Table of Contents
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Volume 7 Issue 5, May 2022

Review Article
Clinical and translational values of spatial transcriptomics
Linlin Zhang,Dongsheng Chen,Dongli Song,Xiaoxia Liu,Yanan Zhang,Xun Xu &…Xiangdong Wang 
https://doi.org/10.1038/s41392-022-00960-w
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Targeted protein degradation: mechanisms, strategies and application
Lin Zhao,Jia Zhao,Kunhong Zhong,Aiping Tong  ORCID: orcid.org/0000-0002-3392-5443 &…Da Jia  ORCID: orcid.org/0000-0002-2205-1998 
https://doi.org/10.1038/s41392-022-00966-4
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Engineering strategies to enhance oncolytic viruses in cancer immunotherapy
Yaomei Tian,Daoyuan Xie &Li Yang 
https://doi.org/10.1038/s41392-022-00951-x
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Targeting non-coding RNAs to overcome cancer therapy resistance
BaoQing Chen,Mihnea P. Dragomir,Chen Yang,Qiaoqiao Li,David Horst &…George A. Calin  ORCID: orcid.org/0000-0002-7427-0578 
https://doi.org/10.1038/s41392-022-00975-3
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Inflammation and atherosclerosis: signaling pathways and therapeutic intervention
Peng Kong,Zi-Yang Cui,Xiao-Fu Huang,Dan-Dan Zhang,Rui-Juan Guo &…Mei Han 
https://doi.org/10.1038/s41392-022-00955-7
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Signaling cascades in the failing heart and emerging therapeutic strategies
Xin He,Tailai Du,Tianxin Long,Xinxue Liao,Yugang Dong &…Zhan-Peng Huang  ORCID: orcid.org/0000-0001-7054-655X 
https://doi.org/10.1038/s41392-022-00972-6
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Microbiota in health and diseases
Kaijian Hou  ORCID: orcid.org/0000-0003-1733-0068,Zhuo-Xun Wu,Xuan-Yu Chen,Jing-Quan Wang,Dongya Zhang,Chuanxing Xiao,Dan Zhu,Jagadish B. Koya,Liuya Wei,Jilin Li &…Zhe-Sheng Chen  ORCID: orcid.org/0000-0002-8289-097X 
https://doi.org/10.1038/s41392-022-00974-4
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Role of main RNA modifications in cancer: N6-methyladenosine, 5-methylcytosine, and pseudouridine
Chen Xue,Qingfei Chu,Qiuxian Zheng,Shiman Jiang,Zhengyi Bao,Yuanshuai Su,Juan Lu &…Lanjuan Li 
https://doi.org/10.1038/s41392-022-01003-0
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SARS-CoV-2 Omicron variant: recent progress and future perspectives
Yao Fan,Xiang Li,Lei Zhang  ORCID: orcid.org/0000-0001-6302-8383,Shu Wan,Long Zhang &…Fangfang Zhou  ORCID: orcid.org/0000-0003-1870-7584 
https://doi.org/10.1038/s41392-022-00997-x
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Alterations in microbiota of patients with COVID-19: potential mechanisms and therapeutic interventions
Bin Wang,Lei Zhang,Yongqiang Wang,Tong Dai,Ziran Qin,Fangfang Zhou  ORCID: orcid.org/0000-0003-1870-7584 &…Long Zhang  ORCID: orcid.org/0000-0001-8139-0474 
https://doi.org/10.1038/s41392-022-00986-0
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Article
Nuclear Aurora kinase A switches m6A reader YTHDC1 to enhance an oncogenic RNA splicing of tumor suppressor RBM4
SiSi Li,YangFan Qi,JiaChuan Yu,YuChao Hao,Bin He,MengJuan Zhang,ZhenWei Dai,TongHui Jiang,SuYi Li,Fang Huang,Ning Chen,Jing Wang,MengYing Yang,DaPeng Liang,Fan An,JinYao Zhao,WenJun Fan,YuJia Pan,ZiQian Deng,YuanYuan Luo,Tao Guo,Fei Peng,ZhiJie Hou,ChunLi Wang,FeiMeng Zheng,LingZhi Xu,Jie Xu,QingPing Wen,BiLian Jin,Yang Wang  ORCID: orcid.org/0000-0001-9385-7393 &…Quentin Liu 
https://doi.org/10.1038/s41392-022-00905-3
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A genetic variant in IL-6 lowering its expression is protective for critical patients with COVID-19
Bo Gong,Lulin Huang,Yongquan He,Wen Xie,Yi Yin,Yi Shi,Jialing Xiao,Ling Zhong,Yi Zhang,Zhilin Jiang,Fang Hao,Yu Zhou,Huan Li,Li Jiang,Xingxiang Yang,Xiangrong Song  ORCID: orcid.org/0000-0002-2853-2696,Yan Kang,Lin Tuo,Yi Huang,Ping Shuai,Yuping Liu,Fang Zheng &…Zhenglin Yang 
https://doi.org/10.1038/s41392-022-00923-1
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Identification of NOXA as a pivotal regulator of resistance to CAR T-cell therapy in B-cell malignancies
Xin Yan,Deyun Chen,Yao Wang,Yelei Guo,Chuan Tong,Jianshu Wei,Yajing Zhang,Zhiqiang Wu &…Weidong Han  ORCID: orcid.org/0000-0003-3207-3899 
https://doi.org/10.1038/s41392-022-00915-1
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A potent human monoclonal antibody with pan-neutralizing activities directly dislocates S trimer of SARS-CoV-2 through binding both up and down forms of RBD
Xiaofei Wang,Ao Hu,Xiangyu Chen,Yixin Zhang,Fei Yu,Shuai Yue,Arong Li,Junsong Zhang,Zhiwei Pan,Yang Yang,Yao Lin,Leiqiong Gao,Jing Zhou,Jing Zhao,Fang Li,Yaling Shi,Feng Huang,Xiaofan Yang,Yi Peng,Luoyang Tu,Huan Zhang,Huanying Zheng,Jun He  ORCID: orcid.org/0000-0003-0270-9729,Hui Zhang  ORCID: orcid.org/0000-0003-3620-610X,Lifan Xu,Qizhao Huang,Yongqun Zhu,Kai Deng  ORCID: orcid.org/0000-0002-9973-8130 &…Lilin Ye  ORCID: orcid.org/0000-0003-0778-3311 
https://doi.org/10.1038/s41392-022-00954-8
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Cannabis suppresses antitumor immunity by inhibiting JAK/STAT signaling in T cells through CNR2
Xinxin Xiong,Siyu Chen,Jianfei Shen,Hua You  ORCID: orcid.org/0000-0002-9630-5284,Han Yang,Chao Yan  ORCID: orcid.org/0000-0002-6029-224X,Ziqian Fang,Jianeng Zhang,Xiuyu Cai,Xingjun Dong,Tiebang Kang,Wende Li &…Penghui Zhou  ORCID: orcid.org/0000-0003-0519-461X 
https://doi.org/10.1038/s41392-022-00918-y
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Identification of the receptor of oncolytic virus M1 as a therapeutic predictor for multiple solid tumors
Deli Song,Xudong Jia  ORCID: orcid.org/0000-0003-2546-2685,Xincheng Liu,Linyi Hu,Kaiying Lin,Tong Xiao,Yangyang Qiao,Jiayu Zhang,Jia Dan,Chunwa Wong,Cheng Hu,Ke Sai,Shoufang Gong,Max Sander,Runling Shen,Xiaoyu Chen,Xiaoting Xiao,Jiehong Chen,Yanming Zhang,Cailv Wei,Xiao Xiao,Jiankai Liang,Qinfen Zhang,Jun Hu,Wenbo Zhu,Guangmei Yan,Yuan Lin &…Jing Cai  ORCID: orcid.org/0000-0003-4128-572X 
https://doi.org/10.1038/s41392-022-00921-3
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Outcome of aggressive B-cell lymphoma with TP53 alterations administered with CAR T-cell cocktail alone or in combination with ASCT
Jia Wei  ORCID: orcid.org/0000-0002-6435-9368,Min Xiao,Zekai Mao,Na Wang,Yang Cao,Yi Xiao,Fankai Meng,Weimin Sun,Ying Wang,Xingcheng Yang,Liting Chen,Yicheng Zhang,Haichuan Zhu,Shangkun Zhang,Tongcun Zhang,Jianfeng Zhou  ORCID: orcid.org/0000-0002-1332-9230 &…Liang Huang  ORCID: orcid.org/0000-0002-8370-3232 
https://doi.org/10.1038/s41392-022-00924-0
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Identifying a confused cell identity for esophageal squamous cell carcinoma
Xiangyu Pan,Jian Wang,Linjie Guo,Feifei Na,Jiajia Du,Xuelan Chen,Ailing Zhong,Lei Zhao,Lu Zhang,Mengsha Zhang,Xudong Wan,Manli Wang,Hongyu Liu,Siqi Dai,Ping Tan,Jingyao Chen,Yu Liu,Bing Hu &…Chong Chen  ORCID: orcid.org/0000-0002-6787-0495 
https://doi.org/10.1038/s41392-022-00946-8
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LSD1 is required for euchromatic origin firing and replication timing
Yue Wang,Yunchao Huang,Edith Cheng,Xinhua Liu,Yu Zhang,Jianguo Yang,Jordan T. F. Young,Grant W. Brown,Xiaohan Yang &…Yongfeng Shang 
https://doi.org/10.1038/s41392-022-00927-x
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PINK1-mediated Drp1S616 phosphorylation modulates synaptic development and plasticity via promoting mitochondrial fission
Qingtao Gao,Runyi Tian,Hailong Han,Jesse Slone,Caifang Wang,Xiao Ke,Tongmei Zhang,Xiangyu Li,Yuhong He,Panlin Liao,Fang Wang,Ye Chen,Shiqing Fu,Kexuan Zhang,Fangfang Zeng,Yingxuan Yang,Zhuo Li,Jieqiong Tan,Jiada Li,Youming Lu,Taosheng Huang,Zhonghua Hu  ORCID: orcid.org/0000-0002-0117-7081 &…Zhuohua Zhang 
https://doi.org/10.1038/s41392-022-00933-z
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Sequential immunizations confer cross-protection against variants of SARS-CoV-2, including Omicron in Rhesus macaques
Wei Deng,Qi Lv,Fengdi Li,Jiangning Liu,Zhiqi Song,Feifei Qi,Qiang Wei,Pin Yu,Mingya Liu,Shasha Zhou,Yaqing Zhang,Hong Gao,Nan Wang  ORCID: orcid.org/0000-0002-9936-9179,Zijing Jia,Kai Gao,Jiayi Liu,Chong Xiao,Haiquan Shang,Xiangxi Wang  ORCID: orcid.org/0000-0003-0635-278X,Linlin Bao  ORCID: orcid.org/0000-0003-4869-3777 &…Chuan Qin  ORCID: orcid.org/0000-0002-6261-1232 
https://doi.org/10.1038/s41392-022-00979-z
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c-Myc-driven glycolysis polarizes functional regulatory B cells that trigger pathogenic inflammatory responses
Xu-Yan Wang,Yuan Wei,Bo Hu,Yuan Liao,Xiaodong Wang,Wen-Hua Wan,Chun-Xiang Huang,Mahepali Mahabati,Zheng-Yu Liu,Jing-Rui Qu,Xiao-Dan Chen,Dong-Ping Chen,Dong-Ming Kuang  ORCID: orcid.org/0000-0003-3570-9717,Xue-Hao Wang  ORCID: orcid.org/0000-0001-5849-0098 &…Yun Chen  ORCID: orcid.org/0000-0002-4118-362X 
https://doi.org/10.1038/s41392-022-00948-6
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WT-PE: Prime editing with nuclease wild-type Cas9 enables versatile large-scale genome editing
Rui Tao,Yanhong Wang,Yun Hu,Yaoge Jiao,Lifang Zhou,Lurong Jiang,Li Li,Xingyu He,Min Li,Yamei Yu,Qiang Chen  ORCID: orcid.org/0000-0002-2398-4482 &…Shaohua Yao 
https://doi.org/10.1038/s41392-022-00936-w
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AAV-ie-K558R mediated cochlear gene therapy and hair cell regeneration
Yong Tao,Xiaoyi Liu  ORCID: orcid.org/0000-0001-6798-978X,Liu Yang,Cenfeng Chu,Fangzhi Tan,Zehua Yu,Junzi Ke,Xiang Li,Xiaofei Zheng,Xingle Zhao,Jieyu Qi,Chao-Po Lin,Renjie Chai,Guisheng Zhong  ORCID: orcid.org/0000-0003-0416-3774 &…Hao Wu  ORCID: orcid.org/0000-0002-5317-902X 
https://doi.org/10.1038/s41392-022-00938-8
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SARS-CoV-2-specific CD4+ T cells are associated with long-term persistence of neutralizing antibodies
Zhongfang Wang,Xiaoyun Yang,Xinyue Mei,Yumin Zhou,Zhiqiang Tang,Guichang Li,Jiaying Zhong,Mengqiu Yu,Mingzhu Huang,Xiaoling Su,Bijia Lin,Pengxing Cao,Ji Yang &…Pixin Ran  ORCID: orcid.org/0000-0001-6651-634X 
https://doi.org/10.1038/s41392-022-00978-0
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NUPR1 promotes the proliferation and metastasis of oral squamous cell carcinoma cells by activating TFE3-dependent autophagy
Tengfei Fan,Xiaoning Wang,Sheng Zhang,Ping Deng,Yi Jiang,Yidan Liang,Sheng Jie,Qing Wang,Chuwen Li,Guocai Tian,Zhen Zhang,Zhenhu Ren,Bo Li,Yanrong Chen,Zhijing He,Yan Luo,Mingliang Chen,Hanjiang Wu,Zhengping Yu,Huifeng Pi,Zhou Zhou &…Zhiyuan Zhang 
https://doi.org/10.1038/s41392-022-00939-7
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Modulation of innate immune response to viruses including SARS-CoV-2 by progesterone
Shan Su,Duo Hua,Jin-Peng Li,Xia-Nan Zhang,Lei Bai,Li-Bo Cao,Yi Guo,Ming Zhang,Jia-Zhen Dong,Xiao-Wei Liang,Ke Lan  ORCID: orcid.org/0000-0002-0384-8598,Ming-Ming Hu &…Hong-Bing Shu  ORCID: orcid.org/0000-0001-9102-3272 
https://doi.org/10.1038/s41392-022-00981-5
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Tracking SARS-CoV-2 Omicron diverse spike gene mutations identifies multiple inter-variant recombination events
Junxian Ou,Wendong Lan,Xiaowei Wu,Tie Zhao,Biyan Duan,Peipei Yang,Yi Ren,Lulu Quan,Wei Zhao,Donald Seto,James Chodosh,Zhen Luo  ORCID: orcid.org/0000-0002-1142-2845,Jianguo Wu  ORCID: orcid.org/0000-0002-8326-2895 &…Qiwei Zhang  ORCID: orcid.org/0000-0002-2770-111X 
https://doi.org/10.1038/s41392-022-00992-2
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An intersegmental single-cell profile reveals aortic heterogeneity and identifies a novel Malat1+ vascular smooth muscle subtype involved in abdominal aortic aneurysm formation
Liwen Yu,Jie Zhang,Amy Gao,Meng Zhang,Zunzhe Wang,Fangpu Yu,Xiaobin Guo,Guohai Su,Yun Zhang,Meng Zhang &…Cheng Zhang 
https://doi.org/10.1038/s41392-022-00943-x
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Broadly neutralizing antibodies against Omicron-included SARS-CoV-2 variants induced by vaccination
Xiangyang Chi,Yingying Guo,Guanying Zhang,Hancong Sun,Jun Zhang  ORCID: orcid.org/0000-0002-9650-112X,Min Li,Zhengshan Chen,Jin Han,Yuanyuan Zhang,Xinghai Zhang,Pengfei Fan,Zhe Zhang,Busen Wang  ORCID: orcid.org/0000-0001-9041-1919,Xiaodong Zai,Xuelian Han,Meng Hao,Ting Fang,Jinghan Xu,Shipo Wu,Yi Chen,Yingying Fang,Yunzhu Dong,Bingjie Sun,Jinlong Zhang,Jianmin Li,Guangyu Zhao,Changming Yu,Qiang Zhou &…Wei Chen 
https://doi.org/10.1038/s41392-022-00987-z
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OVOL1 inhibits breast cancer cell invasion by enhancing the degradation of TGF-β type I receptor
Chuannan Fan  ORCID: orcid.org/0000-0001-8754-4913,Qian Wang,Gerard van der Zon,Jiang Ren,Cedrick Agaser,Roderick C. Slieker  ORCID: orcid.org/0000-0003-0961-9152,Prasanna Vasudevan Iyengar,Hailiang Mei &…Peter ten Dijke 
https://doi.org/10.1038/s41392-022-00944-w
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Research Highlight
A booster with SARS-CoV-2 vaccines: protection against Omicron infection
Yuehong Hu &Qiu Sun  ORCID: orcid.org/0000-0001-5122-2226 
https://doi.org/10.1038/s41392-022-00973-5
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Omicron: Master of immune evasion maintains robust ACE2 binding
Markus Hoffmann  ORCID: orcid.org/0000-0003-4603-7696,Lu Zhang &Stefan Pöhlmann  ORCID: orcid.org/0000-0001-6086-9136 
https://doi.org/10.1038/s41392-022-00965-5
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Novel pyroptosis-independent functions of gasdermins
Ziran Qin,Fangfang Zhou &Long Zhang 
https://doi.org/10.1038/s41392-022-00991-3
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ACSL4, PUFA, and ferroptosis: new arsenal in anti-tumor immunity
Boyi Gan  ORCID: orcid.org/0000-0001-8884-6040 
https://doi.org/10.1038/s41392-022-01004-z
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Collisions and protein aggregations ahead: how aging affects ribosomal elongation dynamics
Pallab Maity &Sebastian Iben 
https://doi.org/10.1038/s41392-022-01001-2
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Mitochondrial Complex I deficiency: guilty in Parkinson’s disease
Melissa Vos  ORCID: orcid.org/0000-0002-9883-7698 
https://doi.org/10.1038/s41392-022-00983-3
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Vaccination versus SARS-CoV-2 Omicron: three vaccine doses win the battle
Grzegorz Maria Popowicz,Krzysztof Pyrc &Kamyar Hadian  ORCID: orcid.org/0000-0001-8727-2575 
https://doi.org/10.1038/s41392-022-01000-3
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Letter
Airway administration of bisphosphate and dexamethasone inhibits SARS-CoV-2 variant infection by targeting alveolar macrophages
Zhenfeng Wang,Yabo Zhou,Linlin Bao  ORCID: orcid.org/0000-0003-4869-3777,Dan Li,Jiadi Lv,Dianheng Wang,Shunshun Li,Jiangning Liu,Chuan Qin  ORCID: orcid.org/0000-0002-6261-1232,Wei-Min Tong &…Bo Huang  ORCID: orcid.org/0000-0001-8476-1138 
https://doi.org/10.1038/s41392-022-00977-1
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Spike protein of SARS‐CoV‐2 Omicron (B.1.1.529) variant has a reduced ability to induce the immune response
Cai He,Xuemei He,Jingyun Yang,Hong Lei,Weiqi Hong  ORCID: orcid.org/0000-0003-1668-2301,Xiangrong Song  ORCID: orcid.org/0000-0002-2853-2696,Li Yang,Jiong Li,Wei Wang  ORCID: orcid.org/0000-0001-7788-1895,Guobo Shen,Guangwen Lu  ORCID: orcid.org/0000-0001-7568-592X &…Xiawei Wei  ORCID: orcid.org/0000-0002-6513-6422 
https://doi.org/10.1038/s41392-022-00980-6
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Aptamer blocking S-TLR4 interaction selectively inhibits SARS-CoV-2 induced inflammation
Gang Yang,Shengnan Zhang,Yuchun Wang,Ling Li,Yu Li,Deyu Yuan,Fatao Luo,Jincun Zhao  ORCID: orcid.org/0000-0003-2515-5589,Xu Song &…Yongyun Zhao 
https://doi.org/10.1038/s41392-022-00968-2
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Oral remdesivir derivative VV116 is a potent inhibitor of respiratory syncytial virus with efficacy in mouse model
Ruxue Zhang,Yumin Zhang,Wei Zheng,Weijuan Shang,Yan Wu,Ning Li,Jun Xiong,Hualiang Jiang  ORCID: orcid.org/0000-0003-0656-6315,Jingshan Shen  ORCID: orcid.org/0000-0001-9679-9934,Gengfu Xiao,Yuanchao Xie &…Leike Zhang  ORCID: orcid.org/0000-0002-2593-2571 
https://doi.org/10.1038/s41392-022-00963-7
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Visual function restoration with a highly sensitive and fast Channelrhodopsin in blind mice
Fei Chen  ORCID: orcid.org/0000-0003-2690-7754,Xiaodong Duan,Yao Yu,Shang Yang  ORCID: orcid.org/0000-0001-6671-7571,Yuanyuan Chen,Christine E. Gee,Georg Nagel,Kang Zhang,Shiqiang Gao  ORCID: orcid.org/0000-0001-6190-9443 &…Yin Shen  ORCID: orcid.org/0000-0002-4201-3948 
https://doi.org/10.1038/s41392-022-00935-x
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Novel potential metabolic biomarker panel for early detection of severe COVID-19 using full-spectrum metabolome and whole-transcriptome analyses
Zhi-Bin Li,Jun Liu,Shan-Qiang Zhang,Yi Yu,Hong-Feng Liang,Qi-Qi Lu,Jing Chen,Yu-Shuai Han,Fan Zhang &…Ji-Cheng Li 
https://doi.org/10.1038/s41392-022-00976-2
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