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Volume 7 Issue 3, Mar 2022

Article
EPHA2 mediates PDGFA activity and functions together with PDGFRA as prognostic marker and therapeutic target in glioblastoma
Qu-Jing Gai,Zhen Fu,Jiang He,Min Mao,Xiao-Xue Yao,Yan Qin,Xi Lan,Lin Zhang,Jing-Ya Miao,Yan-Xia Wang,Jiang Zhu,Fei-Cheng Yang,Hui-Min Lu,Ze-Xuan Yan,Fang-Lin Chen,Yu Shi  ORCID: orcid.org/0000-0001-8436-604X,Yi-Fang Ping,You-Hong Cui,Xia Zhang,Xindong Liu,Xiao-Hong Yao,Sheng-Qing Lv,Xiu-Wu Bian  ORCID: orcid.org/0000-0003-4383-0197 &…Yan Wang  ORCID: orcid.org/0000-0002-8150-5486 
https://doi.org/10.1038/s41392-021-00855-2
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Intracellular CYTL1, a novel tumor suppressor, stabilizes NDUFV1 to inhibit metabolic reprogramming in breast cancer
Wenwen Xue,Xin Li,Wuhao Li,Yixuan Wang,Chengfei Jiang,Lin Zhou,Jian Gao  ORCID: orcid.org/0000-0002-2722-7067,Ying Yu,Yan Shen &…Qiang Xu  ORCID: orcid.org/0000-0002-3530-9855 
https://doi.org/10.1038/s41392-021-00856-1
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Parallel profiling of antigenicity alteration and immune escape of SARS-CoV-2 Omicron and other variants
Cong Sun  ORCID: orcid.org/0000-0003-1786-7420,Yin-Feng Kang,Yuan-Tao Liu,Xiang-Wei Kong,Hui-Qin Xu,Dan Xiong,Chu Xie,Yi-Hao Liu,Sui Peng,Guo-Kai Feng,Zheng Liu &…Mu-Sheng Zeng  ORCID: orcid.org/0000-0003-3509-5591 
https://doi.org/10.1038/s41392-022-00910-6
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An ultrapotent RBD-targeted biparatopic nanobody neutralizes broad SARS-CoV-2 variants
Xiaojing Chi,Xinhui Zhang,Shengnan Pan,Yanying Yu,Yujin Shi,Tianli Lin,Huarui Duan,Xiuying Liu,Wenfang Chen,Xuehua Yang,Lan Chen,Xiaoqian Dong,Lili Ren,Qiang Ding,Jianwei Wang &…Wei Yang 
https://doi.org/10.1038/s41392-022-00912-4
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Sox2 induces glioblastoma cell stemness and tumor propagation by repressing TET2 and deregulating 5hmC and 5mC DNA modifications
Hernando Lopez-Bertoni  ORCID: orcid.org/0000-0001-6618-1092,Amanda Johnson  ORCID: orcid.org/0000-0002-3055-945X,Yuan Rui,Bachchu Lal,Sophie Sall,Maureen Malloy,Jonathan B. Coulter,Maria Lugo-Fagundo,Sweta Shudir,Harmon Khela  ORCID: orcid.org/0000-0002-1962-3844,Christopher Caputo,Jordan J. Green  ORCID: orcid.org/0000-0003-4176-3808 &…John Laterra 
https://doi.org/10.1038/s41392-021-00857-0
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Ionizable liposomal siRNA therapeutics enables potent and persistent treatment of Hepatitis B
Yuanyu Huang  ORCID: orcid.org/0000-0003-3935-7245,Shuquan Zheng,Zhaoxu Guo,Xavier de Mollerat du Jeu,Xing-Jie Liang,Zhiwei Yang,Hong-Yan Zhang,Shan Gao &…Zicai Liang 
https://doi.org/10.1038/s41392-021-00859-y
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Nuclear genome-derived circular RNA circPUM1 localizes in mitochondria and regulates oxidative phosphorylation in esophageal squamous cell carcinoma
Wei Gong,Jiancheng Xu,Yan Wang,Qingjie Min  ORCID: orcid.org/0000-0002-4330-7411,Xu Chen,Weimin Zhang,Jie Chen &…Qimin Zhan  ORCID: orcid.org/0000-0002-1731-938X 
https://doi.org/10.1038/s41392-021-00865-0
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Protein C receptor maintains cancer stem cell properties via activating lipid synthesis in nasopharyngeal carcinoma
Panpan Zhang,Qiuping He,Yaqin Wang,Guanqun Zhou,Yupei Chen  ORCID: orcid.org/0000-0002-0010-3494,Linglong Tang,Yuan Zhang,Xiaohong Hong,Yanping Mao,Qingmei He,Xiaojing Yang,Na Liu  ORCID: orcid.org/0000-0001-8654-3636 &…Jun Ma  ORCID: orcid.org/0000-0002-1137-9349 
https://doi.org/10.1038/s41392-021-00866-z
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Neuronal NR4A1 deficiency drives complement-coordinated synaptic stripping by microglia in a mouse model of lupus
Xiaojuan Han  ORCID: orcid.org/0000-0002-2455-0424,Tianshu Xu,Congzhu Ding,Dandan Wang,Genhong Yao,Hongwei Chen,Qijun Fang,Gang Hu &…Lingyun Sun 
https://doi.org/10.1038/s41392-021-00867-y
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Activation of RAS/MAPK pathway confers MCL-1 mediated acquired resistance to BCL-2 inhibitor venetoclax in acute myeloid leukemia
Qi Zhang  ORCID: orcid.org/0000-0002-7918-8952,Bridget Riley-Gillis,Lina Han,Yannan Jia,Alessia Lodi,Haijiao Zhang,Saravanan Ganesan,Rongqing Pan,Sergej N. Konoplev,Shannon R. Sweeney,Jeremy A. Ryan  ORCID: orcid.org/0000-0002-3327-1283,Yulia Jitkova,Kenneth Dunner Jr,Shaun E. Grosskurth,Priyanka Vijay  ORCID: orcid.org/0000-0002-6032-9081,Sujana Ghosh,Charles Lu,Wencai Ma,Stephen Kurtz,Vivian R. Ruvolo,Helen Ma,Connie C. Weng,Cassandra L. Ramage,Natalia Baran  ORCID: orcid.org/0000-0003-0618-4798,Ce Shi,Tianyu Cai,Richard Eric Davis,Venkata L. Battula  ORCID: orcid.org/0000-0001-5415-9058,Yingchang Mi,Jing Wang,Courtney D. DiNardo,Michael Andreeff  ORCID: orcid.org/0000-0002-1144-1958,Jeffery W. Tyner,Aaron Schimmer,Anthony Letai  ORCID: orcid.org/0000-0002-1993-9013,Rose Ann Padua,Carlos E. Bueso-Ramos,Stefano Tiziani,Joel Leverson,Relja Popovic &…Marina Konopleva 
https://doi.org/10.1038/s41392-021-00870-3
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Targeting polarized phenotype of microglia via IL6/JAK2/STAT3 signaling to reduce NSCLC brain metastasis
Yu Jin  ORCID: orcid.org/0000-0002-3427-4937,Yalin Kang,Minghuan Wang,Bili Wu,Beibei Su,Han Yin,Yang Tang,Qianxia Li,Wenjie Wei,Qi Mei,Guangyuan Hu,Veronika Lukacs-Kornek,Jian Li,Kongming Wu,Xianglin Yuan &…Wei Wang 
https://doi.org/10.1038/s41392-022-00872-9
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Thrombin induces ACSL4-dependent ferroptosis during cerebral ischemia/reperfusion
Qing-zhang Tuo,Yu Liu,Zheng Xiang,Hong-Fa Yan,Ting Zou,Yang Shu,Xu-long Ding,Jin-jun Zou,Shuo Xu,Fei Tang,Yan-qiu Gong,Xiao-lan Li,Yu-jie Guo  ORCID: orcid.org/0000-0002-4794-9921,Zhao-yue Zheng,Ai-ping Deng,Zhang-zhong Yang,Wen-jing Li,Shu-ting Zhang,Scott Ayton,Ashley I. Bush  ORCID: orcid.org/0000-0001-8259-9069,Heng Xu  ORCID: orcid.org/0000-0002-7748-2621,Lunzhi Dai  ORCID: orcid.org/0000-0002-3003-8910,Biao Dong &…Peng Lei  ORCID: orcid.org/0000-0001-5652-1962 
https://doi.org/10.1038/s41392-022-00917-z
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Multi-omic characterization of genome-wide abnormal DNA methylation reveals diagnostic and prognostic markers for esophageal squamous-cell carcinoma
Yiyi Xi,Yuan Lin,Wenjia Guo,Xinyu Wang,Hengqiang Zhao,Chuanwang Miao,Weiling Liu,Yachen Liu,Tianyuan Liu,Yingying Luo,Wenyi Fan  ORCID: orcid.org/0000-0002-7875-7404,Ai Lin,Yamei Chen  ORCID: orcid.org/0000-0002-9072-5157,Yanxia Sun  ORCID: orcid.org/0000-0002-2122-4009,Yulin Ma,Xiangjie Niu,Ce Zhong,Wen Tan,Meng Zhou  ORCID: orcid.org/0000-0001-9987-9024,Jianzhong Su,Chen Wu &…Dongxin Lin  ORCID: orcid.org/0000-0002-8723-8868 
https://doi.org/10.1038/s41392-022-00873-8
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Three doses of prototypic SARS-CoV-2 inactivated vaccine induce cross-protection against its variants of concern
Tianhong Xie,Shuaiyao Lu  ORCID: orcid.org/0000-0003-1675-9735,Zhanlong He,Hongqi Liu,Junbin Wang,Cong Tang,Ting Yang,Wenhai Yu,Hua Li,Yun Yang,Hao Yang,Lei Yue,Yanan Zhou,Fengmei Yang,Zhiwu Luo,Yanyan Li,Hong Xiang,Yuan Zhao,Jie Wang,Haixuan Wang,Runxiang Long,Dexuan Kuang,Wenjie Tan,Xiaozhong Peng  ORCID: orcid.org/0000-0002-8564-0247,Qihan Li &…Zhongping Xie 
https://doi.org/10.1038/s41392-022-00920-4
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Asymmetric, amphiphilic RGD conjugated phthalocyanine for targeted photodynamic therapy of triple negative breast cancer
Rui Li,Yiming Zhou,Yijia Liu,Xingpeng Jiang,Wenlong Zeng,Zhuoran Gong,Gang Zheng,Desheng Sun &…Zhifei Dai 
https://doi.org/10.1038/s41392-022-00906-2
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Phosphorylated NFS1 weakens oxaliplatin-based chemosensitivity of colorectal cancer by preventing PANoptosis
Jin-Fei Lin,Pei-Shan Hu,Yi-Yu Wang,Yue-Tao Tan,Kai Yu,Kun Liao,Qi-Nian Wu,Ting Li,Qi Meng,Jun-Zhong Lin,Ze-Xian Liu  ORCID: orcid.org/0000-0001-9698-0610,Heng-Ying Pu,Huai-Qiang Ju  ORCID: orcid.org/0000-0003-1713-5465,Rui-Hua Xu  ORCID: orcid.org/0000-0001-9771-8534 &…Miao-Zhen Qiu  ORCID: orcid.org/0000-0002-4774-6235 
https://doi.org/10.1038/s41392-022-00889-0
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Single-cell transcriptomic profiling unravels the adenoma-initiation role of protein tyrosine kinases during colorectal tumorigenesis
Xiaobo Zheng  ORCID: orcid.org/0000-0003-1361-6851,Jinen Song,Chune Yu,Zongguang Zhou,Xiaowei Liu,Jing Yu,Guangchao Xu  ORCID: orcid.org/0000-0002-3806-2245,Jiqiao Yang,Xiujing He,Xin Bai,Ya Luo,Yu Bao,Huifang Li,Lie Yang,Mingqing Xu,Nan Song,Xiaodong Su,Jie Xu  ORCID: orcid.org/0000-0001-9163-3898,Xuelei Ma &…Hubing Shi 
https://doi.org/10.1038/s41392-022-00881-8
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Letter
Intervening pyruvate carboxylase stunts tumor growth by strengthening anti-tumor actions of tumor-associated macrophages
Yuxin Shu,Nanfei Yang,Nan Cheng,Zhengyun Zou,Wenlong Zhang,Yuncheng Bei  ORCID: orcid.org/0000-0002-7645-7491,Qian Shi,Menghao Qin,Wei-Guo Zhu &…Pingping Shen 
https://doi.org/10.1038/s41392-021-00807-w
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sRAGE alleviates SARS-CoV-2-induced pneumonia in hamster
Xiuqin Zhang,Dan Li,Rui Sun,Xinli Hu  ORCID: orcid.org/0000-0003-4911-5354,Zhiqi Song,Xiaotian Ni,Hua Zhu,Tiannan Guo  ORCID: orcid.org/0000-0003-3869-7651,Chuan Qin  ORCID: orcid.org/0000-0002-6261-1232 &…Rui-Ping Xiao 
https://doi.org/10.1038/s41392-022-00883-6
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ACE2-Targeting antibody suppresses SARS-CoV-2 Omicron and Delta variants
Jianxia Ou,Yanan Zhang,Yongmei Wang,Zherui Zhang,Hongping Wei  ORCID: orcid.org/0000-0002-9948-8880,Junping Yu,Qi Wang,Guifeng Wang,Bo Zhang  ORCID: orcid.org/0000-0002-8895-3679 &…Chunhe Wang 
https://doi.org/10.1038/s41392-022-00913-3
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Omicron adopts a different strategy from Delta and other variants to adapt to host
Xiaohong Du,Haijun Tang,Long Gao,Zhao Wu,Fang Meng,Ruhong Yan,Shigang Qiao,Jianzhong An,Chen Wang &…F. Xiao-Feng Qin 
https://doi.org/10.1038/s41392-022-00903-5
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Female sex hormone, progesterone, ameliorates the severity of SARS-CoV-2-caused pneumonia in the Syrian hamster model
Lunzhi Yuan,Huachen Zhu,Kun Wu,Ming Zhou,Jian Ma,Rirong Chen,Qiyi Tang  ORCID: orcid.org/0000-0002-6487-2356,Tong Cheng,Yi Guan &…Ningshao Xia  ORCID: orcid.org/0000-0003-0179-5266 
https://doi.org/10.1038/s41392-021-00860-5
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Liposomal Honokiol induces ROS-mediated apoptosis via regulation of ERK/p38-MAPK signaling and autophagic inhibition in human medulloblastoma
Shenglan Li,Jinyi Chen,Yaqiong Fan,Ce Wang,Can Wang,Xiaohong Zheng,Feng Chen &…Wenbin Li 
https://doi.org/10.1038/s41392-021-00869-w
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Characterization of SARS-CoV-2 Omicron spike RBD reveals significantly decreased stability, severe evasion of neutralizing-antibody recognition but unaffected engagement by decoy ACE2 modified for enhanced RBD binding
Sheng Lin,Zimin Chen,Xindan Zhang,Ao Wen,Xin Yuan,Chongzhang Yu,Jing Yang,Bin He,Yu Cao &…Guangwen Lu  ORCID: orcid.org/0000-0001-7568-592X 
https://doi.org/10.1038/s41392-022-00914-2
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Nasal delivery of thermostable and broadly neutralizing antibodies protects mice against SARS-CoV-2 infection
Wenhui Fan,Shanshan Sun,Ning Zhang,Yuan Zhang,Pengtao Jiao,Jian Wang,George F. Gao  ORCID: orcid.org/0000-0002-3869-615X,Wenjun Liu,Yuhai Bi  ORCID: orcid.org/0000-0002-5595-363X &…Limin Yang  ORCID: orcid.org/0000-0002-1158-0800 
https://doi.org/10.1038/s41392-022-00911-5
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Different pathogenesis of SARS-CoV-2 Omicron variant in wild-type laboratory mice and hamsters
Ya-Nan Zhang,Zhe-Rui Zhang,Hong-Qing Zhang,Na Li,Qiu-Yan Zhang,Xiao-Dan Li,Cheng-Lin Deng,Fei Deng,Shuo Shen,Bing Zhu &…Bo Zhang  ORCID: orcid.org/0000-0002-8895-3679 
https://doi.org/10.1038/s41392-022-00930-2
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A novel strategy for identifying biomarker in serum of patient with COVID-19 using immune complex
Fugang Duan,Yifan Wang,Taoyu Chen  ORCID: orcid.org/0000-0002-8966-1264,Zhu Zhu,Meng Yu,Hui Dai,Shangen Zheng,Yinying Lu,Tingting Li &…Xiaoyan Qiu 
https://doi.org/10.1038/s41392-022-00909-z
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Review Article
Emerging new therapeutic antibody derivatives for cancer treatment
Shijie Jin,Yanping Sun,Xiao Liang,Xinyu Gu,Jiangtao Ning,Yingchun Xu,Shuqing Chen &…Liqiang Pan 
https://doi.org/10.1038/s41392-021-00868-x
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Molecular regulations of circadian rhythm and implications for physiology and diseases
Francesca Fagiani,Daniele Di Marino,Alice Romagnoli,Cristina Travelli,Davide Voltan,Lorenzo Di Cesare Mannelli,Marco Racchi,Stefano Govoni  ORCID: orcid.org/0000-0002-7243-6837 &…Cristina Lanni  ORCID: orcid.org/0000-0002-3061-4738 
https://doi.org/10.1038/s41392-022-00899-y
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Therapeutic peptides: current applications and future directions
Lei Wang,Nanxi Wang,Wenping Zhang,Xurui Cheng,Zhibin Yan,Gang Shao,Xi Wang,Rui Wang &…Caiyun Fu  ORCID: orcid.org/0000-0003-4090-885X 
https://doi.org/10.1038/s41392-022-00904-4
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The mechanism underlying extrapulmonary complications of the coronavirus disease 2019 and its therapeutic implication
Qin Ning,Di Wu,Xiaojing Wang,Dong Xi,Tao Chen,Guang Chen,Hongwu Wang,Huiling Lu,Ming Wang,Lin Zhu,Junjian Hu,Tingting Liu,Ke Ma,Meifang Han &…Xiaoping Luo 
https://doi.org/10.1038/s41392-022-00907-1
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Perspective
Cryo-EM advances in RNA structure determination
Haiyun Ma  ORCID: orcid.org/0000-0003-2046-9212,Xinyu Jia,Kaiming Zhang  ORCID: orcid.org/0000-0003-0414-4776 &…Zhaoming Su  ORCID: orcid.org/0000-0002-9279-1721 
https://doi.org/10.1038/s41392-022-00916-0
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