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Volume 7 Issue 4, Apr 2022

Article
Temporal and spatial cellular and molecular pathological alterations with single-cell resolution in the adult spinal cord after injury
Chen Li,Zhourui Wu,Liqiang Zhou,Jingliang Shao,Xiao Hu,Wei Xu,Yilong Ren,Xingfei Zhu,Weihong Ge,Kunshan Zhang,Jiping Liu,Runzhi Huang,Jing Yu,Dandan Luo,Xuejiao Yang,Wenmin Zhu,Rongrong Zhu,Changhong Zheng,Yi Eve Sun &…Liming Cheng 
https://doi.org/10.1038/s41392-022-00885-4
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Immunogenicity and protective efficacy of a recombinant protein subunit vaccine and an inactivated vaccine against SARS-CoV-2 variants in non-human primates
Qian He,Qunying Mao,Xiaozhong Peng  ORCID: orcid.org/0000-0002-8564-0247,Zhanlong He,Shuaiyao Lu  ORCID: orcid.org/0000-0003-1675-9735,Jialu Zhang,Fan Gao,Lianlian Bian,Chaoqiang An,Wenhai Yu,Fengmei Yang,Yanan Zhou,Yun Yang,Yanyan Li,Yadi Yuan,Xujia Yan,Jinghuan Yang,Xing Wu,Weijin Huang  ORCID: orcid.org/0000-0002-4246-8889,Changgui Li,Junzhi Wang,Zhenglun Liang &…Miao Xu 
https://doi.org/10.1038/s41392-022-00926-y
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miR-146a impedes the anti-aging effect of AMPK via NAMPT suppression and NAD+/SIRT inactivation
Hui Gong,Honghan Chen,Peng Xiao,Ning Huang,Xiaojuan Han,Jian Zhang,Yu Yang,Tiepeng Li,Tingting Zhao,Haoran Tai,Weitong Xu,Gongchang Zhang,Chuhui Gong,Ming Yang,Xiaoqiang Tang  ORCID: orcid.org/0000-0003-1314-3417 &…Hengyi Xiao 
https://doi.org/10.1038/s41392-022-00886-3
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Efficacy and safety of low-dose interleukin-2 in combination with methotrexate in patients with active rheumatoid arthritis: a randomized, double-blind, placebo-controlled phase 2 trial
Xiaoying Zhang  ORCID: orcid.org/0000-0002-8130-1889,Miao Miao,Ruijun Zhang,Xu Liu,Xiaozhen Zhao,Miao Shao,Tian Liu,Yuebo Jin,Jiali Chen,Huixin Liu,Xia Zhang,Yun Li,Yunshan Zhou,Yue Yang,Ru Li,Haihong Yao,Yanying Liu,Chun Li,Yuhui Li,Limin Ren,Yin Su,Xiaolin Sun  ORCID: orcid.org/0000-0001-9709-1532,Jing He  ORCID: orcid.org/0000-0003-3904-8928 &…Zhanguo Li  ORCID: orcid.org/0000-0002-2590-6242 
https://doi.org/10.1038/s41392-022-00887-2
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Clinical utility of PDX cohorts to reveal biomarkers of intrinsic resistance and clonal architecture changes underlying acquired resistance to cetuximab in HNSCC
Yanli Yao,Yujue Wang,Lan Chen,Zhen Tian,Guizhu Yang,Rui Wang,Chong Wang,Qi Wu,Yaping Wu,Jiamin Gao,Xindan Kang,Shengzhong Duan,Zhiyuan Zhang &…Shuyang Sun 
https://doi.org/10.1038/s41392-022-00908-0
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Characterization of a small-molecule inhibitor targeting NEMO/IKKβ to suppress colorectal cancer growth
Zhenlong Yu,Jian Gao  ORCID: orcid.org/0000-0001-6723-0490,Xiaolei Zhang,Yulin Peng,Wenlong Wei,Jianrong Xu  ORCID: orcid.org/0000-0002-2168-2296,Zhenwei Li,Chao Wang,Meirong Zhou,Xiangge Tian,Lei Feng,Xiaokui Huo,Min Liu,Mingliang Ye,De-an Guo &…Xiaochi Ma 
https://doi.org/10.1038/s41392-022-00888-1
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ACE2-independent infection of T lymphocytes by SARS-CoV-2
Xu-Rui Shen,Rong Geng,Qian Li,Ying Chen,Shu-Fen Li,Qi Wang,Juan Min,Yong Yang,Bei Li,Ren-Di Jiang,Xi Wang,Xiao-Shuang Zheng,Yan Zhu,Jing-Kun Jia,Xing-Lou Yang,Mei-Qin Liu,Qian-Chun Gong,Yu-Lan Zhang,Zhen-Qiong Guan,Hui-Ling Li,Zhen-Hua Zheng,Zheng-Li Shi  ORCID: orcid.org/0000-0001-8089-163X,Hui-Lan Zhang,Ke Peng  ORCID: orcid.org/0000-0003-0172-8725 &…Peng Zhou  ORCID: orcid.org/0000-0001-9863-4201 
https://doi.org/10.1038/s41392-022-00919-x
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Elevated Kir2.1/nuclear N2ICD defines a highly malignant subtype of non-WNT/SHH medulloblastomas
Yan-Xia Wang,Haibo Wu,Yong Ren,Shengqing Lv,Chengdong Ji,Dongfang Xiang,Mengsi Zhang,Huimin Lu,Wenjuan Fu,Qing Liu,Zexuan Yan,Qinghua Ma,Jingya Miao,Ruili Cai,Xi Lan,Bin Wu,Wenying Wang,Yinhua Liu,Dai-Zhong Wang,Mianfu Cao,Zhicheng He,Yu Shi  ORCID: orcid.org/0000-0001-8436-604X,Yifang Ping,Xiaohong Yao,Xia Zhang,Peng Zhang,Ji Ming Wang,Yan Wang  ORCID: orcid.org/0000-0002-8150-5486,Youhong Cui &…Xiu-Wu Bian  ORCID: orcid.org/0000-0003-4383-0197 
https://doi.org/10.1038/s41392-022-00890-7
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Preventing autosomal-dominant hearing loss in Bth mice with CRISPR/CasRx-based RNA editing
Ziwen Zheng,Guo Li,Chong Cui,Fang Wang,Xiaohan Wang,Zhijiao Xu,Huiping Guo,Yuxin Chen,Honghai Tang,Daqi Wang,Mingqian Huang,Zheng-Yi Chen  ORCID: orcid.org/0000-0002-1452-4193,Xingxu Huang,Huawei Li,Geng-Lin Li,Xiaoxiang Hu  ORCID: orcid.org/0000-0001-7045-0283 &…Yilai Shu 
https://doi.org/10.1038/s41392-022-00893-4
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Exploration and functionalization of M1-macrophage extracellular vesicles for effective accumulation in glioblastoma and strong synergistic therapeutic effects
Xiaojun Wang,Hui Ding,Zongyang Li,Yaonan Peng,Hui Tan,Changlong Wang,Guodong Huang,Weiping Li,Guanghui Ma  ORCID: orcid.org/0000-0001-9154-5556 &…Wei Wei  ORCID: orcid.org/0000-0002-6244-3187 
https://doi.org/10.1038/s41392-022-00894-3
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Hymecromone: a clinical prescription hyaluronan inhibitor for efficiently blocking COVID-19 progression
Shuai Yang,Yun Ling,Fang Zhao,Wei Li,Zhigang Song,Lu Wang,Qiuting Li,Mengxing Liu,Ying Tong,Lu Chen,Daoping Ru,Tongsheng Zhang,Kaicheng Zhou,Baolong Zhang,Peng Xu,Zhicong Yang,Wenxuan Li,Yuanlin Song,Jianqing Xu  ORCID: orcid.org/0000-0003-0896-9273,Tongyu Zhu,Fei Shan,Wenqiang Yu &…Hongzhou Lu 
https://doi.org/10.1038/s41392-022-00952-w
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Therapeutic targeting miR130b counteracts diffuse large B-cell lymphoma progression via OX40/OX40L-mediated interaction with Th17 cells
Rui Sun,Pei-Pei Zhang,Xiang-Qin Weng,Xiao-Dong Gao,Chuan-Xin Huang  ORCID: orcid.org/0000-0003-2667-9587,Li Wang,Xiao-Xia Hu,Peng-Peng Xu,Lin Cheng,Lu Jiang,Di Fu,Bin Qu,Yan Zhao,Yan Feng,Hong-Jing Dou,Zhong Zheng &…Wei-Li Zhao 
https://doi.org/10.1038/s41392-022-00895-2
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The DNMT1-PAS1-PH20 axis drives breast cancer growth and metastasis
Yenan Fu,Xi Zhang,Xiao Liu,Peng Wang,Wenhui Chu,Wei Zhao,Yunling Wang,Guangbiao Zhou,Yu Yu &…Hongquan Zhang 
https://doi.org/10.1038/s41392-022-00896-1
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T cells expressing CD5/CD7 bispecific chimeric antigen receptors with fully human heavy-chain-only domains mitigate tumor antigen escape
Zhenyu Dai  ORCID: orcid.org/0000-0003-1856-5061,Wei Mu,Ya Zhao,Jiali Cheng,Haolong Lin,Kedong Ouyang,Xiangyin Jia,Jianwei Liu,Qiaoe Wei,Meng Wang,Chaohong Liu,Taochao Tan &…Jianfeng Zhou  ORCID: orcid.org/0000-0002-1332-9230 
https://doi.org/10.1038/s41392-022-00898-z
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POD Nanozyme optimized by charge separation engineering for light/pH activated bacteria catalytic/photodynamic therapy
Changyu Cao,Tingbo Zhang,Nan Yang,Xianghong Niu,Zhaobo Zhou,Jinlan Wang,Dongliang Yang,Peng Chen,Liping Zhong,Xiaochen Dong &…Yongxiang Zhao  ORCID: orcid.org/0000-0003-2214-5887 
https://doi.org/10.1038/s41392-022-00900-8
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Downregulation of MEIS1 mediated by ELFN1-AS1/EZH2/DNMT3a axis promotes tumorigenesis and oxaliplatin resistance in colorectal cancer
Yimin Li,Yaqi Gan,Jiaxin Liu,Juanni Li,Zhengwei Zhou,Ruotong Tian,Ruizheng Sun,Jiaqi Liu,Qing Xiao  ORCID: orcid.org/0000-0001-8969-6275,Yuanyuan Li,Pengyan Lu,Yulong Peng,Yuqian Peng,Guang Shu &…Gang Yin  ORCID: orcid.org/0000-0003-3753-0753 
https://doi.org/10.1038/s41392-022-00902-6
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Research Highlight
Overcoming unintended immunogenicity in immunocompetent mouse models of metastasis: the case of GFP
Christoph Schultheiß  ORCID: orcid.org/0000-0001-9789-5776 &Mascha Binder  ORCID: orcid.org/0000-0003-0663-3004 
https://doi.org/10.1038/s41392-022-00929-9
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Controlling glutathione entry into mitochondria: potential roles for SLC25A39 in health and (treatment of) disease
Oliver von Bohlen und Halbach 
https://doi.org/10.1038/s41392-022-00928-w
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A promising strategy against SARS-CoV-2: pyrimidine inhibitors synergize with nucleoside analogues
Long Min &Qiu Sun  ORCID: orcid.org/0000-0001-5122-2226 
https://doi.org/10.1038/s41392-022-00956-6
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Redox signaling-governed drug-tolerant persister cancer cell: a key spark of treatment failure
Liwu Fu &Zhe-Sheng Chen  ORCID: orcid.org/0000-0002-8289-097X 
https://doi.org/10.1038/s41392-022-00940-0
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STING, a critical contributor to SARS-CoV-2 immunopathology
Heyu Li,Fangfang Zhou  ORCID: orcid.org/0000-0003-1870-7584 &Long Zhang 
https://doi.org/10.1038/s41392-022-00967-3
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Review Article
Colorectal liver metastasis: molecular mechanism and interventional therapy
Hui Zhou,Zhongtao Liu,Yongxiang Wang,Xiaoyong Wen,Eric H. Amador,Liqin Yuan,Xin Ran,Li Xiong,Yuping Ran,Wei Chen  ORCID: orcid.org/0000-0002-6989-9830 &…Yu Wen 
https://doi.org/10.1038/s41392-022-00922-2
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Signaling pathways and targeted therapy for myocardial infarction
Qing Zhang,Lu Wang,Shiqi Wang,Hongxin Cheng,Lin Xu,Gaiqin Pei,Yang Wang,Chenying Fu,Yangfu Jiang  ORCID: orcid.org/0000-0002-8696-2651,Chengqi He &…Quan Wei 
https://doi.org/10.1038/s41392-022-00925-z
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The secretion profile of mesenchymal stem cells and potential applications in treating human diseases
Yuyi Han,Jianxin Yang,Jiankai Fang,Yipeng Zhou,Eleonora Candi,Jihong Wang,Dong Hua,Changshun Shao  ORCID: orcid.org/0000-0003-2618-9342 &…Yufang Shi  ORCID: orcid.org/0000-0001-8964-319X 
https://doi.org/10.1038/s41392-022-00932-0
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Antibody drug conjugate: the “biological missile” for targeted cancer therapy
Zhiwen Fu,Shijun Li,Sifei Han,Chen Shi &…Yu Zhang 
https://doi.org/10.1038/s41392-022-00947-7
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Advances in COVID-19 mRNA vaccine development
Enyue Fang,Xiaohui Liu,Miao Li,Zelun Zhang,Lifang Song,Baiyu Zhu,Xiaohong Wu,Jingjing Liu,Danhua Zhao &…Yuhua Li 
https://doi.org/10.1038/s41392-022-00950-y
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Notch signaling pathway: architecture, disease, and therapeutics
Binghan Zhou,Wanling Lin,Yaling Long,Yunkai Yang,Huan Zhang,Kongming Wu &…Qian Chu  ORCID: orcid.org/0000-0001-8192-7630 
https://doi.org/10.1038/s41392-022-00934-y
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Letter
SARS-CoV-2 spike L452R mutation increases Omicron variant fusogenicity and infectivity as well as host glycolysis
Yanan Zhang  ORCID: orcid.org/0000-0002-5039-0348,Ting Zhang,Yihui Fang,Jie Liu,Qinong Ye  ORCID: orcid.org/0000-0001-8032-8919 &…Lihua Ding  ORCID: orcid.org/0000-0002-5280-8162 
https://doi.org/10.1038/s41392-022-00941-z
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Persistent SARS-CoV-2 infection in asymptomatic young adults
Mai-Juan Ma  ORCID: orcid.org/0000-0002-8105-462X,Shao-Fu Qiu,Xiao-Ming Cui,Ming Ni,Hong-Jie Liu,Run-Ze Ye,Lin Yao,Hong-Bo Liu,Wu-Chun Cao &…Hong-Bin Song 
https://doi.org/10.1038/s41392-022-00931-1
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3-dose of RBD vaccine is sufficient to elicit a long-lasting memory response against SARS-CoV-2 infection
Mengqing Cong,Yunru Yang,Haiyang Tong,Ajmeri Sultana Shimu  ORCID: orcid.org/0000-0002-1838-436X,Baolong Wang,Qing Li,Fengyin Li,Yi Yang,Tengchuan Jin  ORCID: orcid.org/0000-0002-1395-188X &…Bofeng Li  ORCID: orcid.org/0000-0002-9110-8804 
https://doi.org/10.1038/s41392-022-00937-9
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Omicron: a chimera of two early SARS-CoV-2 lineages
Xiuliang Liu,Jiasheng Xiong,Zhong Sun  ORCID: orcid.org/0000-0002-3100-5053,Jingjing Hu,Karuppiah Thilakavathy,Mingquan Chen,Qi Zhao,Yi Feng  ORCID: orcid.org/0000-0002-7156-6023,Qingwu Jiang &…Chenglong Xiong 
https://doi.org/10.1038/s41392-022-00949-5
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PKCα phosphorylation of GLT-1 at Ser562/563 induces glutamate excitotoxicity in ischemia in mice
Yuqing Wang  ORCID: orcid.org/0000-0003-3903-8367,Jun Du  ORCID: orcid.org/0000-0002-1686-6226,Shanshan Lu  ORCID: orcid.org/0000-0001-7645-9377,Xia Li  ORCID: orcid.org/0000-0003-4181-576X,Yifei Chen,Chao Yuan,Sheng-Tao Hou &…Yizheng Wang 
https://doi.org/10.1038/s41392-022-00897-0
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Scalable biomimetic SARS-CoV‑2 nanovaccines with robust protective immune responses
Xuenian Chen,Tongfei Shi,Chao Yang,Fangman Chen,Xuan He,Kunbao Zhang,Hanze Hu,Lulu Cai  ORCID: orcid.org/0000-0002-5678-1112,Kam W. Leong &…Dan Shao  ORCID: orcid.org/0000-0002-5243-042X 
https://doi.org/10.1038/s41392-022-00942-y
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Identification of a SARS-CoV-2 virus-encoded small non-coding RNA in association with the neurological disorders in COVID-19 patients
Qian Zhao,Qiong Wang,Bing Zhao,Yixing Wang,Jinhui Lü,Yuefan Guo,Xiaoping Zhu,Lu Qian,Shanshan Yu,Lipeng Hao,Zhongmin Liu &…Zuoren Yu  ORCID: orcid.org/0000-0003-4196-9662 
https://doi.org/10.1038/s41392-022-00969-1
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