Table of Contents
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Volume 6 Issue 9, Sep 2021

Review Article
Liquid–liquid phase separation in human health and diseases
Bin Wang,Lei Zhang  ORCID: orcid.org/0000-0001-6302-8383,Tong Dai,Ziran Qin,Huasong Lu,Long Zhang  ORCID: orcid.org/0000-0001-8139-0474 &…Fangfang Zhou  ORCID: orcid.org/0000-0003-1870-7584 
https://doi.org/10.1038/s41392-021-00678-1
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Pattern recognition receptors in health and diseases
Danyang Li &Minghua Wu 
https://doi.org/10.1038/s41392-021-00687-0
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Technological advances in cancer immunity: from immunogenomics to single-cell analysis and artificial intelligence
Ying Xu,Guan-Hua Su,Ding Ma,Yi Xiao,Zhi-Ming Shao &…Yi-Zhou Jiang 
https://doi.org/10.1038/s41392-021-00729-7
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Applications of laboratory findings in the prevention, diagnosis, treatment, and monitoring of COVID-19
Zirui Meng,Shuo Guo,Yanbing Zhou,Mengjiao Li,Minjin Wang &…Binwu Ying 
https://doi.org/10.1038/s41392-021-00731-z
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Therapeutic targets and interventional strategies in COVID-19: mechanisms and clinical studies
Yu-Wen Zhou,Yao Xie  ORCID: orcid.org/0000-0001-6743-7571,Lian-Sha Tang,Dan Pu,Ya-Juan Zhu,Ji-Yan Liu &…Xue-Lei Ma 
https://doi.org/10.1038/s41392-021-00733-x
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Ribosomal proteins and human diseases: molecular mechanisms and targeted therapy
Jian Kang,Natalie Brajanovski,Keefe T. Chan,Jiachen Xuan,Richard B. Pearson &…Elaine Sanij 
https://doi.org/10.1038/s41392-021-00728-8
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Wnt/β-catenin signaling in cancers and targeted therapies
Fanyuan Yu,Changhao Yu,Feifei Li,Yanqin Zuo,Yitian Wang,Lin Yao,Chenzhou Wu,Chenglin Wang &…Ling Ye 
https://doi.org/10.1038/s41392-021-00701-5
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Letter
SARS-CoV-2-derived fusion inhibitor lipopeptides exhibit highly potent and broad-spectrum activity against divergent human coronaviruses
Yuanmei Zhu,Danwei Yu,Yue Hu,Tong Wu,Huihui Chong &…Yuxian He  ORCID: orcid.org/0000-0003-2048-6696 
https://doi.org/10.1038/s41392-021-00698-x
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Tie2-expressing monocytes/macrophages promote cerebral revascularization in peri-infarct lesions upon ischemic insult
Yuqiao Sheng,Xixi Duan,Yanru Liu,Feng Li  ORCID: orcid.org/0000-0002-3895-0437,Shengli Ma,Xiaoping Shang,Xiao Wang,Yangyang Liu,Rui Xue &…Zhihai Qin 
https://doi.org/10.1038/s41392-021-00637-w
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Thermo-sensitive micelles extend therapeutic potential for febrile seizures
Di Wu,Yangshun Tang,Weishuo Li,Yi You,Jiaying Shi,Cenglin Xu,Yongzhong Du,Zhong Chen  ORCID: orcid.org/0000-0003-4755-9357 &…Yi Wang  ORCID: orcid.org/0000-0002-1350-2961 
https://doi.org/10.1038/s41392-021-00638-9
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WWP1 targeting MUC1 for ubiquitin-mediated lysosomal degradation to suppress carcinogenesis
Chunhua Liao,Liping Yu,Zhi Pang,Huayun Deng,Xiaodong Liao,Shengze Li,Jinke Cheng,Min Qi,Guoqiang Chen &…Lei Huang 
https://doi.org/10.1038/s41392-021-00660-x
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c-Myc regulates neural stem cell quiescence and activation by coordinating the cell cycle and mitochondrial remodeling
Chunhui Cai,Xinyu Hu,Peibin Dai,Tianran Zhang,Mei Jiang,Liefu Wang,Wanhao Hua,Yantao Fan,Xin-Xin Han &…Zhengliang Gao 
https://doi.org/10.1038/s41392-021-00664-7
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Repurposing of a clinically used anti-HPV agent to prevent and treat SARS-CoV-2 infection as an intranasal formulation
Chen Hua,Qinhai Ma,Yun Zhu,Shuai Xia,Zezhong Liu,Lin Li,Lu Lu  ORCID: orcid.org/0000-0002-2255-0391,Nanshan Zhong,Shuwen Liu  ORCID: orcid.org/0000-0001-6346-5006,Zifeng Yang &…Shibo Jiang  ORCID: orcid.org/0000-0001-8283-7135 
https://doi.org/10.1038/s41392-021-00737-7
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Article
TRIM31 facilitates K27-linked polyubiquitination of SYK to regulate antifungal immunity
Xueer Wang,Honghai Zhang,Zhugui Shao,Wanxin Zhuang,Chao Sui,Feng Liu,Xiaorong Chen,Jinxiu Hou,Lingli Kong,Hansen Liu,Yi Zheng,Bingyu Liu,Tian Chen,Lei Zhang,Xinming Jia  ORCID: orcid.org/0000-0002-7245-5560 &…Chengjiang Gao  ORCID: orcid.org/0000-0002-9365-4497 
https://doi.org/10.1038/s41392-021-00711-3
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AHR mediates the aflatoxin B1 toxicity associated with hepatocellular carcinoma
Qing Zhu,Yarui Ma,Junbo Liang,Zhewen Wei,Mo Li,Ying Zhang,Mei Liu,Huan He,Chunfeng Qu,Jianqiang Cai,Xiaobing Wang  ORCID: orcid.org/0000-0002-0907-364X,Yixin Zeng &…Yuchen Jiao  ORCID: orcid.org/0000-0001-7917-8810 
https://doi.org/10.1038/s41392-021-00713-1
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Decreased inhibition of exosomal miRNAs on SARS-CoV-2 replication underlies poor outcomes in elderly people and diabetic patients
Yanbo Wang,Xiaoju Zhu,Xia-Ming Jiang,Jingwei Guo,Zheng Fu,Zhen Zhou,Ping Yang,Hongyuan Guo,Xu Guo,Gaoli Liang,Ping Zeng,Gengfu Xiao,Jizheng Ma,Xin Yin,Lei-Ke Zhang  ORCID: orcid.org/0000-0002-2593-2571,Chao Yan  ORCID: orcid.org/0000-0002-6029-224X &…Chen-Yu Zhang 
https://doi.org/10.1038/s41392-021-00716-y
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Glucose-sensitive acetylation of Seryl tRNA synthetase regulates lipid synthesis in breast cancer
Jin Zhao,Hangming Bai,Xiaoyu Li,Jie Yan,Gengyi Zou,Longlong Wang,Xiru Li,Ze Liu,Rong Xiang  ORCID: orcid.org/0000-0003-3487-7348,Xiang-Lei Yang &…Yi Shi  ORCID: orcid.org/0000-0003-2530-410X 
https://doi.org/10.1038/s41392-021-00714-0
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Dynamic landscape mapping of humoral immunity to SARS-CoV-2 identifies non-structural protein antibodies associated with the survival of critical COVID-19 patients
Linlin Cheng,Xiaomei Zhang,Yu Chen,Dan Wang,Dong Zhang,Songxin Yan,Hongye Wang,Meng Xiao  ORCID: orcid.org/0000-0003-2103-7008,Te Liang,Haolong Li,Meng Xu,Xin Hou,jiayu Dai,Xian Wu,Mingyuan Li,Minya Lu,Dong Wu,Ran Tian,Jing Zhao,Yan Zhang,Wei Cao,Jinglan Wang,Xiaowei Yan,Xiang Zhou  ORCID: orcid.org/0000-0001-8523-8082,Zhengyin Liu,Yingchun Xu,Fuchu He,Yongzhe Li,Xiaobo Yu  ORCID: orcid.org/0000-0003-2352-9866 &…Shuyang Zhang 
https://doi.org/10.1038/s41392-021-00718-w
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HIF-1α promotes SARS-CoV-2 infection and aggravates inflammatory responses to COVID-19
Mingfu Tian,Weiyong Liu,Xiang Li,Peiyi Zhao,Muhammad Adnan Shereen,Chengliang Zhu,Shanyu Huang,Siyu Liu,Xiao Yu,Miaomiao Yue,Pan Pan  ORCID: orcid.org/0000-0002-7214-1393,Wenbiao Wang  ORCID: orcid.org/0000-0003-4944-764X,Yongkui Li,Xulin Chen,Kailang Wu,Zhen Luo  ORCID: orcid.org/0000-0002-1142-2845,Qiwei Zhang  ORCID: orcid.org/0000-0002-2770-111X &…Jianguo Wu  ORCID: orcid.org/0000-0002-8326-2895 
https://doi.org/10.1038/s41392-021-00726-w
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Retro-enantio isomer of angiopep-2 assists nanoprobes across the blood-brain barrier for targeted magnetic resonance/fluorescence imaging of glioblastoma
Ruoxi Xie,Zijun Wu,Fanxin Zeng,Huawei Cai,Dan Wang,Lei Gu,Hongyan Zhu,Su Lui,Gang Guo,Bin Song,Jinxing Li,Min Wu  ORCID: orcid.org/0000-0002-7733-2498 &…Qiyong Gong 
https://doi.org/10.1038/s41392-021-00724-y
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BCL9 regulates CD226 and CD96 checkpoints in CD8+ T cells to improve PD-1 response in cancer
Mei Feng,Zhongen Wu  ORCID: orcid.org/0000-0003-2152-958X,Yan Zhou,Zhuang Wei,Enming Tian,Shenglin Mei,Yuanyuan Zhu,Chenglong Liu,Fenglian He,Huiyu Li,Cao Xie,Joy Jin  ORCID: orcid.org/0000-0002-1283-4665,Jibin Dong,Dehua Yang  ORCID: orcid.org/0000-0003-3028-3243,Ker Yu,Junbin Qian,Diether Lambrechts,Ming-Wei Wang  ORCID: orcid.org/0000-0001-6550-9017 &…Di Zhu 
https://doi.org/10.1038/s41392-021-00730-0
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ACE2-targeting monoclonal antibody as potent and broad-spectrum coronavirus blocker
Yuning Chen,Ya-Nan Zhang,Renhong Yan,Guifeng Wang,Yuanyuan Zhang,Zhe-Rui Zhang,Yaning Li,Jianxia Ou,Wendi Chu,Zhijuan Liang,Yongmei Wang,Yi-Li Chen,Ganjun Chen,Qi Wang,Qiang Zhou,Bo Zhang  ORCID: orcid.org/0000-0002-8895-3679 &…Chunhe Wang 
https://doi.org/10.1038/s41392-021-00740-y
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VAV2 is required for DNA repair and implicated in cancer radiotherapy resistance
Weiling Liu,Chuanwang Miao,Shaosen Zhang,Yachen Liu,Xiangjie Niu,Yiyi Xi,Wenjia Guo,Jiahui Chu,Ai Lin,Hongjin Liu,Xinyu Yang,Xinjie Chen,Ce Zhong,Yuling Ma,Yuqian Wang,Shihao Zhu,Shuning Liu,Wen Tan,Dongxin Lin  ORCID: orcid.org/0000-0002-8723-8868 &…Chen Wu 
https://doi.org/10.1038/s41392-021-00735-9
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A novel missense variant in ACAA1 contributes to early-onset Alzheimer’s disease, impairs lysosomal function, and facilitates amyloid-β pathology and cognitive decline
Rongcan Luo,Yu Fan,Jing Yang,Maosen Ye,Deng-Feng Zhang,Kun Guo,Xiao Li,Rui Bi,Min Xu,Lu-Xiu Yang,Yu Li,Xiaoqian Ran,Hong-Yan Jiang,Chen Zhang,Liwen Tan,Nengyin Sheng &…Yong-Gang Yao  ORCID: orcid.org/0000-0002-2955-0693 
https://doi.org/10.1038/s41392-021-00748-4
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Research Highlight
A silent network’s resounding success: how mutations of core metabolic genes confer antibiotic resistance
Gamal Wareth,Heinrich Neubauer &Lisa D. Sprague 
https://doi.org/10.1038/s41392-021-00717-x
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Cyro-EM structure of human mGlus: leading therapeutic potential to neurological diseases
Huan Xiao &Qiu Sun  ORCID: orcid.org/0000-0001-5122-2226 
https://doi.org/10.1038/s41392-021-00720-2
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“Armed for the future Coronavirus pandemic”: a promising use of the multimeric SARS-CoV-2 receptor binding domain nanoparticle as a new Pan-Coronavirus vaccine
Manoj Kumar &Souhaila Al Khodor 
https://doi.org/10.1038/s41392-021-00721-1
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Nicotinamide mononucleotide: a potential effective natural compound against insulin resistance
Julian Roos,Julia Zinngrebe &Pamela Fischer-Posovszky  ORCID: orcid.org/0000-0003-3402-9840 
https://doi.org/10.1038/s41392-021-00723-z
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Insights from the degradation mechanism of cyclin D into targeted therapy of the cancer cell cycle
Maiwen Caudron-Herger  ORCID: orcid.org/0000-0002-7030-8153 &Sven Diederichs  ORCID: orcid.org/0000-0001-7901-4752 
https://doi.org/10.1038/s41392-021-00732-y
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Adjuvant immunotherapy in resected esophageal squamous cell carcinoma: a gospel to the non-pCRs
Zhihui Zhang,Nan Sun &Jie He  ORCID: orcid.org/0000-0002-0285-5403 
https://doi.org/10.1038/s41392-021-00722-0
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Boosting the cellular potency of embryonic stem cells by spliceosome targeting
Wilfried A. Kues 
https://doi.org/10.1038/s41392-021-00743-9
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