Table of Contents
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Volume 7 Issue 11, Nov 2022

Review Article
Germline stem cells in human
Hanhua Cheng,Dantong Shang &Rongjia Zhou  ORCID: orcid.org/0000-0002-9701-8009 
https://doi.org/10.1038/s41392-022-01197-3
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Cancer metastasis chemoprevention prevents circulating tumour cells from germination
Xiaodong Xie,Yumei Li,Shu Lian,Yusheng Lu &…Lee Jia 
https://doi.org/10.1038/s41392-022-01174-w
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Extrachromosomal circular DNA: biogenesis, structure, functions and diseases
Ludi Yang,Ruobing Jia,Tongxin Ge,Shengfang Ge,Ai Zhuang,Peiwei Chai &…Xianqun Fan  ORCID: orcid.org/0000-0002-9394-3969 
https://doi.org/10.1038/s41392-022-01176-8
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Signaling pathways and targeted therapies in lung squamous cell carcinoma: mechanisms and clinical trials
Zhenyi Niu,Runsen Jin,Yan Zhang &…Hecheng Li 
https://doi.org/10.1038/s41392-022-01200-x
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Signaling pathways and therapeutic interventions in gastric cancer
Zi-Ning Lei,Qiu-Xu Teng,Qin Tian,Wei Chen,Yuhao Xie  ORCID: orcid.org/0000-0003-0319-8270,Kaiming Wu,Qianlin Zeng,Leli Zeng,Yihang Pan,Zhe-Sheng Chen  ORCID: orcid.org/0000-0002-8289-097X &…Yulong He 
https://doi.org/10.1038/s41392-022-01190-w
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Research Highlight
Opening the box of PANTHORA in Alzheimer’s disease
Martin Korte &Reinhard W. Köster 
https://doi.org/10.1038/s41392-022-01204-7
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Hide and seek with SARS-CoV-2: spike receptor-binding domain-specific memory B cells still recognize Omicron variant
Ivan Odak  ORCID: orcid.org/0000-0003-0408-5091,Reinhold Förster &Berislav Bošnjak  ORCID: orcid.org/0000-0003-3374-7488 
https://doi.org/10.1038/s41392-022-01192-8
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Human cross-tissue cell atlases: unprecedented resources towards systematic understanding of physiology and diseases
Peng Zhang &Shao Li 
https://doi.org/10.1038/s41392-022-01201-w
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Bugs improve nerve regeneration: fasting-induced, microbiome-derived metabolite enhances peripheral nerve regeneration
Zerina Kurtovic,Camilla I. Svensson &Emerson Krock 
https://doi.org/10.1038/s41392-022-01186-6
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Oocyte TET3: an epigenetic modifier responsible for maternal inheritance of glucose intolerance
Xiaoxue Jiang  ORCID: orcid.org/0000-0002-8014-6346,Fei Xiao &Feifan Guo 
https://doi.org/10.1038/s41392-022-01170-0
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Targeting metabolic rewiring might decrease spread of tumor cells: Mitochondrial tRNA modifications promote cancer metastasis
Maik Luu &Alexander Visekruna 
https://doi.org/10.1038/s41392-022-01205-6
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IL-17 signaling in skin repair: safeguarding metabolic adaptation of wound epithelial cells
Juan Wang &Xiaolei Ding 
https://doi.org/10.1038/s41392-022-01202-9
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Neoadjuvant PD-1 blockade: a promising nonoperative strategy for mismatch repair–deficient, locally advanced rectal cancer
Mi Mi,Chenyang Ye  ORCID: orcid.org/0000-0002-3695-6309 &Ying Yuan  ORCID: orcid.org/0000-0002-3922-9553 
https://doi.org/10.1038/s41392-022-01216-3
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Cellular heterogeneity in pancreatic cancer: the different faces of gremlin action
Aristidis Moustakas,J. Matthias Löhr &Rainer L. Heuchel  ORCID: orcid.org/0000-0002-2782-585X 
https://doi.org/10.1038/s41392-022-01203-8
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Segregating memories: targeting microenvironment of neuronal ensembles
Ying Liu,Miao Xu &Wei-Guang Li  ORCID: orcid.org/0000-0002-3442-7518 
https://doi.org/10.1038/s41392-022-01214-5
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Unexpected little helpers: microbiota stimulate systemic antiviral defenses
Susanne Klute,Helene Hoenigsperger &Konstantin M. J. Sparrer  ORCID: orcid.org/0000-0002-8682-1779 
https://doi.org/10.1038/s41392-022-01217-2
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Top(ological-operon) secret behind the long-range transcriptional coupling
Lei Zhang  ORCID: orcid.org/0000-0001-6302-8383,Zhibing Wu &Huasong Lu  ORCID: orcid.org/0000-0003-0875-5531 
https://doi.org/10.1038/s41392-022-01195-5
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Article
Glutamate and GABAA receptor crosstalk mediates homeostatic regulation of neuronal excitation in the mammalian brain
Ya Wen,Zhifang Dong,Jun Liu,Peter Axerio-Cilies,Yehong Du,Junjie Li,Long Chen,Lu Zhang,Lidong Liu,Jie Lu,Ning Zhou,Dong Chuan Wu &…Yu Tian Wang 
https://doi.org/10.1038/s41392-022-01148-y
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Single-cell transcriptomic profiling reveals the tumor heterogeneity of small-cell lung cancer
Yanhua Tian  ORCID: orcid.org/0000-0001-7095-8765,Qingqing Li  ORCID: orcid.org/0000-0002-1217-365X,Zhenlin Yang  ORCID: orcid.org/0000-0002-6650-7782,Shu Zhang,Jiachen Xu,Zhijie Wang,Hua Bai,Jianchun Duan,Bo Zheng,Wen Li,Yueli Cui,Xin Wang,Rui Wan,Kailun Fei,Jia Zhong,Shugeng Gao  ORCID: orcid.org/0000-0003-1888-2622,Jie He,Carl M. Gay,Jianjun Zhang  ORCID: orcid.org/0000-0001-7872-3477,Jie Wang &…Fuchou Tang 
https://doi.org/10.1038/s41392-022-01150-4
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Deciphering transcriptome alterations in bone marrow hematopoiesis at single-cell resolution in immune thrombocytopenia
Yan Liu,Xinyi Zuo,Peng Chen,Xiang Hu,Zi Sheng,Anli Liu,Qiang Liu,Shaoqiu Leng,Xiaoyu Zhang,Xin Li,Limei Wang,Qi Feng,Chaoyang Li,Ming Hou,Chong Chu,Shihui Ma,Shuwen Wang &…Jun Peng  ORCID: orcid.org/0000-0003-1434-1490 
https://doi.org/10.1038/s41392-022-01167-9
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A small molecule inhibitor of the UBE2F-CRL5 axis induces apoptosis and radiosensitization in lung cancer
Tiantian Xu,Qisheng Ma,Yanan Li,Qing Yu,Peichen Pan,Yawen Zheng,Zhijian Li,Xiufang Xiong  ORCID: orcid.org/0000-0001-6842-3673,Tingjun Hou  ORCID: orcid.org/0000-0001-7227-2580,Bin Yu,Hongmin Liu &…Yi Sun  ORCID: orcid.org/0000-0002-5841-4287 
https://doi.org/10.1038/s41392-022-01182-w
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Therapeutic strategy targeting host lipolysis limits infection by SARS-CoV-2 and influenza A virus
Yeong-Bin Baek,Hyung-Jun Kwon,Muhammad Sharif,Jeongah Lim,In-Chul Lee,Young Bae Ryu,Jae-In Lee,Ji-Sun Kim,Young-Seung Lee,Dong-Hoon Kim,Sang-Ik Park,Don-Kyu Kim,Jeong-Sun Kim,Hyon E. Choy,Sunwoo Lee,Hueng-Sik Choi  ORCID: orcid.org/0000-0002-3163-1572,Timothy F. Osborne,Tae-Il Jeon  ORCID: orcid.org/0000-0003-0655-8614 &…Kyoung-Oh Cho  ORCID: orcid.org/0000-0002-5477-7021 
https://doi.org/10.1038/s41392-022-01223-4
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Dysregulated ceramides metabolism by fatty acid 2-hydroxylase exposes a metabolic vulnerability to target cancer metastasis
Xuantong Zhou,Furong Huang,Gang Ma,Wenqing Wei,Nan Wu  ORCID: orcid.org/0000-0002-3531-1656 &…Zhihua Liu  ORCID: orcid.org/0000-0003-4242-033X 
https://doi.org/10.1038/s41392-022-01199-1
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Letter
SARS-CoV-2 N protein potentiates host NPM1-snoRNA translation machinery to enhance viral replication
Hui Wang  ORCID: orcid.org/0000-0002-5141-4487,Danrong Shi,Penglei Jiang,Zebin Yu,Yingli Han,Zhaoru Zhang,Peihui Wang,He Huang  ORCID: orcid.org/0000-0002-2723-1621,Hangping Yao  ORCID: orcid.org/0000-0001-6742-7074 &…Pengxu Qian  ORCID: orcid.org/0000-0001-5636-6704 
https://doi.org/10.1038/s41392-022-01210-9
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Characteristics and significance of peripheral blood T-cell receptor repertoire features in patients with indeterminate lung nodules
Huaichao Luo,Ruiling Zu,Ziru Huang,Yingqiang Li,Yulin Liao,Wenxin Luo,Peng Zhou,Dongsheng Wang,Shifu Chen,Weimin Li  ORCID: orcid.org/0000-0003-0985-0311 &…Jian Huang  ORCID: orcid.org/0000-0003-3282-8892 
https://doi.org/10.1038/s41392-022-01169-7
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An mRNA vaccine with broad-spectrum neutralizing protection against Omicron variant sublineages BA.4/5 -included SARS-CoV-2
Ye Sang,Zhen Zhang,Entao Li,Haitao Lu,Jinrong Long,Yiming Cao,Changxiao Yu,Tiecheng Wang,Jing Yang  ORCID: orcid.org/0000-0001-9050-9203 &…Shengqi Wang 
https://doi.org/10.1038/s41392-022-01207-4
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FGF21 alleviates microvascular damage following limb ischemia/reperfusion injury by TFEB-mediated autophagy enhancement and anti-oxidative response
Fanfeng Chen,Jiayu Zhan,Xiaoqing Yan,Abdullah Al Mamun  ORCID: orcid.org/0000-0001-9936-3925,Yu Zhang,Yitie Xu,Hongyu Zhang,Xiaokun Li,Kailiang Zhou  ORCID: orcid.org/0000-0001-7795-576X &…Jian Xiao 
https://doi.org/10.1038/s41392-022-01172-y
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Targeting TM4SF1 exhibits therapeutic potential via inhibition of cancer stem cells
Guang Chen,Xiaofei She  ORCID: orcid.org/0000-0002-8890-1545,Yanxin Yin,Junxian Ma,Yaqun Gao,Hua Gao,Huanlong Qin  ORCID: orcid.org/0000-0002-9315-5866 &…Jianmin Fang 
https://doi.org/10.1038/s41392-022-01177-7
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IKKβ binds NLRP3 providing a shortcut to inflammasome activation for rapid immune responses
Yaw Asare  ORCID: orcid.org/0000-0002-8946-5650,Margarita Shnipova,Luka Živković,Christina Schlegl  ORCID: orcid.org/0000-0001-7314-5954,Federica Tosato  ORCID: orcid.org/0000-0002-2783-4764,Arailym Aronova  ORCID: orcid.org/0000-0002-1337-2415,Markus Brandhofer,Laura Strohm,Nathalie Beaufort,Rainer Malik,Christian Weber,Jürgen Bernhagen &…Martin Dichgans 
https://doi.org/10.1038/s41392-022-01189-3
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S100A7 attenuates immunotherapy by enhancing immunosuppressive tumor microenvironment in lung squamous cell carcinoma
Chengming Liu,Sufei Zheng,Zhiliang Lu,Zhanyu Wang,Sihui Wang,Xiaoli Feng,Yan Wang,Nan Sun &…Jie He  ORCID: orcid.org/0000-0002-0285-5403 
https://doi.org/10.1038/s41392-022-01196-4
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Acetylshikonin inhibits inflammatory responses and Papain-like protease activity in murine model of COVID-19
Ning Lu,Tingxuan Gu,Xueli Tian,Simin Zhao,Guoguo Jin,Fredimoses Mangaladoss,Yan Qiao,Kangdong Liu,Ran Zhao &…Zigang Dong  ORCID: orcid.org/0000-0002-4174-4028 
https://doi.org/10.1038/s41392-022-01220-7
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