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Volume 6 Issue 6, Jun 2021

Letter
LncRNA MIAT impairs cardiac contractile function by acting on mitochondrial translocator protein TSPO in a mouse model of myocardial infarction
Xue Bai,Chao Yang,Lei Jiao,Hongtao Diao,Ziyu Meng,Lei Wang,Hao Cui,Lihua Sun,Yong Zhang &…Baofeng Yang 
https://doi.org/10.1038/s41392-021-00538-y
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NAT10 promotes gastric cancer metastasis via N4-acetylated COL5A1
Yigan Zhang,Yuanxue Jing,Yinxue Wang,Jianming Tang,Xiaoran Zhu,Wei-Lin Jin  ORCID: orcid.org/0000-0001-8011-2405,Yiqing Wang,Wenzhen Yuan,Xiangkai Li &…Xun Li 
https://doi.org/10.1038/s41392-021-00489-4
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SARS-CoV-2 promote autophagy to suppress type I interferon response
Xianfeng Hui,Linliang Zhang,Lei Cao,Kun Huang,Ya Zhao,Yufei Zhang,Xi Chen,Xian Lin,Mingzhou Chen &…Meilin Jin 
https://doi.org/10.1038/s41392-021-00574-8
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Lenalidomide downregulates ACE2 protein abundance to alleviate infection by SARS-CoV-2 spike protein conditioned pseudoviruses
Siyuan Su,Jianfeng Chen,Ying Wang,Lilly M. Wong,Zhichuan Zhu,Guochun Jiang &…Pengda Liu 
https://doi.org/10.1038/s41392-021-00608-1
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Cellular tropism and antigenicity of mink-derived SARS-CoV-2 variants
Li Zhang,Qianqian Li,Jianhui Nie,Ruxia Ding,Haixin Wang,Jiajing Wu,Xuguang Li,Xiaoming Yang,Weijin Huang &…Youchun Wang  ORCID: orcid.org/0000-0001-9769-5141 
https://doi.org/10.1038/s41392-021-00617-0
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Ceftazidime is a potential drug to inhibit SARS-CoV-2 infection in vitro by blocking spike protein–ACE2 interaction
ChangDong Lin,Yue Li,YueBin Zhang  ORCID: orcid.org/0000-0001-8174-7189,ZhaoYuan Liu,Xia Mu,Chenjian Gu,Jing Liu,Yutang Li,GuoHui Li &…JianFeng Chen  ORCID: orcid.org/0000-0002-2892-1691 
https://doi.org/10.1038/s41392-021-00619-y
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CPSF4 promotes triple negative breast cancer metastasis by upregulating MDM4
Kaping Lee,Qiufan Zheng,Qianyi Lu,Fei Xu  ORCID: orcid.org/0000-0001-8543-6636,Ge Qin,Qinglian Zhai,Ruoxi Hong,Miao Chen,Wuguo Deng &…Shusen Wang 
https://doi.org/10.1038/s41392-021-00565-9
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Bardoxolone and bardoxolone methyl, two Nrf2 activators in clinical trials, inhibit SARS-CoV-2 replication and its 3C-like protease
Qi Sun  ORCID: orcid.org/0000-0002-8519-657X,Fei Ye,Hao Liang,Hongbo Liu,Chunmei Li,Roujian Lu,Baoying Huang,Li Zhao,Wenjie Tan &…Luhua Lai 
https://doi.org/10.1038/s41392-021-00628-x
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Article
HLA-mismatched allogeneic adoptive immune therapy in severely immunosuppressed AIDS patients
Ruonan Xu,Ji-Yuan Zhang,Bo Tu,Zhe Xu,Hui-Huang Huang,Lei Huang,Yan-Mei Jiao,Tao Yang,Chao Zhang,En-Qiang Qin,Tian-Jun Jiang,Yun-Bo Xie,Yuan-Yuan Li,Lei Jin,Chun-Bao Zhou,Ming Shi,Mei Guo,Hui-Sheng Ai  ORCID: orcid.org/0000-0001-7002-1702,Linqi Zhang &…Fu-Sheng Wang  ORCID: orcid.org/0000-0002-8043-6685 
https://doi.org/10.1038/s41392-021-00550-2
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Viral dynamics and antibody responses in people with asymptomatic SARS-CoV-2 infection
Zhiwei Sui,Xinhua Dai,Qingbin Lu  ORCID: orcid.org/0000-0002-2804-0827,Yulan Zhang,Min Huang,Shufen Li,Tao Peng,Jie Xie,Yongzhuo Zhang,Chunchen Wu,Jianbo Xia  ORCID: orcid.org/0000-0002-8912-9921,Lianhua Dong,Jiayi Yang,Wenfeng Huang,Siyuan Liu,Ziquan Wang,Ke Li,Qingfang Yang,Xi Zhou,Ying Wu,Wei Liu,Xiang Fang &…Ke Peng  ORCID: orcid.org/0000-0003-0172-8725 
https://doi.org/10.1038/s41392-021-00596-2
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The interferon-stimulated exosomal hACE2 potently inhibits SARS-CoV-2 replication through competitively blocking the virus entry
Junsong Zhang,Feng Huang,Baijin Xia,Yaochang Yuan,Fei Yu,Guanwen Wang,Qianyu Chen,Qian Wang,Yuzhuang Li,Rong Li,Zheng Song,Ting Pan,Jingliang Chen,Gen Lu &…Hui Zhang 
https://doi.org/10.1038/s41392-021-00604-5
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Activation of transmembrane receptor tyrosine kinase DDR1-STAT3 cascade by extracellular matrix remodeling promotes liver metastatic colonization in uveal melanoma
Wei Dai,Shenglan Liu,Shubo Wang,Li Zhao,Xiao Yang,Jingfeng Zhou,Yun Wang,Jing Zhang,Ping Zhang,Ke Ding,Yangqiu Li &…Jingxuan Pan 
https://doi.org/10.1038/s41392-021-00563-x
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Metagenomic analysis reveals oropharyngeal microbiota alterations in patients with COVID-19
Shengli Ma,Fan Zhang,Fengxia Zhou,Hui Li,Wenyu Ge,Rui Gan,Huan Nie,Biao Li,Yindong Wang,Meng Wu,Duo Li,Dongmei Wang,Zheng Wang,Yuhong You &…Zhiwei Huang  ORCID: orcid.org/0000-0002-8201-9391 
https://doi.org/10.1038/s41392-021-00614-3
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Rapid isolation and immune profiling of SARS-CoV-2 specific memory B cell in convalescent COVID-19 patients via LIBRA-seq
Bing He,Shuning Liu,Yuanyuan Wang,Mengxin Xu,Wei Cai,Jia Liu,Wendi Bai,Shupei Ye,Yong Ma,Hengrui Hu,Huicui Meng,Tao Sun,Yanling Li,Huanle Luo,Mang Shi,Xiangjun Du  ORCID: orcid.org/0000-0001-8184-8430,Wenjing Zhao,Shoudeng Chen,Jingyi Yang,Haipeng Zhu,Yusheng Jie,Yuedong Yang  ORCID: orcid.org/0000-0002-6782-2813,Deyin Guo  ORCID: orcid.org/0000-0002-8297-0814,Qiao Wang,Yuwen Liu,Huimin Yan  ORCID: orcid.org/0000-0002-7243-8429,Manli Wang  ORCID: orcid.org/0000-0001-8701-3530 &…Yao-Qing Chen  ORCID: orcid.org/0000-0002-4659-1550 
https://doi.org/10.1038/s41392-021-00610-7
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Safety and efficacy of meplazumab in healthy volunteers and COVID-19 patients: a randomized phase 1 and an exploratory phase 2 trial
Huijie Bian  ORCID: orcid.org/0000-0003-4690-4622,Zhao-Hui Zheng,Ding Wei,Aidong Wen,Zheng Zhang,Jian-Qi Lian,Wen-Zhen Kang,Chun-Qiu Hao,Jing Wang,Rong-Hua Xie,Ke Dong,Jie-Lai Xia,Jin-Lin Miao,Wen Kang,Guoquan Li,Di Zhang,Mingru Zhang,Xiu-Xuan Sun,Likun Ding,Kui Zhang,Junfeng Jia,Jin Ding,Zhiqin Li,Yanyan Jia,Lin-Na Liu,Zhe Zhang,Zhao-Wei Gao,Hong Du,Na Yao,Qing Wang,Ke Wang,Jie-Jie Geng,Bin Wang,Ting Guo,Ruo Chen,Yu-Meng Zhu,Li-Juan Wang,Qian He,Rui-Rui Yao,Ying Shi,Xiang-Min Yang,Jian-Sheng Zhou,Yi-Nan Ma,Ya-Tao Wang,Xue Liang,Fei Huo,Zhe Wang,Yang Zhang,Xu Yang,Ye Zhang,Lu-Hua Gao,Ling Wang,Xiao-Chun Chen,Hao Tang,Shuang-Shuang Liu,Qing-Yi Wang,Zhi-Nan Chen &…Ping Zhu 
https://doi.org/10.1038/s41392-021-00603-6
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UBQLN1 mediates sorafenib resistance through regulating mitochondrial biogenesis and ROS homeostasis by targeting PGC1β in hepatocellular carcinoma
Junjie Xu,Lin Ji,Yeling Ruan,Zhe Wan,Zhongjie Lin,Shunjie Xia,Liye Tao,Junhao Zheng,Liuxin Cai,Yifan Wang,Xiao Liang &…Xiujun Cai  ORCID: orcid.org/0000-0002-6457-0577 
https://doi.org/10.1038/s41392-021-00594-4
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Dynamics of neutralizing antibody responses to SARS-CoV-2 in patients with COVID-19: an observational study
Xin Xu,Sheng Nie,Yanqun Wang,Quanxin Long  ORCID: orcid.org/0000-0003-1857-2798,Hong Zhu,Xiaoyong Zhang,Jian Sun,Qinglang Zeng,Jincun Zhao  ORCID: orcid.org/0000-0003-2515-5589,Li Liu,Ling Li,Ailong Huang,Jinlin Hou &…Fan Fan Hou  ORCID: orcid.org/0000-0003-3117-7418 
https://doi.org/10.1038/s41392-021-00611-6
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Sequential infection with H1N1 and SARS-CoV-2 aggravated COVID-19 pathogenesis in a mammalian model, and co-vaccination as an effective method of prevention of COVID-19 and influenza
Linlin Bao,Wei Deng,Feifei Qi,Qi Lv,Zhiqi Song,Jiangning Liu,Hong Gao,Qiang Wei,Pin Yu,Yanfeng Xu,Yajin Qu,Fengdi Li,Jing Xue  ORCID: orcid.org/0000-0002-9113-2433,Shuran Gong,Mingya Liu,Guanpeng Wang,Shunyi Wang,Binbin Zhao,Bin Cong &…Chuan Qin  ORCID: orcid.org/0000-0002-6261-1232 
https://doi.org/10.1038/s41392-021-00618-z
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FLT3 tyrosine kinase inhibitors synergize with BCL-2 inhibition to eliminate FLT3/ITD acute leukemia cells through BIM activation
Ruiqi Zhu,Li Li,Bao Nguyen,Jaesung Seo,Min Wu,Tessa Seale,Mark Levis,Amy Duffield,Yu Hu  ORCID: orcid.org/0000-0002-2815-4568 &…Donald Small 
https://doi.org/10.1038/s41392-021-00578-4
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Exosomal S100A4 derived from highly metastatic hepatocellular carcinoma cells promotes metastasis by activating STAT3
Haoting Sun,Chaoqun Wang,Beiyuan Hu,Xiaomei Gao,Tiantian Zou,Qin Luo,Mo Chen,Yan Fu,Yuanyuan Sheng,Kaili Zhang,Yan Zheng,Xudong Ren,Shican Yan,Yan Geng,Luyu Yang,Qiongzhu Dong  ORCID: orcid.org/0000-0002-2433-7199 &…Lunxiu Qin 
https://doi.org/10.1038/s41392-021-00579-3
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Cyst(e)ine in nutrition formulation promotes colon cancer growth and chemoresistance by activating mTORC1 and scavenging ROS
Jiao Wu,Sai-Ching Jim Yeung,Sicheng Liu,Aiham Qdaisat,Dewei Jiang,Wenli Liu,Zhuo Cheng,Wenjing Liu,Haixia Wang,Lu Li,Zhongmei Zhou,Rong Liu,Chuanyu Yang,Ceshi Chen &…Runxiang Yang 
https://doi.org/10.1038/s41392-021-00581-9
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A core-shell structured COVID-19 mRNA vaccine with favorable biodistribution pattern and promising immunity
Ren Yang  ORCID: orcid.org/0000-0002-8134-4010,Yao Deng,Baoying Huang,Lei Huang,Ang Lin  ORCID: orcid.org/0000-0001-5662-1576,Yuhua Li,Wenling Wang,Jingjing Liu,Shuaiyao Lu,Zhenzhen Zhan,Yufei Wang,Ruhan A,Wen Wang,Peihua Niu,Li Zhao,Shiqiang Li,Xiaopin Ma,Luyao Zhang,Yujian Zhang,Weiguo Yao,Xingjie Liang,Jincun Zhao  ORCID: orcid.org/0000-0003-2515-5589,Zhongmin Liu,Xiaozhong Peng  ORCID: orcid.org/0000-0002-8564-0247,Hangwen Li &…Wenjie Tan 
https://doi.org/10.1038/s41392-021-00634-z
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Research Highlight
EpiMap: Fine-tuning integrative epigenomics maps to understand complex human regulatory genomic circuitry
Dave S. B. Hoon,Negin Rahimzadeh &Matias A. Bustos  ORCID: orcid.org/0000-0001-9625-1127 
https://doi.org/10.1038/s41392-021-00620-5
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Fecal microbiota transplantation: can it circumvent resistance to PD-1 blockade in melanoma?
Lisa Derosa &Laurence Zitvogel 
https://doi.org/10.1038/s41392-021-00585-5
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Gut Phage Database: phage mining in the cave of wonders
Magdalena Unterer,Mohammadali Khan Mirzaei &Li Deng  ORCID: orcid.org/0000-0003-0225-0663 
https://doi.org/10.1038/s41392-021-00615-2
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SARS-CoV-2 mutations, vaccines, and immunity: implication of variants of concern
Ji Yun Noh,Hye Won Jeong &Eui-Cheol Shin 
https://doi.org/10.1038/s41392-021-00623-2
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SARS-CoV-2 nanobodies 2.0
Fabien Labroussaa  ORCID: orcid.org/0000-0002-8712-3024 &Joerg Jores 
https://doi.org/10.1038/s41392-021-00632-1
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Pancreatic tumor initiation: the potential role of IL-33
Xing Huang  ORCID: orcid.org/0000-0002-8886-2777,Gang Zhang &Tingbo Liang 
https://doi.org/10.1038/s41392-021-00636-x
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Novel Cryo-EM structures of the D1 dopamine receptor unlock its therapeutic potential
David R. Sibley  ORCID: orcid.org/0000-0002-0624-962X,Kathryn D. Luderman,R. Benjamin Free  ORCID: orcid.org/0000-0002-2428-0487 &…Lei Shi 
https://doi.org/10.1038/s41392-021-00630-3
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Membrane-destabilizing ionizable phospholipids: Novel components for organ-selective mRNA delivery and CRISPR–Cas gene editing
Ning Meng &Dirk Grimm 
https://doi.org/10.1038/s41392-021-00642-z
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Review Article
Application of 3D bioprinting in the prevention and the therapy for human diseases
Hee-Gyeong Yi,Hyeonji Kim,Junyoung Kwon,Yeong-Jin Choi,Jinah Jang &…Dong-Woo Cho  ORCID: orcid.org/0000-0001-5869-4330 
https://doi.org/10.1038/s41392-021-00566-8
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Protein kinase CK2: a potential therapeutic target for diverse human diseases
Christian Borgo,Claudio D’Amore,Stefania Sarno,Mauro Salvi &…Maria Ruzzene  ORCID: orcid.org/0000-0001-8712-8151 
https://doi.org/10.1038/s41392-021-00567-7
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Targeting circular RNAs as a therapeutic approach: current strategies and challenges
Alina T. He,Jinglei Liu,Feiya Li &…Burton B. Yang 
https://doi.org/10.1038/s41392-021-00569-5
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Small molecules in targeted cancer therapy: advances, challenges, and future perspectives
Lei Zhong,Yueshan Li  ORCID: orcid.org/0000-0003-2343-1252,Liang Xiong  ORCID: orcid.org/0000-0003-1174-5609,Wenjing Wang,Ming Wu,Ting Yuan,Wei Yang,Chenyu Tian,Zhuang Miao,Tianqi Wang &…Shengyong Yang 
https://doi.org/10.1038/s41392-021-00572-w
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Perspective
COVID-19 vaccines: progress and understanding on quality control and evaluation
Qunying Mao,Miao Xu,Qian He,Changgui Li,Shufang Meng,Yiping Wang,Bopei Cui,Zhenglun Liang &…Junzhi Wang 
https://doi.org/10.1038/s41392-021-00621-4
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