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Volume 6 Issue 10, Oct 2021

Article
Melatonin enhances radiofrequency-induced NK antitumor immunity, causing cancer metabolism reprogramming and inhibition of multiple pulmonary tumor development
Ming Li,Bingjie Hao,Menghuan Zhang,Russel J. Reiter,Shumeng Lin,Tiansheng Zheng,Xiangyun Chen,Yanbei Ren,Liduo Yue,Baigenzhin Abay,Guojie Chen,Xiao Xu,Yufeng Shi &…Lihong Fan 
https://doi.org/10.1038/s41392-021-00745-7
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A dual-role of SARS-CoV-2 nucleocapsid protein in regulating innate immune response
Yinghua Zhao,Liyan Sui,Ping Wu,Wenfang Wang,Zedong Wang,Yang Yu,Zhijun Hou,Guangyun Tan,Quan Liu  ORCID: orcid.org/0000-0003-3411-3196 &…Guoqing Wang  ORCID: orcid.org/0000-0001-9326-3755 
https://doi.org/10.1038/s41392-021-00742-w
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Detection of an anti-angina therapeutic module in the effective population treated by a multi-target drug Danhong injection: a randomized trial
Jun Liu,Dan-Dan Li,Wei Dong,Yu-Qi Liu,Yang Wu,Da-Xuan Tang,Fu-Chun Zhang,Meng Qiu,Qi Hua,Jing-Yu He,Jun Li,Bai Du,Ting-Hai Du,Lin-Lin Niu,Xue-Jun Jiang,Bo Cui,Jiang-Bin Chen,Yang-Gan Wang,Hai-Rong Wang,Qin Yu,Jing He,Yi-Lin Mao,Xiao-Fang Bin,Yue Deng,Yu-Dan Tian,Qing-Hua Han,Da-Jin Liu,Li-Qin Duan,Ming-Jun Zhao,Cui-Ying Zhang,Hai-Ying Dai,Ze-Hua Li,Ying Xiao,You-Zhi Hu,Xiao-Yu Huang,Kun Xing,Xin Jiang,Chao-Feng Liu,Jing An,Feng-Chun Li,Tao Tao,Jin-Fa Jiang,Ying Yang,Yao-Rong Dong,Lei Zhang,Guang Fu,Ying Li,Shu-Wei Huang,Li-Ping Dou,Lan-Jun Sun,Ying-Qiang Zhao,Jie Li,Yun Xia,Jun Liu,Fan Liu,Wen-Jin He,Ying Li,Jian-Cong Tan,Yang Lin,Ya-Bin Zhou,Jian-Fei Yang,Guo-Qing Ma,Hui-Jun Chen,He-Ping Liu,Zong-Wu Liu,Jian-Xiong Liu,Xiao-Jia Luo,Xiao-Hong Bin,Ya-Nan Yu,Hai-Xia Dang,Bing Li,Fei Teng  ORCID: orcid.org/0000-0003-4913-7094,Wang-Min Qiao,Xiao-Long Zhu,Bing-Wei Chen,Qi-Guang Chen,Chun-Ti Shen,Yong-Yan Wang,Yun-Dai Chen &…Zhong Wang 
https://doi.org/10.1038/s41392-021-00741-x
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Pro-inflammatory microenvironment and systemic accumulation of CXCR3+ cell exacerbate lung pathology of old rhesus macaques infected with SARS-CoV-2
Hong-Yi Zheng,Xiao-Yan He,Wei Li,Tian-Zhang Song,Jian-Bao Han,Xiang Yang,Feng-Liang Liu  ORCID: orcid.org/0000-0002-5038-5012,Rong-Hua Luo,Ren-Rong Tian,Xiao-Li Feng,Yu-Hua Ma,Chao Liu,Ming-Hua Li &…Yong-Tang Zheng  ORCID: orcid.org/0000-0001-5469-0324 
https://doi.org/10.1038/s41392-021-00734-w
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Targeting cancer cell plasticity by HDAC inhibition to reverse EBV-induced dedifferentiation in nasopharyngeal carcinoma
Jiajun Xie,Zifeng Wang  ORCID: orcid.org/0000-0001-7400-5224,Wenjun Fan,Youping Liu,Fang Liu,Xiangbo Wan  ORCID: orcid.org/0000-0001-9437-6188,Meiling Liu,Xuan Wang,Deshun Zeng,Yan Wang,Bin He,Min Yan,Zijian Zhang,Mengjuan Zhang,Zhijie Hou,Chunli Wang,Zhijie Kang,Wenfeng Fang,Li Zhang,Eric W-F Lam  ORCID: orcid.org/0000-0003-1274-3576,Xiang Guo,Jinsong Yan,Yixin Zeng,Mingyuan Chen &…Quentin Liu 
https://doi.org/10.1038/s41392-021-00702-4
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SARS-CoV-2 crosses the blood–brain barrier accompanied with basement membrane disruption without tight junctions alteration
Ling Zhang,Li Zhou  ORCID: orcid.org/0000-0003-1945-3491,Linlin Bao,Jiangning Liu,Hua Zhu,Qi Lv,Ruixue Liu,Wei Chen,Wei Tong,Qiang Wei,Yanfeng Xu,Wei Deng,Hong Gao,Jing Xue  ORCID: orcid.org/0000-0002-9113-2433,Zhiqi Song,Pin Yu,Yunlin Han,Yu Zhang,Xiuping Sun,Xuan Yu  ORCID: orcid.org/0000-0001-6826-7260 &…Chuan Qin  ORCID: orcid.org/0000-0002-6261-1232 
https://doi.org/10.1038/s41392-021-00719-9
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The self-assembled nanoparticle-based trimeric RBD mRNA vaccine elicits robust and durable protective immunity against SARS-CoV-2 in mice
Wenqiang Sun,Lihong He,He Zhang,Xiaodong Tian,Zhihua Bai,Lei Sun  ORCID: orcid.org/0000-0003-0141-2093,Limin Yang  ORCID: orcid.org/0000-0002-1158-0800,Xiaojuan Jia,Yuhai Bi  ORCID: orcid.org/0000-0002-5595-363X,Tingrong Luo,Gong Cheng,Wenhui Fan,Wenjun Liu &…Jing Li  ORCID: orcid.org/0000-0001-9588-5291 
https://doi.org/10.1038/s41392-021-00750-w
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AIM2 deficiency in B cells ameliorates systemic lupus erythematosus by regulating Blimp-1–Bcl-6 axis-mediated B-cell differentiation
Ming Yang,Di Long,Longyuan Hu,Zhidan Zhao,Qianwen Li,Yunkai Guo,Zhenghao He,Ming Zhao,Liwei Lu,Fen Li,Hai Long,Haijing Wu &…Qianjin Lu 
https://doi.org/10.1038/s41392-021-00725-x
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S19W, T27W, and N330Y mutations in ACE2 enhance SARS-CoV-2 S-RBD binding toward both wild-type and antibody-resistant viruses and its molecular basis
Fei Ye,Xi Lin,Zimin Chen,Fanli Yang,Sheng Lin,Jing Yang,Hua Chen,Honglu Sun,Lingling Wang,Ao Wen,Xindan Zhang,Yushan Dai,Yu Cao,Jingyun Yang,Guobo Shen,Li Yang,Jiong Li,Zhenling Wang,Wei Wang  ORCID: orcid.org/0000-0001-7788-1895,Xiawei Wei  ORCID: orcid.org/0000-0002-6513-6422 &…Guangwen Lu  ORCID: orcid.org/0000-0001-7568-592X 
https://doi.org/10.1038/s41392-021-00756-4
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Single-cell immune profiling reveals distinct immune response in asymptomatic COVID-19 patients
Xiang-Na Zhao,Yue You  ORCID: orcid.org/0000-0003-3883-445X,Xiao-Ming Cui,Hui-Xia Gao,Guo-Lin Wang  ORCID: orcid.org/0000-0002-5393-9500,Sheng-Bo Zhang  ORCID: orcid.org/0000-0003-3870-0590,Lin Yao,Li-Jun Duan,Ka-Li Zhu,Yu-Ling Wang,Li Li,Jian-Hua Lu,Hai-Bin Wang,Jing-Fang Fan,Huan-Wei Zheng,Er-Hei Dai,Lu-Yi Tian  ORCID: orcid.org/0000-0003-3420-3685 &…Mai-Juan Ma  ORCID: orcid.org/0000-0002-8105-462X 
https://doi.org/10.1038/s41392-021-00753-7
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SARS-CoV-2 infection causes immunodeficiency in recovered patients by downregulating CD19 expression in B cells via enhancing B-cell metabolism
Yukai Jing,Li Luo,Ying Chen,Lisa S. Westerberg,Peng Zhou  ORCID: orcid.org/0000-0001-9863-4201,Zhiping Xu,Andrés A. Herrada,Chan-Sik Park,Masato Kubo,Heng Mei,Yu Hu  ORCID: orcid.org/0000-0002-2815-4568,Pamela Pui-Wah Lee,Bing Zheng,Zhiwei Sui,Wei Xiao,Quan Gong,Zhongxin Lu &…Chaohong Liu 
https://doi.org/10.1038/s41392-021-00749-3
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Antibody-dependent cellular cytotoxicity response to SARS-CoV-2 in COVID-19 patients
Yuanling Yu,Meiyu Wang,Xiaoai Zhang,Shufen Li,Qingbin Lu,Haolong Zeng,Hongyan Hou,Hao Li,Mengyi Zhang,Fei Jiang,Jiajing Wu,Ruxia Ding,Zehua Zhou,Min Liu,Weixue Si,Tao Zhu,Hangwen Li,Jie Ma,Yuanyuan Gu,Guangbiao She,Xiaokun Li,Yulan Zhang,Ke Peng  ORCID: orcid.org/0000-0003-0172-8725,Weijin Huang,Wei Liu &…Youchun Wang  ORCID: orcid.org/0000-0001-9769-5141 
https://doi.org/10.1038/s41392-021-00759-1
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CD147 antibody specifically and effectively inhibits infection and cytokine storm of SARS-CoV-2 and its variants delta, alpha, beta, and gamma
Jiejie Geng,Liang Chen,Yufeng Yuan,Ke Wang,Youchun Wang  ORCID: orcid.org/0000-0001-9769-5141,Chuan Qin  ORCID: orcid.org/0000-0002-6261-1232,Guizhen Wu,Ruo Chen,Zheng Zhang,Ding Wei,Peng Du,Jun Zhang  ORCID: orcid.org/0000-0002-9650-112X,Peng Lin,Kui Zhang,Yongqiang Deng  ORCID: orcid.org/0000-0002-2306-1039,Ke Xu,Jiangning Liu,Xiuxuan Sun,Ting Guo,Xu Yang,Jiao Wu,Jianli Jiang,Ling Li,Kun Zhang,Zhe Wang,Jing Zhang,Qingguo Yan,Hua Zhu,Zhaohui Zheng,Jinlin Miao,Xianghui Fu,Fengfan Yang,Xiaochun Chen,Hao Tang,Yang Zhang,Ying Shi,Yumeng Zhu,Zhuo Pei,Fei Huo,Xue Liang,Yatao Wang,Qingyi Wang,Wen Xie,Yirong Li,Mingyan Shi,Huijie Bian  ORCID: orcid.org/0000-0003-4690-4622,Ping Zhu &…Zhi-Nan Chen 
https://doi.org/10.1038/s41392-021-00760-8
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Letter
LIX1-like protein drives hepatic stellate cell activation to promote liver fibrosis by regulation of chemokine mRNA stability
Xiaoyun Zhu,Yanqiu Zhang,Yucheng Zhao,Dejuan Xiang,Jie Zou,Ourania Andrisani,Hao Zhang &…Lingyi Kong 
https://doi.org/10.1038/s41392-021-00665-6
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A multivalent biparatopic EGFR-targeting nanobody drug conjugate displays potent anticancer activity in solid tumor models
Jiansheng Fan,Xinlei Zhuang,Xiaoyue Yang,Yingchun Xu,Zhan Zhou  ORCID: orcid.org/0000-0002-2730-5483,Liqiang Pan &…Shuqing Chen 
https://doi.org/10.1038/s41392-021-00666-5
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SARS-CoV-2 leads to myocardial injury in rhesus macaque
Yufan Feng,Xiaomin Song,Yongfa Huang,Wei Deng,Man Li,Xiaoxiao Guo,Chuan Qin  ORCID: orcid.org/0000-0002-6261-1232,Wei-Min Tong,Jiangning Liu  ORCID: orcid.org/0000-0003-2410-5408 &…Jing Wang 
https://doi.org/10.1038/s41392-021-00747-5
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MG149 inhibits histone acetyltransferase KAT8-mediated IL-33 acetylation to alleviate allergic airway inflammation and airway hyperresponsiveness
Yahui Liu  ORCID: orcid.org/0000-0002-4997-2973,Juan Du,Xinnan Liu,Lingbiao Wang,Yichao Han,Chunrong Huang,Rui Liang,Fang Zheng,Guochao Shi &…Bin Li  ORCID: orcid.org/0000-0002-7640-8884 
https://doi.org/10.1038/s41392-021-00667-4
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A new paradigm for artesunate anticancer function: considerably enhancing the cytotoxicity via conjugating artesunate with aptamer
Yingying Li,Yongbo Peng,Yan Tan,Wenjing Xuan,Ting Fu,Xue-Qiang Wang  ORCID: orcid.org/0000-0003-1631-9158 &…Weihong Tan  ORCID: orcid.org/0000-0002-8066-1524 
https://doi.org/10.1038/s41392-021-00671-8
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Targeting chaperon protein HSP70 as a novel therapeutic strategy for FLT3-ITD-positive acute myeloid leukemia
Chen Hu,Fengming Zou,Aoli Wang,Weili Miao,Qianmao Liang,Ellen L. Weisberg,Yinsheng Wang,Jing Liu,Wenchao Wang &…Qingsong Liu  ORCID: orcid.org/0000-0002-7829-2547 
https://doi.org/10.1038/s41392-021-00672-7
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GOLM1 suppresses autophagy-mediated anti-tumor immunity in hepatocellular carcinoma
Tianqi Sui,Xiaoyang Wang,Lili Li,Junxiao Liu,Nan Qiao,Lihua Duan,Minxin Shi,Jianfei Huang,Heng Yang  ORCID: orcid.org/0000-0002-1491-4490 &…Genhong Cheng  ORCID: orcid.org/0000-0002-6713-2783 
https://doi.org/10.1038/s41392-021-00673-6
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Disruption of KDM4C-ALDH1A3 feed-forward loop inhibits stemness, tumorigenesis and chemoresistance of gastric cancer stem cells
Tingyuan Lang,Jia Xu,Lei Zhou,Zhiqi Zhang,Xinli Ma,Jiayi Gu,Jingshu Liu,Yunzhe Li,Dongyan Ding &…Jiangfeng Qiu  ORCID: orcid.org/0000-0003-1220-5727 
https://doi.org/10.1038/s41392-021-00674-5
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High-throughput screening and evaluation of repurposed drugs targeting the SARS-CoV-2 main protease
Yan Li,Jinyong Zhang,Zilei Duan,Ning Wang,Xiangcheng Sun  ORCID: orcid.org/0000-0003-1943-4979,Yanjing Zhang,Li Fu,Kaiyun Liu,Yongjun Yang,Shulei Pan,Yun Shi,Hao Zeng,Gang Guo,Ren Lai &…Quanming Zou 
https://doi.org/10.1038/s41392-021-00763-5
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Research Highlight
Converting fibroblastic fates leads to wound healing without scar
Dongsheng Jiang  ORCID: orcid.org/0000-0003-0961-2671 &Yuval Rinkevich 
https://doi.org/10.1038/s41392-021-00738-6
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SARS-CoV-2 Variants of Concern Delta: a great challenge to prevention and control of COVID-19
Maochen Li  ORCID: orcid.org/0000-0001-8786-5039,Fuxing Lou  ORCID: orcid.org/0000-0002-5217-6281 &Huahao Fan  ORCID: orcid.org/0000-0001-5007-2158 
https://doi.org/10.1038/s41392-021-00767-1
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An anti-tumor coup: TIM3 ablation activates the immune arsenal
Kıvanç Görgülü  ORCID: orcid.org/0000-0002-1613-1422,Derya Kabacaoğlu &Hana Algül 
https://doi.org/10.1038/s41392-021-00757-3
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Perspective
Mesenchymal stem cell therapy for severe COVID-19
Lei Shi,Lifeng Wang,Ruonan Xu,Chao Zhang  ORCID: orcid.org/0000-0001-8126-8145,Yunbo Xie,Kai Liu,Tiantian Li,Wei Hu,Cheng Zhen &…Fu-Sheng Wang  ORCID: orcid.org/0000-0002-8043-6685 
https://doi.org/10.1038/s41392-021-00754-6
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Review Article
Human genetic basis of coronavirus disease 2019
Hao Deng  ORCID: orcid.org/0000-0003-3240-4352,Xue Yan &Lamei Yuan 
https://doi.org/10.1038/s41392-021-00736-8
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