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Volume 6 Issue 12, Dec 2021

Article
Mefatinib as first-line treatment of patients with advanced EGFR-mutant non-small-cell lung cancer: a phase Ib/II efficacy and biomarker study
Pingli Wang,Yuping Li,Dongqing Lv,Lingge Yang,Liren Ding,Jianya Zhou,Wei Hong,Youfei Chen,Dongqing Zhang,Susu He,Jianying Zhou &…Kai Wang 
https://doi.org/10.1038/s41392-021-00773-3
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A non-ACE2 competing human single-domain antibody confers broad neutralization against SARS-CoV-2 and circulating variants
Zhenlin Yang,Yulu Wang,Yujia Jin,Yuanfei Zhu,Yanling Wu,Cheng Li,Yu Kong,Wenping Song,Xiaolong Tian,Wuqiang Zhan,Ailing Huang,Shanshan Zhou,Shuai Xia,Xiaoxu Tian,Chao Peng  ORCID: orcid.org/0000-0002-6814-2676,Cuicui Chen,Yibing Shi,Gaowei Hu,Shujuan Du,Yuyan Wang,Youhua Xie  ORCID: orcid.org/0000-0002-2416-7708,Shibo Jiang  ORCID: orcid.org/0000-0001-8283-7135,Lu Lu  ORCID: orcid.org/0000-0002-2255-0391,Lei Sun,Yuanlin Song &…Tianlei Ying  ORCID: orcid.org/0000-0002-9597-2843 
https://doi.org/10.1038/s41392-021-00810-1
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Sensing of cytoplasmic chromatin by cGAS activates innate immune response in SARS-CoV-2 infection
Zhuo Zhou,Xinyi Zhang  ORCID: orcid.org/0000-0002-9972-3115,Xiaobo Lei,Xia Xiao,Tao Jiao,Ruiyi Ma,Xiaojing Dong,Qi Jiang,Wenjing Wang,Yujin Shi,Tian Zheng,Jian Rao,Zichun Xiang,Lili Ren,Tao Deng,Zhengfan Jiang  ORCID: orcid.org/0000-0002-1247-1382,Zhixun Dou,Wensheng Wei  ORCID: orcid.org/0000-0002-8053-2423 &…Jianwei Wang 
https://doi.org/10.1038/s41392-021-00800-3
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The existence of a nonclassical TCA cycle in the nucleus that wires the metabolic-epigenetic circuitry
Xujun Liu,Wenzhe Si,Lin He,Jianguo Yang,Yani Peng,Jie Ren,Xiaoping Liu,Tong Jin,Huajing Yu,Zihan Zhang,Xiao Cheng,Wenting Zhang,Lu Xia,Yunchao Huang,Yue Wang,Shumeng Liu,Lin Shan,Yu Zhang,Xiaohan Yang,Haixia Li,Jing Liang,Luyang Sun  ORCID: orcid.org/0000-0003-3917-473X &…Yongfeng Shang 
https://doi.org/10.1038/s41392-021-00774-2
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Restoration of HBV-specific CD8+ T-cell responses by sequential low-dose IL-2 treatment in non-responder patients after IFN-α therapy
Dongyao Wang,Binqing Fu,Xiaokun Shen,Chuang Guo,Yanyan Liu,Junfei Zhang,Rui Sun,Ying Ye,Jiabin Li,Zhigang Tian &…Haiming Wei 
https://doi.org/10.1038/s41392-021-00776-0
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Enhanced protective immunity against SARS-CoV-2 elicited by a VSV vector expressing a chimeric spike protein
Hongyue Li,Yuhang Zhang,Dong Li,Yong-Qiang Deng  ORCID: orcid.org/0000-0002-2306-1039,Hongde Xu,Chaoyue Zhao,Jiandong Liu,Dan Wen,Jianguo Zhao,Yongchun Li,Yong Wu,Shujun Liu,Jiankai Liu,Junfeng Hao,Fei Yuan,Shuguang Duo,Cheng-Feng Qin  ORCID: orcid.org/0000-0002-0632-2807 &…Aihua Zheng  ORCID: orcid.org/0000-0002-2184-227X 
https://doi.org/10.1038/s41392-021-00797-9
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Identification of a TGF-β/SMAD/lnc-UTGF positive feedback loop and its role in hepatoma metastasis
Meng-Zhi Wu,Yi-chuan Yuan,Bi-Yu Huang,Jin-Xi Chen,Bin-Kui Li,Jian-Hong Fang  ORCID: orcid.org/0000-0002-7723-5348 &…Shi-Mei Zhuang  ORCID: orcid.org/0000-0002-2512-3942 
https://doi.org/10.1038/s41392-021-00781-3
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Safety and efficacy of thalidomide in patients with transfusion-dependent β-thalassemia: a randomized clinical trial
Jiang-Ming Chen,Wei-Jian Zhu,Jie Liu,Gui-Zhen Wang,Xiao-Qin Chen,Yun Tan,Wei-Wei Xu,Li-Wei Qu,Jin-Yan Li,Huan-Ju Yang,Lan Huang,Ning Cai,Wei-Da Wang  ORCID: orcid.org/0000-0002-8272-5421,Ken Huang,Jian-Quan Xu,Guo-Hui Li,Sheng He,Tian-Ying Luo,Yi Huang,Song-Hua Liu,Wen-Qiang Wu,Qi-Yang Lu,Mei-Guang Zhou,Shu-Ying Chen,Rong-Lan Li,Mei-Ling Hu,Ying Huang,Jin-Hua Wei,Jun-Min Li,Sai-Juan Chen &…Guang-Biao Zhou 
https://doi.org/10.1038/s41392-021-00811-0
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Fusobacterium nucleatum enhances the efficacy of PD-L1 blockade in colorectal cancer
Yaohui Gao,Dexi Bi,Ruting Xie,Man Li,Jing Guo,Hu Liu,Xianling Guo,Juemin Fang,Tingting Ding,Huiyuan Zhu,Yuan Cao,Meichun Xing,Jiayi Zheng,Qing Xu,Qian Xu,Qing Wei &…Huanlong Qin 
https://doi.org/10.1038/s41392-021-00795-x
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GOLM1 exacerbates CD8+ T cell suppression in hepatocellular carcinoma by promoting exosomal PD-L1 transport into tumor-associated macrophages
Jinhong Chen,Zhifei Lin,Lu Liu,Rui Zhang,Yan Geng,Minghao Fan,Wenwei Zhu,Ming Lu,Lu Lu,Huliang Jia,Jubo Zhang &…Lun-Xiu Qin 
https://doi.org/10.1038/s41392-021-00784-0
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HACE1-mediated NRF2 activation causes enhanced malignant phenotypes and decreased radiosensitivity of glioma cells
Chenxing Da,Jun Pu,Zhe Liu,Jing Wei,Yiping Qu,Yongxing Wu,Bingyin Shi,Jian Yang,Nongyue He &…Peng Hou 
https://doi.org/10.1038/s41392-021-00793-z
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Paradoxical effects of DNA tumor virus oncogenes on epithelium-derived tumor cell fate during tumor progression and chemotherapy response
Jiang He,Liyu Liu,Feiyu Tang,You Zhou,Huan Liu,Can Lu,Deyun Feng,Hong Zhu,Yitao Mao,Zhi Li,Lu Zhang,Yuemei Duan,Zhi Xiao,Musheng Zeng,Liang Weng &…Lun-Quan Sun  ORCID: orcid.org/0000-0002-0558-5250 
https://doi.org/10.1038/s41392-021-00787-x
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Natural killer cell-derived exosomal miR-1249-3p attenuates insulin resistance and inflammation in mouse models of type 2 diabetes
Ying Wang,Mengwei Li,Lin Chen,Huan Bian,Xiangying Chen,Huilin Zheng,Peiwei Yang,Quan Chen &…Hanmei Xu 
https://doi.org/10.1038/s41392-021-00805-y
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Letter
m6A demethylase FTO attenuates cardiac dysfunction by regulating glucose uptake and glycolysis in mice with pressure overload-induced heart failure
Beijian Zhang,Hao Jiang,Jian Wu,Yun Cai,Zhen Dong,Yongchao Zhao,Qinfeng Hu,Kai Hu,Aijun Sun &…Junbo Ge  ORCID: orcid.org/0000-0002-9360-7332 
https://doi.org/10.1038/s41392-021-00699-w
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RBD206-sc-dimer induced robust cross-neutralization against SARS-CoV-2 and variants of concern
Chuge Zhou  ORCID: orcid.org/0000-0003-2074-4608,Xiaodong Zai,Ziqing Zhou,Ruihua Li,Yue Zhang,Yaohui Li,Ying Yin,Jun Zhang  ORCID: orcid.org/0000-0002-9650-112X,Junjie Xu &…Wei Chen 
https://doi.org/10.1038/s41392-021-00798-8
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Generating 3D-cultured organoids for pre-clinical modeling and treatment of degenerative joint disease
Ye Sun,Qiang Wu,Kerong Dai,Yongqing You &…Wenbo Jiang 
https://doi.org/10.1038/s41392-021-00675-4
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Phosphoproteomics reveals therapeutic targets of esophageal squamous cell carcinoma
Yi Li,Bin Yang,Yanchun Ma,Xiaojun Peng,Zhiyu Wang,Bin Sheng,Zichao Wei,Yongping Cui &…Zhihua Liu  ORCID: orcid.org/0000-0003-4242-033X 
https://doi.org/10.1038/s41392-021-00682-5
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Research Highlight
How to package and SEND mRNA: a novel “humanized” vector system based on endogenous retroviruses
Kristoffer Riecken  ORCID: orcid.org/0000-0001-9050-6766,Dawid Głów &Boris Fehse  ORCID: orcid.org/0000-0001-9780-7211 
https://doi.org/10.1038/s41392-021-00803-0
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Persistent astrocytic IL-3 stimulation of microglia slows disease in Alzheimer’s: treatment perspectives for Alzheimer’s
Natja Haag &Hans Zempel  ORCID: orcid.org/0000-0002-7510-3077 
https://doi.org/10.1038/s41392-021-00806-x
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Dysregulated neutrophilic cell death in SLE: a spotlight on ferroptosis
Kim Ohl,Thomas Rauen &Klaus Tenbrock 
https://doi.org/10.1038/s41392-021-00804-z
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Managing stress granule disassembly with ubiquitin and its cousin
Stefan Müller 
https://doi.org/10.1038/s41392-021-00782-2
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CAR-T: a potential gene carrier targeting solid tumor immune microenvironment
Minjie Wang,Chaocai Zhang &Xiaobing Jiang 
https://doi.org/10.1038/s41392-021-00812-z
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A pan-cancer fingerprint: common molecular denominators of the human tumor microenvironment
Susanna S. Ng  ORCID: orcid.org/0000-0002-8494-7722,Sonia Leonardelli &Michael Hölzel 
https://doi.org/10.1038/s41392-021-00814-x
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Review Article
Targeting lysosomes in human disease: from basic research to clinical applications
Mengdie Cao,Xiangyuan Luo,Kongming Wu &…Xingxing He  ORCID: orcid.org/0000-0003-0001-8473 
https://doi.org/10.1038/s41392-021-00778-y
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The way of SARS-CoV-2 vaccine development: success and challenges
Yetian Dong,Tong Dai,Bin Wang,Lei Zhang  ORCID: orcid.org/0000-0001-6302-8383,Ling-hui Zeng,Jun Huang  ORCID: orcid.org/0000-0002-7837-653X,Haiyan Yan,Long Zhang  ORCID: orcid.org/0000-0001-8139-0474 &…Fangfang Zhou  ORCID: orcid.org/0000-0003-1870-7584 
https://doi.org/10.1038/s41392-021-00796-w
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Roles and mechanisms of exosomal non-coding RNAs in human health and diseases
Chen Li,Yu-Qing Ni,Hui Xu,Qun-Yan Xiang,Yan Zhao,Jun-Kun Zhan,Jie-Yu He,Shuang Li &…You-Shuo Liu  ORCID: orcid.org/0000-0001-9835-4074 
https://doi.org/10.1038/s41392-021-00779-x
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The glycosylation in SARS-CoV-2 and its receptor ACE2
Yanqiu Gong,Suideng Qin,Lunzhi Dai  ORCID: orcid.org/0000-0002-3003-8910 &…Zhixin Tian 
https://doi.org/10.1038/s41392-021-00809-8
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KRAS mutation: from undruggable to druggable in cancer
Lamei Huang,Zhixing Guo,Fang Wang &…Liwu Fu 
https://doi.org/10.1038/s41392-021-00780-4
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Circulating tumor cells: biology and clinical significance
Danfeng Lin,Lesang Shen,Meng Luo,Kun Zhang,Jinfan Li,Qi Yang,Fangfang Zhu,Dan Zhou,Shu Zheng,Yiding Chen &…Jiaojiao Zhou  ORCID: orcid.org/0000-0003-0442-6183 
https://doi.org/10.1038/s41392-021-00817-8
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Neurological complications and infection mechanism of SARS-CoV-2
Dandan Wan,Tingfu Du,Weiqi Hong  ORCID: orcid.org/0000-0003-1668-2301,Li Chen,Haiying Que,Shuaiyao Lu  ORCID: orcid.org/0000-0003-1675-9735 &…Xiaozhong Peng  ORCID: orcid.org/0000-0002-8564-0247 
https://doi.org/10.1038/s41392-021-00818-7
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Crosstalk between circRNAs and the PI3K/AKT signaling pathway in cancer progression
Chen Xue,Ganglei Li,Juan Lu &…Lanjuan Li 
https://doi.org/10.1038/s41392-021-00788-w
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Signaling pathways and intervention therapies in sepsis
Yun-yu Zhang &Bo-tao Ning 
https://doi.org/10.1038/s41392-021-00816-9
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The JAK/STAT signaling pathway: from bench to clinic
Xiaoyi Hu  ORCID: orcid.org/0000-0002-2786-4234,Jing li,Maorong Fu,Xia Zhao &…Wei Wang  ORCID: orcid.org/0000-0001-7788-1895 
https://doi.org/10.1038/s41392-021-00791-1
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