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Volume 7 Issue 8, Aug 2022

Letter
Unravelling the enhanced vaccine immunity by heterologous KCONVAC/Ad5-nCoV COVID-19 vaccination
Weijun Zhao,Huajun Zhao,Baoying Huang,Tongyi Zhao,Limei Wang,Jian Zhang,Yong Yang  ORCID: orcid.org/0000-0002-2841-8420,Xinying Tang,Wenjie Tan &…Ang Lin  ORCID: orcid.org/0000-0001-5662-1576 
https://doi.org/10.1038/s41392-022-01079-8
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Mutually exclusive epigenetic modification on SIX6 with hypermethylation for precancerous stage and metastasis emergence tracing
Shihua Dong,Zhicong Yang,Peng Xu,Wanxiang Zheng,Baolong Zhang,Fangqiu Fu,Zhanrui Mao,Jianlin Yuan  ORCID: orcid.org/0000-0001-9166-3528,Haiquan Chen &…Wenqiang Yu 
https://doi.org/10.1038/s41392-022-01026-7
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Rapidly developable therapeutic-grade equine immunoglobulin against the SARS-CoV-2 infection in rhesus macaques
Xiaolei Liu,Yi Liu,Xuemin Jin,Zhanlong He,Zhen Huang,Shumin Sun,Yuwei Gao,Jingyu Li,Qin Ning,Zhongping Xie,Ningyi Jin &…Mingyuan Liu 
https://doi.org/10.1038/s41392-022-01095-8
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STAT3-NAV2 axis as a new therapeutic target for rheumatoid arthritis via activating SSH1L/Cofilin-1 signaling pathway
Ran Wang  ORCID: orcid.org/0000-0002-2203-0097,Jianghong Cai,Keyuan Chen,Menglin Zhu,Zhaoyi Li,Hua Liu,Tiantian Liu,Jianchun Mao,Qian Ding &…Yi Zhun Zhu  ORCID: orcid.org/0000-0001-7700-8041 
https://doi.org/10.1038/s41392-022-01050-7
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Umbilical cord artery-derived perivascular stem cells for treatment of ovarian failure through CD146 signaling
Lu Xu,Yanjun Yang,Lingling Zhang,Guijun Yan,Shiyuan Li,Yifan Li,Yali Hu,Lijun Ding,Bruno Péault &…Haixiang Sun 
https://doi.org/10.1038/s41392-022-01029-4
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SeHed, a novel gene expression system with stress-evoked hydrogen peroxide elimination property and anti-aging effect
Ning Huang,Honghan Chen,Hui Gong,Haoran Tai,Xiaojuan Han,Xiaobo Wang,Chuhui Gong,Tingting Zhao,Yu Yang &…Hengyi Xiao 
https://doi.org/10.1038/s41392-022-01047-2
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CD24Fc ameliorates immune-related adverse events while preserving anti-tumor therapeutic effect
Mingyue Liu,Xu Wang,Xuexiang Du,Yan Zhang,Chunxia Ai,Siwen Hu-Lieskovan,Tianhong Li,Martin Devenport,Yang Liu  ORCID: orcid.org/0000-0002-9442-700X &…Pan Zheng 
https://doi.org/10.1038/s41392-022-01030-x
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Spatial control of robust transgene expression in mouse artery endothelium under ultrasound guidance
Renfa Liu,Shuai Qu,Yunxue Xu,Hanjoong Jo  ORCID: orcid.org/0000-0003-1833-372X &…Zhifei Dai 
https://doi.org/10.1038/s41392-022-01031-w
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Heterologous mRNA vaccine booster increases neutralization of SARS-CoV-2 Omicron BA.2 variant
Gen Li,Zhongcheng Zhou,Peng Du  ORCID: orcid.org/0000-0002-8730-8520,Meixiao Zhan,Ning Li,Xinxin Xiong,Shengjun Tang,Miao Man,Daniel T. Baptista-Hon  ORCID: orcid.org/0000-0002-5358-1035 &…Ligong Lu 
https://doi.org/10.1038/s41392-022-01062-3
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Research Highlight
SARS-CoV-2 Omicron: a new challenge for pandemic and vaccine
Xiantao Zhang,Hui Zhang  ORCID: orcid.org/0000-0003-3620-610X &Xin He  ORCID: orcid.org/0000-0002-2131-2092 
https://doi.org/10.1038/s41392-022-01088-7
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Substrates of the m6A demethylase FTO: FTO-LINE1 RNA axis regulates chromatin state in mESCs
Pia Sommerkamp 
https://doi.org/10.1038/s41392-022-01085-w
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Prime time for base editing in the mitochondria
Michael A. Morgan,Lucas Lange &Axel Schambach 
https://doi.org/10.1038/s41392-022-01068-x
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T-ISAAC: a novel TCR cloning system derived from T cells’ cis activation
Zehua Tian 
https://doi.org/10.1038/s41392-022-01086-9
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Macrophage invasion: here, there and everywhere
Lola C. Hernandez &Pablo J. Sáez  ORCID: orcid.org/0000-0003-0521-9426 
https://doi.org/10.1038/s41392-022-01074-z
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Stachel-mediated activation of adhesion G protein-coupled receptors: insights from cryo-EM studies
Ines Liebscher  ORCID: orcid.org/0000-0003-4480-8987,Torsten Schöneberg &Doreen Thor  ORCID: orcid.org/0000-0002-9522-5098 
https://doi.org/10.1038/s41392-022-01083-y
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STING cg16983159 methylation: a key factor for glioblastoma immunosuppression
Lei Qiu,Yang Meng &Junhong Han  ORCID: orcid.org/0000-0002-3371-8698 
https://doi.org/10.1038/s41392-022-01093-w
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SARS-CoV-2 infection and the brain: direct evidence for brain changes in milder cases
Nico Sollmann  ORCID: orcid.org/0000-0002-8120-2223,Ambros J. Beer &Frank Kirchhoff  ORCID: orcid.org/0000-0002-7052-2360 
https://doi.org/10.1038/s41392-022-01072-1
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A new way to maintain CD8+ T-cell quiescence: interaction between CD8α and PILRα
Ke Jin  ORCID: orcid.org/0000-0001-5371-3440 &Bowen Wu 
https://doi.org/10.1038/s41392-022-01094-9
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Chemoimmunotherapy in advanced esophageal squamous cell carcinoma: optimizing chemotherapy regimens for immunotherapy combinations
Zhichao Liu  ORCID: orcid.org/0000-0003-3542-0905,Jun Liu &Zhigang Li  ORCID: orcid.org/0000-0001-5086-5334 
https://doi.org/10.1038/s41392-022-01077-w
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Hypocretin neuron hyperexcitability in the hypothalamus: a newly discovered culprit in aging-related sleep impairment
Tianbai Li,Congcong Jia &Weidong Le 
https://doi.org/10.1038/s41392-022-01091-y
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Epstein-Barr virus infection: the leading cause of multiple sclerosis
Ruirui He,Yanyun Du &Chenhui Wang 
https://doi.org/10.1038/s41392-022-01100-0
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Restored oligodendrogenesis by fibroblast growth factor 17: molecular mechanism for rejuvenating ageing-related memory deficit
Xiao-Yi Xiong,Alexey Semyanov &Yong Tang  ORCID: orcid.org/0000-0002-2543-066X 
https://doi.org/10.1038/s41392-022-01092-x
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ESCRT machinery: role of membrane repair mechanisms in escaping cell death
Lisa Gregor  ORCID: orcid.org/0000-0002-3300-7167,Sophia Stock  ORCID: orcid.org/0000-0002-5072-5013 &Sebastian Kobold  ORCID: orcid.org/0000-0002-5612-4673 
https://doi.org/10.1038/s41392-022-01108-6
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Back to pluripotency: fully chemically induced reboot of human somatic cells
Lucas Lange,Miguel A. Esteban &Axel Schambach 
https://doi.org/10.1038/s41392-022-01109-5
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The beginning of a new era: pioneering direct screens for RNA modulators
F. X. Reymond Sutandy,Rebecca George Tharyan &Christian Münch  ORCID: orcid.org/0000-0003-3832-090X 
https://doi.org/10.1038/s41392-022-01069-w
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Olfactory receptor 2 activation in macrophages: novel mediator of atherosclerosis progression
Zuowen He &Dao Wen Wang 
https://doi.org/10.1038/s41392-022-01115-7
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TMPRSS2, a novel host-directed drug target against SARS-CoV-2
Christian Keller  ORCID: orcid.org/0000-0002-0075-7199,Eva Böttcher-Friebertshäuser &Michael Lohoff 
https://doi.org/10.1038/s41392-022-01084-x
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SARS-CoV-2 infection of monocytes: balancing acts of antibodies and inflammasomes
R. Camille Brewer,William H. Robinson  ORCID: orcid.org/0000-0003-4385-704X &Tobias V. Lanz  ORCID: orcid.org/0000-0001-7106-8801 
https://doi.org/10.1038/s41392-022-01112-w
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Trilateral interaction between innervation, leukocyte, and adventitia: a new driver of atherosclerotic plaque formation
Yahya Sohrabi,Holger Reinecke &Oliver Soehnlein 
https://doi.org/10.1038/s41392-022-01121-9
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Review Article
The role of histone modifications: from neurodevelopment to neurodiseases
Jisu Park,Kyubin Lee,Kyunghwan Kim  ORCID: orcid.org/0000-0001-5622-2452 &…Sun-Ju Yi 
https://doi.org/10.1038/s41392-022-01078-9
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Signaling pathways involved in ischemic stroke: molecular mechanisms and therapeutic interventions
Chuan Qin  ORCID: orcid.org/0000-0001-5162-3150,Sheng Yang,Yun-Hui Chu,Hang Zhang,Xiao-Wei Pang,Lian Chen,Luo-Qi Zhou,Man Chen,Dai-Shi Tian &…Wei Wang 
https://doi.org/10.1038/s41392-022-01064-1
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Trends in insulin resistance: insights into mechanisms and therapeutic strategy
Mengwei Li,Xiaowei Chi,Ying Wang,Sarra Setrerrahmane,Wenwei Xie &…Hanmei Xu 
https://doi.org/10.1038/s41392-022-01073-0
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Hypoxia signaling in human health and diseases: implications and prospects for therapeutics
Zhen Luo  ORCID: orcid.org/0000-0002-1142-2845,Mingfu Tian,Ge Yang,Qiaoru Tan,Yubing Chen,Geng Li,Qiwei Zhang  ORCID: orcid.org/0000-0002-2770-111X,Yongkui Li,Pin Wan &…Jianguo Wu  ORCID: orcid.org/0000-0002-8326-2895 
https://doi.org/10.1038/s41392-022-01080-1
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Animal models for COVID-19: advances, gaps and perspectives
Changfa Fan,Yong Wu,Xiong Rui,Yuansong Yang,Chen Ling,Susu Liu,Shunan Liu &…Youchun Wang  ORCID: orcid.org/0000-0001-9769-5141 
https://doi.org/10.1038/s41392-022-01087-8
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Liquid–liquid phase separation in tumor biology
Xuhui Tong,Rong Tang,Jin Xu,Wei Wang,Yingjun Zhao  ORCID: orcid.org/0000-0002-9678-6276,Xianjun Yu  ORCID: orcid.org/0000-0002-6697-7143 &…Si Shi 
https://doi.org/10.1038/s41392-022-01076-x
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Signalling pathways in autism spectrum disorder: mechanisms and therapeutic implications
Chen-Chen Jiang,Li-Shan Lin,Sen Long,Xiao-Yan Ke,Kohji Fukunaga,Ying-Mei Lu &…Feng Han 
https://doi.org/10.1038/s41392-022-01081-0
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Nanoparticles in the diagnosis and treatment of vascular aging and related diseases
Hui Xu,Shuang Li &You-Shuo Liu  ORCID: orcid.org/0000-0001-9835-4074 
https://doi.org/10.1038/s41392-022-01082-z
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Alveolar macrophages: Achilles’ heel of SARS-CoV-2 infection
Zhenfeng Wang,Shunshun Li &Bo Huang  ORCID: orcid.org/0000-0001-8476-1138 
https://doi.org/10.1038/s41392-022-01106-8
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Dietary regulation in health and disease
Qi Wu  ORCID: orcid.org/0000-0001-6182-5274,Zhi-Jie Gao,Xin Yu &…Ping Wang  ORCID: orcid.org/0000-0002-9922-5407 
https://doi.org/10.1038/s41392-022-01104-w
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Radiotherapy combined with immunotherapy: the dawn of cancer treatment
Zengfu Zhang,Xu Liu,Dawei Chen &…Jinming Yu 
https://doi.org/10.1038/s41392-022-01102-y
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Article
Berberine treats atherosclerosis via a vitamine-like effect down-regulating Choline-TMA-TMAO production pathway in gut microbiota
Shu-Rong Ma,Qian Tong,Yuan Lin,Li-Bin Pan,Jie Fu,Ran Peng,Xian-Feng Zhang,Zhen-Xiong Zhao,Yang Li,Jin-Bo Yu,Lin Cong,Pei Han,Zheng-Wei Zhang,Hang Yu,Yan Wang &…Jian-Dong Jiang  ORCID: orcid.org/0000-0003-1173-685X 
https://doi.org/10.1038/s41392-022-01027-6
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Dihydroartemisinin regulates immune cell heterogeneity by triggering a cascade reaction of CDK and MAPK phosphorylation
Qilong Li,Quan Yuan,Ning Jiang,Yiwei Zhang,Ziwei Su,Lei Lv,Xiaoyu Sang,Ran Chen,Ying Feng &…Qijun Chen 
https://doi.org/10.1038/s41392-022-01028-5
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RNA-binding protein ZCCHC4 promotes human cancer chemoresistance by disrupting DNA-damage-induced apoptosis
Ha Zhu,Kun Chen,Yali Chen,Juan Liu,Xiaomin Zhang,Yumei Zhou,Qiuyan Liu,Bingjing Wang,Taoyong Chen &…Xuetao Cao 
https://doi.org/10.1038/s41392-022-01033-8
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Inhibition of pancreatic EZH2 restores progenitor insulin in T1D donor
Keith Al-Hasani  ORCID: orcid.org/0000-0001-6109-5603,Ishant Khurana,Lina Mariana,Thomas Loudovaris,Scott Maxwell  ORCID: orcid.org/0000-0002-7801-0714,K. N. Harikrishnan,Jun Okabe  ORCID: orcid.org/0000-0002-7196-0522,Mark E. Cooper &…Assam El-Osta  ORCID: orcid.org/0000-0001-7968-7375 
https://doi.org/10.1038/s41392-022-01034-7
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Identification of heptapeptides targeting a lethal bacterial strain in septic mice through an integrative approach
Xiaoyan Zhang,Shan Li,Haihua Luo,Shuyue He,Huangda Yang,Lei Li,Tian Tian,Qizheng Han,Jiacong Ye,Chenyang Huang,Aihua Liu &…Yong Jiang  ORCID: orcid.org/0000-0002-8087-5717 
https://doi.org/10.1038/s41392-022-01035-6
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Cross-reactivity of eight SARS-CoV-2 variants rationally predicts immunogenicity clustering in sarbecoviruses
Qianqian Li,Li Zhang,Ziteng Liang,Nan Wang  ORCID: orcid.org/0000-0002-9936-9179,Shuo Liu,Tao Li,Yuanling Yu,Qianqian Cui,Xi Wu,Jianhui Nie,Jiajing Wu,Zhimin Cui,Qiong Lu,Xiangxi Wang  ORCID: orcid.org/0000-0003-0635-278X,Weijin Huang  ORCID: orcid.org/0000-0002-4246-8889 &…Youchun Wang  ORCID: orcid.org/0000-0001-9769-5141 
https://doi.org/10.1038/s41392-022-01123-7
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SARS-CoV-2 nucleocapsid protein triggers hyperinflammation via protein-protein interaction-mediated intracellular Cl− accumulation in respiratory epithelium
Lei Chen  ORCID: orcid.org/0000-0002-9488-1173,Wei-Jie Guan,Zhuo-Er Qiu,Jian-Bang Xu,Xu Bai,Xiao-Chun Hou,Jing Sun,Su Qu,Ze-Xin Huang,Tian-Lun Lei,Zi-Yang Huang,Jincun Zhao  ORCID: orcid.org/0000-0003-2515-5589,Yun-Xin Zhu,Ke-Nan Ye,Zhao-Rong Lun,Wen-Liang Zhou  ORCID: orcid.org/0000-0001-9124-3144,Nan-Shan Zhong &…Yi-Lin Zhang  ORCID: orcid.org/0000-0001-5350-8279 
https://doi.org/10.1038/s41392-022-01048-1
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Functional isolation, culture and cryopreservation of adult human primary cardiomyocytes
Bingying Zhou,Xun Shi,Xiaoli Tang,Quanyi Zhao,Le Wang,Fang Yao,Yongfeng Hou,Xianqiang Wang,Wei Feng,Liqing Wang,Xiaogang Sun,Li Wang  ORCID: orcid.org/0000-0002-5570-1336 &…Shengshou Hu 
https://doi.org/10.1038/s41392-022-01044-5
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Comparative characterization of antibody responses induced by Ad5-vectored spike proteins of emerging SARS-CoV-2 VOCs
Busen Wang  ORCID: orcid.org/0000-0001-9041-1919,Jinghan Xu,Shipo Wu,Zhe Zhang,Zhenghao Zhao,Jun Zhang  ORCID: orcid.org/0000-0002-9650-112X,Ling Fu,Xiaodong Zai,Yudong Wang,Guanying Zhang,ZhengShan Chen,Yi Chen,Hancong Sun,Xiaohong Song,Jinlong Zhang,Lianhui Zhu,Lihua Hou &…Wei Chen  ORCID: orcid.org/0000-0001-5805-2469 
https://doi.org/10.1038/s41392-022-01065-0
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Cardiomyocytes induced from hiPSCs by well-defined compounds have therapeutic potential in heart failure by secreting PDGF-BB
Hongmei Li,Fenfang Wu,Guangrui Huang,Di Wu,Ting Wang,Xiashuang Wang,Kai Wang,Yuyin Feng &…Anlong Xu 
https://doi.org/10.1038/s41392-022-01045-4
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Perspective
Origin, virological features, immune evasion and intervention of SARS-CoV-2 Omicron sublineages
Shuai Xia,Lijue Wang,Yun Zhu  ORCID: orcid.org/0000-0001-9382-8592,Lu Lu  ORCID: orcid.org/0000-0002-2255-0391 &…Shibo Jiang  ORCID: orcid.org/0000-0001-8283-7135 
https://doi.org/10.1038/s41392-022-01105-9
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