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Volume 7 Issue 1, Jan 2022

Article
Fis1 phosphorylation by Met promotes mitochondrial fission and hepatocellular carcinoma metastasis
Yan Yu,Xiao-Dan Peng,Xiao-Jun Qian,Kai-Ming Zhang,Xiang Huang,Yu-Hong Chen,Yun-Tian Li,Gong-Kan Feng,Hai-Liang Zhang,Xue-Lian Xu,Shun Li,Xuan Li,Jia Mai,Zhi-Ling Li,Yun Huang,Dong Yang,Li-Huan Zhou,Zhuo-Yan Zhong,Jun-Dong Li,Rong Deng &…Xiao-Feng Zhu  ORCID: orcid.org/0000-0002-1250-0796 
https://doi.org/10.1038/s41392-021-00790-2
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Generation of in situ CRISPR-mediated primary and metastatic cancer from monkey liver
Liping Zhong,Yong Huang,Jian He,Nuo Yang,Banghao Xu,Yun Ma,Junjie Liu,Chao Tang,Chengpiao Luo,Pan Wu,Zongqiang Lai,Yu Huo,Tao Lu,Dongni Huang,Wenlin Gong,Lu Gan,Yiqun Luo,Zhikun Zhang,Xiyu Liu &…Yongxiang Zhao  ORCID: orcid.org/0000-0003-2214-5887 
https://doi.org/10.1038/s41392-021-00799-7
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Azvudine is a thymus-homing anti-SARS-CoV-2 drug effective in treating COVID-19 patients
Jin-Lan Zhang,Yu-Huan Li,Lu-Lu Wang,Hong-Qi Liu,Shuai-Yao Lu,Yong Liu,Ke Li,Bin Liu,Su-Yun Li,Feng-Min Shao,Kun Wang,Ning Sheng,Rui Li,Jin-Jin Cui,Pei-Chun Sun,Chun-Xia Ma,Bo Zhu,Zhe Wang,Yuan-Hao Wan,Shi-Shan Yu,Yongsheng Che,Chao-Yang Wang,Chen Wang,Qiangqian Zhang,Li-Min Zhao,Xiao-Zhong Peng,Zhenshun Cheng,Jun-Biao Chang &…Jian-Dong Jiang  ORCID: orcid.org/0000-0003-1173-685X 
https://doi.org/10.1038/s41392-021-00835-6
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Endothelial dysfunction contributes to severe COVID-19 in combination with dysregulated lymphocyte responses and cytokine networks
Louisa Ruhl,Isabell Pink,Jenny F. Kühne,Kerstin Beushausen,Jana Keil,Stella Christoph,Andrea Sauer,Lennart Boblitz,Julius Schmidt,Sascha David,Hans-Martin Jäck,Edith Roth,Markus Cornberg,Thomas F. Schulz,Tobias Welte,Marius M. Höper &…Christine S. Falk  ORCID: orcid.org/0000-0003-1376-7318 
https://doi.org/10.1038/s41392-021-00819-6
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Infection of wild-type mice by SARS-CoV-2 B.1.351 variant indicates a possible novel cross-species transmission route
Ting Pan,Ran Chen,Xin He  ORCID: orcid.org/0000-0002-2131-2092,Yaochang Yuan,Xiaohui Deng,Rong Li,Haiping Yan,Shumei Yan,Jun Liu,Yiwen Zhang  ORCID: orcid.org/0000-0002-5232-0335,Xiantao Zhang,Fei Yu,Mo Zhou,Changwen Ke,Xiancai Ma  ORCID: orcid.org/0000-0002-4934-4221 &…Hui Zhang  ORCID: orcid.org/0000-0003-3620-610X 
https://doi.org/10.1038/s41392-021-00848-1
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COVID-19 induces new-onset insulin resistance and lipid metabolic dysregulation via regulation of secreted metabolic factors
Xi He,Chenshu Liu,Jiangyun Peng,Zilun Li,Fang Li,Jian Wang,Ao Hu,Meixiu Peng,Kan Huang,Dongxiao Fan,Na Li,Fuchun Zhang,Weiping Cai,Xinghua Tan,Zhongwei Hu,Xilong Deng,Yueping Li,Xiaoneng Mo,Linghua Li,Yaling Shi,Li Yang,Yuanyuan Zhu,Yanrong Wu,Huichao Liang,Baolin Liao,Wenxin Hong,Ruiying He,Jiaojiao Li,Pengle Guo,Youguang Zhuo,Lingzhai Zhao,Fengyu Hu,Wenxue Li,Wei Zhu,Zefeng Zhang,Zeling Guo,Wei Zhang,Xiqiang Hong,Weikang Cai,Lei Gu,Ziming Du,Yang Zhang,Jin Xu  ORCID: orcid.org/0000-0003-0944-9835,Tao Zuo  ORCID: orcid.org/0000-0001-8450-5281,Kai Deng  ORCID: orcid.org/0000-0002-9973-8130,Li Yan,Xinwen Chen,Sifan Chen &…Chunliang Lei 
https://doi.org/10.1038/s41392-021-00822-x
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SARS-CoV-2-triggered mast cell rapid degranulation induces alveolar epithelial inflammation and lung injury
Meng-Li Wu,Feng-Liang Liu  ORCID: orcid.org/0000-0002-5038-5012,Jing Sun,Xin Li,Xiao-Yan He,Hong-Yi Zheng,Yan-Heng Zhou,Qihong Yan,Ling Chen,Guo-Ying Yu,Junbiao Chang,Xia Jin,Jincun Zhao  ORCID: orcid.org/0000-0003-2515-5589,Xin-Wen Chen,Yong-Tang Zheng  ORCID: orcid.org/0000-0001-5469-0324 &…Jian-Hua Wang 
https://doi.org/10.1038/s41392-021-00849-0
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An RNA–RNA crosstalk network involving HMGB1 and RICTOR facilitates hepatocellular carcinoma tumorigenesis by promoting glutamine metabolism and impedes immunotherapy by PD-L1+ exosomes activity
Yanping Wei,Xuewu Tang,Yibin Ren,Yun Yang,Fengliang Song,Jingbo Fu,Shuowu Liu,Miao Yu,Jing Chen,Suyang Wang,Kecheng Zhang,Yexiong Tan,Zhipeng Han,Lixin Wei,Baohua Zhang,Zhangjun Cheng,Liang Li &…Hongyang Wang  ORCID: orcid.org/0000-0002-4709-3334 
https://doi.org/10.1038/s41392-021-00801-2
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Inactivated SARS-CoV-2 induces acute respiratory distress syndrome in human ACE2-transgenic mice
Zhenfei Bi,Weiqi Hong  ORCID: orcid.org/0000-0003-1668-2301,Haiying Que,Cai He,Wenyan Ren  ORCID: orcid.org/0000-0001-6333-8496,Jingyun Yang,Tianqi Lu,Li Chen,Shuaiyao Lu  ORCID: orcid.org/0000-0003-1675-9735,Xiaozhong Peng  ORCID: orcid.org/0000-0002-8564-0247 &…Xiawei Wei  ORCID: orcid.org/0000-0002-6513-6422 
https://doi.org/10.1038/s41392-021-00851-6
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Long-term stability and protection efficacy of the RBD-targeting COVID-19 mRNA vaccine in nonhuman primates
Hui Zhao  ORCID: orcid.org/0000-0003-0576-1012,Tie-Cheng Wang,Xiao-Feng Li,Na-Na Zhang,Liang Li,Chao Zhou,Yong-Qiang Deng  ORCID: orcid.org/0000-0002-2306-1039,Tian-Shu Cao,Guan Yang,Rui-Ting Li,Yi-Jiao Huang,Yuan-Guo Li,Yi-Ming Zhang,Fang-Xu Li,Yu-Ren Zhou,Yu-Hang Jiang,Xi-Shan Lu,Shi-Hui Sun,Meng-Li Cheng,Kai-Ping Gu,Mei Zhang,Qing-Qing Ma,Xiao Yang,Bo Ying,Yu-Wei Gao &…Cheng-Feng Qin  ORCID: orcid.org/0000-0002-0632-2807 
https://doi.org/10.1038/s41392-021-00861-4
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Research Highlight
A novel model of molnupiravir against SARS-CoV-2 replication: accumulated RNA mutations to induce error catastrophe
Yuxi Zhao,Gu He  ORCID: orcid.org/0000-0002-1536-8882 &Wei Huang  ORCID: orcid.org/0000-0003-0832-1864 
https://doi.org/10.1038/s41392-021-00837-4
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First-line anti-VEGF plus EGFR-TKI in EGFR-mutant NSCLC: adding the ARTEMIS trial to the puzzle of current evidence
Susanne Hafner  ORCID: orcid.org/0000-0003-0663-8382 
https://doi.org/10.1038/s41392-021-00813-y
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Neutrophil swarm control: what goes up must come down
Stefan Uderhardt,Jasmin Knopf &Martin Herrmann 
https://doi.org/10.1038/s41392-021-00836-5
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New strategy for cancer immunotherapy: using live engineered bacteria for metabolic modulation
Tong Li &Wenjing Wang 
https://doi.org/10.1038/s41392-021-00829-4
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Greasy hair against obesity
Sandra Nickel &Bruno Christ 
https://doi.org/10.1038/s41392-021-00850-7
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Melanoma development: stage-dependent cancer competence of the melanocytic lineage
Manfred Kunz 
https://doi.org/10.1038/s41392-021-00854-3
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“Moonlighting” at the power plant: how mitochondria facilitate serial killing by CD8+ cytotoxic T cells
Dimitrios Mougiakakos &Sascha Kahlfuss 
https://doi.org/10.1038/s41392-021-00846-3
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Acquired cancer tyrosine kinase inhibitor resistance: ROS as critical determinants
Sander Bekeschus  ORCID: orcid.org/0000-0002-8773-8862 
https://doi.org/10.1038/s41392-021-00844-5
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MEOX1: a novel druggable target that orchestrates the activation of fibroblasts in cardiac fibrosis
David Schumacher  ORCID: orcid.org/0000-0002-2308-6543,Fabian Peisker  ORCID: orcid.org/0000-0003-0123-8179 &Rafael Kramann 
https://doi.org/10.1038/s41392-021-00842-7
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Letter
Aiphanol, a native compound, suppresses angiogenesis via dual-targeting VEGFR2 and COX2
Shanmei Chen,Junnan Feng,Chuanke Zhao,Lixin Wang,Lin Meng,Caiyun Liu,Shaoqing Cai,Yanxing Jia,Like Qu &…Chengchao Shou 
https://doi.org/10.1038/s41392-021-00739-5
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Heterologous prime-boost with AdC68- and mRNA-based COVID-19 vaccines elicit potent immune responses in mice
Wenjuan Li,Xingxing Li,Danhua Zhao,Jingjing Liu,Ling Wang,Miao Li,Xinyu Liu,Jia Li,Xiaohong Wu &…Yuhua Li 
https://doi.org/10.1038/s41392-021-00843-6
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SARS-CoV-2 Omicron strain exhibits potent capabilities for immune evasion and viral entrance
Xiantao Zhang,Shijian Wu,Bolin Wu,Qirui Yang,Achun Chen,Yuzhuang Li,Yiwen Zhang  ORCID: orcid.org/0000-0002-5232-0335,Ting Pan,Hui Zhang  ORCID: orcid.org/0000-0003-3620-610X &…Xin He  ORCID: orcid.org/0000-0002-2131-2092 
https://doi.org/10.1038/s41392-021-00852-5
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Escaping alveolar macrophage endosomal retention explains massive expansion of SARS-CoV-2 delta variant
Zhenfeng Wang,Yabo Zhou,Linlin Bao,Dan Li,Jiadi Lv,Dianheng Wang,Shunshun Li,Wei-Min Tong,Jiangning Liu,Chuan Qin  ORCID: orcid.org/0000-0002-6261-1232 &…Bo Huang  ORCID: orcid.org/0000-0001-8476-1138 
https://doi.org/10.1038/s41392-021-00845-4
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Tamoxifen and clomiphene inhibit SARS-CoV-2 infection by suppressing viral entry
Shulong Zu,Dan Luo,Lili Li,Qing Ye,Rui-Ting Li,Yanan Wang,Meiling Gao,Heng Yang  ORCID: orcid.org/0000-0002-1491-4490,Yong-Qiang Deng  ORCID: orcid.org/0000-0002-2306-1039 &…Genhong Cheng  ORCID: orcid.org/0000-0002-6713-2783 
https://doi.org/10.1038/s41392-021-00853-4
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Review Article
T cell receptor (TCR) signaling in health and disease
Kinjal Shah,Amr Al-Haidari,Jianmin Sun &…Julhash U. Kazi  ORCID: orcid.org/0000-0002-0719-5336 
https://doi.org/10.1038/s41392-021-00823-w
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Current hydrogel advances in physicochemical and biological response-driven biomedical application diversity
Huan Cao,Lixia Duan,Yan Zhang,Jun Cao &…Kun Zhang  ORCID: orcid.org/0000-0002-6971-1164 
https://doi.org/10.1038/s41392-021-00830-x
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Targeting PI3K/Akt signal transduction for cancer therapy
Yan He,Miao Miao Sun,Guo Geng Zhang,Jing Yang,Kui Sheng Chen,Wen Wen Xu &…Bin Li  ORCID: orcid.org/0000-0002-8979-610X 
https://doi.org/10.1038/s41392-021-00828-5
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Insights into the post-translational modification and its emerging role in shaping the tumor microenvironment
Wen Li,Feifei Li,Xia Zhang,Hui-Kuan Lin &…Chuan Xu  ORCID: orcid.org/0000-0002-5320-2277 
https://doi.org/10.1038/s41392-021-00825-8
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Signal pathways of melanoma and targeted therapy
Weinan Guo,Huina Wang &Chunying Li  ORCID: orcid.org/0000-0003-3004-5376 
https://doi.org/10.1038/s41392-021-00827-6
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An overview of kinase downregulators and recent advances in discovery approaches
Beilei Wang,Hong Wu,Chen Hu,Haizhen Wang,Jing Liu,Wenchao Wang &…Qingsong Liu  ORCID: orcid.org/0000-0002-7829-2547 
https://doi.org/10.1038/s41392-021-00826-7
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