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Volume 6 Issue 11, Nov 2021

Article
A novel inactivated whole-cell Pseudomonas aeruginosa vaccine that acts through the cGAS-STING pathway
Cuicui Ma,Xiao Ma,Boguang Jiang,Hailong Pan,Xueyuan Liao,Li Zhang,Wenfang Li,Yingjie Luo,Zhixue Shen,Xingjun Cheng,Mao Lian &…Zhenling Wang 
https://doi.org/10.1038/s41392-021-00752-8
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BUB1B and circBUB1B_544aa aggravate multiple myeloma malignancy through evoking chromosomal instability
Xiaozhu Tang,Mengjie guo,Pinggang Ding,Zhendong Deng,Mengying Ke,Yuxia Yuan,Yanyan Zhou,Zigen Lin,Muxi Li,Chunyan Gu  ORCID: orcid.org/0000-0001-7408-8840,Xiaosong Gu &…Ye Yang 
https://doi.org/10.1038/s41392-021-00746-6
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SARS-CoV-2 immunity and functional recovery of COVID-19 patients 1-year after infection
Yan Zhan,Yufang Zhu,Shanshan Wang,Shijun Jia,Yunling Gao,Yingying Lu,Caili Zhou,Ran Liang,Dingwen Sun,Xiaobo Wang,Zhibing Hou,Qiaoqiao Hu,Peng Du,Hao Yu,Chang Liu,Miao Cui  ORCID: orcid.org/0000-0002-3402-8664,Gangling Tong,Zhihua Zheng,Yunsheng Xu,Linyu Zhu,Jin Cheng,Feng Wu,Yulan Zheng,Peijun Liu &…Peng Hong  ORCID: orcid.org/0000-0002-3879-303X 
https://doi.org/10.1038/s41392-021-00777-z
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Toripalimab plus chemotherapy as second-line treatment in previously EGFR-TKI treated patients with EGFR-mutant-advanced NSCLC: a multicenter phase-II trial
Tao Jiang  ORCID: orcid.org/0000-0002-9205-8183,Pingyang Wang,Jie Zhang,Yanqiu Zhao,Jianying Zhou,Yun Fan,Yongqian Shu,Xiaoqing Liu,Helong Zhang,Jianxing He,Guanghui Gao,Xiaoqian Mu,Zhang Bao,Yanjun Xu,Renhua Guo,Hong Wang,Lin Deng,Ningqiang Ma,Yalei Zhang,Hui Feng,Sheng Yao,Jiarui Wu,Luonan Chen,Caicun Zhou  ORCID: orcid.org/0000-0002-1072-9941 &…Shengxiang Ren 
https://doi.org/10.1038/s41392-021-00751-9
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XBP1 regulates the protumoral function of tumor-associated macrophages in human colorectal cancer
Yahui Zhao,Weina Zhang,Miaomiao Huo,Peng Wang,Xianghe Liu,Yu Wang,Yinuo Li,Zhixiang Zhou,Ningzhi Xu &…Hongxia Zhu  ORCID: orcid.org/0000-0001-8890-6373 
https://doi.org/10.1038/s41392-021-00761-7
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Mesenchymal stem cell-derived small extracellular vesicles mitigate oxidative stress-induced senescence in endothelial cells via regulation of miR-146a/Src
Xian Xiao,Meiqian Xu,Hongliang Yu,Liping Wang,Xiaoxia Li,Janusz Rak,Shihua Wang &…Robert Chunhua Zhao 
https://doi.org/10.1038/s41392-021-00765-3
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Intranasal delivery of replicating mRNA encoding neutralizing antibody against SARS-CoV-2 infection in mice
Jia-Qi Li,Zhe-Rui Zhang,Hong-Qing Zhang,Ya-Nan Zhang,Xiang-Yue Zeng,Qiu-Yan Zhang,Cheng-Lin Deng,Xiao-Dan Li,Bo Zhang  ORCID: orcid.org/0000-0002-8895-3679 &…Han-Qing Ye  ORCID: orcid.org/0000-0001-7770-4071 
https://doi.org/10.1038/s41392-021-00783-1
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Sintilimab for relapsed/refractory extranodal NK/T cell lymphoma: a multicenter, single-arm, phase 2 trial (ORIENT-4)
Rong Tao,Lei Fan,Yongping Song,Yu Hu  ORCID: orcid.org/0000-0002-2815-4568,Wei Zhang,Yafei Wang,Wei Xu &…Jianyong Li 
https://doi.org/10.1038/s41392-021-00768-0
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Pancreatic cancer cells render tumor-associated macrophages metabolically reprogrammed by a GARP and DNA methylation-mediated mechanism
Mengwen Zhang,Xingyi Pan,Kenji Fujiwara,Noelle Jurcak,Stephen Muth,Jiaojiao Zhou  ORCID: orcid.org/0000-0003-0442-6183,Qian Xiao,Anqi Li,Xu Che,Zihai Li &…Lei Zheng 
https://doi.org/10.1038/s41392-021-00769-z
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Research Highlight
ELANE: an emerging lane to selective anticancer therapy
Boqiang Peng,Jiankun Hu &Xianghui Fu  ORCID: orcid.org/0000-0001-9808-3892 
https://doi.org/10.1038/s41392-021-00766-2
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Combination therapy for HCC: from CRISPR screening to the design of clinical therapies
Yunguang Wang,Ling Kui &Guangchuan Wang  ORCID: orcid.org/0000-0001-5315-1599 
https://doi.org/10.1038/s41392-021-00775-1
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Context-specific chromatin remodeling activity of mSWI/SNF complexes depends on the epigenetic landscape
Godwin Sokpor  ORCID: orcid.org/0000-0002-7120-0793,Huu Phuc Nguyen &Tran Tuoc  ORCID: orcid.org/0000-0003-2079-7259 
https://doi.org/10.1038/s41392-021-00770-6
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Keep quiet—how stress regulates hair follicle stem cells
Sven R. Quist  ORCID: orcid.org/0000-0002-9548-7813 &Jennifer Quist 
https://doi.org/10.1038/s41392-021-00772-4
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Targeted prebiotics alter the obese gut microbiome in humans
Junjun She,Chi Chun Wong &Jun Yu 
https://doi.org/10.1038/s41392-021-00758-2
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cGAS-like receptors: new RNA sensors in Drosophila
Yao Fan,Long Zhang  ORCID: orcid.org/0000-0001-8139-0474 &Fangfang Zhou  ORCID: orcid.org/0000-0003-1870-7584 
https://doi.org/10.1038/s41392-021-00785-z
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Pharmacologic RNA splicing modulation: a novel mechanism to enhance neoantigen-directed anti-tumor immunity and immunotherapy response
Kerryn Elliott,Jonas Nilsson &Jimmy Van den Eynden 
https://doi.org/10.1038/s41392-021-00789-9
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Letter
Impact of mechanical circulatory support and immunomodulation therapy on outcome of patients with fulminant myocarditis: Chinese registry of fulminant myocarditis
Ning Zhou,Yuhua Zhao,Jiangang Jiang,Lan Shen,Junming Li,Jing Wan,Xueping Ma,Jing Zhang,Enrico Ammirati &…Dao Wen Wang 
https://doi.org/10.1038/s41392-021-00700-6
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NOL7 facilitates melanoma progression and metastasis
Yumei Li,Chunlian Zhong,Jie Wang,Fan Chen,Weiyu Shen,Bifei Li,Ning Zheng,Yusheng Lu,Vladimir L. Katanaev  ORCID: orcid.org/0000-0002-7909-5617 &…Lee Jia 
https://doi.org/10.1038/s41392-021-00676-3
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Attenuating innate immunity and facilitating β-coronavirus infection by NSP1 of SARS-CoV-2 through specific redistributing hnRNP A2/B1 cellular localization
Fanghang Zhou,Qianya Wan,Sheng Chen  ORCID: orcid.org/0000-0003-3741-3872,Ying Chen,Pui-Hui Wang,Xi Yao  ORCID: orcid.org/0000-0001-8986-3571 &…Ming-liang He 
https://doi.org/10.1038/s41392-021-00786-y
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Review Article
Myeloid-derived suppressor cells as immunosuppressive regulators and therapeutic targets in cancer
Kai Li,Houhui Shi,Benxia Zhang,Xuejin Ou,Qizhi Ma,Yue Chen,Pei Shu,Dan Li &…Yongsheng Wang 
https://doi.org/10.1038/s41392-021-00670-9
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The biological applications of DNA nanomaterials: current challenges and future directions
Wenjuan Ma,Yuxi Zhan,Yuxin Zhang,Chenchen Mao,Xueping Xie &…Yunfeng Lin  ORCID: orcid.org/0000-0003-1224-6561 
https://doi.org/10.1038/s41392-021-00727-9
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Signaling pathways in the regulation of cytokine release syndrome in human diseases and intervention therapy
Xia Li,Mi Shao,Xiangjun Zeng,Pengxu Qian &…He Huang  ORCID: orcid.org/0000-0002-2723-1621 
https://doi.org/10.1038/s41392-021-00764-4
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Myeloid cells in COVID-19 microenvironment
Guohui Qin,Shasha Liu,Li Yang,Weina Yu &…Yi Zhang  ORCID: orcid.org/0000-0001-9861-4681 
https://doi.org/10.1038/s41392-021-00792-0
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