Table of Contents
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Volume 7 Issue 2, Feb 2022

Review Article
Wnt/β-catenin signalling: function, biological mechanisms, and therapeutic opportunities
Jiaqi Liu,Qing Xiao,Jiani Xiao,Chenxi Niu,Yuanyuan Li,Xiaojun Zhang,Zhengwei Zhou,Guang Shu &…Gang Yin  ORCID: orcid.org/0000-0003-3753-0753 
https://doi.org/10.1038/s41392-021-00762-6
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Ketogenic diet for human diseases: the underlying mechanisms and potential for clinical implementations
Huiyuan Zhu,Dexi Bi,Youhua Zhang,Cheng Kong,Jiahao Du,Xiawei Wu,Qing Wei &…Huanlong Qin 
https://doi.org/10.1038/s41392-021-00831-w
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Structural biology of SARS-CoV-2: open the door for novel therapies
Weizhu Yan,Yanhui Zheng,Xiaotao Zeng,Bin He &…Wei Cheng 
https://doi.org/10.1038/s41392-022-00884-5
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Letter
Non-cell-autonomous manner of AAV administration to attenuate cardiomyocyte hypertrophy by targeting paracrine signaling on ECM to reduce viral dosage
Lei Liu,Peng Yue,Yue Zhang,Yimin Hua,Wenwei Bi,Hualin Yan,Hongyu Liao,Jiawen Li,Kaiyu Zhou &…Yifei Li  ORCID: orcid.org/0000-0002-3096-4287 
https://doi.org/10.1038/s41392-021-00715-z
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Mutations of MSH5 in nonobstructive azoospermia (NOA) and rescued via in vivo gene editing
Min Chen,Chencheng Yao,Yingying Qin,Xiuhong Cui,Peng Li,Zhiyong Ji,Limei Lin,Haowei Wu,Zhi Zhou,Yaoting Gui,Zheng Li &…Fei Gao  ORCID: orcid.org/0000-0002-4029-6411 
https://doi.org/10.1038/s41392-021-00710-4
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ASTE1 frameshift mutation triggers the immune response in Epstein-Barr virus-associated gastric cancer
Binhao Huang,Qin Li,Qirong Geng,Jiawen Lao,Jing Guo,Shenglin Huang &…Dazhi Xu 
https://doi.org/10.1038/s41392-021-00771-5
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SARS-CoV-2 Omicron RBD shows weaker binding affinity than the currently dominant Delta variant to human ACE2
Leyun Wu,Liping Zhou,Mengxia Mo,Tingting Liu,Chengkun Wu,Chunye Gong,Kai Lu,Likun Gong,Weiliang Zhu  ORCID: orcid.org/0000-0001-6699-5299 &…Zhijian Xu  ORCID: orcid.org/0000-0002-3063-8473 
https://doi.org/10.1038/s41392-021-00863-2
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A binding-enhanced but enzymatic activity-eliminated human ACE2 efficiently neutralizes SARS-CoV-2 variants
Anqi Zheng,Lili Wu,Renyi Ma  ORCID: orcid.org/0000-0002-6152-9050,Pu Han,Baoying Huang,Chengpeng Qiao,Qihui Wang  ORCID: orcid.org/0000-0003-3768-0401,Wenjie Tan,George F. Gao  ORCID: orcid.org/0000-0002-3869-615X &…Pengcheng Han 
https://doi.org/10.1038/s41392-021-00821-y
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PDCD1 (PD-1) is a direct target of miR-15a-5p and miR-16-5p
Alexey Palamarchuk,Liudmyla Tsyba,Luisa Tomasello,Yuri Pekarsky &…Carlo M. Croce 
https://doi.org/10.1038/s41392-021-00832-9
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From prodrug to pro-prodrug: hypoxia-sensitive antibody–drug conjugates
Yanming Wang,Dian Xiao,Jiaguo Li,Shiyong Fan,Fei Xie,Wu Zhong  ORCID: orcid.org/0000-0002-0536-620X,Xinbo Zhou &…Song Li 
https://doi.org/10.1038/s41392-021-00833-8
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A non-ACE2-blocking neutralizing antibody against Omicron-included SARS-CoV-2 variants
Xiaomin Duan,Rui Shi,Pulan Liu,Qingrui Huang,Fengze Wang,Xinyu Chen,Hui Feng,Weijin Huang  ORCID: orcid.org/0000-0002-4246-8889,Junyu Xiao  ORCID: orcid.org/0000-0003-1822-1701 &…Jinghua Yan  ORCID: orcid.org/0000-0003-0502-3829 
https://doi.org/10.1038/s41392-022-00879-2
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Proteomic and phosphoproteomic profiling of COVID-19-associated lung and liver injury: a report based on rhesus macaques
Jiang-Feng Liu,Ya-Nan Zhou,Shuai-Yao Lu  ORCID: orcid.org/0000-0003-1675-9735,Ye-Hong Yang,Song-Feng Wu,De-Pei Liu,Xiao-Zhong Peng  ORCID: orcid.org/0000-0002-8564-0247 &…Jun-Tao Yang 
https://doi.org/10.1038/s41392-022-00882-7
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Article
USP10 regulates B cell response to SARS-CoV-2 or HIV-1 nanoparticle vaccines through deubiquitinating AID
Yuewen Luo,Xiantao Zhang,Ran Chen,Rong Li,Yang Liu,Junsong Zhang,Qin liu,Meijun Si,Jun Liu,Bolin Wu,Xuemei Wang,Shijian Wu,Yiwen Zhang,Xu Zhang,Deyin Guo  ORCID: orcid.org/0000-0002-8297-0814,Xin He  ORCID: orcid.org/0000-0002-2131-2092,Ting Pan &…Hui Zhang  ORCID: orcid.org/0000-0003-3620-610X 
https://doi.org/10.1038/s41392-021-00858-z
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FSAP aggravated endothelial dysfunction and neurological deficits in acute ischemic stroke due to large vessel occlusion
Dai-Shi Tian,Chuan Qin  ORCID: orcid.org/0000-0001-5162-3150,Luo-Qi Zhou,Sheng Yang,Man Chen,Jun Xiao,Ke Shang,Dale B. Bosco,Long-Jun Wu &…Wei Wang 
https://doi.org/10.1038/s41392-021-00802-1
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Integrated single-cell RNA sequencing analysis reveals distinct cellular and transcriptional modules associated with survival in lung cancer
Li Zhang,Yiming Zhang  ORCID: orcid.org/0000-0002-5099-3894,Chengdi Wang,Ying Yang,Yinyun Ni,Zhoufeng Wang,Tingting Song,Menglin Yao,Zhiqiang Liu,Ningning Chao,Yongfeng Yang,Jun Shao,Zhidan Li,Ran Zhou,Li Chen,Dan Zhang,Yuancun Zhao,Wei Liu,Yupeng Li,Ping He,Jing-wen Lin,Yuan Wang  ORCID: orcid.org/0000-0002-6324-6134,Kang Zhang,Lu Chen  ORCID: orcid.org/0000-0002-1083-9729 &…Weimin Li  ORCID: orcid.org/0000-0003-0985-0311 
https://doi.org/10.1038/s41392-021-00824-9
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The antigenicity of SARS-CoV-2 Delta variants aggregated 10 high-frequency mutations in RBD has not changed sufficiently to replace the current vaccine strain
Jiajing Wu,Jianhui Nie,Li Zhang,Hao Song  ORCID: orcid.org/0000-0002-2811-0370,Yimeng An,Ziteng Liang,Jing Yang,Ruxia Ding,Shuo Liu,Qianqian Li,Tao Li,Zhimin Cui,Mengyi Zhang,Peng He,Youchun Wang  ORCID: orcid.org/0000-0001-9769-5141,Xiaowang Qu,Zhongyu Hu,Qihui Wang  ORCID: orcid.org/0000-0003-3768-0401 &…Weijin Huang  ORCID: orcid.org/0000-0002-4246-8889 
https://doi.org/10.1038/s41392-022-00874-7
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Interleukin-37 promotes colitis-associated carcinogenesis via SIGIRR-mediated cytotoxic T cells dysfunction
Zhen Wang,Fan-lian Zeng,Ya-wen Hu,Xiao-yan Wang,Fu-lei Zhao,Pei Zhou,Jing Hu,Yuan-yuan Xiao,Zhong-lan Hu,Ming-feng Guo,Xiao-qiong Wei,Xiao Liu,Nong-yu Huang,Jun Zhang,Shu-wen Chen,Juan Cheng,Hua-ping Zheng,Hong Zhou,Qi-xiang Zhao,Chen Zhang,Yan Hao,Song Zou,Yi-yue Gui,Jia-dong Yu,Lin-na Gu,Cheng-cheng Yue,Hao-zhou Zhang,Wen-ling Wu,Yi-fan Zhou,Xi-kun Zhou  ORCID: orcid.org/0000-0001-6768-2382,Guo-bo Shen,Xiu Teng &…Jiong Li  ORCID: orcid.org/0000-0002-3742-630X 
https://doi.org/10.1038/s41392-021-00820-z
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SARS-CoV-2 NSP5 and N protein counteract the RIG-I signaling pathway by suppressing the formation of stress granules
Yi Zheng  ORCID: orcid.org/0000-0001-9579-1711,Jian Deng,Lulu Han,Meng-Wei Zhuang,Yanwen Xu,Jing Zhang,Mei-Ling Nan,Yang Xiao,Peng Zhan,Xinyong Liu,Chengjiang Gao  ORCID: orcid.org/0000-0002-9365-4497 &…Pei-Hui Wang  ORCID: orcid.org/0000-0001-6853-2423 
https://doi.org/10.1038/s41392-022-00878-3
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MARCH3 negatively regulates IL-3-triggered inflammatory response by mediating K48-linked polyubiquitination and degradation of IL-3Rα
Lu Feng,Chen Li,Lin-Wen Zeng,Deng Gao,Yu-Hao Sun,Li Zhong,Heng Lin,Hong-Bing Shu  ORCID: orcid.org/0000-0001-9102-3272 &…Shu Li 
https://doi.org/10.1038/s41392-021-00834-7
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Whole-genome sequencing reveals the evolutionary trajectory of HBV-related hepatocellular carcinoma early recurrence
Shao-Lai Zhou  ORCID: orcid.org/0000-0002-8526-5221,Zheng-Jun Zhou,Cheng-Li Song,Hao-Yang Xin,Zhi-Qiang Hu,Chu-Bin Luo,Yi-Jie Luo,Jia Li,Zhi Dai  ORCID: orcid.org/0000-0002-4032-9201,Xin-Rong Yang  ORCID: orcid.org/0000-0002-2716-9338,Ying-Hong Shi,Zheng Wang,Xiao-Wu Huang,Jia Fan  ORCID: orcid.org/0000-0001-5158-629X &…Jian Zhou  ORCID: orcid.org/0000-0002-2118-1117 
https://doi.org/10.1038/s41392-021-00838-3
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Safety and activity of WX-0593 (Iruplinalkib) in patients with ALK- or ROS1-rearranged advanced non-small cell lung cancer: a phase 1 dose-escalation and dose-expansion trial
Yuankai Shi  ORCID: orcid.org/0000-0002-3342-4964,Jian Fang,Xuezhi Hao,Shucai Zhang,Yunpeng Liu,Lin Wang,Jianhua Chen,Yi Hu,Xiaosheng Hang,Juan Li,Chunling Liu,Yiping Zhang,Zhehai Wang,Yanping Hu,Kangsheng Gu,Jian’an Huang,Liangming Zhang,Jinlu Shan,Weiwei Ouyang,Yanqiu Zhao,Wu Zhuang,Yan Yu,Jun Zhao,Helong Zhang,Pei Lu,Weidong Li,Meimei Si,Mingjing Ge &…Huaize Geng 
https://doi.org/10.1038/s41392-021-00841-8
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Integrated histopathological, lipidomic, and metabolomic profiles reveal mink is a useful animal model to mimic the pathogenicity of severe COVID-19 patients
Zhiqi Song,Linlin Bao,Wei Deng,Jiangning Liu,Erjun Ren,Qi Lv,Mingya Liu,Feifei Qi,Ting Chen,Ran Deng,Fengdi Li,Yunpeng Liu,Qiang Wei,Hong Gao,Pin Yu,Yunlin Han,Wenjie Zhao,Junjun Zheng,Xujian Liang,Fuhe Yang &…Chuan Qin  ORCID: orcid.org/0000-0002-6261-1232 
https://doi.org/10.1038/s41392-022-00891-6
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LncRNAs LCETRL3 and LCETRL4 at chromosome 4q12 diminish EGFR-TKIs efficiency in NSCLC through stabilizing TDP43 and EIF2S1
Yankang Li,Yue Shen,Mengyu Xie,Bowen Wang,Teng Wang,Jiajia Zeng,Hui Hua,Jinming Yu &…Ming Yang  ORCID: orcid.org/0000-0003-0310-5839 
https://doi.org/10.1038/s41392-021-00847-2
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Research Highlight
Phenotypic characteristics and T cell receptor properties in melanoma: deciphering the correlation at single-cell resolution
Yier Lu,Chenyang Ye &Ying Yuan  ORCID: orcid.org/0000-0002-3922-9553 
https://doi.org/10.1038/s41392-021-00864-1
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A new perspective on immune evasion: escaping immune surveillance by inactivating tumor suppressors
Svenja Mergener  ORCID: orcid.org/0000-0002-0825-6938 &Samuel Peña-Llopis  ORCID: orcid.org/0000-0003-3847-1353 
https://doi.org/10.1038/s41392-022-00875-6
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Barring the gates to the battleground: DDR1 promotes immune exclusion in solid tumors
Dimitrios L. Wagner  ORCID: orcid.org/0000-0002-2189-3579 &Enrico Klotzsch 
https://doi.org/10.1038/s41392-022-00877-4
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Signals from the interface: protein nanoclusters stabilize biomolecular condensates
Christian Hoffmann,Branislava Rankovic &Dragomir Milovanovic  ORCID: orcid.org/0000-0002-6625-1879 
https://doi.org/10.1038/s41392-022-00876-5
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SARS-CoV-2 variant Omicron: currently the most complete “escapee” from neutralization by antibodies and vaccines
Maochen Li  ORCID: orcid.org/0000-0001-8786-5039,Fuxing Lou  ORCID: orcid.org/0000-0002-5217-6281 &Huahao Fan  ORCID: orcid.org/0000-0001-5007-2158 
https://doi.org/10.1038/s41392-022-00880-9
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NK cell dysfunction in severe COVID-19: TGF-β-induced downregulation of integrin beta-2 restricts NK cell cytotoxicity
Joana Barros-Martins  ORCID: orcid.org/0000-0002-3370-4990,Reinhold Förster &Berislav Bošnjak  ORCID: orcid.org/0000-0003-3374-7488 
https://doi.org/10.1038/s41392-022-00892-5
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