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Volume 6 Issue 7, Jul 2021

Letter
Identification of proteasome and caspase inhibitors targeting SARS-CoV-2 Mpro
Zhengyuan Wang,Yao Zhao,Qingxing Wang  ORCID: orcid.org/0000-0003-1028-1267,Yangfei Xing,Lu Feng,Juan Kong,Chao Peng  ORCID: orcid.org/0000-0002-6814-2676,Leike Zhang  ORCID: orcid.org/0000-0002-2593-2571,Haitao Yang &…Min Lu  ORCID: orcid.org/0000-0001-6902-3751 
https://doi.org/10.1038/s41392-021-00639-8
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The natural analgesic conolidine targets the newly identified opioid scavenger ACKR3/CXCR7
Martyna Szpakowska  ORCID: orcid.org/0000-0002-5659-8377,Ann M. Decker,Max Meyrath  ORCID: orcid.org/0000-0001-8585-0474,Christie B. Palmer,Bruce E. Blough,Ojas A. Namjoshi &…Andy Chevigné  ORCID: orcid.org/0000-0003-4768-6743 
https://doi.org/10.1038/s41392-021-00548-w
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PIM1 kinase facilitates Zika virus replication by suppressing host cells’ natural immunity
Fanghang Zhou,Qianya Wan,Ying Chen,Sheng Chen &…Ming-liang He 
https://doi.org/10.1038/s41392-021-00539-x
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Sera proteomic features of active and recovered COVID-19 patients: potential diagnostic and prognostic biomarkers
Ling Leng  ORCID: orcid.org/0000-0002-6519-012X,Mansheng Li,Wei Li,Danlei Mou,Guopeng Liu,Jie Ma,Shuyang Zhang  ORCID: orcid.org/0000-0002-1532-0029,Hongjun Li,Ruiyuan Cao &…Wu Zhong  ORCID: orcid.org/0000-0002-0536-620X 
https://doi.org/10.1038/s41392-021-00612-5
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FBXO15 plays a critical suppressive functional role in regulation of breast cancer progression
Yi Zhao,Nayeon Shim,Yan-Hong Cui,Jae-Hyeok Kang,Ki-Chun Yoo,Seungmo Kim,Joo Mi Yi,Min-Jung Kim,Jai Hoon Yoon &…Su-Jae Lee 
https://doi.org/10.1038/s41392-021-00605-4
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Targeting of VPS18 by the lysosomotropic agent RDN reverses TFE3-mediated drug resistance
Huanmin Niu,Lilin Qian,Yanhai Luo,Fang Wang,Hongbo Zheng,Yanhui Gao,Hanbo Wang,Xuelei Hu,Huiqing Yuan &…Hongxiang Lou 
https://doi.org/10.1038/s41392-021-00547-x
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Coagulation factors and the incidence of COVID-19 severity: Mendelian randomization analyses and supporting evidence
Yao Zhou  ORCID: orcid.org/0000-0002-6527-9802,Xinyi Qian,Zipeng Liu,Hongxi Yang,Tong Liu,Kexin Chen,Yaogang Wang,Pak Chung Sham,Ying Yu  ORCID: orcid.org/0000-0002-6476-1752 &…Mulin Jun Li 
https://doi.org/10.1038/s41392-021-00640-1
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STN–ANT plasticity is crucial for the motor control in Parkinson’s disease model
Hui Zhang,Chunkui Zhang,Zhongwei Qu  ORCID: orcid.org/0000-0002-6994-0530,Bing Li,Yujuan Su,Xia Li,Yan Gao &…Yizheng Wang 
https://doi.org/10.1038/s41392-021-00545-z
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Identification of SARS-CoV-2-against aptamer with high neutralization activity by blocking the RBD domain of spike protein 1
Ge Yang,Ziyue Li,Irfan Mohammed,Liping Zhao,Wei Wei,Haihua Xiao  ORCID: orcid.org/0000-0001-8159-8187,Weisheng Guo,Yongxiang Zhao  ORCID: orcid.org/0000-0003-2214-5887,Feng Qu &…Yuanyu Huang  ORCID: orcid.org/0000-0003-3935-7245 
https://doi.org/10.1038/s41392-021-00649-6
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Palmitoylation of SARS-CoV-2 S protein is essential for viral infectivity
Zhuanchang Wu,Zhaoying Zhang,Xin Wang,Jing Zhang,Caiyue Ren,Yuming Li,Lifen Gao,Xiaohong Liang,Peihui Wang  ORCID: orcid.org/0000-0001-6853-2423 &…Chunhong Ma  ORCID: orcid.org/0000-0002-8121-4718 
https://doi.org/10.1038/s41392-021-00651-y
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GPR160 is a potential biomarker associated with prostate cancer
Wanjing Guo,Junyu Zhang,Yan Zhou,Caihong Zhou,Yunjie Yang,Zhaotong Cong,Jibin Dong,Dehua Yang,Bo Dai &…Ming-Wei Wang  ORCID: orcid.org/0000-0001-6550-9017 
https://doi.org/10.1038/s41392-021-00583-7
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Review Article
The STING1 network regulates autophagy and cell death
Ruoxi Zhang,Rui Kang &Daolin Tang 
https://doi.org/10.1038/s41392-021-00613-4
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Recent progress in targeted delivery vectors based on biomimetic nanoparticles
Li Chen,Weiqi Hong  ORCID: orcid.org/0000-0003-1668-2301,Wenyan Ren,Ting Xu,Zhiyong Qian &…Zhiyao He  ORCID: orcid.org/0000-0001-7888-211X 
https://doi.org/10.1038/s41392-021-00631-2
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Signaling pathways in cancer-associated fibroblasts and targeted therapy for cancer
Fanglong Wu,Jin Yang,Junjiang Liu,Ye Wang,Jingtian Mu,Qingxiang Zeng,Shuzhi Deng &…Hongmei Zhou 
https://doi.org/10.1038/s41392-021-00641-0
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Molecular mechanism of interaction between SARS-CoV-2 and host cells and interventional therapy
Qianqian Zhang,Rong Xiang,Shanshan Huo,Yunjiao Zhou,Shibo Jiang  ORCID: orcid.org/0000-0001-8283-7135,Qiao Wang &…Fei Yu 
https://doi.org/10.1038/s41392-021-00653-w
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Spatiotemporal control of CRISPR/Cas9 gene editing
Chenya Zhuo,Jiabin Zhang,Jung-Hwan Lee,Ju Jiao,Du Cheng,Li Liu,Hae-Won Kim,Yu Tao &…Mingqiang Li  ORCID: orcid.org/0000-0002-5178-4138 
https://doi.org/10.1038/s41392-021-00645-w
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Inflammation, epigenetics, and metabolism converge to cell senescence and ageing: the regulation and intervention
Xudong Zhu,Zhiyang Chen,Weiyan Shen,Gang Huang,John M. Sedivy,Hu Wang &…Zhenyu Ju 
https://doi.org/10.1038/s41392-021-00646-9
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Molecular mechanisms underpinning sarcomas and implications for current and future therapy
Victoria Damerell  ORCID: orcid.org/0000-0003-0161-869X,Michael S. Pepper  ORCID: orcid.org/0000-0001-6406-2380 &Sharon Prince  ORCID: orcid.org/0000-0002-6975-5255 
https://doi.org/10.1038/s41392-021-00647-8
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Research Highlight
Targeting H3K36 methyltransferases NSDs: a promising strategy for tumor targeted therapy
Xuerun Peng,Qian Peng &Lei Zhong 
https://doi.org/10.1038/s41392-021-00616-1
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The arsenal of TP53 mutants therapies: neoantigens and bispecific antibodies
Chang Yang,Ge Lou &Wei-Lin Jin 
https://doi.org/10.1038/s41392-021-00635-y
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High-throughput base editing: a promising technology for precision medicine and drug discovery
Agapios Sachinidis 
https://doi.org/10.1038/s41392-021-00633-0
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Cell-to-cell proteome variability: life in a cycle
Tsz Kin Suen,Burcu Al &Katarzyna Placek  ORCID: orcid.org/0000-0002-4944-6375 
https://doi.org/10.1038/s41392-021-00655-8
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The paradox of immunotherapy in NASH-HCC
Yao Peng,Chi Chun Wong &Jun Yu 
https://doi.org/10.1038/s41392-021-00654-9
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Exploiting a chink in the armor: engineering broadly neutralizing monoclonal antibodies for SARS-like viruses
Mirko Cortese &Christopher J. Neufeldt  ORCID: orcid.org/0000-0002-4551-1811 
https://doi.org/10.1038/s41392-021-00661-w
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Blastoids: a new model for human blastocyst development
Heiner Niemann &Bob Seamark 
https://doi.org/10.1038/s41392-021-00663-8
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Structure of serotonin receptors: molecular underpinning of receptor activation and modulation
Markus Zweckstetter  ORCID: orcid.org/0000-0002-2536-6581,Alexander Dityatev  ORCID: orcid.org/0000-0002-0472-0553 &Evgeni Ponimaskin  ORCID: orcid.org/0000-0002-4570-5130 
https://doi.org/10.1038/s41392-021-00668-3
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DHODH tangoing with GPX4 on the ferroptotic stage
Fudi Wang  ORCID: orcid.org/0000-0001-8730-0003 &Junxia Min  ORCID: orcid.org/0000-0001-8099-6327 
https://doi.org/10.1038/s41392-021-00656-7
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Article
Bitter receptor TAS2R138 facilitates lipid droplet degradation in neutrophils during Pseudomonas aeruginosa infection
Qinqin Pu,Kai Guo,Ping Lin  ORCID: orcid.org/0000-0002-4281-2440,Zhihan Wang,Shugang Qin,Pan Gao,Colin Combs,Nadeem Khan,Zhenwei Xia &…Min Wu  ORCID: orcid.org/0000-0003-1205-982X 
https://doi.org/10.1038/s41392-021-00602-7
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Human umbilical cord mesenchymal stem cell transfusion in immune non-responders with AIDS: a multicenter randomized controlled trial
Lifeng Wang,Zheng Zhang,Ruonan Xu,Xicheng Wang,Zhanjun Shu,Xiejie Chen,Siyu Wang,Jiaye Liu,Yuanyuan Li,Li Wang,Mi Zhang,Wei Yang,Ying Wang,Huihuang Huang,Bo Tu,Zhiwei Liang,Linghua Li,Jingxin Li,Yuying Hou,Ming Shi &…Fu-Sheng Wang  ORCID: orcid.org/0000-0002-8043-6685 
https://doi.org/10.1038/s41392-021-00607-2
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CD38 deficiency alleviates Ang II-induced vascular remodeling by inhibiting small extracellular vesicle-mediated vascular smooth muscle cell senescence in mice
Lu Gan,Demin Liu,Jing Liu,Erya Chen,Chan Chen  ORCID: orcid.org/0000-0001-5823-8247,Lian Liu,Hang Hu,Xiaohui Guan,Wen Ma,Yanzi Zhang,Yarong He,Bofu Liu,Songling Tang,Wei Jiang  ORCID: orcid.org/0000-0001-6589-2247,Jianxin Xue &…Hongbo Xin 
https://doi.org/10.1038/s41392-021-00625-0
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Phosphatidylserine externalized on the colonic capillaries as a novel pharmacological target for IBD therapy
Xuerui Zhang,Lulu Song,Lin Li,Banghui Zhu,Lina Huo,Zhaoqing Hu,Xinran Wang,Jie Wang,Mengyue Gao,Jing Zhang &…Zichun Hua 
https://doi.org/10.1038/s41392-021-00626-z
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M2 macrophages, but not M1 macrophages, support megakaryopoiesis by upregulating PI3K-AKT pathway activity
Hong-Yan Zhao,Yuan-Yuan Zhang,Tong Xing,Shu-Qian Tang,Qi Wen,Zhong-Shi Lyu,Meng Lv  ORCID: orcid.org/0000-0001-6625-9523,Yu Wang,Lan-Ping Xu,Xiao-Hui Zhang,Yuan Kong &…Xiao-Jun Huang  ORCID: orcid.org/0000-0002-2145-6643 
https://doi.org/10.1038/s41392-021-00627-y
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Interaction between HLA-G and NK cell receptor KIR2DL4 orchestrates HER2-positive breast cancer resistance to trastuzumab
Guoxu Zheng,Zhangyan Guo,Weimiao Li,Wenjin Xi,Baile Zuo,Rui Zhang,Weihong Wen,An-Gang Yang  ORCID: orcid.org/0000-0002-8854-4672 &…Lintao Jia 
https://doi.org/10.1038/s41392-021-00629-w
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Long non-coding RNA AFAP1-AS1 accelerates lung cancer cells migration and invasion by interacting with SNIP1 to upregulate c-Myc
Yu Zhong,Liting Yang,Fang Xiong,Yi He,Yanyan Tang,Lei Shi,Songqing Fan,Zheng Li,Shanshan Zhang,Zhaojian Gong,Can Guo,Qianjin Liao,Yujuan Zhou,Ming Zhou,Bo Xiang,Xiaoling Li,Yong Li  ORCID: orcid.org/0000-0001-8838-1714,Zhaoyang Zeng,Guiyuan Li &…Wei Xiong  ORCID: orcid.org/0000-0003-1635-8173 
https://doi.org/10.1038/s41392-021-00562-y
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Lactate dehydrogenases amplify reactive oxygen species in cancer cells in response to oxidative stimuli
Hao Wu,Yuqi Wang,Minfeng Ying,Chengmeng Jin,Jiangtao Li &…Xun Hu 
https://doi.org/10.1038/s41392-021-00595-3
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Perspective
Fast-spreading SARS-CoV-2 variants: challenges to and new design strategies of COVID-19 vaccines
Weilin Zhou &Wei Wang  ORCID: orcid.org/0000-0001-7788-1895 
https://doi.org/10.1038/s41392-021-00644-x
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