Table of Contents
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Volume 7 Issue 10, Oct 2022

Review Article
JMJD family proteins in cancer and inflammation
Wang Manni,Xue Jianxin,Hong Weiqi  ORCID: orcid.org/0000-0003-1668-2301,Chen Siyuan &…Shi Huashan 
https://doi.org/10.1038/s41392-022-01145-1
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Lactate metabolism in human health and disease
Xiaolu Li,Yanyan Yang,Bei Zhang,Xiaotong Lin,Xiuxiu Fu,Yi An,Yulin Zou,Jian-Xun Wang,Zhibin Wang &…Tao Yu 
https://doi.org/10.1038/s41392-022-01151-3
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Exercise training maintains cardiovascular health: signaling pathways involved and potential therapeutics
Huihua Chen,Chen Chen,Michail Spanos,Guoping Li,Rong Lu,Yihua Bei &…Junjie Xiao  ORCID: orcid.org/0000-0002-9202-0003 
https://doi.org/10.1038/s41392-022-01153-1
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The evolving view of thermogenic fat and its implications in cancer and metabolic diseases
Xinpeng Yin,Yuan Chen,Rexiati Ruze  ORCID: orcid.org/0000-0002-0891-5307,Ruiyuan Xu,Jianlu Song,Chengcheng Wang &…Qiang Xu 
https://doi.org/10.1038/s41392-022-01178-6
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Protein tyrosine kinase inhibitor resistance in malignant tumors: molecular mechanisms and future perspective
Yang Yang,Shuo Li,Yujiao Wang,Yi Zhao &…Qiu Li 
https://doi.org/10.1038/s41392-022-01168-8
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Therapeutic targets and biomarkers of tumor immunotherapy: response versus non-response
Dong-Rui Wang,Xian-Lin Wu &Ying-Li Sun 
https://doi.org/10.1038/s41392-022-01136-2
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RNA modifications: importance in immune cell biology and related diseases
Lian Cui,Rui Ma,Jiangluyi Cai,Chunyuan Guo,Zeyu Chen,Lingling Yao,Yuanyuan Wang,Rui Fan,Xin Wang &…Yuling Shi  ORCID: orcid.org/0000-0002-1273-7881 
https://doi.org/10.1038/s41392-022-01175-9
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Applications of human organoids in the personalized treatment for digestive diseases
Qinying Wang,Fanying Guo,Yutao Jin &…Yanlei Ma 
https://doi.org/10.1038/s41392-022-01194-6
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Article
Suppression of PFKFB3-driven glycolysis restrains endothelial-to-mesenchymal transition and fibrotic response
Hao Zeng,Ting Pan,Meiling Zhan,Renaguli Hailiwu,Baolin Liu,Hua Yang &…Ping Li 
https://doi.org/10.1038/s41392-022-01097-6
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Mesenchymal stromal cells alleviate acute respiratory distress syndrome through the cholinergic anti-inflammatory pathway
Xiaoran Zhang,Xuxia Wei,Yiwen Deng,Xiaofeng Yuan,Jiahao Shi,Weijun Huang,Jing Huang,Xiaoyong Chen,Shuwei Zheng,Jieying Chen,Keyu Chen,Ruiming Xu,Hongmiao Wang,Weiqiang Li  ORCID: orcid.org/0000-0003-4741-6778,Shiyue Li,Huimin Yi &…Andy Peng Xiang  ORCID: orcid.org/0000-0003-3409-5012 
https://doi.org/10.1038/s41392-022-01124-6
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Multiomics approach reveals the ubiquitination-specific processes hijacked by SARS-CoV-2
Gang Xu  ORCID: orcid.org/0000-0003-0687-8108,Yezi Wu,Tongyang Xiao,Furong Qi,Lujie Fan,Shengyuan Zhang,Jian Zhou,Yanhua He,Xiang Gao,Hongxiang Zeng,Yunfei Li &…Zheng Zhang  ORCID: orcid.org/0000-0002-3544-1389 
https://doi.org/10.1038/s41392-022-01156-y
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Tobacco carcinogen induces tryptophan metabolism and immune suppression via induction of indoleamine 2,3-dioxygenase 1
Fan Liang,Gui-Zhen Wang,Yan Wang,Ya-Ning Yang,Zhe-Sheng Wen,Dong-Ni Chen,Wen-Feng Fang,Bin Zhang,Lu Yang,Chen Zhang,Si-Chong Han,Fu-Ying Yang,Di Wang,Li-Jun Liang,Zheng Wang,Yong Zhao  ORCID: orcid.org/0000-0003-2850-3008,Chang-Li Wang,Li Zhang &…Guang-Biao Zhou 
https://doi.org/10.1038/s41392-022-01127-3
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Elaiophylin triggers paraptosis and preferentially kills ovarian cancer drug-resistant cells by inducing MAPK hyperactivation
Guan-Nan Li,Xue-Jiao Zhao,Zhen Wang,Meng-Shi Luo,Shen-Nan Shi,Dan-Mei Yan,Hua-Yi Li,Jia-Hao Liu,Yang Yang,Jia-Hong Tan,Ze-Yu Zhang,Ru-Qi Chen,Hui-Ling Lai,Xiao-Yuan Huang  ORCID: orcid.org/0000-0002-7684-6294,Jian-Feng Zhou  ORCID: orcid.org/0000-0002-1332-9230,Ding Ma,Yong Fang &…Qing-Lei Gao  ORCID: orcid.org/0000-0002-9448-3423 
https://doi.org/10.1038/s41392-022-01131-7
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Highly pathogenic coronavirus N protein aggravates inflammation by MASP-2-mediated lectin complement pathway overactivation
Ting Gao,Lin Zhu  ORCID: orcid.org/0000-0001-5772-9482,Hainan Liu,Xiaopeng Zhang,Tingting Wang,Yangbo Fu,Hongzhen Li,Qincai Dong,Yong Hu,Zhang Zhang,Jing Jin,Zijing Liu,Weihong Yang,Yaoning Liu,Yanwen Jin,Kaitong Li,Yongjiu Xiao,Junli Liu,Huailong Zhao,Yue Liu,Ping Li,Jibo Song,Lu Zhang,Yuwei Gao,Sisi Kang,Shoudeng Chen  ORCID: orcid.org/0000-0002-7634-2141,Qingjun Ma,Xiuwu Bian  ORCID: orcid.org/0000-0003-4383-0197,Wei Chen  ORCID: orcid.org/0000-0001-5805-2469,Xuan Liu  ORCID: orcid.org/0000-0001-6369-9259,Qing Mao &…Cheng Cao  ORCID: orcid.org/0000-0001-7981-6114 
https://doi.org/10.1038/s41392-022-01133-5
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Dendritic cell-derived IL-27 p28 regulates T cell program in pathogenicity and alleviates acute graft-versus-host disease
Huanle Gong,Shoubao Ma,Jia Chen,Bingyu Yang,Shuangzhu Liu,Xin Liu,Jingjing Han,Xiaojin Wu  ORCID: orcid.org/0000-0003-3894-0631,Lei Lei,Zhinan Yin,Hongjian Sun,Di Yu,Haiyan Liu  ORCID: orcid.org/0000-0002-4652-469X,Yang Xu  ORCID: orcid.org/0000-0003-4643-2098 &…Depei Wu  ORCID: orcid.org/0000-0002-6312-3863 
https://doi.org/10.1038/s41392-022-01147-z
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Letter
A protective AAV vaccine for SARS-CoV-2
Simeng Zhao,Junzi Ke,Boyu Yang,Fangzhi Tan,Jie Yang,Chao-Po Lin,Haopeng Wang  ORCID: orcid.org/0000-0002-4995-0838 &…Guisheng Zhong  ORCID: orcid.org/0000-0003-0416-3774 
https://doi.org/10.1038/s41392-022-01158-w
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Pro-senescence neddylation inhibitor combined with a senescence activated β-galactosidase prodrug to selectively target cancer cells
Shuaishuai Ni,Qian Liu,Xin Chen,Lele Ding,Lili Cai,Fei Mao  ORCID: orcid.org/0000-0001-5871-6878,Donglei Shi,Robert M. Hoffman,Jian Li  ORCID: orcid.org/0000-0002-7521-8798 &…Lijun Jia 
https://doi.org/10.1038/s41392-022-01128-2
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Comparative neutralization profiles of naive and breakthrough infections with Delta, Omicron BA.1 and BA.2 variants of SARS-CoV-2
Yang Yang,Xiaohua Gong,Jun Wang,Shisong Fang,Jiaqi Zhang,Xuejiao Liao,Yuan Guan,Weihua Wu,Yingxia Liu  ORCID: orcid.org/0000-0001-6335-3346 &…Hongzhou Lu 
https://doi.org/10.1038/s41392-022-01166-w
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An updated RBD-Fc fusion vaccine booster increases neutralization of SARS-CoV-2 Omicron variants
Deyan Luo,Xiaolan Yang,Tao Li,Nianzhi Ning,Song Jin,Zhuangzhuang Shi,Hongjing Gu,Deyu Li,Yuwei Gao &…Hui Wang  ORCID: orcid.org/0000-0003-4011-9631 
https://doi.org/10.1038/s41392-022-01185-7
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SARS-CoV-2 Spike protein promotes vWF secretion and thrombosis via endothelial cytoskeleton-associated protein 4 (CKAP4)
Kan Li,Liu Yao  ORCID: orcid.org/0000-0001-9395-0096,Jin Wang,Hao Song,Yan-hong Zhang,Xue Bai,Kai Zhang,Dong-ming Zhou,Ding Ai &…Yi Zhu  ORCID: orcid.org/0000-0001-7725-9166 
https://doi.org/10.1038/s41392-022-01183-9
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Clusterin transduces Alzheimer-risk signals to amyloidogenesis
Xi Liu,Rongbo Che,Wenping Liang,Yun Zhang,Liyong Wu,Chao Han,Hong Lu,Weihong Song  ORCID: orcid.org/0000-0001-9928-889X,Yili Wu &…Zhe Wang  ORCID: orcid.org/0000-0003-4255-6763 
https://doi.org/10.1038/s41392-022-01157-x
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Intratumoral bacteria interact with metabolites and genetic alterations in hepatocellular carcinoma
Chen Xue,Junjun Jia,Xinyu Gu,Lin Zhou,Juan Lu,Qiuxian Zheng,Yuanshuai Su,Shusen Zheng &…Lanjuan Li 
https://doi.org/10.1038/s41392-022-01159-9
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Research Highlight
The cannabis paradox: contrasting role for marijuana in cardiovascular disease
Lin Deng,Bin Leng  ORCID: orcid.org/0000-0002-7909-6388 &Xiaowei Nie 
https://doi.org/10.1038/s41392-022-01160-2
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Circulating tumor DNA analysis: potential to revise adjuvant therapy for stage II colorectal cancer
Ning Zhu,Hanguang Hu &Ying Yuan  ORCID: orcid.org/0000-0002-3922-9553 
https://doi.org/10.1038/s41392-022-01164-y
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For the sake of longevity: eating less and eating at the right time
Fei Sun,Si Wang &Guang-Hui Liu  ORCID: orcid.org/0000-0001-9289-8177 
https://doi.org/10.1038/s41392-022-01163-z
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The interferon-γ receptor pathway: a new way to regulate CAR T cell-solid tumor cell adhesion
Lingjuan Hong &Lupeng Ye 
https://doi.org/10.1038/s41392-022-01165-x
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SLC7A11: a new regulator in diabetic wound healing
Shunli Rui,Yu Ma &Wuquan Deng 
https://doi.org/10.1038/s41392-022-01171-z
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The monkeypox outbreak in 2022: adaptive evolution associated with APOBEC3 may account for
Yangzhen Chen,Maochen Li  ORCID: orcid.org/0000-0001-8786-5039 &Huahao Fan  ORCID: orcid.org/0000-0001-5007-2158 
https://doi.org/10.1038/s41392-022-01181-x
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Structural insights into the Omicron spike trimer: tackling the challenges of continuously evolving SARS-CoV-2 variants
Junxian Ou,Jianguo Wu  ORCID: orcid.org/0000-0002-8326-2895 &Qiwei Zhang  ORCID: orcid.org/0000-0002-2770-111X 
https://doi.org/10.1038/s41392-022-01179-5
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Cytotoxic innate lymphoid cells sense tumor-derived IL-15: a novel mechanism of cancer immunosurveillance
Tobias Franz,Jonas Negele &Sascha Kahlfuss 
https://doi.org/10.1038/s41392-022-01173-x
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Cocktails of defined chemical compounds: sufficient to induce totipotency in embryonic stem cells
Wilfried A. Kues  ORCID: orcid.org/0000-0002-0850-8103 &Dharmendra Kumar 
https://doi.org/10.1038/s41392-022-01184-8
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Activated microglia nibbling glycosaminoglycans from spinal cord perineural nets: a new mechanism for neuropathic pain
Christa E. Müller &Tobias Claff  ORCID: orcid.org/0000-0001-8186-107X 
https://doi.org/10.1038/s41392-022-01162-0
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Cis-regulatory decoy disrupts autorepression: a potential escape-resistant anti-viral therapy
Jia Hu,Yuanqin Min &Xiulian Sun 
https://doi.org/10.1038/s41392-022-01187-5
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Four-wheel-drive immune protection
Fabian Heinrich  ORCID: orcid.org/0000-0002-2922-4863 &Susanne Krasemann  ORCID: orcid.org/0000-0001-8795-818X 
https://doi.org/10.1038/s41392-022-01180-y
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Omicron spike protein: a clue for viral entry and immune evasion
G. M. N. Behrens,A. Cossmann &M. Hoffmann  ORCID: orcid.org/0000-0003-4603-7696 
https://doi.org/10.1038/s41392-022-01193-7
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