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Volume 7 Issue 7, Jul 2022

Article
BOD1 regulates the cerebellar IV/V lobe-fastigial nucleus circuit associated with motor coordination
Xiu-Xiu Liu,Xing-Hui Chen,Zhi-Wei Zheng,Qin Jiang,Chen Li,Lin Yang,Xiang Chen,Xing-Feng Mao,Hao-Yang Yuan  ORCID: orcid.org/0000-0002-4059-3184,Li-Li Feng,Quan Jiang,Wei-Xing Shi,Takuya Sasaki,Kohji Fukunaga,Zhong Chen  ORCID: orcid.org/0000-0003-4755-9357,Feng Han &…Ying-Mei Lu 
https://doi.org/10.1038/s41392-022-00989-x
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Excessive branched-chain amino acid accumulation restricts mesenchymal stem cell-based therapy efficacy in myocardial infarction
Fuyang Zhang  ORCID: orcid.org/0000-0002-6335-9809,Guangyu Hu  ORCID: orcid.org/0000-0002-9091-4484,Xiyao Chen,Ling Zhang,Lanyan Guo,Congye Li,Hang Zhao,Zhe Cui,Xiong Guo,Fangfang Sun,Dandan Song,Wenjun Yan,Yunlong Xia,Shan Wang,Miaomiao Fan &…Ling Tao 
https://doi.org/10.1038/s41392-022-00971-7
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Immunogenicity and safety of NVSI-06-07 as a heterologous booster after priming with BBIBP-CorV: a phase 2 trial
Nawal Al Kaabi,Yun Kai Yang,Jing Zhang,Ke Xu,Yu Liang,Yun Kang,Ji Guo Su,Tian Yang,Salah Hussein,Mohamed Saif ElDein,Shuai Shao,Sen Sen Yang,Wenwen Lei,Xue Jun Gao,Zhiwei Jiang,Hui Wang,Meng Li,Hanadi Mekki Mekki,Walid Zaher,Sally Mahmoud  ORCID: orcid.org/0000-0003-1348-9063,Xue Zhang,Chang Qu,Dan Ying Liu,Jing Zhang,Mengjie Yang,Islam Eltantawy,Peng Xiao,Zhao Nian Wang,Jin Liang Yin,Xiao Yan Mao,Jin Zhang,Ning Liu,Fu Jie Shen,Liang Qu,Yun Tao Zhang,Xiao Ming Yang  ORCID: orcid.org/0000-0002-2598-4355,Guizhen Wu &…Qi Ming Li  ORCID: orcid.org/0000-0001-8284-7106 
https://doi.org/10.1038/s41392-022-00984-2
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LDL receptor-related protein 1 (LRP1), a novel target for opening the blood-labyrinth barrier (BLB)
Xi Shi,Zihao Wang,Wei Ren  ORCID: orcid.org/0000-0003-1975-6046,Long Chen  ORCID: orcid.org/0000-0002-7802-5094,Cong Xu,Menghua Li,Shiyong Fan,Yuru Xu,Mengbing Chen,Fanjun Zheng,Wenyuan Zhang,Xinbo Zhou,Yue Zhang,Shiwei Qiu,Liyuan Wu,Peng Zhou,Xinze Lv,Tianyu Cui,Yuehua Qiao,Hui Zhao,Weiwei Guo,Wei Chen,Song Li,Wu Zhong  ORCID: orcid.org/0000-0002-0536-620X,Jian Lin  ORCID: orcid.org/0000-0002-1519-9679 &…Shiming Yang 
https://doi.org/10.1038/s41392-022-00995-z
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RING finger 138 deregulation distorts NF-кB signaling and facilities colitis switch to aggressive malignancy
Yalan Lu,Rong Huang,Jianming Ying,Xingchen Li,Tao Jiao,Lei Guo,Haitao Zhou,Han Wang,Amannisa Tuersuntuoheti,Jianmei Liu,Qichen Chen,Yanhong Wang,Luying Su,Changyuan Guo,Fu Xu,Ziyi Wang,Yan Lu,Kai Li,Junbo Liang,Zhen Huang,Xiao Chen,Jinjie Yao,Hanjie Hu,Xiaowen Cheng,Yufeng Wan,Xinyan Chen,Ning Zhang,Shiying Miao,Jianqiang Cai,Linfang Wang,Changzheng Liu,Wei Song &…Hong Zhao 
https://doi.org/10.1038/s41392-022-00985-1
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Chimeric cerebral organoids reveal the essentials of neuronal and astrocytic APOE4 for Alzheimer’s tau pathology
Shichao Huang,Zhen Zhang,Junwei Cao,Yongchun Yu &…Gang Pei 
https://doi.org/10.1038/s41392-022-01006-x
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Chronic spinal cord injury repair by NT3-chitosan only occurs after clearance of the lesion scar
Can Zhao,Jia-Sheng Rao  ORCID: orcid.org/0000-0002-5196-0912,Hongmei Duan,Peng Hao,Junkui Shang,Yubo Fan,Wen Zhao,Yudan Gao,Zhaoyang Yang,Yi Eve Sun &…Xiaoguang Li 
https://doi.org/10.1038/s41392-022-01010-1
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Dietary folate drives methionine metabolism to promote cancer development by stabilizing MAT IIA
Jin-Tao Li,Hai Yang,Ming-Zhu Lei,Wei-Ping Zhu,Ying Su,Kai-Yue Li,Wen-Ying Zhu,Jian Wang,Lei Zhang,Jia Qu,Lei Lv,Hao-Jie Lu,Zheng-Jun Chen,Lu Wang,Miao Yin &…Qun-Ying Lei  ORCID: orcid.org/0000-0002-8547-8518 
https://doi.org/10.1038/s41392-022-01017-8
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CB1R-stabilized NLRP3 inflammasome drives antipsychotics cardiotoxicity
Liliang Li,Pan Gao,Xinru Tang,Zheng Liu,Mengying Cao,Ruoyu Luo,Xiaoqing Li,Jing Wang,Xinyi Lin,Chao Peng  ORCID: orcid.org/0000-0002-6814-2676,Zhihong Li,Jianhua Zhang,Xian Zhang,Zhonglian Cao,Yunzeng Zou &…Li Jin 
https://doi.org/10.1038/s41392-022-01018-7
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m6A demethylase ALKBH5 is required for antibacterial innate defense by intrinsic motivation of neutrophil migration
Yang Liu  ORCID: orcid.org/0000-0002-5636-030X,Renjie Song,Lu Zhao,Zhike Lu,Yini Li,Xinyi Zhan,Fengjiao Lu,Jiang Yang,Yamei Niu  ORCID: orcid.org/0000-0003-2078-0780 &…Xuetao Cao 
https://doi.org/10.1038/s41392-022-01020-z
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Letter
Development of a ferritin-based nanoparticle vaccine against the SARS-CoV-2 Omicron variant
Wanbo Tai,Benjie Chai,Shengyong Feng,Xinyu Zhuang,Jun Ma,Mujia Pang,Lin Pan,Zi Yang,Mingyao Tian &…Gong Cheng 
https://doi.org/10.1038/s41392-022-01041-8
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Waning humoral immune responses to inactivated SARS-CoV-2 vaccines in patients with severe liver disease
Zhiwei Chen,Yingzhi Zhang,Rui Song,Lu Wang,Xiaoxiao Hu,Hu Li,Dachuan Cai,Peng Hu,Xiaofeng Shi &…Hong Ren 
https://doi.org/10.1038/s41392-022-01032-9
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A robust reporting system for measurement of SARS-CoV-2 spike fusion efficiency
Cong Huang,Yang Yang,Peng Yang,Fei Wang,Xinyu Li,Xiang Song,Yiming Wang,Cuiyun Yu,Xuejun Wang  ORCID: orcid.org/0000-0001-5895-936X &…Shengqi Wang 
https://doi.org/10.1038/s41392-022-01037-4
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The role of CTHRC1 in promotion of cutaneous wound healing
Xianlan Duan,Xingyu Yuan,Bin Yao,Wei Song,Zhao Li, Enhejirigala,Yi Kong,Yuzhen Wang,Xiaobing Fu &…Sha Huang  ORCID: orcid.org/0000-0001-8868-2680 
https://doi.org/10.1038/s41392-022-01008-9
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Targeted B-domain deletion restores F8 function in human endothelial cells and mice
Zhiqing Hu,Zhuo Li,Yong Wu,Junya Zhao,Lingqian Wu,Miaojin Zhou &…Desheng Liang  ORCID: orcid.org/0000-0002-9451-8585 
https://doi.org/10.1038/s41392-022-01016-9
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RIP3 deficiency attenuated hepatic stellate cell activation and liver fibrosis in schistosomiasis through JNK-cJUN/Egr1 downregulation
Li-Jun Song,Xu-Ren Yin,Sheng-Wen Guan,Hong Gao,Pan-Pan Dong,Cong-Jin Mei,Ying-Ying Yang,Ying Zhang,Chuan-Xin Yu &…Zi-Chun Hua 
https://doi.org/10.1038/s41392-022-01019-6
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Clinical characteristics and vaccine effectiveness against SARS-CoV-2 Omicron subvariant BA.2 in the children
Xiaohe Li,Liwen Wu,Youzhi Qu,Mengli Cao,Jiaqi Feng,Hua Huang,Yi Liu,Hongzhou Lu,Quanying Liu &…Yingxia Liu  ORCID: orcid.org/0000-0001-6335-3346 
https://doi.org/10.1038/s41392-022-01023-w
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Review Article
Targeting protein phosphatases for the treatment of inflammation-related diseases: From signaling to therapy
Jie Pan,Lisha Zhou,Chenyang Zhang,Qiang Xu &…Yang Sun  ORCID: orcid.org/0000-0003-1425-0089 
https://doi.org/10.1038/s41392-022-01038-3
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Signaling pathways of chronic kidney diseases, implications for therapeutics
Qian Yuan,Ben Tang &Chun Zhang  ORCID: orcid.org/0000-0003-3565-8024 
https://doi.org/10.1038/s41392-022-01036-5
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PROTACs: great opportunities for academia and industry (an update from 2020 to 2021)
Ming He,Chaoguo Cao,Zhihao Ni,Yongbo Liu,Peilu Song,Shuang Hao,Yuna He,Xiuyun Sun &…Yu Rao  ORCID: orcid.org/0000-0002-4356-8531 
https://doi.org/10.1038/s41392-022-00999-9
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Cell deaths: Involvement in the pathogenesis and intervention therapy of COVID-19
Xue Li,Ziqi Zhang,Zhenling Wang,Pedro Gutiérrez-Castrellón  ORCID: orcid.org/0000-0002-9885-9635 &…Huashan Shi 
https://doi.org/10.1038/s41392-022-01043-6
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Signal pathways and precision therapy of small-cell lung cancer
Min Yuan,Yu Zhao,Hendrik-Tobias Arkenau,Tongnei Lao,Li Chu &…Qing Xu 
https://doi.org/10.1038/s41392-022-01013-y
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Autophagy, ferroptosis, pyroptosis, and necroptosis in tumor immunotherapy
Weitong Gao,Xueying Wang,Yang Zhou,Xueqian Wang &…Yan Yu 
https://doi.org/10.1038/s41392-022-01046-3
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Targeting signaling pathways in prostate cancer: mechanisms and clinical trials
Yundong He,Weidong Xu,Yu-Tian Xiao,Haojie Huang,Di Gu &…Shancheng Ren  ORCID: orcid.org/0000-0001-9205-7888 
https://doi.org/10.1038/s41392-022-01042-7
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Epigenetic regulation in cardiovascular disease: mechanisms and advances in clinical trials
Yuncong Shi,Huanji Zhang,Suli Huang,Li Yin,Feng Wang,Pei Luo &…Hui Huang  ORCID: orcid.org/0000-0001-5716-4012 
https://doi.org/10.1038/s41392-022-01055-2
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Pseudomonas aeruginosa: pathogenesis, virulence factors, antibiotic resistance, interaction with host, technology advances and emerging therapeutics
Shugang Qin,Wen Xiao,Chuanmin Zhou,Qinqin Pu,Xin Deng,Lefu Lan  ORCID: orcid.org/0000-0002-5551-5496,Haihua Liang,Xiangrong Song  ORCID: orcid.org/0000-0002-2853-2696 &…Min Wu  ORCID: orcid.org/0000-0003-1205-982X 
https://doi.org/10.1038/s41392-022-01056-1
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Molecular characteristics, immune evasion, and impact of SARS-CoV-2 variants
Cong Sun,Chu Xie,Guo-Long Bu,Lan-Yi Zhong &…Mu-Sheng Zeng 
https://doi.org/10.1038/s41392-022-01039-2
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Natural killer cell homing and trafficking in tissues and tumors: from biology to application
Guang he Ran,Yu qing Lin,Lei Tian,Tao Zhang,Dong mei Yan,Jian hua Yu  ORCID: orcid.org/0000-0002-0326-3223 &…You cai Deng  ORCID: orcid.org/0000-0001-5488-8576 
https://doi.org/10.1038/s41392-022-01058-z
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Targeting fibrosis: mechanisms and clinical trials
Manyu Zhao,Liqun Wang,Mengzhu Wang,Shijie Zhou,Ying Lu,Huijie Cui,Alexandra C. Racanelli,Ling Zhang,Tinghong Ye  ORCID: orcid.org/0000-0002-3296-6753,Bisen Ding  ORCID: orcid.org/0000-0001-9578-3738,Ben Zhang,Jinliang Yang &…Yuqin Yao  ORCID: orcid.org/0000-0003-2097-6978 
https://doi.org/10.1038/s41392-022-01070-3
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Research Highlight
Low-dose metformin and PEN2-dependent lysosomal AMPK activation: benefits outnumber side effects
Longlong Liu,Pradeep Kumar Patnana &Subbaiah Chary Nimmagadda 
https://doi.org/10.1038/s41392-022-01040-9
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Multiregional neural pathway: from movement planning to initiation
Xing-feng Mao,Shuai-shuai Wang &Feng Han 
https://doi.org/10.1038/s41392-022-01021-y
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Route, origin & valence matter: towards sophisticated next-generation vaccines to cope with the COVID-19 pandemic
Julia Volckmar,Lars Melcher &Dunja Bruder 
https://doi.org/10.1038/s41392-022-01053-4
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Boosting with variant-matched vaccines: an opportunity to win the race against Omicron
Jiayu Wang,Tianxia Lan &Qiu Sun  ORCID: orcid.org/0000-0001-5122-2226 
https://doi.org/10.1038/s41392-022-01049-0
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PLA2G7: a new player in shaping energy metabolism and lifespan
Lena Susanna Candels,Svea Becker &Christian Trautwein  ORCID: orcid.org/0000-0003-2762-8247 
https://doi.org/10.1038/s41392-022-01052-5
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Light shed on a non-canonical TCA cycle: cell state regulation beyond mitochondrial energy production
Ivona Mateska &Vasileia Ismini Alexaki 
https://doi.org/10.1038/s41392-022-01060-5
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Cytotoxic FCER1G+ innate-like T cells: new potential for tumour immunotherapy
Emma Morrish &Jürgen Ruland  ORCID: orcid.org/0000-0002-8381-3597 
https://doi.org/10.1038/s41392-022-01061-4
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