Xu Zhang,Yuxiang Wang ORCID: orcid.org/0000-0002-5275-1709,Xi Zhang,Yanyan Shen,Kang Yang,Qingyang Ma,Yuemei Qiao,Jiajie Shi,Yi Wang,Lan Xu,Biyu Yang,Gaoxiang Ge ORCID: orcid.org/0000-0003-3189-8928,Landian Hu,Xiangyin Kong,Chunhao Yang ORCID: orcid.org/0000-0001-5767-5808,Yi Chen,Jian Ding ORCID: orcid.org/0000-0002-5815-4956 &…Linghua Meng ORCID: orcid.org/0000-0001-7722-8685

https://doi.org/10.1038/s41392-023-01359-x

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Tumor heterogeneity in VHL drives metastasis in clear cell renal cell carcinoma

Junhui Hu ORCID: orcid.org/0000-0001-9260-2858,Ping Tan,Moe Ishihara ORCID: orcid.org/0000-0003-3893-2666,Nicholas A. Bayley,Shiruyeh Schokrpur,Jeremy G. Reynoso,Yangjun Zhang,Raymond J. Lim,Camelia Dumitras,Lu Yang,Steven M. Dubinett,Parmjit S. Jat,Jacques Van Snick,Jiaoti Huang ORCID: orcid.org/0000-0003-1195-1998,Arnold I. Chin,Robert M. Prins,Thomas G. Graeber,Hua Xu ORCID: orcid.org/0000-0001-9730-7276 &…Lily Wu

https://doi.org/10.1038/s41392-023-01362-2

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Intranasal booster using an Omicron vaccine confers broad mucosal and systemic immunity against SARS-CoV-2 variants

Qian Wang,Chenchen Yang,Li Yin,Jing Sun,Wei Wang,Hengchun Li,Zhengyuan Zhang,Si Chen,Bo Liu,Zijian Liu,Linjing Shi,Xiaolin Liu,Suhua Guan,Chunhua Wang,Linbing Qu,Ying Feng,Xuefeng Niu,Liqiang Feng,Jincun Zhao ORCID: orcid.org/0000-0003-2515-5589,Pingchao Li,Ling Chen &…Nanshan Zhong

https://doi.org/10.1038/s41392-023-01423-6

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Combination therapy with saxagliptin and vitamin D for the preservation of β-cell function in adult-onset type 1 diabetes: a multi-center, randomized, controlled trial

Xiang Yan,Xia Li,Bingwen Liu,Jiaqi Huang,Yufei Xiang,Yuhang Hu,Xiaohan Tang,Ziwei Zhang,Gan Huang,Zhiguo Xie,Houde Zhou,Zhenqi Liu,Xiangbing Wang,Richard David Leslie ORCID: orcid.org/0000-0002-1786-1531 &…Zhiguang Zhou

https://doi.org/10.1038/s41392-023-01369-9

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RBM4 dictates ESCC cell fate switch from cellular senescence to glutamine-addiction survival through inhibiting LKB1-AMPK-axis

Lei Chen,Wenjing Zhang ORCID: orcid.org/0000-0002-0617-5886,Dan Chen,Quan Yang,Siwen Sun,Zhenwei Dai,Zhengzheng Li,Xuemei Liang,Chaoqun Chen,Yuexia Jiao,Lili Zhi,Lianmei Zhao,Jinrui Zhang,Xuefeng Liu,Jinyao Zhao,Man Li,Yang Wang ORCID: orcid.org/0000-0001-9385-7393 &…Yangfan Qi

https://doi.org/10.1038/s41392-023-01367-x

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Preventive and therapeutic benefits of nelfinavir in rhesus macaques and human beings infected with SARS-CoV-2

Zhijian Xu ORCID: orcid.org/0000-0002-3063-8473,Danrong Shi,Jian-Bao Han,Yun Ling,Xiangrui Jiang,Xiangyun Lu,Chuan Li,Likun Gong,Guangbo Ge,Yani Zhang,Yi Zang,Tian-Zhang Song,Xiao-Li Feng,Ren-Rong Tian,Jia Ji,Miaojin Zhu,Nanping Wu,Chunhui Wu,Zhen Wang,Yechun Xu,Cheng Peng,Min Zheng ORCID: orcid.org/0000-0001-6159-9879,Junling Yang,Feifei Du,Junliang Wu,Peipei Wang,Jingshan Shen ORCID: orcid.org/0000-0001-9679-9934,Jianliang Zhang,Yong-Tang Zheng ORCID: orcid.org/0000-0001-5469-0324,Hangping Yao ORCID: orcid.org/0000-0001-6742-7074 &…Weiliang Zhu ORCID: orcid.org/0000-0001-6699-5299

https://doi.org/10.1038/s41392-023-01429-0

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Phase-separated nucleocapsid protein of SARS-CoV-2 suppresses cGAS-DNA recognition by disrupting cGAS-G3BP1 complex

Sihui Cai,Chenqiu Zhang,Zhen Zhuang,Shengnan Zhang,Ling Ma,Shuai Yang,Tao Zhou,Zheyu Wang,Weihong Xie,Shouheng Jin ORCID: orcid.org/0000-0002-2728-2859,Jincun Zhao ORCID: orcid.org/0000-0003-2515-5589,Xiangdong Guan,Jianfeng Wu,Jun Cui ORCID: orcid.org/0000-0002-8000-3708 &…Yaoxing Wu

https://doi.org/10.1038/s41392-023-01420-9

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Overcoming resistance to immunotherapy by targeting GPR84 in myeloid-derived suppressor cells

Guohui Qin,Shasha Liu,Jinyan Liu,Hongwei Hu,Li Yang,Qitai Zhao,Congcong Li,Bin Zhang ORCID: orcid.org/0000-0002-6631-7647 &…Yi Zhang ORCID: orcid.org/0000-0001-9861-4681

https://doi.org/10.1038/s41392-023-01388-6

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Monkeypox virus quadrivalent mRNA vaccine induces immune response and protects against vaccinia virus

Ye Sang,Zhen Zhang,Fan Liu,Haitao Lu,Changxiao Yu,Huisheng Sun,Jinrong Long,Yiming Cao,Jierui Mai,Yiqi Miao,Xin Wang,Jiaxin Fang,Youchun Wang,Weijin Huang ORCID: orcid.org/0000-0002-4246-8889,Jing Yang ORCID: orcid.org/0000-0001-9050-9203 &…Shengqi Wang

https://doi.org/10.1038/s41392-023-01432-5

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Letter

Low-dose IL-2 mitigates glucocorticoid-induced Treg impairment and promotes improvement of SLE

Haotian Zhou,Xiaozhen Zhao,Ruijun Zhang,Miao Miao,Wenwen Pei,Zijun Li,Yimin Li,Jing He,Zhanguo Li ORCID: orcid.org/0000-0002-2590-6242 &…Xiaolin Sun

https://doi.org/10.1038/s41392-023-01350-6

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SARS-CoV-2 N protein induces acute kidney injury in diabetic mice via the Smad3-Ripk3/MLKL necroptosis pathway

Liying Liang,Wenbiao Wang,Junzhe Chen,Wenjing Wu,Xiao-Ru Huang,Biao Wei,Yu Zhong,Ronald C. W. Ma,Xueqing Yu &…Hui-Yao Lan ORCID: orcid.org/0000-0003-4283-9755

https://doi.org/10.1038/s41392-023-01410-x

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Two vs three cycles of neoadjuvant sintilimab plus chemotherapy for resectable non-small-cell lung cancer: neoSCORE trial

Miner Shao,Jie Yao,Yunke Wang,Lufeng Zhao,Baizhou Li,Lili Li,Zuqun Wu,Zexin Chen,Junqiang Fan &…Fuming Qiu ORCID: orcid.org/0000-0001-5793-1023

https://doi.org/10.1038/s41392-023-01355-1

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The protective nasal boosting of a triple-RBD subunit vaccine against SARS-CoV-2 following inactivated virus vaccination

Jingyi Yang,Mei-Qin Liu,Lin Liu,Xian Li,Mengxin Xu,Haofeng Lin,Min Li,Huimin Yan ORCID: orcid.org/0000-0002-7243-8429,Yao-Qing Chen ORCID: orcid.org/0000-0002-4659-1550 &…Zheng-Li Shi ORCID: orcid.org/0000-0001-8089-163X

https://doi.org/10.1038/s41392-023-01421-8

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The main protease of SARS-CoV-2 downregulates innate immunity via a translational repression

Weifeng Liang,Ming Gu ORCID: orcid.org/0000-0001-5584-9755,Lingxiang Zhu,Ziqi Yan,Dominik Schenten,Shelby Herrick,Hongmin Li,Subodh Kumar Samrat,Jiapeng Zhu ORCID: orcid.org/0000-0002-9165-0126 &…Yin Chen

https://doi.org/10.1038/s41392-023-01418-3

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A thermodynamic model showing that information recording can drive active ion transport

Xiang Zou,Kun Song,Minbiao Ji,Lingzhao Min,Liangfu Zhou,Ying Mao &…Liang Chen

https://doi.org/10.1038/s41392-023-01361-3

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Alterations of the oral and gut mycobiome and cytokines during long-term follow-up of COVID-19 convalescents

Zhigang Ren ORCID: orcid.org/0000-0003-0798-3444,Shanshuo Liu,Qiong Wang,Benchen Rao,Zhaohai Zeng,Yakun Xu,Haiyu Wang,Hong Luo,Jianjun Gou &…Zujiang Yu

https://doi.org/10.1038/s41392-023-01417-4

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A bacteria-based system expressing anti-TNF-α nanobody for enhanced cancer immunotherapy

Lina Liu,Xing Liu,Wenjie Xin,Lulu Zhou,Baolian Huang,Chao Han,Zhiting Cao &…Zichun Hua

https://doi.org/10.1038/s41392-023-01364-0

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The chemokine CCL17 is a novel therapeutic target for cardiovascular aging

Yang Zhang ORCID: orcid.org/0000-0001-5856-9783,Xiaoqiang Tang ORCID: orcid.org/0000-0003-1314-3417,Zeyuan Wang,Lun Wang,Zhangwei Chen,Ju-Ying Qian,Zhuang Tian &…Shu-Yang Zhang ORCID: orcid.org/0000-0002-1532-0029

https://doi.org/10.1038/s41392-023-01363-1

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Distinct and relatively mild clinical characteristics of SARS-CoV-2 BA.5 infections against BA.2

Liping Guo,Xue Liu,Yuchen Gu,Jinyan Jiang,Ziyue Yang,Qiuying Lv,Deyin Guo ORCID: orcid.org/0000-0002-8297-0814,Yang Yang ORCID: orcid.org/0000-0002-6489-4459,Hongzhou Lu &…Jing Yuan ORCID: orcid.org/0000-0002-8937-9568

https://doi.org/10.1038/s41392-023-01443-2

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Epidemiological and clinical features of children with the Omicron BA.5.2 subvariant in Guangzhou

Feng Li,Yinghua He,Xianglong Lan,Lu Li,Fei Gu,Zhao Ye,Lv Wang,Zhenghui Cen,Weichun Zhu &…Haisheng Yu ORCID: orcid.org/0000-0002-1757-1411

https://doi.org/10.1038/s41392-023-01372-0

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Standardized neutralization antibody analytical procedure for clinical samples based on the AQbD concept

Jianyang Liu,Yu Bai,Mingchen Liu,Dejiang Tan,Jing Li,Zhongfang Wang,Zhenglun Liang,Miao Xu,Junzhi Wang &…Qunying Mao

https://doi.org/10.1038/s41392-023-01389-5

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An RBD virus-like particle vaccine for SARS-CoV-2 induces cross-variant antibody responses in mice and macaques

Yuanyuan Li ORCID: orcid.org/0000-0002-9143-8029,Yanan Zhang,Yu Zhou,Yan Li,Jiao Xu,Yuanbao Ai,Lei Xu,Xiuli Xiao,Bo Zhang ORCID: orcid.org/0000-0002-8895-3679 &…Jing Jin

https://doi.org/10.1038/s41392-023-01425-4

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Neutralization of Omicron BA.1, BA.5.1.6, BQ.1.3 and XBB1.1 induced by heterologous vaccination Ad5-nCoV and mRNA-1273

Jesús Hernández ORCID: orcid.org/0000-0002-5131-3600,Freddy Dehesa-Canseco,Alma B. Vázquez-López,Mónica Reséndiz-Sandoval,Graciela Caire-Juvera,Mario Solís-Hernández,Olivia Valenzuela ORCID: orcid.org/0000-0002-4456-2107,Bruno Gómez-Gil &…Verónica Mata-Haro ORCID: orcid.org/0000-0002-7394-4569

https://doi.org/10.1038/s41392-023-01447-y

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Review Article

Cdc2-like kinases: structure, biological function and therapeutic targets for diseases

Mengqiu Song,Luping Pang ORCID: orcid.org/0000-0002-8224-9250,Mengmeng Zhang,Yingzi Qu,Kyle Vaughn Laster &…Zigang Dong ORCID: orcid.org/0000-0002-4174-4028

https://doi.org/10.1038/s41392-023-01409-4

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Viral vectored vaccines: design, development, preventive and therapeutic applications in human diseases

Shen Wang,Bo Liang,Weiqi Wang,Ling Li,Na Feng,Yongkun Zhao,Tiecheng Wang,Feihu Yan,Songtao Yang &…Xianzhu Xia

https://doi.org/10.1038/s41392-023-01408-5

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Diabetic vascular diseases: molecular mechanisms and therapeutic strategies

Yiwen Li,Yanfei Liu,Shiwei Liu,Mengqi Gao,Wenting Wang,Keji Chen,Luqi Huang &…Yue Liu ORCID: orcid.org/0000-0002-0084-863X

https://doi.org/10.1038/s41392-023-01400-z

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Oncolytic virotherapy: basic principles, recent advances and future directions

Danni Lin,Yinan Shen &Tingbo Liang ORCID: orcid.org/0000-0003-0143-3353

https://doi.org/10.1038/s41392-023-01407-6

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Patient-derived xenograft models in cancer therapy: technologies and applications

Yihan Liu,Wantao Wu,Changjing Cai,Hao Zhang,Hong Shen &…Ying Han

https://doi.org/10.1038/s41392-023-01419-2

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Signaling pathways in vascular function and hypertension: molecular mechanisms and therapeutic interventions

Jun Ma ORCID: orcid.org/0000-0002-3442-4595,Yanan Li,Xiangyu Yang,Kai Liu,Xin Zhang,Xianghao Zuo,Runyu Ye,Ziqiong Wang,Rufeng Shi,Qingtao Meng &…Xiaoping Chen

https://doi.org/10.1038/s41392-023-01430-7

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Research Highlight

Control of CAR-T cell activity in space and time: the next level of anti-tumor action

Jessica Hoppstädter &Alexandra K. Kiemer ORCID: orcid.org/0000-0002-7224-9900

https://doi.org/10.1038/s41392-023-01424-5

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Mutated trimeric RBD vaccines: a platform against variants of concern

Belén Aparicio,Juan J. Lasarte &Pablo Sarobe

https://doi.org/10.1038/s41392-023-01426-3

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