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Volume 8 Issue 6, Jun 2023

Article
Integrative multi-omics and drug–response characterization of patient-derived prostate cancer primary cells
Ziruoyu Wang,Yanan Li,Wensi Zhao,Shuai Jiang,Yuqi Huang  ORCID: orcid.org/0000-0002-3060-8418,Jun Hou,Xuelu Zhang,Zhaoyu Zhai,Chen Yang,Jiaqi Wang,Jiying Zhu,Jianbo Pan,Wei Jiang  ORCID: orcid.org/0000-0001-7615-0900,Zengxia Li,Mingliang Ye  ORCID: orcid.org/0000-0002-5872-9326,Minjia Tan  ORCID: orcid.org/0000-0002-6784-9653,Haowen Jiang &…Yongjun Dang  ORCID: orcid.org/0000-0001-7237-1132 
https://doi.org/10.1038/s41392-023-01393-9
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Comparing T- and B-cell responses to COVID-19 vaccines across varied immune backgrounds
Zhen Cui,Wenxin Luo,Ruihong Chen,Yalun Li,Zhoufeng Wang,Yong Liu,Shuo Liu,LeiLei Feng,Zijing Jia,Ruixin Cheng,Jun Tang,Weijin Huang,Yanjun Zhang,Huawen Liu,Xiangxi Wang &…Weimin Li  ORCID: orcid.org/0000-0003-0985-0311 
https://doi.org/10.1038/s41392-023-01422-7
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Cell-cycle dependent nuclear gene delivery enhances the effects of E-cadherin against tumor invasion and metastasis
Liting Xie,Jieqiong Wang,Liming Song,Tianan Jiang &…Fei Yan 
https://doi.org/10.1038/s41392-023-01398-4
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SARS-CoV-2 N protein enhances the anti-apoptotic activity of MCL-1 to promote viral replication
Pan Pan  ORCID: orcid.org/0000-0002-7214-1393,Weiwei Ge,Zhiwei Lei  ORCID: orcid.org/0000-0002-9406-2127,Wei luo,Yuqing Liu,Zhanwen Guan,Lumiao Chen,Zhenyang Yu,Miaomiao Shen,Dingwen Hu,Qi Xiang,Wenbiao Wang  ORCID: orcid.org/0000-0003-4944-764X,Pin Wan,Mingfu Tian  ORCID: orcid.org/0000-0003-0122-6397,Yang Yu,Zhen Luo  ORCID: orcid.org/0000-0002-1142-2845,Xulin Chen,Heng Xiao,Qiwei Zhang,Xujing Liang,Xin Chen,Yongkui Li  ORCID: orcid.org/0000-0002-1532-4855 &…Jianguo Wu  ORCID: orcid.org/0000-0002-8326-2895 
https://doi.org/10.1038/s41392-023-01459-8
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A ribosomal gene panel predicting a novel synthetic lethality in non-BRCAness tumors
Chao Zhang,Qiang Guo,Lifeng Chen,Zheming Wu,Xiao-Jian Yan,Chengyang Zou,Qiuxue Zhang,Jiahong Tan,Tian Fang,Qunxian Rao,Yang Li,Shizhen Shen,Min Deng  ORCID: orcid.org/0000-0003-1987-9775,Liewei Wang,Huanyao Gao,Jia Yu  ORCID: orcid.org/0000-0001-8342-5423,Hu Li  ORCID: orcid.org/0000-0001-5957-5472,Cheng Zhang,Somaira Nowsheen,Jake Kloeber  ORCID: orcid.org/0000-0002-6646-564X,Fei Zhao,Ping Yin,Chunbo Teng,Zhongqiu Lin,Kun Song  ORCID: orcid.org/0000-0001-6110-2770,Shuzhong Yao,Liangqing Yao,Lingying Wu,Yong Zhang,Xiaodong Cheng,Qinglei Gao  ORCID: orcid.org/0000-0002-9448-3423,Jian Yuan,Zhenkun Lou  ORCID: orcid.org/0000-0003-1938-3091 &…Jin-San Zhang 
https://doi.org/10.1038/s41392-023-01401-y
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A kidney-brain neural circuit drives progressive kidney damage and heart failure
Wei Cao,Zhichen Yang,Xiaoting Liu,Siqiang Ren  ORCID: orcid.org/0000-0002-3244-4330,Huanjuan Su,Bihui Yang,Youhua Liu  ORCID: orcid.org/0000-0002-4740-805X,Christopher S. Wilcox &…Fan Fan Hou  ORCID: orcid.org/0000-0003-3117-7418 
https://doi.org/10.1038/s41392-023-01402-x
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SYK-mediated epithelial cell state is associated with response to c-Met inhibitors in c-Met-overexpressing lung cancer
Ji Zhou,Xu-Chao Zhang,Shan Xue,Mengdi Dai,Yueliang Wang,Xia Peng,Jianjiao Chen,Xinyi Wang,Yanyan Shen,Hui Qin,Bi Chen,Yu Zheng,Xiwen Gao,Zuoquan Xie,Jian Ding  ORCID: orcid.org/0000-0002-5815-4956,Handong Jiang,Yi-Long Wu  ORCID: orcid.org/0000-0002-3611-0258,Meiyu Geng &…Jing Ai 
https://doi.org/10.1038/s41392-023-01403-w
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Excitatory somatostatin interneurons in the dentate gyrus drive a widespread seizure network in cortical dysplasia
Yang Zheng,Cenglin Xu  ORCID: orcid.org/0000-0002-4337-3777,Jinyi Sun,Wenjie Ming,Sijie Dai  ORCID: orcid.org/0000-0003-0607-0125,Yuying Shao,Xiaoyun Qiu,Menghan Li,Chunhong Shen,Jinghong Xu,Fan Fei,Jiajia Fang,Xuhong Jiang,Guoqing Zheng,Weiwei Hu,Yi Wang  ORCID: orcid.org/0000-0002-1350-2961,Shuang Wang,Meiping Ding &…Zhong Chen  ORCID: orcid.org/0000-0003-4755-9357 
https://doi.org/10.1038/s41392-023-01404-9
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FBXW7β loss-of-function enhances FASN-mediated lipogenesis and promotes colorectal cancer growth
Wenxia Wei,Baifu Qin,Weijie Wen,Boyu Zhang,Haidan Luo,Yuzhi Wang,Hui Xu,Xiaoshan Xie,Sicheng Liu,Xin Jiang,Mengan Wang,Qin Tang,Jiayu Zhang,Runxiang Yang,Zongmin Fan,Haiwen Lyu,Junzhong Lin  ORCID: orcid.org/0000-0003-4038-1939,Kai Li &…Mong-Hong Lee 
https://doi.org/10.1038/s41392-023-01405-8
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Inside-out assembly of viral antigens for the enhanced vaccination
Fengqiang Cao,Sha Peng,Yaling An,Kun Xu,Tianyi Zheng,Lianpan Dai  ORCID: orcid.org/0000-0001-8352-1327,Kenji Ogino,To Ngai  ORCID: orcid.org/0000-0002-7207-6878,Yufei Xia &…Guanghui Ma  ORCID: orcid.org/0000-0001-9154-5556 
https://doi.org/10.1038/s41392-023-01414-7
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3-Hydroxybutyrate ameliorates insulin resistance by inhibiting PPARγ Ser273 phosphorylation in type 2 diabetic mice
Yudian Zhang,Zihua Li,Xinyi Liu,Xinyu Chen,Shujie Zhang,Yuemeng Chen,Jiangnan Chen,Jin Chen,Fuqing Wu &…Guo-Qiang Chen  ORCID: orcid.org/0000-0002-7226-1782 
https://doi.org/10.1038/s41392-023-01415-6
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Biomarker and genomic analyses reveal molecular signatures of non-cardioembolic ischemic stroke
Lingling Ding  ORCID: orcid.org/0000-0003-0114-8157,Yu Liu,Xia Meng,Yong Jiang,Jinxi Lin,Si Cheng,Zhe Xu,Xingquan Zhao,Hao Li,Yongjun Wang &…Zixiao Li 
https://doi.org/10.1038/s41392-023-01465-w
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Review Article
G protein-coupled receptors in neurodegenerative diseases and psychiatric disorders
Thian-Sze Wong,Guangzhi Li,Shiliang Li  ORCID: orcid.org/0000-0003-4414-237X,Wei Gao,Geng Chen,Shiyi Gan,Manzhan Zhang,Honglin Li  ORCID: orcid.org/0000-0003-2270-1900,Song Wu &…Yang Du  ORCID: orcid.org/0000-0001-8107-6397 
https://doi.org/10.1038/s41392-023-01427-2
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Signaling pathways in cancer metabolism: mechanisms and therapeutic targets
Mengshu You,Zhuolin Xie,Nan Zhang,Yixuan Zhang,Desheng Xiao  ORCID: orcid.org/0000-0003-2204-5042,Shuang Liu  ORCID: orcid.org/0000-0002-7206-7277,Wei Zhuang,Lili Li &…Yongguang Tao  ORCID: orcid.org/0000-0003-2354-5321 
https://doi.org/10.1038/s41392-023-01442-3
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Targetable elements in SARS-CoV-2 S2 subunit for the design of pan-coronavirus fusion inhibitors and vaccines
Liyan Guo,Sheng Lin,Zimin Chen,Yu Cao,Bin He &…Guangwen Lu  ORCID: orcid.org/0000-0001-7568-592X 
https://doi.org/10.1038/s41392-023-01472-x
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Angiogenic signaling pathways and anti-angiogenic therapy for cancer
Zhen-Ling Liu,Huan-Huan Chen,Li-Li Zheng,Li-Ping Sun &…Lei Shi  ORCID: orcid.org/0000-0002-3820-3693 
https://doi.org/10.1038/s41392-023-01460-1
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Applications of synthetic biology in medical and pharmaceutical fields
Xu Yan,Xu Liu,Cuihuan Zhao &…Guo-Qiang Chen  ORCID: orcid.org/0000-0002-7226-1782 
https://doi.org/10.1038/s41392-023-01440-5
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Immunosenescence: molecular mechanisms and diseases
Zaoqu Liu,Qimeng Liang,Yuqing Ren,Chunguang Guo,Xiaoyong Ge,Libo Wang,Quan Cheng  ORCID: orcid.org/0000-0003-2401-5349,Peng Luo,Yi Zhang  ORCID: orcid.org/0000-0001-9861-4681 &…Xinwei Han  ORCID: orcid.org/0000-0003-4407-4864 
https://doi.org/10.1038/s41392-023-01451-2
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Role of the gut microbiota in anticancer therapy: from molecular mechanisms to clinical applications
Lin-Yong Zhao,Jia-Xin Mei,Gang Yu,Lei Lei,Wei-Han Zhang,Kai Liu,Xiao-Long Chen,Damian Kołat  ORCID: orcid.org/0000-0002-1086-3796,Kun Yang &…Jian-Kun Hu  ORCID: orcid.org/0000-0002-3294-3471 
https://doi.org/10.1038/s41392-023-01406-7
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Targeting strategies for bone diseases: signaling pathways and clinical studies
Hao Xu,Wentao Wang,Xin Liu,Wei Huang,Chen Zhu,Yaozeng Xu,Huilin Yang,Jiaxiang Bai &…Dechun Geng  ORCID: orcid.org/0000-0003-4375-2803 
https://doi.org/10.1038/s41392-023-01467-8
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Evolving cognition of the JAK-STAT signaling pathway: autoimmune disorders and cancer
Chen Xue,Qinfan Yao,Xinyu Gu,Qingmiao Shi,Xin Yuan,Qingfei Chu,Zhengyi Bao,Juan Lu &…Lanjuan Li 
https://doi.org/10.1038/s41392-023-01468-7
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Radiation-induced tumor immune microenvironments and potential targets for combination therapy
Siyu Guo,Yihan Yao,Yang Tang,Zengfeng Xin,Dang Wu,Chao Ni,Jian Huang  ORCID: orcid.org/0000-0003-3340-5007,Qichun Wei &…Ting Zhang  ORCID: orcid.org/0000-0002-2044-2610 
https://doi.org/10.1038/s41392-023-01462-z
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Epigenetic regulation in the tumor microenvironment: molecular mechanisms and therapeutic targets
Jing Yang,Jin Xu,Wei Wang,Bo Zhang,Xianjun Yu  ORCID: orcid.org/0000-0002-6697-7143 &…Si Shi 
https://doi.org/10.1038/s41392-023-01480-x
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Macrophages in immunoregulation and therapeutics
Shanze Chen,Abdullah F.U.H. Saeed,Quan Liu,Qiong Jiang,Haizhao Xu,Gary Guishan Xiao,Lang Rao  ORCID: orcid.org/0000-0001-5010-0729 &…Yanhong Duo 
https://doi.org/10.1038/s41392-023-01452-1
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Targeting small GTPases: emerging grasps on previously untamable targets, pioneered by KRAS
Guowei Yin  ORCID: orcid.org/0000-0003-2669-7160,Jing Huang,Johnny Petela  ORCID: orcid.org/0000-0002-9352-8490,Hongmei Jiang,Yuetong Zhang,Siqi Gong,Jiaxin Wu,Bei Liu,Jianyou Shi  ORCID: orcid.org/0000-0002-1026-0282 &…Yijun Gao  ORCID: orcid.org/0000-0003-4978-3205 
https://doi.org/10.1038/s41392-023-01441-4
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Pathophysiological mechanisms and therapeutic approaches in obstructive sleep apnea syndrome
Renjun Lv,Xueying Liu,Yue Zhang,Na Dong,Xiao Wang,Yao He,Hongmei Yue &…Qingqing Yin 
https://doi.org/10.1038/s41392-023-01496-3
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The blood–brain barrier: Structure, regulation and drug delivery
Di Wu  ORCID: orcid.org/0000-0002-2176-2691,Qi Chen  ORCID: orcid.org/0000-0002-5152-0079,Xiaojie Chen,Feng Han,Zhong Chen  ORCID: orcid.org/0000-0003-4755-9357 &…Yi Wang  ORCID: orcid.org/0000-0002-1350-2961 
https://doi.org/10.1038/s41392-023-01481-w
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Targeting protein modifications in metabolic diseases: molecular mechanisms and targeted therapies
Xiumei Wu  ORCID: orcid.org/0000-0002-9549-7341,Mengyun Xu,Mengya Geng,Shuo Chen  ORCID: orcid.org/0000-0002-7852-8345,Peter J. Little  ORCID: orcid.org/0000-0002-0335-3835,Suowen Xu  ORCID: orcid.org/0000-0002-5488-5217 &…Jianping Weng  ORCID: orcid.org/0000-0002-7889-1697 
https://doi.org/10.1038/s41392-023-01439-y
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Letter
Gut microbiota as a potential key to modulating humoral immunogenicity of new platform COVID-19 vaccines
Hye Seong,Bo Kyu Choi,Young-Hee Han,Jun Hyoung Kim,Jeong-An Gim,Sooyeon Lim,Ji Yun Noh,Hee Jin Cheong,Woo Joo Kim &…Joon Young Song 
https://doi.org/10.1038/s41392-023-01445-0
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Venetoclax and Azacitidine in Chinese patients with untreated acute myeloid leukemia ineligible for intensive chemotherapy
Leiming Xia  ORCID: orcid.org/0000-0002-6760-0153,Wanlu Tian,Yiming Zhao,Lingling Jiang,Wei Qian,Lei Jiang,Ling Ge,Jianjun Li,Fengbo Jin &…Mingzhen Yang 
https://doi.org/10.1038/s41392-023-01394-8
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Carbon nanotube promotes contraction and electrical activity of neonatal cardiomyocytes by targeting sodium/calcium exchanger NCX1
Xiao Zhang,Yuan Shen,Zhen Cao,Ying Zhu,Wei Liu,Wei Wu,Chunlan Wang,Siwei Li,Jin Zhou &…Changyong Wang 
https://doi.org/10.1038/s41392-023-01397-5
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Relevance of Spike/Estrogen Receptor-α interaction for endothelial-based coagulopathy induced by SARS-CoV-2
Silvia Stella Barbieri  ORCID: orcid.org/0000-0002-7486-2637,Franca Cattani,Leonardo Sandrini,Magda Maria Grillo,Alessandra Amendola,Carmen Valente,Carmine Talarico,Daniela Iaconis,Gabriele Turacchio,Miriam Lucariello,Lucia Lione,Erika Salvatori,Patrizia Amadio,Gloria Garoffolo,Mariano Maffei,Francesca Galli,Andrea Rosario Beccari,Giuseppe Sberna  ORCID: orcid.org/0000-0003-0955-2074,Emanuele Marra,Marica Zoppi,Michael Michaelides  ORCID: orcid.org/0000-0003-0398-4917,Giuseppe Roscilli,Luigi Aurisicchio,Riccardo Bertini,Marcello Allegretti &…Maurizio Pesce  ORCID: orcid.org/0000-0002-3097-8961 
https://doi.org/10.1038/s41392-023-01488-3
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SARS-CoV-2 inhibition and specific targeting of infected cells by VSV particles carrying the ACE2 receptor
Fabian Zech,Stefanie Weber,Hanna Dietenberger,Linyun Zhang,Sabrina Noettger,Meta Volcic,Tim Bergner,Clarissa Read,Konstantin M. J. Sparrer  ORCID: orcid.org/0000-0002-8682-1779,Thomas F. E. Barth &…Frank Kirchhoff  ORCID: orcid.org/0000-0002-7052-2360 
https://doi.org/10.1038/s41392-023-01492-7
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Discovery of novel non-peptidic and non-covalent small-molecule 3CLpro inhibitors as potential candidate for COVID-19 treatment
Zhidong Jiang,Bo Feng,Yumin Zhang  ORCID: orcid.org/0000-0003-0767-1221,Tianqing Nie,Hong Liu  ORCID: orcid.org/0000-0003-3685-6268,Jia Li  ORCID: orcid.org/0000-0003-3224-001X,Haixia Su,Leike Zhang  ORCID: orcid.org/0000-0002-2593-2571,Yi Zang &…Yu Zhou 
https://doi.org/10.1038/s41392-023-01482-9
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Deciphering dynamic changes of the aging transcriptome with COVID-19 progression and convalescence in the human blood
Ran Li,Jing Zou,Dongling Pei,Ting Pan,Bing Yang,Xianzhi Liu,Yan Chen,Fangfang Zhou  ORCID: orcid.org/0000-0003-1870-7584 &…Long Zhang  ORCID: orcid.org/0000-0001-8139-0474 
https://doi.org/10.1038/s41392-023-01466-9
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Repression of interferon regulatory factor-4 (IRF4) hyperactivation restricts murine lupus
Shijun He  ORCID: orcid.org/0000-0002-9207-3631,Huihua Ding,Li Chen,Yiwei Shen,Yuting Liu,Fenghua Zhu,Xiaoqian Yang,Nan Shen,Zemin Lin  ORCID: orcid.org/0000-0002-3665-874X &…Jianping Zuo 
https://doi.org/10.1038/s41392-023-01413-8
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Evolutionary characteristics of SARS-CoV-2 Omicron subvariants adapted to the host
Haijun Tang,Yun Shao,Yi Huang,Shigang Qiao,Jianzhong An,Ruhong Yan,Xin Zhao,Fang Meng,Xiaohong Du &…F. Xiao-Feng Qin 
https://doi.org/10.1038/s41392-023-01449-w
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Enhancement of SARS-CoV-2 vaccine-induced immunity by a Toll-like receptor 7 agonist adjuvant
Gen Li,Meixing Yu,Qiong Ke,Jing Sun,Yanwen Peng,Chuanfeng Xiong,Olivia Monteiro  ORCID: orcid.org/0000-0003-0191-5547,COVID-19 Infection and Immunity Investigation Group,Jincun Zhao  ORCID: orcid.org/0000-0003-2515-5589 &…Andy P. Xiang 
https://doi.org/10.1038/s41392-023-01485-6
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Nuclear AhR and membranous PD-L1 in predicting response of non-small cell lung cancer to PD-1 blockade
Si-Chong Han,Gui-Zhen Wang,Ya-Ning Yang,Wen-Feng Fang,Bei-Bei Sun,Jian-Dong Zhang,Hua-Qiang Zhou,Li Zhang,Yan Wang &…Guang-Biao Zhou 
https://doi.org/10.1038/s41392-023-01416-5
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Molecular mechanisms underlying the high mortality of hypervirulent Klebsiella pneumoniae and its effective therapy development
Qi Xu,Miaomiao Xie,Xiaoxuan Liu,Heng Heng,Han Wang  ORCID: orcid.org/0000-0001-6946-6229,Chen Yang,Edward Wai-Chi Chan,Rong Zhang,Guan Yang  ORCID: orcid.org/0000-0002-2131-8435 &…Sheng Chen  ORCID: orcid.org/0000-0003-3526-7808 
https://doi.org/10.1038/s41392-023-01490-9
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Research Highlight
Spatial TIME landscape and its prognostic value in the lung and brain tumor: location matters
Yunke Wang,Anne E. Geller &Jun Yan  ORCID: orcid.org/0000-0003-2922-422X 
https://doi.org/10.1038/s41392-023-01473-w
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Cap snatch prevention: a novel approach to tackle influenza viruses
Konstantin M. J. Sparrer  ORCID: orcid.org/0000-0002-8682-1779 &Frank Kirchhoff  ORCID: orcid.org/0000-0002-7052-2360 
https://doi.org/10.1038/s41392-023-01474-9
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FAP senescence: a critical event in muscle regeneration
Xia Kang,Yuqi Gao,So-ichiro Fukada &…Hongming Miao  ORCID: orcid.org/0000-0001-6355-3612 
https://doi.org/10.1038/s41392-023-01411-w
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CD5: from antiquated T cell marker to immunotherapy’s new hope
Sandra Schwarz  ORCID: orcid.org/0000-0002-8112-4392 &Michael Linnebacher  ORCID: orcid.org/0000-0001-8054-1402 
https://doi.org/10.1038/s41392-023-01494-5
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Synaptic dysfunction in Down syndrome: an emerging role for circulating β2-microglobulin
Xu-Qiao Chen 
https://doi.org/10.1038/s41392-023-01493-6
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