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Volume 8 Issue 3, Mar 2023

Article
GPR162 activates STING dependent DNA damage pathway as a novel tumor suppressor and radiation sensitizer
Yao Long,Jiaxing Guo,Jielin Chen,Jingyue Sun,Haiyan Wang,Xin Peng  ORCID: orcid.org/0000-0003-0601-4991,Zuli Wang,WeiWei Lai,Na Liu  ORCID: orcid.org/0000-0001-5162-3791,Long Shu,Ling Chen,Ying Shi  ORCID: orcid.org/0000-0003-4671-4896,Desheng Xiao  ORCID: orcid.org/0000-0003-2204-5042,Shuang Liu  ORCID: orcid.org/0000-0002-7206-7277 &…Yongguang Tao  ORCID: orcid.org/0000-0003-2354-5321 
https://doi.org/10.1038/s41392-022-01224-3
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Celastrol suppresses colorectal cancer via covalent targeting peroxiredoxin 1
Heng Xu,Hongfang Zhao,Chunyong Ding  ORCID: orcid.org/0000-0003-2379-8740,Defang Jiang,Zijie Zhao,Yang Li,Xiaoyu Ding,Jing Gao,Hu Zhou  ORCID: orcid.org/0000-0001-7006-4737,Cheng Luo  ORCID: orcid.org/0000-0003-3864-8382,Guoqiang Chen,Ao Zhang  ORCID: orcid.org/0000-0001-7205-9202,Ying Xu &…Hao Zhang  ORCID: orcid.org/0000-0002-6166-2089 
https://doi.org/10.1038/s41392-022-01231-4
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The E3 ligase RNF5 restricts SARS-CoV-2 replication by targeting its envelope protein for degradation
Zhaolong Li,Pengfei Hao,Zhilei Zhao,Wenying Gao,Chen Huan,Letian Li,Xiang Chen,Hong Wang,Ningyi Jin,Zhao-Qing Luo,Chang Li  ORCID: orcid.org/0000-0002-3267-1859 &…Wenyan Zhang 
https://doi.org/10.1038/s41392-023-01335-5
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Dual-AAV split prime editor corrects the mutation and phenotype in mice with inherited retinal degeneration
Kaiqin She,Yi Liu,Qinyu Zhao,Xiu Jin,Yiliu Yang,Jing Su,Ruiting Li,Li Song,Jianlu Xiao,Shaohua Yao,Fang Lu,Yuquan Wei &…Yang Yang 
https://doi.org/10.1038/s41392-022-01234-1
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Transarterial chemoembolization with PD-(L)1 inhibitors plus molecular targeted therapies for hepatocellular carcinoma (CHANCE001)
Hai-Dong Zhu,Hai-Liang Li,Ming-Sheng Huang,Wei-Zhu Yang,Guo-Wen Yin,Bin-Yan Zhong  ORCID: orcid.org/0000-0001-9716-1211,Jun-Hui Sun,Zhi-Cheng Jin  ORCID: orcid.org/0000-0002-6114-154X,Jian-Jian Chen,Nai-Jian Ge,Wen-Bin Ding,Wen-Hui Li,Jin-Hua Huang,Wei Mu,Shan-Zhi Gu,Jia-Ping Li,Hui Zhao,Shu-Wei Wen,Yan-Ming Lei,Yu-Sheng Song,Chun-Wang Yuan,Wei-Dong Wang,Ming Huang,Wei Zhao,Jian-Bing Wu,Song Wang,Xu Zhu,Jian-Jun Han,Wei-Xin Ren,Zai-Ming Lu,Wen-Ge Xing,Yong Fan,Hai-Lan Lin,Zi-Shu Zhang,Guo-Hui Xu,Wen-Hao Hu,Qiang Tu,Hong-Ying Su,Chuan-Sheng Zheng,Yong Chen,Xu-Ya Zhao,Zhu-Ting Fang,Qi Wang,Jin-Wei Zhao,Ai-Bing Xu,Jian Xu,Qing-Hua Wu,Huan-Zhang Niu,Jian Wang,Feng Dai,Dui-Ping Feng,Qing-Dong Li,Rong-Shu Shi,Jia-Rui Li,Guang Yang,Hai-Bin Shi,Jian-Song Ji,Yu-E Liu,Zheng Cai,Po Yang,Yang Zhao,Xiao-Li Zhu,Li-Gong Lu &Gao-Jun Tengfor the CHANCE001 Investigators
https://doi.org/10.1038/s41392-022-01235-0
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O-GlcNAcylation of YTHDF2 promotes HBV-related hepatocellular carcinoma progression in an N6-methyladenosine-dependent manner
Yang Yang,Yu Yan,Jiaxin Yin,Ni Tang  ORCID: orcid.org/0000-0001-5830-8786,Kai Wang  ORCID: orcid.org/0000-0002-0137-1247,Luyi Huang  ORCID: orcid.org/0000-0002-0377-877X,Jie Hu,Zhongqi Feng,Qingzhu Gao &…Ailong Huang  ORCID: orcid.org/0000-0003-0148-7423 
https://doi.org/10.1038/s41392-023-01316-8
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MiR146a-loaded engineered exosomes released from silk fibroin patch promote diabetic wound healing by targeting IRAK1
Qiankun Li,Wenzhi Hu,Qilin Huang,Jie Yang,Bingmin Li,Kui Ma,Qian Wei,Yaxi Wang,Jianlong Su,Mengli Sun,Shengnan Cui,Rungong Yang,Haihong Li,Xiaobing Fu &…Cuiping Zhang 
https://doi.org/10.1038/s41392-022-01263-w
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Targeting PSAT1 to mitigate metastasis in tumors with p53-72Pro variant
Jingwen Jiang,Hai-Ning Chen  ORCID: orcid.org/0000-0003-0104-8498,Ping Jin,Li Zhou,Liyuan Peng,Zhao Huang,Siyuan Qin,Bowen Li,Hui Ming,Maochao Luo,Na Xie,Wei Gao,Edouard C. Nice  ORCID: orcid.org/0000-0001-5480-4715,Qiang Yu &…Canhua Huang  ORCID: orcid.org/0000-0003-2247-7750 
https://doi.org/10.1038/s41392-022-01266-7
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B-lymphoid tyrosine kinase-mediated FAM83A phosphorylation elevates pancreatic tumorigenesis through interacting with β-catenin
Cefan Zhou  ORCID: orcid.org/0000-0003-0680-3843,Xiaoting Zhu,Nanxi Liu,Xueying Dong,Xuewen Zhang,Huili Huang,Yu Tang,Shicheng Liu,Mengyu Hu,Ming Wang  ORCID: orcid.org/0000-0002-2836-1217,Xiaoling Deng,Shi Li,Rui Zhang,Yuan Huang,Hao Lyu,Shuai Xiao,Sang Luo,Declan William Ali,Marek Michalak,Xing-Zhen Chen,Zhentian Wang &…Jingfeng Tang  ORCID: orcid.org/0000-0002-5524-4518 
https://doi.org/10.1038/s41392-022-01268-5
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Structural insights into substrate recognition and translocation of human peroxisomal ABC transporter ALDP
Chao Xiong  ORCID: orcid.org/0000-0003-2133-9305,Li-Na Jia,Wei-Xi Xiong,Xin-Tong Wu,Liu-Lin Xiong,Ting-Hua Wang,Dong Zhou,Zhen Hong,Zheng Liu &…Lin Tang 
https://doi.org/10.1038/s41392-022-01280-9
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From tuberculosis bedside to bench: UBE2B splicing as a potential biomarker and its regulatory mechanism
Mengyuan Lyu,Jian Zhou,Yanbing Zhou,Weelic Chong,Wei Xu,Hongli Lai,Lu Niu,Yang Hai,Xiaojun Yao,Sheng Gong,Qinglan Wang,Yi Chen,Yili Wang,Liyu Chen, Zengwanggema,Jiongjiong Zeng,Chengdi Wang  ORCID: orcid.org/0000-0002-5284-2889 &…Binwu Ying 
https://doi.org/10.1038/s41392-023-01346-2
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TRAF3 activates STING-mediated suppression of EV-A71 and target of viral evasion
Wenwen Zheng,Zhenbang Zhou,Yajuan Rui,Runxin Ye,Fengyan Xia,Fei Guo,Xiaoman Liu,Jiaming Su,Meng Lou &…Xiao-Fang Yu  ORCID: orcid.org/0000-0002-8748-7186 
https://doi.org/10.1038/s41392-022-01287-2
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Erlotinib versus gemcitabine plus cisplatin as neoadjuvant treatment of stage IIIA-N2 EGFR-mutant non-small-cell lung cancer: final overall survival analysis of the EMERGING-CTONG 1103 randomised phase II trial
Wen-Zhao Zhong,Hong-Hong Yan  ORCID: orcid.org/0000-0002-6228-2096,Ke-Neng Chen,Chun Chen,Chun-Dong Gu,Jun Wang,Xue-Ning Yang,Wei-Min Mao,Qun Wang,Gui-Bin Qiao,Ying Cheng  ORCID: orcid.org/0000-0001-9908-597X,Lin Xu,Chang-Li Wang,Ming-Wei Chen,Xiao-Zheng Kang,Wan-Pu Yan,Ri-Qiang Liao,Jin-Ji Yang,Xu-Chao Zhang,Si-Yang Liu,Qing Zhou &…Yi-Long Wu  ORCID: orcid.org/0000-0002-3611-0258 
https://doi.org/10.1038/s41392-022-01286-3
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Integrative phosphoproteomics defines two biologically distinct groups of KMT2A rearranged acute myeloid leukaemia with different drug response phenotypes
Pedro Casado  ORCID: orcid.org/0000-0002-4207-9349,Ana Rio-Machin  ORCID: orcid.org/0000-0001-6733-9752,Juho J. Miettinen  ORCID: orcid.org/0000-0002-3987-1693,Findlay Bewicke-Copley,Kevin Rouault-Pierre,Szilvia Krizsan  ORCID: orcid.org/0000-0002-1782-9275,Alun Parsons,Vinothini Rajeeve,Farideh Miraki-Moud,David C. Taussig,Csaba Bödör,John Gribben,Caroline Heckman  ORCID: orcid.org/0000-0002-4324-8706,Jude Fitzgibbon &…Pedro R. Cutillas  ORCID: orcid.org/0000-0002-3426-2274 
https://doi.org/10.1038/s41392-022-01288-1
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Letter
Phase I study of camrelizumab in patients with advanced solid tumors
Yuxiang Ma,Jiaxin Cao  ORCID: orcid.org/0000-0002-8020-3603,Yang Zhang,Qianwen Liu,Wenfeng Fang,Yunpeng Yang,Yuanyuan Zhao,Qing Yang,Hongyun Zhao &…Li Zhang 
https://doi.org/10.1038/s41392-022-01213-6
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Increased type III interferons and NK cell functions in SARS-CoV-2-infected children
Seong Dong Jeong,Hoyoung Lee,Ju Young Chang,Seong Yong Lee,Ji Eun Choi,Eunmi Yang,Hye Won Jeong,Jae-Phil Choi,Mi Seon Han &…Eui-Cheol Shin  ORCID: orcid.org/0000-0002-6308-9503 
https://doi.org/10.1038/s41392-023-01340-8
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Discovery of C19-9 as a novel non-RGD inhibitor of αvβ3 to overcome enzalutamide resistance in castration-resistant prostate cancer
Xiaocong Pang,Xiaojiao Sun,Yanlun Gu,Xu He,Kan Gong  ORCID: orcid.org/0000-0001-7195-677X,Song Song,Jixin Zhang,Jie Xia,Zhenming Liu &…Yimin Cui 
https://doi.org/10.1038/s41392-022-01236-z
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Combating inconsistent evaluation of intra-tumor immune status by a novel transcriptomic signature in hepatocellular carcinoma
Linmeng Zhang,Ning Tang,Chen Yang,Haigang Geng,Hualian Hang,Wenxin Qin  ORCID: orcid.org/0000-0002-1989-3027 &…Cun Wang  ORCID: orcid.org/0000-0002-4977-2189 
https://doi.org/10.1038/s41392-022-01262-x
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Diverse structures and antihepatoma effect of sesquiterpenoid dimers from Artemisia eriopoda by AKT/STAT signaling pathway
Xiaofeng He,Wenjing Ma,Jing Hu,Tianze Li,Changan Geng,Yunbao Ma,Mengfei Wang,Kexin Yang,Xuemei Zhang &…Ji-Jun Chen 
https://doi.org/10.1038/s41392-022-01267-6
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circGLS2 inhibits hepatocellular carcinoma recurrence via regulating hsa-miR-222-3p–PTEN–AKT signaling
Xi Chen,Ting Wu,Linfeng Xian,Longteng Ma,Nan Li,Wenbin Liu,Peng Cai,Xiaojie Tan,Jianhua Yin &…Guangwen Cao 
https://doi.org/10.1038/s41392-022-01275-6
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Targeting the m6A mRNA demethylase FTO suppresses vascular endothelial growth factor release and choroidal neovascularization
Shao-bin Wang  ORCID: orcid.org/0000-0002-6699-9406,Yosuke Nagasaka,Dionne Argyle,Ayami Nagasaka,Praveen Yerramothu,Bradley D. Gelfand &…Jayakrishna Ambati 
https://doi.org/10.1038/s41392-022-01277-4
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Mutation N856K in spike reduces fusogenicity and infectivity of Omicron BA.1
Chunyun Sun,Huiyu Wang,Ji Yang,Desheng Kong,Yuning Chen,Haiyue Wang,Lingling Sun,Jianbo Lu,Min Teng &…Liangzhi Xie  ORCID: orcid.org/0000-0003-4504-7622 
https://doi.org/10.1038/s41392-022-01281-8
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Regeneration and functional recovery of the completely transected optic nerve in adult rats by CNTF-chitosan
Xiao Liu,Fei Hao,Peng Hao,Jingxue Zhang,Liqiang Wang,Si-Wei You,Ningli Wang,Zhaoyang Yang,Kwok-Fai So &…Xiaoguang Li 
https://doi.org/10.1038/s41392-022-01289-0
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Lymphocyte integrins mediate entry and dysregulation of T cells by SARS-CoV-2
Mengwen Huang,Xingchao Pan,Xinling Wang,Qingfei Ren,Bei Tong,Xianchi Dong,Gaoxiang Ge  ORCID: orcid.org/0000-0003-3189-8928,Lu Lu  ORCID: orcid.org/0000-0002-2255-0391,Shibo Jiang  ORCID: orcid.org/0000-0001-8283-7135 &…Jianfeng Chen  ORCID: orcid.org/0000-0002-2892-1691 
https://doi.org/10.1038/s41392-023-01348-0
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Universal selenium nanoadjuvant with immunopotentiating and redox-shaping activities inducing high-quality immunity for SARS-CoV-2 vaccine
Haoqiang Lai,Ligeng Xu,Chang Liu,Sujiang Shi,Yalin Jiang,Yangyang Yu,Bo Deng &…Tianfeng Chen  ORCID: orcid.org/0000-0001-6953-1342 
https://doi.org/10.1038/s41392-023-01371-1
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Elemene sensitizes pancreatic cancer cells to bortezomib by enhancing proteasome inhibition via molecular patch mechanism
Shurong Hou,Zhenzhen Li,Xiaoling Chen,Wenxin Wang,Ting Duan,Louis Scampavia,Yaxia Yuan,Timothy P. Spicer,Xiabin Chen &…Tian Xie 
https://doi.org/10.1038/s41392-023-01373-z
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A novel Trmt5-deficient zebrafish model with spontaneous inflammatory bowel disease-like phenotype
Qiong Zhao,Hui Chang,Jing Zheng,Ping Li,Lidan Ye,Ruolang Pan,Di Li,Jian-Zhong Shao,Robert Chunhua Zhao &…Ye Chen  ORCID: orcid.org/0000-0003-3671-2504 
https://doi.org/10.1038/s41392-023-01318-6
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Research Highlight
Gonadotropin releasing hormone (GnRH): a hormone therapy boosts cognition in Down syndrome and dementia
Keenan Sterling,Ruixue Cao &Weihong Song 
https://doi.org/10.1038/s41392-023-01321-x
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The fungal mycobiome: a new hallmark of cancer revealed by pan-cancer analyses
Zhi Zong,Fangfang Zhou  ORCID: orcid.org/0000-0003-1870-7584 &Long Zhang  ORCID: orcid.org/0000-0001-8139-0474 
https://doi.org/10.1038/s41392-023-01334-6
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Metabolic interaction: tumor-derived lactate inhibiting CD8+ T cell cytotoxicity in a novel route
Ke Wang  ORCID: orcid.org/0000-0001-8913-7115,Yong Zhang &Zhi-Nan Chen 
https://doi.org/10.1038/s41392-023-01320-y
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Single-cell transcriptome profiling of human HSCs during development: new insights into HSC ontogeny
Edgar Grinstein &Csaba Mahotka 
https://doi.org/10.1038/s41392-022-01301-7
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Tumor neutrophils ferroptosis: a targetable immunosuppressive mechanism for cancer immunotherapy
Songtao Du,Furong Zeng &Guangtong Deng  ORCID: orcid.org/0000-0002-4424-9727 
https://doi.org/10.1038/s41392-023-01357-z
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RNA methylation into m1A era: a new regulation over T-cell function
Ping Lin,Guoping Li &Min Wu 
https://doi.org/10.1038/s41392-023-01360-4
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CRISPR-mediated RNA base editing: a promising strategy to rescue deafness
Wenyi Liu,Min Wu &Guanwang Shen 
https://doi.org/10.1038/s41392-023-01349-z
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Review Article
Osteoarthritis: pathogenic signaling pathways and therapeutic targets
Qing Yao,Xiaohao Wu,Chu Tao,Weiyuan Gong,Mingjue Chen,Minghao Qu,Yiming Zhong,Tailin He  ORCID: orcid.org/0000-0002-1032-5445,Sheng Chen  ORCID: orcid.org/0000-0003-1770-5018 &…Guozhi Xiao  ORCID: orcid.org/0000-0002-4269-2450 
https://doi.org/10.1038/s41392-023-01330-w
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The mechanism and therapy of aortic aneurysms
Jianing Gao,Huanhuan Cao,Gaofei Hu,Yufei Wu,Yangkai Xu,Hongtu Cui,Hong S. Lu &…Lemin Zheng 
https://doi.org/10.1038/s41392-023-01325-7
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Signaling pathways in rheumatoid arthritis: implications for targeted therapy
Qian Ding,Wei Hu,Ran Wang,Qinyan Yang,Menglin Zhu,Meng Li,Jianghong Cai,Peter Rose,Jianchun Mao &…Yi Zhun Zhu  ORCID: orcid.org/0000-0001-7700-8041 
https://doi.org/10.1038/s41392-023-01331-9
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Epigenetic regulation in hematopoiesis and its implications in the targeted therapy of hematologic malignancies
Ailin Zhao,Hui Zhou,Jinrong Yang,Meng Li &…Ting Niu 
https://doi.org/10.1038/s41392-023-01342-6
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Hypoxic microenvironment in cancer: molecular mechanisms and therapeutic interventions
Zhou Chen,Fangfang Han,Yan Du,Huaqing Shi &…Wence Zhou 
https://doi.org/10.1038/s41392-023-01332-8
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Targeting epigenetic regulators to overcome drug resistance in cancers
Nan Wang,Ting Ma &Bin Yu  ORCID: orcid.org/0000-0002-0531-2236 
https://doi.org/10.1038/s41392-023-01341-7
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Signaling pathways in Parkinson’s disease: molecular mechanisms and therapeutic interventions
Xu Dong-Chen,Chen Yong,Xu Yang,ShenTu Chen-Yu &…Peng Li-Hua  ORCID: orcid.org/0000-0001-9763-383X 
https://doi.org/10.1038/s41392-023-01353-3
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Molecular and functional imaging in cancer-targeted therapy: current applications and future directions
Jing-Wen Bai,Si-Qi Qiu &Guo-Jun Zhang 
https://doi.org/10.1038/s41392-023-01366-y
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