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Volume 6 Issue 5, May 2021

Research Highlight
Small molecule induced polymerization of BCL6 facilitates SIAH1 mediated degradation
Sandeep Rana &Amarnath Natarajan  ORCID: orcid.org/0000-0001-5067-0203 
https://doi.org/10.1038/s41392-021-00556-w
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Therapeutic utility of Lung-MAP: ushering into an era of genomic and biomarker-driven clinical trials
Chenyue Zhang &Haiyong Wang 
https://doi.org/10.1038/s41392-021-00557-9
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Landscapes of SARS-CoV-2-reactive CD8+ T cells: heterogeneity of host immune responses against SARS-CoV-2
June-Young Koh  ORCID: orcid.org/0000-0002-2043-6624 &Eui-Cheol Shin 
https://doi.org/10.1038/s41392-021-00589-1
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FcγRIIb blockage: a promising immunotherapy target for severe COVID-19
Xuemei He,Manni Wang &Min Wu  ORCID: orcid.org/0000-0003-1205-982X 
https://doi.org/10.1038/s41392-021-00590-8
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SARS-CoV-2 variants: a new challenge to convalescent serum and mRNA vaccine neutralization efficiency
Maochen Li  ORCID: orcid.org/0000-0001-8786-5039,Fuxing Lou &Huahao Fan  ORCID: orcid.org/0000-0001-5007-2158 
https://doi.org/10.1038/s41392-021-00592-6
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The anti-inflammatory astrocyte revealed: the role of the microbiome in shaping brain defences
Alexei Verkhratsky  ORCID: orcid.org/0000-0003-2592-9898,Peter Illes,Yong Tang  ORCID: orcid.org/0000-0002-2543-066X &…Alexey Semyanov  ORCID: orcid.org/0000-0002-6800-0942 
https://doi.org/10.1038/s41392-021-00577-5
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HIV protease: late action to prevent immune detection
Konstantin M. J. Sparrer  ORCID: orcid.org/0000-0002-8682-1779 &Frank Kirchhoff  ORCID: orcid.org/0000-0002-7052-2360 
https://doi.org/10.1038/s41392-021-00588-2
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COVID-19: complexity of disease severity revealed by systemic and localized single cell immune atlas
Nehad M. Alajez 
https://doi.org/10.1038/s41392-021-00587-3
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CRISPR base editor treats premature-aging syndrome
Ping Lin  ORCID: orcid.org/0000-0002-4281-2440,Jianxin Jiang &Min Wu  ORCID: orcid.org/0000-0003-1205-982X 
https://doi.org/10.1038/s41392-021-00576-6
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Surveilling microglia dampens neuronal activity: operation of a purinergically mediated negative feedback mechanism
Peter Illes,Alexei Verkhratsky  ORCID: orcid.org/0000-0003-2592-9898 &Yong Tang  ORCID: orcid.org/0000-0002-2543-066X 
https://doi.org/10.1038/s41392-021-00586-4
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Adapt or perish: SARS-CoV-2 antibody escape variants defined by deletions in the Spike N-terminal Domain
Marta Ribes  ORCID: orcid.org/0000-0001-7269-1507,Carlos Chaccour  ORCID: orcid.org/0000-0001-9812-050X &Gemma Moncunill 
https://doi.org/10.1038/s41392-021-00601-8
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Lactate-avid regulatory T cells: metabolic plasticity controls immunosuppression in tumour microenvironment
Gabriele Multhoff &Peter Vaupel 
https://doi.org/10.1038/s41392-021-00598-0
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Letter
Antimicrobial peptide DP7 with potential activity against SARS coronavirus infections
Rui Zhang,Xiaohua Jiang,Jingxin Qiao,Zeng Wang,Aiping Tong  ORCID: orcid.org/0000-0002-3392-5443,Jinliang Yang,Shengyong Yang &…Li Yang 
https://doi.org/10.1038/s41392-021-00551-1
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MTA2 triggered R-loop trans-regulates BDH1-mediated β-hydroxybutyrylation and potentiates propagation of hepatocellular carcinoma stem cells
Heng Zhang  ORCID: orcid.org/0000-0002-9003-9624,Zhi Chang,Lu-ning Qin,Bin Liang,Jing-xia Han,Kai-liang Qiao,Cheng Yang  ORCID: orcid.org/0000-0001-9431-290X,Yan-rong Liu,Hong-gang Zhou &…Tao Sun 
https://doi.org/10.1038/s41392-021-00464-z
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Targeting cellular senescence prevents glucocorticoid-induced bone loss through modulation of the DPP4-GLP-1 axis
Tiantian Wang  ORCID: orcid.org/0000-0002-7623-7245,Lin Yang,Zejun Liang,Lin Wang,Feijing Su,Xiangxiu Wang,Xuanhe You &…Chengqi He 
https://doi.org/10.1038/s41392-021-00528-0
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SAHA attenuates Takotsubo-like myocardial injury by targeting an epigenetic Ac/Dc axis
Ishant Khurana  ORCID: orcid.org/0000-0001-9050-2749,Scott Maxwell  ORCID: orcid.org/0000-0002-7801-0714,Simon Royce  ORCID: orcid.org/0000-0001-5841-1775,Prabhu Mathiyalagan  ORCID: orcid.org/0000-0002-8202-9266,Tom Karagiannis  ORCID: orcid.org/0000-0002-9967-1546,Nadia Mazarakis  ORCID: orcid.org/0000-0001-7681-2775,Jitraporn Vongsvivut  ORCID: orcid.org/0000-0003-0699-3464,Harikrishnan K.N.  ORCID: orcid.org/0000-0002-4662-659X,Jun Okabe  ORCID: orcid.org/0000-0002-7196-0522,Keith Al-Hasani  ORCID: orcid.org/0000-0001-6109-5603,Chrishan Samuel  ORCID: orcid.org/0000-0003-0295-4214 &…Assam El-Osta  ORCID: orcid.org/0000-0001-7968-7375 
https://doi.org/10.1038/s41392-021-00546-y
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Proteome-wide epitope mapping identifies a resource of antibodies for SARS-CoV-2 detection and neutralization
Te Liang,Mengli Cheng,Fei Teng,Hongye Wang,Yongqiang Deng  ORCID: orcid.org/0000-0002-2306-1039,Jiahui Zhang,Chengfeng Qin  ORCID: orcid.org/0000-0002-0632-2807,Shubin Guo,Hui Zhao &…Xiaobo Yu  ORCID: orcid.org/0000-0003-2352-9866 
https://doi.org/10.1038/s41392-021-00573-9
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Berbamine inhibits SARS-CoV-2 infection by compromising TRPMLs-mediated endolysosomal trafficking of ACE2
Lihong Huang  ORCID: orcid.org/0000-0002-5179-474X,Terrence Tsz-Tai Yuen,Zuodong Ye  ORCID: orcid.org/0000-0002-9575-6198,Shuyan Liu,Guoliang Zhang  ORCID: orcid.org/0000-0002-3617-5449,Hin Chu &…Jianbo Yue  ORCID: orcid.org/0000-0001-6384-5447 
https://doi.org/10.1038/s41392-021-00584-6
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Article
Mutant KRAS triggers functional reprogramming of tumor-associated macrophages in colorectal cancer
Huashan Liu,Zhenxing Liang,Chi Zhou,Ziwei Zeng,Fengwei Wang,Tuo Hu,Xiaowen He,Xiaojian Wu,Xianrui Wu &…Ping Lan  ORCID: orcid.org/0000-0002-8901-8498 
https://doi.org/10.1038/s41392-021-00534-2
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GOLM1 restricts colitis and colon tumorigenesis by ensuring Notch signaling equilibrium in intestinal homeostasis
Yang Pu,Ya Song,Mengdi Zhang,Caifeng Long,Jie Li,Yanan Wang,Yinzhe Xu,Fei Pan,Na Zhao,Xinyu Zhang,Yanan Xu,Jianxin Cui,Hongying Wang,Yan Li,Yong Zhao,Di Jin &…Hongbing Zhang  ORCID: orcid.org/0000-0001-6291-1027 
https://doi.org/10.1038/s41392-021-00535-1
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Nucleoside reverse transcriptase inhibitors and Kamuvudines inhibit amyloid-β induced retinal pigmented epithelium degeneration
Siddharth Narendran,Felipe Pereira  ORCID: orcid.org/0000-0001-8884-2816,Praveen Yerramothu,Ivana Apicella,Shao-bin Wang,Kameshwari Ambati,Shuichiro Hirahara,Younghee Kim,Meenakshi Ambati,Vidya L. Ambati,Peirong Huang,Akhil Varshney,Yosuke Nagasaka,Shinichi Fukuda,Kirstie L. Baker,Kenneth M. Marion  ORCID: orcid.org/0000-0003-1275-5729,Jan M. Deussing,Srinivas R. Sadda,Bradley D. Gelfand &…Jayakrishna Ambati 
https://doi.org/10.1038/s41392-021-00537-z
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Multi-platform omics analysis reveals molecular signature for COVID-19 pathogenesis, prognosis and drug target discovery
Yuming Li,Guixue Hou,Haibo Zhou,Yanqun Wang,Hein Min Tun  ORCID: orcid.org/0000-0001-7597-5062,Airu Zhu,Jingxian Zhao,Fei Xiao,Shanwen Lin,Dongdong Liu,Dunrong Zhou,Lang Mai,Lu Zhang,Zhaoyong Zhang,Lijun Kuang,Jiao Guan,Qiushi Chen,Liyan Wen,Yanjun Zhang,Jianfen Zhuo,Fang Li,Zhen Zhuang,Zhao Chen,Ling Luo,Donglan Liu,Chunke Chen,Mian Gan,Nanshan Zhong,Jincun Zhao  ORCID: orcid.org/0000-0003-2515-5589,Yan Ren  ORCID: orcid.org/0000-0002-4007-8625 &…Yonghao Xu 
https://doi.org/10.1038/s41392-021-00508-4
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Clinical effect and antiviral mechanism of T-705 in treating severe fever with thrombocytopenia syndrome
Hao Li,Xia-Ming Jiang,Ning Cui,Chun Yuan,Shao-Fei Zhang,Qing-Bin Lu,Zhen-Dong Yang,Qin-Lin Xin  ORCID: orcid.org/0000-0002-1087-2422,Ya-Bin Song,Xiao-Ai Zhang,Hai-Zhou Liu,Juan Du,Xue-Juan Fan,Lan Yuan,Yi-Mei Yuan,Zhen Wang,Juan Wang,Lan Zhang,Dong-Na Zhang,Zhi-Bo Wang,Ke Dai,Jie-Ying Bai,Zhao-Nian Hao,Hang Fan,Li-Qun Fang,Gengfu Xiao,Yang Yang,Ke Peng  ORCID: orcid.org/0000-0003-0172-8725,Hong-Quan Wang,Jian-Xiong Li,Lei-Ke Zhang  ORCID: orcid.org/0000-0002-2593-2571 &…Wei Liu 
https://doi.org/10.1038/s41392-021-00541-3
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Nlp promotes autophagy through facilitating the interaction of Rab7 and FYCO1
Wenchang Xiao,Danna Yeerken,Jia Li,Zhangfu Li,Lanfang Jiang,Dan Li  ORCID: orcid.org/0000-0002-5586-4055,Ming Fu,Liying Ma,Yongmei Song  ORCID: orcid.org/0000-0002-7789-0158,Weimin Zhang &…Qimin Zhan  ORCID: orcid.org/0000-0002-1731-938X 
https://doi.org/10.1038/s41392-021-00543-1
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Ketogenic diet alleviates colitis by reduction of colonic group 3 innate lymphoid cells through altering gut microbiome
Cheng Kong,Xuebing Yan,Yongqiang Liu,Linsheng Huang,Yefei Zhu,Jide He,Renyuan Gao,Matthew F. Kalady,Ajay Goel  ORCID: orcid.org/0000-0003-1396-6341,Huanlong Qin &…Yanlei Ma 
https://doi.org/10.1038/s41392-021-00549-9
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RNA-induced liquid phase separation of SARS-CoV-2 nucleocapsid protein facilitates NF-κB hyper-activation and inflammation
Yaoxing Wu,Ling Ma,Sihui Cai,Zhen Zhuang,Zhiyao Zhao,Shouheng Jin  ORCID: orcid.org/0000-0002-2728-2859,Weihong Xie,Lingli Zhou,Lei Zhang,Jincun Zhao  ORCID: orcid.org/0000-0003-2515-5589 &…Jun Cui  ORCID: orcid.org/0000-0002-8000-3708 
https://doi.org/10.1038/s41392-021-00575-7
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An integrative drug repositioning framework discovered a potential therapeutic agent targeting COVID-19
Yiyue Ge  ORCID: orcid.org/0000-0002-4839-5334,Tingzhong Tian  ORCID: orcid.org/0000-0003-4899-0632,Suling Huang,Fangping Wan,Jingxin Li,Shuya Li,Xiaoting Wang,Hui Yang,Lixiang Hong,Nian Wu,Enming Yuan,Yunan Luo,Lili Cheng,Chengliang Hu,Yipin Lei,Hantao Shu,Xiaolong Feng,Ziyuan Jiang,Yunfu Wu,Ying Chi,Xiling Guo,Lunbiao Cui,Liang Xiao,Zeng Li,Chunhao Yang,Zehong Miao  ORCID: orcid.org/0000-0002-0833-6583,Ligong Chen  ORCID: orcid.org/0000-0002-7893-7173,Haitao Li  ORCID: orcid.org/0000-0002-6686-1677,Hainian Zeng,Dan Zhao  ORCID: orcid.org/0000-0003-0195-6031,Fengcai Zhu,Xiaokun Shen &…Jianyang Zeng  ORCID: orcid.org/0000-0003-0950-7716 
https://doi.org/10.1038/s41392-021-00568-6
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The olfactory route is a potential way for SARS-CoV-2 to invade the central nervous system of rhesus monkeys
Li Jiao,Yun Yang,Wenhai Yu,Yuan Zhao,Haiting Long,Jiahong Gao,Kaiyun Ding,Chunxia Ma,Jingmei Li,Siwen Zhao,Haixuan Wang,Haiyan Li,Mengli Yang,Jingwen Xu,Junbin Wang,Jing Yang,Dexuan Kuang,Fangyu Luo,Xingli Qian,Longjiang Xu,Bin Yin,Wei Liu,Hongqi Liu,Shuaiyao Lu &…Xiaozhong Peng  ORCID: orcid.org/0000-0002-8564-0247 
https://doi.org/10.1038/s41392-021-00591-7
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Review Article
Extracellular matrix and its therapeutic potential for cancer treatment
Jiacheng Huang,Lele Zhang,Dalong Wan,Lin Zhou,Shusen Zheng,Shengzhang Lin &…Yiting Qiao 
https://doi.org/10.1038/s41392-021-00544-0
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From purines to purinergic signalling: molecular functions and human diseases
Zhao Huang,Na Xie,Peter Illes,Francesco Di Virgilio,Henning Ulrich,Alexey Semyanov  ORCID: orcid.org/0000-0002-6800-0942,Alexei Verkhratsky  ORCID: orcid.org/0000-0003-2592-9898,Beata Sperlagh,Shu-Guang Yu,Canhua Huang  ORCID: orcid.org/0000-0003-2247-7750 &…Yong Tang  ORCID: orcid.org/0000-0002-2543-066X 
https://doi.org/10.1038/s41392-021-00553-z
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Cytosolic DNA sensing by cGAS: regulation, function, and human diseases
Le Yu &Pengda Liu 
https://doi.org/10.1038/s41392-021-00554-y
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