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Volume 7 Issue 9, Sep 2022

Article
APOE interacts with ACE2 inhibiting SARS-CoV-2 cellular entry and inflammation in COVID-19 patients
Hongsheng Zhang,Lin Shao,Zhihao Lin,Quan-Xin Long  ORCID: orcid.org/0000-0003-1857-2798,Huilong Yuan,Lujian Cai,Guangtong Jiang,Xiaoyi Guo,Renzhi Yang,Zepeng Zhang,Bingchang Zhang,Fan Liu,Zhiyong Li,Qilin Ma,Yun-Wu Zhang,Ai-Long Huang  ORCID: orcid.org/0000-0003-0148-7423,Zhanxiang Wang,Yingjun Zhao &…Huaxi Xu  ORCID: orcid.org/0000-0001-7031-7853 
https://doi.org/10.1038/s41392-022-01118-4
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Cardiomyocyte-specific knockout of ADAM17 ameliorates left ventricular remodeling and function in diabetic cardiomyopathy of mice
Fei Xue,Jing Cheng,Yanping Liu,Cheng Cheng,Meng Zhang,Wenhai Sui,Wenqiang Chen,Panpan Hao,Yun Zhang &…Cheng Zhang 
https://doi.org/10.1038/s41392-022-01054-3
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Peptidic defective interfering gene nanoparticles against Omicron, Delta SARS-CoV-2 variants and influenza A virus in vivo
Hanjun Zhao,Chuyuan Zhang,Hoiyan Lam,Xinjie Meng,Zheng Peng,Man Lung Yeung,Jasper Fuk-Woo Chan  ORCID: orcid.org/0000-0001-6336-6657,Kelvin Kai-Wang To  ORCID: orcid.org/0000-0002-1921-5824 &…Kwok-Yung Yuen 
https://doi.org/10.1038/s41392-022-01138-0
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Targeting HECTD3-IKKα axis inhibits inflammation-related metastasis
Fubing Li,Huichun Liang,Hua You  ORCID: orcid.org/0000-0002-9630-5284,Ji Xiao,Houjun Xia,Xi Chen,Maobo Huang,Zhuo Cheng,Chuanyu Yang,Wenjing Liu,Hailin Zhang,Li Zeng,Yingying Wu,Fei Ge,Zhen Li,Wenhui Zhou,Yi Wen,Zhongmei Zhou,Rong Liu  ORCID: orcid.org/0000-0001-6123-9152,Dewei Jiang  ORCID: orcid.org/0000-0002-7773-5449,Ni Xie,Bin Liang,Zhenzhen Liu,Yanjie Kong &…Ceshi Chen  ORCID: orcid.org/0000-0001-6398-3516 
https://doi.org/10.1038/s41392-022-01057-0
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Human umbilical cord mesenchymal stem cells for psoriasis: a phase 1/2a, single-arm study
Lamei Cheng  ORCID: orcid.org/0000-0002-8685-3674,Siqi Wang,Cong Peng  ORCID: orcid.org/0000-0001-7104-5490,Xiao Zou,Chao Yang,Hua Mei,Chuang Li,Xian Su,Na Xiao,Qi Ouyang,Mi Zhang,Qiaolin Wang,Yan Luo,Minxue Shen,Qun Qin,Honglin Wang,Wu Zhu  ORCID: orcid.org/0000-0002-3645-7059,Guangxiu Lu,Ge Lin,Yehong Kuang  ORCID: orcid.org/0000-0002-1133-1791 &…Xiang Chen  ORCID: orcid.org/0000-0001-8187-636X 
https://doi.org/10.1038/s41392-022-01059-y
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ALOX15-launched PUFA-phospholipids peroxidation increases the susceptibility of ferroptosis in ischemia-induced myocardial damage
Xiao-Hui Ma,Jiang-Han-Zi Liu,Chun-Yu Liu,Wan-Yang Sun,Wen-Jun Duan,Guan Wang,Hiroshi Kurihara,Rong-Rong He,Yi-Fang Li,Yang Chen &…Hongcai Shang  ORCID: orcid.org/0000-0001-5505-5672 
https://doi.org/10.1038/s41392-022-01090-z
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DDX39B drives colorectal cancer progression by promoting the stability and nuclear translocation of PKM2
Gang Zhao,Hang Yuan,Qin Li,Jie Zhang,Yafei Guo,Tianyu Feng,Rui Gu,Deqiong Ou,Siqi Li,Kai Li &…Ping Lin  ORCID: orcid.org/0000-0001-8982-8397 
https://doi.org/10.1038/s41392-022-01096-7
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Multi-omics analysis reveals RNA splicing alterations and their biological and clinical implications in lung adenocarcinoma
Quanyou Wu,Lin Feng,Yaru Wang,Yousheng Mao,Xuebing Di,Kaitai Zhang,Shujun Cheng &…Ting Xiao  ORCID: orcid.org/0000-0002-9000-1909 
https://doi.org/10.1038/s41392-022-01098-5
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The heterogeneous immune landscape between lung adenocarcinoma and squamous carcinoma revealed by single-cell RNA sequencing
Chengdi Wang  ORCID: orcid.org/0000-0002-5284-2889,Qiuxiao Yu,Tingting Song,Zhoufeng Wang,Lujia Song,Ying Yang,Jun Shao,Jingwei Li,Yinyun Ni,Ningning Chao,Li Zhang &…Weimin Li  ORCID: orcid.org/0000-0003-0985-0311 
https://doi.org/10.1038/s41392-022-01130-8
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A potent neutralizing antibody provides protection against SARS-CoV-2 Omicron and Delta variants via nasal delivery
Xinghai Zhang,Huajun Zhang  ORCID: orcid.org/0000-0001-8161-3949,Tingting Li,Shaohong Chen,Feiyang Luo,Junhui Zhou,Peiyi Zheng,Shuyi Song,Yan Wu,Tengchuan Jin  ORCID: orcid.org/0000-0002-1395-188X,Ni Tang  ORCID: orcid.org/0000-0001-5830-8786,Aishun Jin,Chengyong Yang,Guofeng Cheng,Rui Gong  ORCID: orcid.org/0000-0001-9222-5642,Sandra Chiu  ORCID: orcid.org/0000-0001-9034-5755 &…Ailong Huang  ORCID: orcid.org/0000-0003-0148-7423 
https://doi.org/10.1038/s41392-022-01135-3
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p53 positively regulates the proliferation of hepatic progenitor cells promoted by laminin-521
Mingyang Ma,Shuyao Hua,Xiangde Min,Liang Wang,Jun Li,Ping Wu,Huifang Liang,Bixiang Zhang,Xiaoping Chen  ORCID: orcid.org/0000-0001-8636-0493 &…Shuai Xiang 
https://doi.org/10.1038/s41392-022-01107-7
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Research Highlight
Linking B cell metabolism to immune regulation: the neurotransmitter GABA
Yang Shi 
https://doi.org/10.1038/s41392-022-01120-w
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Ketogenic diet: new avenues to overcome colorectal cancer
Yuancai Xiang,Meng Wang &Hongming Miao  ORCID: orcid.org/0000-0001-6355-3612 
https://doi.org/10.1038/s41392-022-01113-9
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Structural insights into Cas9 mismatch: promising for development of high-fidelity Cas9 variants
Honghai Tang,Daqi Wang &Yilai Shu 
https://doi.org/10.1038/s41392-022-01139-z
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Targeting folliculin to selectively inhibit mTORC1: a promising strategy for treating nonalcoholic fatty liver disease
Yan Ling,Yanpeng Li &Liang Li  ORCID: orcid.org/0000-0002-9410-6513 
https://doi.org/10.1038/s41392-022-01111-x
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Curse and blessing: upregulation of oncogenes upon treatment with hypomethylating agents in myelodysplastic syndrome
Juliane Grimm &Mascha Binder  ORCID: orcid.org/0000-0003-0663-3004 
https://doi.org/10.1038/s41392-022-01143-3
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Enhancer-promoter communication: unraveling enhancer strength and positioning within a given topologically associating domain (TAD)
Benedetto Daniele Giaimo &Tilman Borggrefe 
https://doi.org/10.1038/s41392-022-01114-8
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Mitochondrial pyruvate carrier: a metabolic-epigenetic checkpoint orchestrating T cell differentiation
Yu Chen,Jingchun Wang &Yongsheng Li  ORCID: orcid.org/0000-0003-2175-9449 
https://doi.org/10.1038/s41392-022-01101-z
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Time’s up: mutation rate and lifespan
Anjali Cremer,Wesley T. Abplanalp  ORCID: orcid.org/0000-0001-5996-8997 &Michael A. Rieger 
https://doi.org/10.1038/s41392-022-01122-8
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Engineered virus-like particles: paving the way for effective somatic genome editing
Chenya Zhuo,Yu Tao &Mingqiang Li  ORCID: orcid.org/0000-0002-5178-4138 
https://doi.org/10.1038/s41392-022-01089-6
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Dynamic mechanism of GPCR-mediated β-arrestin: a potential therapeutic agent discovery of biased drug
Zheng Xu &Zhenhua Shao  ORCID: orcid.org/0000-0001-7204-801X 
https://doi.org/10.1038/s41392-022-01140-6
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Gut microbes regulate the feeding center: a new discovery of Gut Brain Axis
Fengwu Chen,Kaijian Hou &Zhe-Sheng Chen  ORCID: orcid.org/0000-0002-8289-097X 
https://doi.org/10.1038/s41392-022-01117-5
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Mitochondrial apoptosis: facilitator of NK cell-mediated immunotherapy
Evelyn Ullrich  ORCID: orcid.org/0000-0001-8530-1192,Meike Vogler &Ivana von Metzler 
https://doi.org/10.1038/s41392-022-01126-4
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Supporting tumor therapy by exercise: boosting T cell immunity by myokines
Kristina Gebhardt &Karsten Krüger  ORCID: orcid.org/0000-0003-1506-8254 
https://doi.org/10.1038/s41392-022-01116-6
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Caspase-7 and acid sphingomyelinase: partner repairmans of gasdermin and perforin pores
Ke Jin  ORCID: orcid.org/0000-0001-5371-3440 &Guofang Shen 
https://doi.org/10.1038/s41392-022-01144-2
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Limited cross-variant neutralization after primary Omicron infection: consideration for a variant-containing booster
Harold Marcotte,Lennart Hammarström &Qiang Pan-Hammarström 
https://doi.org/10.1038/s41392-022-01146-0
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Stretching on chromosomes sheds light on their architecture
Ramona Jühlen &Wolfram Antonin 
https://doi.org/10.1038/s41392-022-01141-5
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T-cell immunity: a barrier to Omicron immune evasion
Fei Yu,Wanbo Tai &Gong Cheng 
https://doi.org/10.1038/s41392-022-01142-4
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A new insight for stem cell therapy: apoptotic stem cells as a key player
Yuhe Huang,Ziyi Bai &Kang Zhang 
https://doi.org/10.1038/s41392-022-01066-z
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Sensation of pleasant touch: from molecules to circuits and behaviours
Ruining Hu &Rongfeng K. Hu 
https://doi.org/10.1038/s41392-022-01161-1
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Review Article
Regulation of cholesterol homeostasis in health and diseases: from mechanisms to targeted therapeutics
Yajun Duan,Ke Gong,Suowen Xu,Feng Zhang,Xianshe Meng &…Jihong Han 
https://doi.org/10.1038/s41392-022-01125-5
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Stem cell-based therapy for human diseases
Duc M. Hoang  ORCID: orcid.org/0000-0001-5444-561X,Phuong T. Pham,Trung Q. Bach,Anh T. L. Ngo,Quyen T. Nguyen,Trang T. K. Phan,Giang H. Nguyen,Phuong T. T. Le,Van T. Hoang,Nicholas R. Forsyth,Michael Heke &…Liem Thanh Nguyen 
https://doi.org/10.1038/s41392-022-01134-4
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Targeted therapeutics and novel signaling pathways in non-alcohol-associated fatty liver/steatohepatitis (NAFL/NASH)
Xiaohan Xu,Kyle L. Poulsen,Lijuan Wu,Shan Liu,Tatsunori Miyata,Qiaoling Song,Qingda Wei,Chenyang Zhao  ORCID: orcid.org/0000-0002-4716-2002,Chunhua Lin &…Jinbo Yang 
https://doi.org/10.1038/s41392-022-01119-3
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Regulated cell death (RCD) in cancer: key pathways and targeted therapies
Fu Peng,Minru Liao,Rui Qin,Shiou Zhu,Cheng Peng,Leilei Fu  ORCID: orcid.org/0000-0002-0857-2682,Yi Chen &…Bo Han 
https://doi.org/10.1038/s41392-022-01110-y
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Classical epithelial-mesenchymal transition (EMT) and alternative cell death process-driven blebbishield metastatic-witch (BMW) pathways to cancer metastasis
Goodwin G. Jinesh  ORCID: orcid.org/0000-0002-2170-3245 &Andrew S. Brohl 
https://doi.org/10.1038/s41392-022-01132-6
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Signaling pathways in obesity: mechanisms and therapeutic interventions
Xue Wen,Bohan Zhang  ORCID: orcid.org/0000-0003-0337-1002,Beiyi Wu,Haitao Xiao,Zehua Li,Ruoyu Li,Xuewen Xu &…Tao Li  ORCID: orcid.org/0000-0002-7988-3090 
https://doi.org/10.1038/s41392-022-01149-x
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The RING finger protein family in health and disease
Chunmei Cai,Yan-Dong Tang,Jingbo Zhai &…Chunfu Zheng  ORCID: orcid.org/0000-0002-8797-1322 
https://doi.org/10.1038/s41392-022-01152-2
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Letter
A cis-eQTL in NSUN2 promotes esophageal squamous-cell carcinoma progression and radiochemotherapy resistance by mRNA-m5C methylation
Xiangjie Niu,Linna Peng,Weiling Liu,Chuanwang Miao,Xinjie Chen,Jiahui Chu,Xinyu Yang,Wen Tan,Chen Wu &…Dongxin Lin  ORCID: orcid.org/0000-0002-8723-8868 
https://doi.org/10.1038/s41392-022-01063-2
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Multi-omics characterization and therapeutic liability of ferroptosis in melanoma
Yi He,Yu Dong,Yong Chen,Guanxiong Zhang,Hailun Zhang,Guang Lei,Yanhua Du,Xiang Chen  ORCID: orcid.org/0000-0001-8187-636X,Youqiong Ye  ORCID: orcid.org/0000-0001-8332-4710 &…Hong Liu 
https://doi.org/10.1038/s41392-022-01067-y
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A dual-specific CRISPR-Cas nanosystem for precision therapeutic editing of liver disorders
Xiaojie Xu,Honglin Tang,Jiajing Guo,Huhu Xin &…Yuan Ping 
https://doi.org/10.1038/s41392-022-01071-2
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Cross-neutralization and cross-protection among SARS-CoV-2 viruses bearing different variant spikes
Yang Liu  ORCID: orcid.org/0000-0002-0029-3718,Jianying Liu,Jing Zou,Birte Kalveram,Rafael R. G. Machado,Ping Ren,Sina Türeli,Derek J. Smith  ORCID: orcid.org/0000-0002-2393-1890,Scott C. Weaver,Xuping Xie  ORCID: orcid.org/0000-0003-0918-016X &…Pei-Yong Shi 
https://doi.org/10.1038/s41392-022-01137-1
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Discovery of a mammalian FASN inhibitor against xenografts of non-small cell lung cancer and melanoma
Danfeng Cao,Jie Yang,Youchao Deng,Meng Su,Yeji Wang,Xueqiong Feng,Yi Xiong,Enhe Bai,Yanwen Duan &…Yong Huang  ORCID: orcid.org/0000-0002-3163-1716 
https://doi.org/10.1038/s41392-022-01099-4
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Artesunate suppresses Th17 response via inhibiting IRF4-mediated glycolysis and ameliorates Sjog̈ren’s syndrome
Fan Xiao,Ke Rui,Man Han,Liyun Zou,Enyu Huang,Jie Tian,Lijun Zhang,Quan Jiang,Yuzhang Wu &…Liwei Lu 
https://doi.org/10.1038/s41392-022-01103-x
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