Table of Contents
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Volume 8 Issue 1, Jan 2023

Review Article
Recent advances in developing active targeting and multi-functional drug delivery systems via bioorthogonal chemistry
Wenzhe Yi,Ping Xiao,Xiaochen Liu,Zitong Zhao,Xiangshi Sun,Jue Wang,Lei Zhou,Guanru Wang,Haiqiang Cao,Dangge Wang &…Yaping Li  ORCID: orcid.org/0000-0002-0574-6966 
https://doi.org/10.1038/s41392-022-01250-1
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Small molecules in the treatment of COVID-19
Sibei Lei,Xiaohua Chen,Jieping Wu,Xingmei Duan &…Ke Men 
https://doi.org/10.1038/s41392-022-01249-8
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Aging and aging-related diseases: from molecular mechanisms to interventions and treatments
Jun Guo,Xiuqing Huang,Lin Dou,Mingjing Yan,Tao Shen  ORCID: orcid.org/0000-0001-5856-0818,Weiqing Tang &…Jian Li 
https://doi.org/10.1038/s41392-022-01251-0
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Multifaceted functions of STING in human health and disease: from molecular mechanism to targeted strategy
Zili Zhang,Haifeng Zhou,Xiaohu Ouyang,Yalan Dong,Alexey Sarapultsev,Shanshan Luo &…Desheng Hu 
https://doi.org/10.1038/s41392-022-01252-z
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The sirtuin family in health and disease
Qi-Jun Wu,Tie-Ning Zhang,Huan-Huan Chen,Xue-Fei Yu,Jia-Le Lv,Yu-Yang Liu,Ya-Shu Liu,Gang Zheng,Jun-Qi Zhao,Yi-Fan Wei,Jing-Yi Guo,Fang-Hua Liu,Qing Chang,Yi-Xiao Zhang,Cai-Gang Liu  ORCID: orcid.org/0000-0003-4244-6855 &…Yu-Hong Zhao 
https://doi.org/10.1038/s41392-022-01257-8
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Protein acylation: mechanisms, biological functions and therapeutic targets
Shuang Shang,Jing Liu &Fang Hua  ORCID: orcid.org/0000-0001-6214-1384 
https://doi.org/10.1038/s41392-022-01245-y
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Letter
Identification of a class of potent USP25/28 inhibitors with broad-spectrum anti-cancer activity
Jin Peng,Kun Jiang,Xiao Sun,Lingzhi Wu,Jiewei Wang,Xiaomei Xi,Xu Tan,Tingbo Liang  ORCID: orcid.org/0000-0003-0143-3353,Changheng Tan &…Pumin Zhang 
https://doi.org/10.1038/s41392-022-01209-2
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An alphavirus replicon particle delivering prefusion-stabilized spike protein provides potent immunoprotection against SARS-CoV-2 Omicron variant
Hong-Qing Zhang,Ya-Nan Zhang,Zhe-Rui Zhang,Xiao-Ling Chen,Yan-Yan Hu,Yu-Jia Shi,Jing Wang,Cheng-lin Deng,Bo Zhang  ORCID: orcid.org/0000-0002-8895-3679,Xiao-Dan Li &…Han-Qing Ye  ORCID: orcid.org/0000-0001-7770-4071 
https://doi.org/10.1038/s41392-022-01246-x
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Strong attenuation of SARS-CoV-2 Omicron BA.1 and increased replication of the BA.5 subvariant in human cardiomyocytes
Rayhane Nchioua,Federica Diofano,Sabrina Noettger,Pascal von Maltitz  ORCID: orcid.org/0000-0003-0533-6999,Steffen Stenger,Fabian Zech,Jan Münch  ORCID: orcid.org/0000-0001-7316-7141,Konstantin M. J. Sparrer  ORCID: orcid.org/0000-0002-8682-1779,Steffen Just &…Frank Kirchhoff  ORCID: orcid.org/0000-0002-7052-2360 
https://doi.org/10.1038/s41392-022-01256-9
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Article
Targeting CRL4 suppresses chemoresistant ovarian cancer growth by inducing mitophagy
Yang Meng,Lei Qiu,Xinyi Zeng,Xiaoyan Hu,Yaguang Zhang  ORCID: orcid.org/0000-0002-9216-1834,Xiaowen Wan,Xiaobing Mao,Jian Wu,Yongfeng Xu,Qunli Xiong,Zhixin Chen,Bo Zhang &…Junhong Han  ORCID: orcid.org/0000-0002-3371-8698 
https://doi.org/10.1038/s41392-022-01253-y
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Antibody and T cell responses against wild-type and Omicron SARS-CoV-2 after third-dose BNT162b2 in adolescents
Xiaofeng Mu,Carolyn A. Cohen,Daniel Leung,Jaime S. Rosa Duque,Samuel M. S. Cheng  ORCID: orcid.org/0000-0001-7293-2331,Yuet Chung,Howard H. W. Wong  ORCID: orcid.org/0000-0001-6240-2409,Amos M. T. Lee,Wing Yan Li,Issan Y. S. Tam  ORCID: orcid.org/0000-0003-2152-8632,Jennifer H. Y. Lam,Derek H. L. Lee  ORCID: orcid.org/0000-0002-2387-4822,Sau Man Chan,Leo C. H. Tsang,Karl C. K. Chan,John K. C. Li,Leo L. H. Luk,Sara Chaothai,Kelvin K. H. Kwan,Nym Coco Chu,Masashi Mori,Trushar Jeevan,Ahmed Kandeil,Richard J. Webby,Wenwei Tu  ORCID: orcid.org/0000-0002-6801-8798,Sophie A. Valkenburg,Malik Peiris &…Yu Lung Lau  ORCID: orcid.org/0000-0002-4780-0289 
https://doi.org/10.1038/s41392-022-01282-7
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Analogous comparison unravels heightened antiviral defense and boosted viral infection upon immunosuppression in bat organoids
Xiaojuan Liu,Cun Li,Zhixin Wan,Man Chun Chiu,Jingjing Huang,Yifei Yu,Lin Zhu  ORCID: orcid.org/0000-0002-2801-3626,Jian-Piao Cai,Lei Rong,You-qiang Song,Hin Chu  ORCID: orcid.org/0000-0003-2855-9837,Zongwei Cai  ORCID: orcid.org/0000-0002-8724-7684,Shibo Jiang  ORCID: orcid.org/0000-0001-8283-7135,Kwok-yung Yuen &…Jie Zhou  ORCID: orcid.org/0000-0002-2948-3873 
https://doi.org/10.1038/s41392-022-01247-w
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Tripterin liposome relieves severe acute respiratory syndrome as a potent COVID-19 treatment
Haiying Que,Weiqi Hong  ORCID: orcid.org/0000-0003-1668-2301,Tianxia Lan,Hao Zeng,Li Chen,Dandan Wan,Zhenfei Bi,Wenyan Ren  ORCID: orcid.org/0000-0001-6333-8496,Min Luo  ORCID: orcid.org/0000-0002-6875-7945,Jingyun Yang,Cai He,Ailing Zhong &…Xiawei Wei  ORCID: orcid.org/0000-0002-6513-6422 
https://doi.org/10.1038/s41392-022-01283-6
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SARS-CoV-2 hijacks cellular kinase CDK2 to promote viral RNA synthesis
Saisai Guo,Xiaobo Lei,Yan Chang,Jianyuan Zhao,Jing Wang,Xiaojing Dong,Qian Liu,Zixiong Zhang,Lidan Wang,Dongrong Yi,Ling Ma,Quanjie Li,Yongxin Zhang,Jiwei Ding,Chen Liang,Xiaoyu Li,Fei Guo,Jianwei Wang &…Shan Cen 
https://doi.org/10.1038/s41392-022-01239-w
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Research Highlight
cBAF and MYC: decision makers for T cell memory differentiation
Kaili Ma,Hongcheng Cheng &Lianjun Zhang  ORCID: orcid.org/0000-0001-9448-7718 
https://doi.org/10.1038/s41392-022-01238-x
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