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Volume 8 Issue 2, Feb 2023

Article
SCGN deficiency is a risk factor for autism spectrum disorder
Zhe Liu,Shuai Tan,Lianyu Zhou  ORCID: orcid.org/0000-0002-6094-683X,Li Chen,Mingfeng Liu,Wang Wang,Yingying Tang,Qin Yang,Sensen Chi,Peiyan Jiang,Yue Zhang,Yonghua Cui,Junhong Qin,Xiao Hu,Shenglong Li,Qi Liu,Lu Chen  ORCID: orcid.org/0000-0002-1083-9729,Song Li,Ezra Burstein  ORCID: orcid.org/0000-0003-4341-6367,Wei Li,Xiaohu Zhang,Xianming Mo &…Da Jia  ORCID: orcid.org/0000-0002-2205-1998 
https://doi.org/10.1038/s41392-022-01225-2
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Safety and immunogenicity of a mosaic vaccine booster against Omicron and other SARS-CoV-2 variants: a randomized phase 2 trial
Nawal Al Kaabi  ORCID: orcid.org/0000-0003-2180-4158,Yun Kai Yang,Yu Liang,Ke Xu,Xue Feng Zhang,Yun Kang,Yu Qin Jin,Jun Wei Hou,Jing Zhang,Tian Yang,Salah Hussein,Mohamed Saif ElDein,Ze Hua Lei,Hao Zhang,Shuai Shao,Zhao Ming Liu,Ning Liu,Xiang Zheng,Ji Guo Su,Sen Sen Yang,Xiangfeng Cong,Yao Tan,Wenwen Lei,Xue Jun Gao,Zhiwei Jiang,Hui Wang,Meng Li,Hanadi Mekki Mekki,Walid Zaher  ORCID: orcid.org/0000-0002-5868-7568,Sally Mahmoud  ORCID: orcid.org/0000-0003-1348-9063,Xue Zhang,Chang Qu,Dan Ying Liu,Jing Zhang,Mengjie Yang,Islam Eltantawy,Peng Xiao,Fu Jie Shen,Jin Juan Wu,Zi Bo Han,Li Fang Du,Fang Tang,Shi Chen,Zhi Jing Ma,Fan Zheng,Ya Nan Hou,Xin Yu Li,Xin Li,Zhao Nian Wang,Jin Liang Yin,Xiao Yan Mao,Jin Zhang,Liang Qu,Yun Tao Zhang,Xiao Ming Yang  ORCID: orcid.org/0000-0002-2598-4355,Guizhen Wu &…Qi Ming Li  ORCID: orcid.org/0000-0001-8284-7106 
https://doi.org/10.1038/s41392-022-01295-2
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Anti-BCMA CAR T-cell therapy CT103A in relapsed or refractory AQP4-IgG seropositive neuromyelitis optica spectrum disorders: phase 1 trial interim results
Chuan Qin,Dai-Shi Tian  ORCID: orcid.org/0000-0002-7627-0811,Luo-Qi Zhou,Ke Shang,Liang Huang  ORCID: orcid.org/0000-0002-8370-3232,Ming-Hao Dong,Yun-Fan You,Jun Xiao,Ying Xiong,Wen Wang  ORCID: orcid.org/0000-0003-3215-3020,Hao Pang,Jing-Jing Guo,Song-Bai Cai,Di Wang,Chun-Rui Li,Min Zhang,Bi-Tao Bu &…Wei Wang 
https://doi.org/10.1038/s41392-022-01278-3
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Histone deacetylase inhibitors promote breast cancer metastasis by elevating NEDD9 expression
Zonglong Hu,Fan Wei,Yi Su,Yafang Wang,Yanyan Shen,Yanfen Fang,Jian Ding  ORCID: orcid.org/0000-0002-5815-4956 &…Yi Chen 
https://doi.org/10.1038/s41392-022-01221-6
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COVID-19-associated monocytic encephalitis (CAME): histological and proteomic evidence from autopsy
Pei-Pei Zhang,Zhi-Cheng He,Xiao-Hong Yao,Rui Tang,Jie Ma,Tao Luo,Chuhong Zhu,Tian-Ran Li,Xindong Liu,Dingyu Zhang,Shuyang Zhang  ORCID: orcid.org/0000-0002-1532-0029,Yi-Fang Ping,Ling Leng  ORCID: orcid.org/0000-0002-6519-012X &…Xiu-Wu Bian  ORCID: orcid.org/0000-0003-4383-0197 
https://doi.org/10.1038/s41392-022-01291-6
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Blockade of NMT1 enzymatic activity inhibits N-myristoylation of VILIP3 protein and suppresses liver cancer progression
Xiang-Peng Tan,Yan He,Jing Yang,Xian Wei,You-Long Fan,Guo-Geng Zhang,Yi-Dong Zhu,Zheng-Qiu Li,Hua-Xin Liao,Da-Jiang Qin,Xin-Yuan Guan  ORCID: orcid.org/0000-0002-4485-6017 &…Bin Li  ORCID: orcid.org/0000-0002-8979-610X 
https://doi.org/10.1038/s41392-022-01248-9
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Oxidative stress-triggered Wnt signaling perturbation characterizes the tipping point of lung adeno-to-squamous transdifferentiation
Zhaoyuan Fang,Xiangkun Han,Yueqing Chen,Xinyuan Tong,Yun Xue,Shun Yao,Shijie Tang,Yunjian Pan,Yihua Sun,Xue Wang,Yujuan Jin,Haiquan Chen,Liang Hu  ORCID: orcid.org/0000-0002-0984-9807,Lijian Hui,Lin Li,Luonan Chen &…Hongbin Ji  ORCID: orcid.org/0000-0003-0891-6390 
https://doi.org/10.1038/s41392-022-01227-0
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Discovery of IHMT-337 as a potent irreversible EZH2 inhibitor targeting CDK4 transcription for malignancies
Husheng Mei,Hong Wu,Jing Yang,Bin Zhou,Aoli Wang,Chen Hu,Shuang Qi,Zongru Jiang,Fengming Zou,Beilei Wang,Feiyang Liu,Yongfei Chen,Wenchao Wang,Jing Liu &…Qingsong Liu  ORCID: orcid.org/0000-0002-7829-2547 
https://doi.org/10.1038/s41392-022-01240-3
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Chemo-drugs in cell microparticles reset antitumor activity of macrophages by activating lysosomal P450 and nuclear hnRNPA2B1
Keke Wei,Huafeng Zhang,Shuaishuai Yang,Yuxiao Cui,Bingxia Zhang,Jincheng Liu,Liang Tang,Yaoyao Tan,Simin Liu,Shiqi Chen,Wu Yuan,Xiao Luo,Chen Chen,Fei Li,Junwei Liu,Jie Chen,Pingwei Xu,Jiadi Lv,Ke Tang,Yi Zhang  ORCID: orcid.org/0000-0001-9861-4681,Jingwei Ma &…Bo Huang  ORCID: orcid.org/0000-0001-8476-1138 
https://doi.org/10.1038/s41392-022-01212-7
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Application of metabolomics in urolithiasis: the discovery and usage of succinate
Xiu-zhen Zhang,Xiong-xin Lei,Yan-lin Jiang,Long-mei Zhao,Chen-yu Zou,Yun-jin Bai,Ya-xing Li,Rui Wang,Qian-jin Li,Qiu-zhu Chen,Ming-hui Fan,Yu-ting Song,Wen-qian Zhang,Yi Zhang,Jesse Li-Ling &…Hui-qi Xie 
https://doi.org/10.1038/s41392-023-01311-z
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Immunological and metabolic characteristics of the Omicron variants infection
Jiejie Geng,Xu Yang,Kun Wang,Ke Wang  ORCID: orcid.org/0000-0001-8913-7115,Ruo Chen,Zhi-Nan Chen,Chuan Qin  ORCID: orcid.org/0000-0002-6261-1232,Guizhen Wu,Youchun Wang  ORCID: orcid.org/0000-0001-9769-5141,Ke Xu,Peng Du,Jiangning Liu,Shirui Chen,Tao Zhang,Xiuxuan Sun,Ting Guo,Ying Shi,Zheng Zhang,Ding Wei,Peng Lin,Qingyi Wang,Jing Yuan  ORCID: orcid.org/0000-0002-8937-9568,Jiuxin Qu,Jin Zou,Yingxia Liu,Hongzhou Lu,Ping Zhu,Huijie Bian  ORCID: orcid.org/0000-0003-4690-4622 &…Liang Chen 
https://doi.org/10.1038/s41392-022-01265-8
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Proximity-enabled covalent binding of IL-2 to IL-2Rα selectively activates regulatory T cells and suppresses autoimmunity
Bo Zhang  ORCID: orcid.org/0000-0002-9652-1120,Jiaqi Sun,Yeshuang Yuan,Dezhong Ji,Yeting Sun,Yudong Liu,Shengjie Li,Xingxing Zhu,Xunyao Wu,Jin Hu,Qiu Xie,Ling Wu,Lulu Liu,Boyang Cheng,Yuanjie Zhang,Lingjuan Jiang,Lidan Zhao,Fei Yu,Wei Song,Min Wang,Yue Xu,Shiliang Ma,Yunyun Fei,Lihe Zhang,Demin Zhou &…Xuan Zhang 
https://doi.org/10.1038/s41392-022-01208-3
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Fc effector of anti-Aβ antibody induces synapse loss and cognitive deficits in Alzheimer’s disease-like mouse model
Xiao-ying Sun,Xiao-lin Yu,Jie Zhu,Ling-jie Li,Lun Zhang,Ya-ru Huang,Dong-qun Liu,Mei Ji,Xun Sun,Ling-xiao Zhang,Wei-wei Zhou,Dongming Zhang,Jianwei Jiao  ORCID: orcid.org/0000-0002-7893-0721 &…Rui-tian Liu  ORCID: orcid.org/0000-0002-4297-4765 
https://doi.org/10.1038/s41392-022-01273-8
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Single-cell RNA-sequencing reveals radiochemotherapy-induced innate immune activation and MHC-II upregulation in cervical cancer
Chao Liu,Xiaohui Li,Qingyu Huang,Min Zhang,Tianyu Lei,Fuhao Wang,Wenxue Zou,Rui Huang,Xiaoyu Hu,Cong Wang,Xiaoling Zhang,Bing Sun,Ligang Xing,Jinbo Yue &…Jinming Yu 
https://doi.org/10.1038/s41392-022-01264-9
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Meplazumab in hospitalized adults with severe COVID-19 (DEFLECT): a multicenter, seamless phase 2/3, randomized, third-party double-blind clinical trial
Huijie Bian  ORCID: orcid.org/0000-0003-4690-4622,Liang Chen,Zhao-Hui Zheng,Xiu-Xuan Sun,Jie-Jie Geng,Ruo Chen,Ke Wang  ORCID: orcid.org/0000-0001-8913-7115,Xu Yang,Shi-Rui Chen,Si-Yu Chen,Rong-Hua Xie,Kui Zhang,Jin-Lin Miao,Jun-Feng Jia,Hao Tang,Shuang-Shuang Liu,Hong-Wei Shi,Yong Yang,Xiao-Chun Chen,Vinay Malhotra,Nosheen Nasir  ORCID: orcid.org/0000-0003-1610-8748,Iffat Khanum,Faisal Mahmood,Saeed Hamid,Claudio Marcel Berdun Stadnik,Kengi Itinose,Caroline Cândida Carvalho de Oliveira,Cesar Dusilek,Lucas Rivabem,Adilson Joaquim Westheimer Cavalcante,Suzara Souto Lopes,Wladmir Faustino Saporito,Fábio José Concilio Fucci,Jesus Abraham Simon-Campos,Ling Wang,Lin-Na Liu,Qing-Yi Wang,Ding Wei,Zheng Zhang,Zhi-Nan Chen &…Ping Zhu 
https://doi.org/10.1038/s41392-023-01323-9
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Intestinal dysbiosis exacerbates the pathogenesis of psoriasis-like phenotype through changes in fatty acid metabolism
Qixiang Zhao,Jiadong Yu,Hong Zhou,Xiaoyan Wang,Chen Zhang,Jing Hu,Yawen Hu,Huaping Zheng  ORCID: orcid.org/0000-0002-0716-8987,Fanlian Zeng,Chengcheng Yue,Linna Gu,Zhen Wang,Fulei Zhao,Pei Zhou,Haozhou Zhang,Nongyu Huang,Wenling Wu,Yifan Zhou &…Jiong Li  ORCID: orcid.org/0000-0002-3742-630X 
https://doi.org/10.1038/s41392-022-01219-0
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Review Article
Targeting integrin pathways: mechanisms and advances in therapy
Xiaocong Pang,Xu He,Zhiwei Qiu,Hanxu Zhang,Ran Xie,Zhiyan Liu,Yanlun Gu,Nan Zhao,Qian Xiang &…Yimin Cui 
https://doi.org/10.1038/s41392-022-01259-6
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Signaling pathways in brain tumors and therapeutic interventions
Shenglan Li,Can Wang,Jinyi Chen,Yanjie Lan,Weichunbai Zhang,Zhuang Kang,Yi Zheng,Rong Zhang,Jianyu Yu &…Wenbin Li 
https://doi.org/10.1038/s41392-022-01260-z
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Neoantigens: promising targets for cancer therapy
Na Xie,Guobo Shen,Wei Gao,Zhao Huang,Canhua Huang  ORCID: orcid.org/0000-0003-2247-7750 &…Li Fu  ORCID: orcid.org/0000-0003-2643-6278 
https://doi.org/10.1038/s41392-022-01270-x
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Ribosome biogenesis in disease: new players and therapeutic targets
Lijuan Jiao,Yuzhe Liu,Xi-Yong Yu,Xiangbin Pan,Yu Zhang,Junchu Tu,Yao-Hua Song &…Yangxin Li  ORCID: orcid.org/0000-0002-2364-3207 
https://doi.org/10.1038/s41392-022-01285-4
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Intratumoral microbiota: roles in cancer initiation, development and therapeutic efficacy
Li Yang,Aitian Li,Ying Wang &…Yi Zhang  ORCID: orcid.org/0000-0001-9861-4681 
https://doi.org/10.1038/s41392-022-01304-4
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Targeted therapy for head and neck cancer: signaling pathways and clinical studies
Qingfang Li,Yan Tie,Aqu Alu  ORCID: orcid.org/0000-0002-9981-0120,Xuelei Ma &…Huashan Shi 
https://doi.org/10.1038/s41392-022-01297-0
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CRISPR/Cas9 therapeutics: progress and prospects
Tianxiang Li,Yanyan Yang,Hongzhao Qi,Weigang Cui,Lin Zhang,Xiuxiu Fu,Xiangqin He,Meixin Liu,Pei-feng Li  ORCID: orcid.org/0000-0002-0969-9407 &…Tao Yu 
https://doi.org/10.1038/s41392-023-01309-7
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Epigenetic and post-translational modifications in autophagy: biological functions and therapeutic targets
Feng Shu,Han Xiao,Qiu-Nuo Li,Xiao-Shuai Ren,Zhi-Gang Liu,Bo-Wen Hu,Hong-Sheng Wang  ORCID: orcid.org/0000-0002-0054-4820,Hao Wang &…Guan-Min Jiang 
https://doi.org/10.1038/s41392-022-01300-8
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Nucleic acid drug vectors for diagnosis and treatment of brain diseases
Zhi-Guo Lu,Jie Shen,Jun Yang,Jing-Wen Wang,Rui-Chen Zhao,Tian-Lu Zhang,Jing Guo &…Xin Zhang 
https://doi.org/10.1038/s41392-022-01298-z
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Research Highlight
PIEZO1 channels in cutaneous free nerve endings: novel insights into itch-scratch-mechanisms
Manuel Pedro Pereira,Henning Wiegmann &Sonja Ständer 
https://doi.org/10.1038/s41392-022-01271-w
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RNA interfering machinery: new insight into the Dicer-2 complexes in the dsRNA-processing cycle
Xiaocui Wei,Junxia Li &Yang Li  ORCID: orcid.org/0000-0002-6065-4706 
https://doi.org/10.1038/s41392-022-01272-9
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Omicron variant: a booster depending on infection histories
Jiayu Wang,Tianxia Lan,Yuquan Wei &…Yoshimasa Tanaka  ORCID: orcid.org/0000-0002-5024-0614 
https://doi.org/10.1038/s41392-022-01279-2
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ADAR1: a mast regulator of aging and immunity
Yigan Zhang,Jinyue Zhang &Yuanchao Xue  ORCID: orcid.org/0000-0002-8113-2333 
https://doi.org/10.1038/s41392-022-01276-5
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B cell engineering in vivo: Accelerating induction of broadly neutralizing antibodies against HIV-1 infection
Caijun Sun  ORCID: orcid.org/0000-0002-2000-7053,Teng Zuo &Ziyu Wen 
https://doi.org/10.1038/s41392-022-01269-4
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Cold snap for cancer: cold-induced brown fat thermogenesis starves tumor growth
Ziqing Chen &Yibin Kang 
https://doi.org/10.1038/s41392-022-01284-5
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Landscape of antitumor CD4+ T cells in melanoma:unraveling novel HLA class II-driven immune escape
Xiangjie Xue,Ji Wang &Chenyang Ye  ORCID: orcid.org/0000-0002-3695-6309 
https://doi.org/10.1038/s41392-022-01307-1
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Age-induced changes in lung microenvironment: from melanoma dormancy to outgrowth
Juan Jin,Li Li &Caiyun Fu  ORCID: orcid.org/0000-0003-4090-885X 
https://doi.org/10.1038/s41392-022-01303-5
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ASGR1: an emerging therapeutic target in hypercholesterolemia
Wenqi Zhao,Suowen Xu &Jianping Weng  ORCID: orcid.org/0000-0002-5488-5217 
https://doi.org/10.1038/s41392-023-01319-5
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The cGAS-STING pathway: a therapeutic target in chromosomally unstable cancers
Haiyan Yan,Weiguo Lu &Fangwei Wang 
https://doi.org/10.1038/s41392-023-01328-4
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Letter
Host cell cycle checkpoint as antiviral target for SARS-CoV-2 revealed by integrative transcriptome and proteome analyses
Liyan Sui,Letian Li,Yinghua Zhao,Yicheng Zhao,Pengfei Hao,Xuerui Guo,Wenfang Wang,Guoqing Wang  ORCID: orcid.org/0000-0001-9326-3755,Chang Li  ORCID: orcid.org/0000-0002-3267-1859 &…Quan Liu  ORCID: orcid.org/0000-0003-3411-3196 
https://doi.org/10.1038/s41392-022-01296-1
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G-quadruplexes folding mediates downregulation of PBX1 expression in melanoma
Yutong Sui,Feilin Liu,Song Zheng  ORCID: orcid.org/0000-0002-6271-4004,Xiaomei Liu,Pingli Sun,Chunli Yao,Yingyao Zhang,Hongwen Gao,Xinghua Gao &…Jinyu Liu 
https://doi.org/10.1038/s41392-022-01222-5
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Antibody response and cross-neutralization after Omicron BA.2 infection
Yiwen Zhang  ORCID: orcid.org/0000-0002-5232-0335,Rong Li,Yuzhuang Li,Hong Yang,Liqiong Zhou,Jing Yuan  ORCID: orcid.org/0000-0002-8937-9568,Ting Pan,Bingfeng Liu,Hui Zhang  ORCID: orcid.org/0000-0003-3620-610X &…Yaqing He 
https://doi.org/10.1038/s41392-022-01305-3
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DRC3 is an assembly adapter of the nexin-dynein regulatory complex functional components during spermatogenesis in humans and mice
Shushu Zhou,Shimin Yuan,Jintao Zhang,Lanlan Meng,Xin Zhang,Siyu Liu,Guangxiu Lu,Ge Lin,Mingxi Liu &…Yue-Qiu Tan  ORCID: orcid.org/0000-0002-8359-4654 
https://doi.org/10.1038/s41392-022-01293-4
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Preclinical characterization and anti-SARS-CoV-2 efficacy of ATV014: an oral cyclohexanecarboxylate prodrug of 1′-CN-4-aza-7,9-dideazaadenosine C-nucleoside
Qifan Zhou,Sidi Yang,Liu Cao,Yang Yang,Tiefeng Xu,Qishu Chen,Hongzhou Lu,Yingjun Li,Deyin Guo  ORCID: orcid.org/0000-0002-8297-0814 &…Xumu Zhang 
https://doi.org/10.1038/s41392-023-01310-0
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Single-cell analysis reveals the potential mechanisms of pyrotinib resistance in non-small cell lung cancer
Xinfeng Wang,Yuan Li,Runsen Jin,Sufei Zheng,Yuejun Luo,Peng Wu,Zhanyu Wang,Yuxin Yao,Nan Sun &…Jie He  ORCID: orcid.org/0000-0002-0285-5403 
https://doi.org/10.1038/s41392-022-01226-1
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Peptide targeting the interaction of S protein cysteine-rich domain with Ezrin restricts pan-coronavirus infection
Zhuanchang Wu,Xiaobo Lei,Xin Wang,Zhaoying Zhang,Yuming Li,Lifen Gao  ORCID: orcid.org/0000-0003-2404-7439,Xiaohong Liang  ORCID: orcid.org/0000-0002-7626-3478,Peihui Wang,Jianwei Wang &…Chunhong Ma  ORCID: orcid.org/0000-0002-8121-4718 
https://doi.org/10.1038/s41392-022-01244-z
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Diffuse midline glioma treated with epigenetic agent-based immunotherapy
Linkai Jing,Zhihong Qian,Qiang Gao,Rui Sun,Zili Zhen,Guihuai Wang,Xuejun Yang,Haitao Li  ORCID: orcid.org/0000-0002-6686-1677,Tiannan Guo  ORCID: orcid.org/0000-0003-3869-7651 &…Wei Zhang 
https://doi.org/10.1038/s41392-022-01274-7
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Tumor-derived miR-20b-5p promotes lymphatic metastasis of esophageal squamous cell carcinoma by remodeling the tumor microenvironment
Zitong Zhao,Liyan Xue,Leilei Zheng,Liying Ma,Zhuo Li,Ning Lu,Qimin Zhan  ORCID: orcid.org/0000-0002-1731-938X &…Yongmei Song  ORCID: orcid.org/0000-0002-7789-0158 
https://doi.org/10.1038/s41392-022-01242-1
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Metformin suppresses calcium oxalate crystal-induced kidney injury by promoting Sirt1 and M2 macrophage-mediated anti-inflammatory activation
Haoran Liu,Chen Duan,Xiaoqi Yang,Jianhe Liu,Yaoliang Deng,Hans-Göran Tiselius,Zhangqun Ye,Tao Wang,Jinchun Xing &…Hua Xu  ORCID: orcid.org/0000-0001-9730-7276 
https://doi.org/10.1038/s41392-022-01232-3
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Role of the miR-301a/Fra-2/GLIPR1 axis in lung cancer cisplatin resistance
Gian Luca Rampioni Vinciguerra  ORCID: orcid.org/0000-0003-0739-1668,Marina Capece  ORCID: orcid.org/0000-0002-7624-8059,Rosario Distefano  ORCID: orcid.org/0000-0001-7241-7751,Giovanni Nigita,Andrea Vecchione  ORCID: orcid.org/0000-0002-5497-6856,Francesca Lovat &…Carlo M. Croce 
https://doi.org/10.1038/s41392-022-01228-z
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