Table of Contents
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Volume 7 Issue 6, Jun 2022

Review Article
High-throughput single-сell sequencing in cancer research
Qingzhu Jia,Han Chu,Zheng Jin,Haixia Long &…Bo Zhu  ORCID: orcid.org/0000-0003-0224-8512 
https://doi.org/10.1038/s41392-022-00990-4
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COVID-19 vaccine development: milestones, lessons and prospects
Maochen Li  ORCID: orcid.org/0000-0001-8786-5039,Han Wang  ORCID: orcid.org/0000-0001-5298-8194,Lili Tian,Zehan Pang  ORCID: orcid.org/0000-0003-4537-2441,Qingkun Yang  ORCID: orcid.org/0000-0002-1548-498X,Tianqi Huang,Junfen Fan,Lihua Song,Yigang Tong &…Huahao Fan  ORCID: orcid.org/0000-0001-5007-2158 
https://doi.org/10.1038/s41392-022-00996-y
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Artificial intelligence in cancer target identification and drug discovery
Yujie You,Xin Lai  ORCID: orcid.org/0000-0003-4913-5822,Yi Pan,Huiru Zheng,Julio Vera,Suran Liu,Senyi Deng &…Le Zhang  ORCID: orcid.org/0000-0002-3708-1727 
https://doi.org/10.1038/s41392-022-00994-0
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mRNA-based therapeutics: powerful and versatile tools to combat diseases
Shugang Qin,Xiaoshan Tang,Yuting Chen,Kepan Chen,Na Fan,Wen Xiao,Qian Zheng,Guohong Li,Yuqing Teng,Min Wu  ORCID: orcid.org/0000-0003-1205-982X &…Xiangrong Song  ORCID: orcid.org/0000-0002-2853-2696 
https://doi.org/10.1038/s41392-022-01007-w
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Human organoids in basic research and clinical applications
Xiao-Yan Tang,Shanshan Wu,Da Wang,Chu Chu,Yuan Hong,Mengdan Tao,Hao Hu,Min Xu,Xing Guo &…Yan Liu 
https://doi.org/10.1038/s41392-022-01024-9
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Article
MrgprF acts as a tumor suppressor in cutaneous melanoma by restraining PI3K/Akt signaling
Qiushuo Shen,Yanfei Han,Kai Wu,Yaomei He,Xiulin Jiang,Peishen Liu,Cuifeng Xia,Qiuxia Xiong,Rui Liu,Qianming Chen,Yong Zhang,Song Zhao,Cuiping Yang &…Yongbin Chen  ORCID: orcid.org/0000-0001-6534-6991 
https://doi.org/10.1038/s41392-022-00945-9
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TRIM47 is a novel endothelial activation factor that aggravates lipopolysaccharide-induced acute lung injury in mice via K63-linked ubiquitination of TRAF2
Yisong Qian,Ziwei Wang,Hongru Lin,Tianhua Lei,Zhou Zhou,Weilu Huang,Xuehan Wu,Li Zuo,Jie Wu,Yu Liu,Ling-Fang Wang,Xiao-Hui Guan,Ke-Yu Deng,Mingui Fu  ORCID: orcid.org/0000-0001-6315-8372 &…Hong-Bo Xin 
https://doi.org/10.1038/s41392-022-00953-9
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Klotho in Osx+-mesenchymal progenitors exerts pro-osteogenic and anti-inflammatory effects during mandibular alveolar bone formation and repair
Yi Fan,Chen Cui,Clifford J. Rosen,Tadatoshi Sato,Ruoshi Xu,Peiran Li,Xi Wei,Ruiye Bi,Quan Yuan  ORCID: orcid.org/0000-0002-2836-1081 &…Chenchen Zhou 
https://doi.org/10.1038/s41392-022-00957-5
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Gefitinib and fostamatinib target EGFR and SYK to attenuate silicosis: a multi-omics study with drug exploration
Mingyao Wang  ORCID: orcid.org/0000-0003-4731-3488,Zhe Zhang,Jiangfeng Liu,Meiyue Song,Tiantian Zhang,Yiling Chen,Huiyuan Hu,Peiran Yang,Bolun Li,Xiaomin Song,Junling Pang,Yanjiang Xing,Zhujie Cao,Wenjun Guo,Hao Yang,Jing Wang  ORCID: orcid.org/0000-0003-1180-391X,Juntao Yang  ORCID: orcid.org/0000-0003-2410-5408 &…Chen Wang 
https://doi.org/10.1038/s41392-022-00959-3
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Intranasal administration of a recombinant RBD vaccine induces long-term immunity against Omicron-included SARS-CoV-2 variants
Hong Lei,Aqu Alu  ORCID: orcid.org/0000-0002-9981-0120,Jingyun Yang,Wenyan Ren,Cai He,Tianxia Lan,Xuemei He,Li Yang,Jiong Li,Zhenling Wang,Xiangrong Song  ORCID: orcid.org/0000-0002-2853-2696,Wei Wang  ORCID: orcid.org/0000-0001-7788-1895,Guangwen Lu  ORCID: orcid.org/0000-0001-7568-592X &…Xiawei Wei  ORCID: orcid.org/0000-0002-6513-6422 
https://doi.org/10.1038/s41392-022-01002-1
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Integrating single-cell RNA sequencing with spatial transcriptomics reveals immune landscape for interstitial cystitis
Liao Peng,Xi Jin,Bo-ya Li,Xiao Zeng,Bang-hua Liao,Tao Jin,Jia-wei Chen,Xiao-shuai Gao,Wei Wang,Qing He,Guo Chen,Li-Na Gong,Hong Shen,Kun-jie Wang,Hong Li &…De-yi Luo 
https://doi.org/10.1038/s41392-022-00962-8
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Lipid metabolism dysfunction induced by age-dependent DNA methylation accelerates aging
Xin Li,Jiaqiang Wang,LeYun Wang,Yuanxu Gao,Guihai Feng,Gen Li,Jun Zou,Meixin Yu,Yu Fei Li,Chao Liu,Xue Wei Yuan,Ling Zhao,Hong Ouyang  ORCID: orcid.org/0000-0002-7622-7733,Jian-Kang Zhu,Wei Li  ORCID: orcid.org/0000-0001-7864-404X,Qi Zhou &…Kang Zhang 
https://doi.org/10.1038/s41392-022-00964-6
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Research Highlight
Surrogate cytokine agonists: promising agents against COVID-19
Zemin Lin,Jianping Zuo &Shijun He  ORCID: orcid.org/0000-0002-9207-3631 
https://doi.org/10.1038/s41392-022-01015-w
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Prokaryotic gasdermins: ancestors of eukaryotic counterparts direct the pyroptosis and cell fates
Yingying Liu,Chen Zhang &Min Wu  ORCID: orcid.org/0000-0003-1205-982X 
https://doi.org/10.1038/s41392-022-01005-y
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Omicron: increased transmissibility and decreased pathogenicity
Gábor Bálint,Barbara Vörös-Horváth &Aleksandar Széchenyi  ORCID: orcid.org/0000-0001-9207-2551 
https://doi.org/10.1038/s41392-022-01009-8
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Suicide signaling by GSDMA: a single-molecule mechanism for recognition and defense against SpeB-expressing GAS
Judit Symmank  ORCID: orcid.org/0000-0001-9347-0172,Collin Jacobs &Ulrike Schulze-Späte 
https://doi.org/10.1038/s41392-022-01011-0
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Cuproptosis: lipoylated TCA cycle proteins-mediated novel cell death pathway
Su-Ran Li,Lin-Lin Bu &Lulu Cai  ORCID: orcid.org/0000-0002-5678-1112 
https://doi.org/10.1038/s41392-022-01014-x
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Nivolumab plus ipilimumab: a potential regimen to rewrite treatment guidelines for ESCC
Yuejun Luo,Nan Sun &Jie He  ORCID: orcid.org/0000-0002-0285-5403 
https://doi.org/10.1038/s41392-022-01022-x
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Letter
Recombinant human erythropoietin ameliorates cognitive dysfunction of APP/PS1 mice by attenuating neuron apoptosis via HSP90β
Hua-Li Wan,Bing-Ge Zhang,Chongyang Chen,Qian Liu,Ting Li,Ye He,Yongmei Xie  ORCID: orcid.org/0000-0002-7913-0283,Xifei Yang,Jian-Zhi Wang &…Gong-Ping Liu  ORCID: orcid.org/0000-0001-8501-998X 
https://doi.org/10.1038/s41392-022-00998-w
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A heme-activatable probe and its application in the high-throughput screening of Plasmodium falciparum ring-stage inhibitors
Sheng Liu,Chunyan Wei,Tian Liu,Shuang-Gang Ma,Chen Chen,Hao Lin,Lianhui Zhang,Heng Wang,Chong-Jing Zhang &…Shi-Shan Yu 
https://doi.org/10.1038/s41392-022-00961-9
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PIKfyve inhibitors against SARS-CoV-2 and its variants including Omicron
Jingyi Su,Jing Zheng,Wei Huang,Yali Zhang,Cairui Lv,Baoding Zhang,Lina Jiang,Tong Cheng,Quan Yuan  ORCID: orcid.org/0000-0001-5487-561X,Ningshao Xia  ORCID: orcid.org/0000-0003-0179-5266,Jianming Zhang,Li Li,Li Li &…Xianming Deng  ORCID: orcid.org/0000-0002-9354-5864 
https://doi.org/10.1038/s41392-022-01025-8
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PROTAC mediated FKBP12 degradation enhances Hepcidin expression via BMP signaling without immunosuppression activity
Tianbai Zhong,Xiuyun Sun,Li Yu,Yongbo Liu,Xin Lin,Yu Rao &…Wei Wu 
https://doi.org/10.1038/s41392-022-00970-8
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Deconstructing the intra-tumor subclonal heterogeneity of lung synchronous ground-glass nodules using whole-genome sequencing
Yijiu Ren,Minfang Song,Yunlang She,Huikang Xie,Hui Zheng,Chang Chen &…Yiwen Zhang 
https://doi.org/10.1038/s41392-022-00982-4
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Master microRNA-222 regulates cardiac microRNA maturation and triggers Tetralogy of Fallot
Chao Li,Hongdou Li,Xiaoying Yao,Dong Liu,Yongming Wang,Xinyi Huang,Zhongzhou Yang,Wufan Tao,Jian-Yuan Zhao  ORCID: orcid.org/0000-0001-9861-0330 &…Hongyan Wang  ORCID: orcid.org/0000-0002-9422-5264 
https://doi.org/10.1038/s41392-022-00993-1
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