng,Yongji Zou,Yong Xiong &…Sidi Chen  ORCID: orcid.org/0000-0002-3819-5005 
https://doi.org/10.1038/s41392-023-01509-1
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Research Highlight
Structure of human NCC: insights into the inhibition mechanism of thiazides
Livia de Souza Goncalves,Pattareeya Yottasan &Onur Cil 
https://doi.org/10.1038/s41392-023-01527-z
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Cx26 heterozygous mutations: role in hyperacusis and vulnerability to noise
Karen Tawk &Mehdi Abouzari  ORCID: orcid.org/0000-0002-3585-698X 
https://doi.org/10.1038/s41392-023-01525-1
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Restoring expression of Stathmin-2: a novel strategy to treat TDP-43 proteinopathies
Sonja Menge,Lorena Decker &Axel Freischmidt 
https://doi.org/10.1038/s41392-023-01533-1
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A histone tale that enCOMPASSes pausing: new insights into the functional repertoire of H3K4me3
Thomas K. Albert  ORCID: orcid.org/0000-0002-2488-0706 &Kornelius Kerl 
https://doi.org/10.1038/s41392-023-01529-x
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Neutrophil-sourced TNF in cancer: deciphering an intricate orchestrator of immunosuppressive communication in the tumor microenvironment
Xinyuan Zhao,Ye Lu &Li Cui 
https://doi.org/10.1038/s41392-023-01530-4
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Cysteine carboxyethylation: a novel post-translational modification associated with autoimmune arthritis
Alessandro Didonna 
https://doi.org/10.1038/s41392-023-01532-2
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Review Article
TRP (transient receptor potential) ion channel family: structures, biological functions and therapeutic interventions for diseases
Miao Zhang,Yueming Ma,Xianglu Ye,Ning Zhang,Lei Pan &…Bing Wang  ORCID: orcid.org/0000-0001-9646-0404 
https://doi.org/10.1038/s41392-023-01464-x
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Adverse effects of tyrosine kinase inhibitors in cancer therapy: pathophysiology, mechanisms and clinical management
Sunitha Shyam Sunder  ORCID: orcid.org/0000-0002-8167-0369,Umesh C. Sharma &Saraswati Pokharel 
https://doi.org/10.1038/s41392-023-01469-6
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Role of neuroinflammation in neurodegeneration development
Weifeng Zhang  ORCID: orcid.org/0000-0002-6176-4907,Dan Xiao,Qinwen Mao &…Haibin Xia  ORCID: orcid.org/0000-0002-2038-5759 
https://doi.org/10.1038/s41392-023-01486-5
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Vaccine adjuvants: mechanisms and platforms
Tingmei Zhao  ORCID: orcid.org/0000-0003-0979-1374,Yulong Cai,Yujie Jiang,Xuemei He,Yuquan Wei,Yifan Yu &…Xiaohe Tian  ORCID: orcid.org/0000-0002-2294-3945 
https://doi.org/10.1038/s41392-023-01557-7
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Cellular mechanotransduction in health and diseases: from molecular mechanism to therapeutic targets
Xingpeng Di  ORCID: orcid.org/0000-0002-1921-5509,Xiaoshuai Gao,Liao Peng,Jianzhong Ai,Xi Jin,Shiqian Qi  ORCID: orcid.org/0000-0002-7589-8877,Hong Li,Kunjie Wang  ORCID: orcid.org/0000-0001-8289-2791 &…Deyi Luo 
https://doi.org/10.1038/s41392-023-01501-9
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