Table of Contents
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Volume 6 Issue 4, Apr 2021

Letter
Metformin targets Clusterin to control lipogenesis and inhibit the growth of bladder cancer cells through SREBP-1c/FASN axis
Jun Deng,Mei Peng,Sichun Zhou,Di Xiao,Xin Hu,Simeng Xu,Jingtao Wu &…Xiaoping Yang 
https://doi.org/10.1038/s41392-021-00493-8
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TMPRSS2 activity may mediate sex differences in COVID-19 severity
Derick Okwan-Duodu  ORCID: orcid.org/0000-0003-1479-5759,Eun-Cheon Lim,Sungyong You &…David M. Engman  ORCID: orcid.org/0000-0001-5869-9844 
https://doi.org/10.1038/s41392-021-00513-7
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Prognostic value of lymphocyte count in severe COVID-19 patients with corticosteroid treatment
Chenyang Lu,Yi Liu,Bo Chen,Hang Yang,Huifang Hu,Yi Liu &…Yi Zhao 
https://doi.org/10.1038/s41392-021-00517-3
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Study on the promotion of lymphocytes in patients with COVID-19 by broad-spectrum chemokine receptor inhibitor vMIP-II and its Mechanism of signal transmission in vitro
Shiyu Li,Shuting Liu,Zhenyou Jiang,Lixia Feng,Yong Gao,Youyu Chen,Anding Xu,Wenhua Huang,Nuofu Zhang &…Hanxiao Sun  ORCID: orcid.org/0000-0002-1793-493X 
https://doi.org/10.1038/s41392-021-00516-4
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LPS-induced mitochondrial DNA synthesis and release facilitate RAD50-dependent acute lung injury
Xueqin Zhan,Rui Cui,Xinwei Geng,Jiaqian Li,Yunlian Zhou,Lulu He,Chao Cao,Chao Zhang,Zhimin Chen &…Songmin Ying  ORCID: orcid.org/0000-0003-1770-8956 
https://doi.org/10.1038/s41392-021-00494-7
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SARS-CoV-2 non-structural protein 13 (nsp13) hijacks host deubiquitinase USP13 and counteracts host antiviral immune response
Guijie Guo,Ming Gao,Xiaochen Gao,Bibo Zhu,Jinzhou Huang,Kuntian Luo,Yong Zhang,Jie Sun,Min Deng &…Zhenkun Lou  ORCID: orcid.org/0000-0003-1938-3091 
https://doi.org/10.1038/s41392-021-00509-3
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Stem cell-derived exosomes repair ischemic muscle injury by inhibiting the tumor suppressor Rb1-mediated NLRP3 inflammasome pathway
Yanli Wang,Wenping Xie,Bin Liu,Hui Huang,Wei Luo,Yu Zhang,Xiangbin Pan,Xi-Yong Yu,Zhenya Shen &…Yangxin Li 
https://doi.org/10.1038/s41392-021-00520-8
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The impact of receptor-binding domain natural mutations on antibody recognition of SARS-CoV-2
Cheng Li,Xiaolong Tian,Xiaodong Jia,Jinkai Wan,Lu Lu  ORCID: orcid.org/0000-0002-2255-0391,Shibo Jiang  ORCID: orcid.org/0000-0001-8283-7135,Fei Lan,Yinying Lu,Yanling Wu &…Tianlei Ying 
https://doi.org/10.1038/s41392-021-00536-0
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Identification of bis-benzylisoquinoline alkaloids as SARS-CoV-2 entry inhibitors from a library of natural products
Chang-Long He,Lu-Yi Huang,Kai Wang  ORCID: orcid.org/0000-0002-0137-1247,Chen-Jian Gu,Jie Hu,Gui-Ji Zhang,Wei Xu,You-Hua Xie  ORCID: orcid.org/0000-0002-2416-7708,Ni Tang &…Ai-Long Huang  ORCID: orcid.org/0000-0003-0148-7423 
https://doi.org/10.1038/s41392-021-00531-5
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Administration of B7-H3 targeted chimeric antigen receptor-T cells induce regression of glioblastoma
Xin Tang,Yuelong Wang,Jianhan Huang,Zongliang Zhang,Fujun Liu,Jianguo Xu,Gang Guo,Wei Wang  ORCID: orcid.org/0000-0001-7788-1895,Aiping Tong  ORCID: orcid.org/0000-0002-3392-5443 &…Liangxue Zhou 
https://doi.org/10.1038/s41392-021-00505-7
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Longitudinal dynamics of antibody responses in recovered COVID-19 patients
Meng-Li Cheng,Hui-Ying Liu,Hui Zhao,Guo-Qing Wang  ORCID: orcid.org/0000-0001-9326-3755,Chao Zhou,Jing Zheng,Xiao-Feng Li,Fan Li,Chang-Qing Bai &…Cheng-Feng Qin  ORCID: orcid.org/0000-0002-0632-2807 
https://doi.org/10.1038/s41392-021-00559-7
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PI3Kα inhibitor impairs AKT phosphorylation and synergizes with novel angiogenesis inhibitor AL3810 in human hepatocellular carcinoma
Qin Xie,Shuaishuai Chi,Yanfen Fang,Yiming Sun,Linghua Meng  ORCID: orcid.org/0000-0001-7722-8685,Jian Ding &…Yi Chen 
https://doi.org/10.1038/s41392-021-00522-6
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Research Highlight
D614G and SARS-CoV-2 replication fitness
Kathleen D. Engelman &Alan N. Engelman 
https://doi.org/10.1038/s41392-021-00498-3
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Mutation D614G increases SARS-CoV-2 transmission
Prerna Arora  ORCID: orcid.org/0000-0002-0618-8652,Stefan Pöhlmann  ORCID: orcid.org/0000-0001-6086-9136 &Markus Hoffmann  ORCID: orcid.org/0000-0003-4603-7696 
https://doi.org/10.1038/s41392-021-00502-w
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COVID-19: cross-immunity of viral epitopes may influence severity of infection and immune response
Junaid Kashir,Khaled AlKattan  ORCID: orcid.org/0000-0002-1372-9883 &Ahmed Yaqinuddin  ORCID: orcid.org/0000-0001-7536-910X 
https://doi.org/10.1038/s41392-021-00490-x
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‘nAb’ the self-reactive activity in the COVID-19 combat
Madhusudhanan Narasimhan,Lenin Mahimainathan &Alagarraju Muthukumar 
https://doi.org/10.1038/s41392-021-00518-2
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Targeting PCSK9: a promising adjuvant strategy in cancer immunotherapy
Catarina R. Almeida  ORCID: orcid.org/0000-0001-6670-6004,Beatriz H. Ferreira &Iola F. Duarte  ORCID: orcid.org/0000-0003-4289-9256 
https://doi.org/10.1038/s41392-021-00530-6
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Targeting glucose metabolism for treatment of COVID-19
Amin Ardestani  ORCID: orcid.org/0000-0002-0685-8564 &Zahra Azizi 
https://doi.org/10.1038/s41392-021-00532-4
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Apaf-1/caspase-4 pyroptosome: a mediator of mitochondrial permeability transition-triggered pyroptosis
Gang Shao,Lingfei Wang,Xi Wang &…Caiyun Fu  ORCID: orcid.org/0000-0003-4090-885X 
https://doi.org/10.1038/s41392-021-00524-4
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IL4I1-driven AHR signature: a new avenue for cancer therapy
Zuli Wang,Tiansheng Li,Chao Mao  ORCID: orcid.org/0000-0002-8685-8539,Wenliang Liu &…Yongguang Tao  ORCID: orcid.org/0000-0003-2354-5321 
https://doi.org/10.1038/s41392-021-00529-z
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All ways lead to Rome: assembly of retromer on membranes with different sorting nexins
Xin Yong,Daniel D. Billadeau &Da Jia  ORCID: orcid.org/0000-0002-2205-1998 
https://doi.org/10.1038/s41392-021-00561-z
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Newly synthesized Mpro inhibitors as potential oral anti-SARS-CoV-2 agents
Lin Li &Shile Huang  ORCID: orcid.org/0000-0002-3239-1072 
https://doi.org/10.1038/s41392-021-00560-0
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Article
Clinical evidence of an interferon–glucocorticoid therapeutic synergy in COVID-19
Yingying Lu,Feng Liu,Gangling Tong,Feng Qiu,Pinhong Song,Xiaolin Wang,Xiafei Zou,Deyun Wan,Miao Cui  ORCID: orcid.org/0000-0002-3402-8664,Yunsheng Xu,Zhihua Zheng &…Peng Hong  ORCID: orcid.org/0000-0002-3879-303X 
https://doi.org/10.1038/s41392-021-00496-5
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SRSF1 inhibits autophagy through regulating Bcl-x splicing and interacting with PIK3C3 in lung cancer
Yuesheng Lv,Wenjing Zhang,Jinyao Zhao,Bing Sun,Yangfan Qi,Haoyu Ji,Chaoqun Chen,Jinrui Zhang,Junxiu Sheng,Taishu Wang,Daniel Dominguez,Han Liu,Quentin Liu,Songshu Meng,Xiaoling Li &…Yang Wang  ORCID: orcid.org/0000-0001-9385-7393 
https://doi.org/10.1038/s41392-021-00495-6
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Dynamic blood single-cell immune responses in patients with COVID-19
Lulin Huang,Yi Shi,Bo Gong,Li Jiang,Zhixin Zhang,Xiaoqi Liu,Jialiang Yang,Yongquan He,Zhilin Jiang,Ling Zhong,Juan Tang,Chunfang You,Qi Jiang,Bo Long,Tao Zeng,Mei Luo,Fanwei Zeng,Fanxin Zeng,Shuqiang Wang,Xingxiang Yang &…Zhenglin Yang 
https://doi.org/10.1038/s41392-021-00526-2
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The dichotomous and incomplete adaptive immunity in COVID-19 patients with different disease severity
Leiqiong Gao,Jing Zhou,Sen Yang,Lisha Wang,Xiangyu Chen,Yang Yang,Ren Li,Zhiwei Pan,Jing Zhao,Zhirong Li,Qizhao Huang,Jianfang Tang,Li Hu,Pinghuang Liu,Guozhong Zhang,Yaokai Chen  ORCID: orcid.org/0000-0002-3229-0108 &…Lilin Ye  ORCID: orcid.org/0000-0003-0778-3311 
https://doi.org/10.1038/s41392-021-00525-3
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Targeting Erbin in B cells for therapy of lung metastasis of colorectal cancer
Tong Shen,Jing-Lin Liu,Chu-Yi Wang,Youlutuziayi Rixiati,Shi Li,Ling-Dong Cai,Yuan-Yuan Zhao &…Jian-Ming Li 
https://doi.org/10.1038/s41392-021-00501-x
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Unique and complementary suppression of cGAS-STING and RNA sensing- triggered innate immune responses by SARS-CoV-2 proteins
Yajuan Rui,Jiaming Su,Si Shen,Ying Hu,Dingbo Huang,Wenwen Zheng,Meng Lou,Yifei Shi,Meng Wang,Shiqi Chen,Na Zhao,Qi Dong,Yong Cai,Rongzhen Xu,Shu Zheng &…Xiao-Fang Yu  ORCID: orcid.org/0000-0002-8748-7186 
https://doi.org/10.1038/s41392-021-00515-5
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FGF1ΔHBS prevents diabetic cardiomyopathy by maintaining mitochondrial homeostasis and reducing oxidative stress via AMPK/Nur77 suppression
Dezhong Wang,Yuan Yin,Shuyi Wang,Tianyang Zhao,Fanghua Gong,Yushuo Zhao,Beibei Wang,Yuli Huang,Zizhao Cheng,Guanghui Zhu,Zengshou Wang,Yang Wang,Jun Ren,Guang Liang  ORCID: orcid.org/0000-0002-8278-849X,Xiaokun Li &…Zhifeng Huang 
https://doi.org/10.1038/s41392-021-00542-2
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The lncRNA Snhg1-Vps13D vesicle trafficking system promotes memory CD8 T cell establishment via regulating the dual effects of IL-7 signaling
Yanyan Zhang  ORCID: orcid.org/0000-0002-6037-5918,Baohua Li,Qiang Bai  ORCID: orcid.org/0000-0001-7423-0712,Pengcheng Wang,Gang Wei,Zhirong Li,Li Hu,Qin Tian,Jing Zhou,Qizhao Huang,Zhiming Wang,Shuai Yue,Jialin Wu,Liuqing Yang  ORCID: orcid.org/0000-0002-6518-474X,Xinyuan Zhou,Lubin Jiang,Ting Ni,Lilin Ye  ORCID: orcid.org/0000-0003-0778-3311 &…Yuzhang Wu 
https://doi.org/10.1038/s41392-021-00492-9
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Cathepsin L plays a key role in SARS-CoV-2 infection in humans and humanized mice and is a promising target for new drug development
Miao-Miao Zhao,Wei-Li Yang  ORCID: orcid.org/0000-0003-3646-7772,Fang-Yuan Yang,Li Zhang,Wei-Jin Huang,Wei Hou,Chang-Fa Fan,Rong-Hua Jin,Ying-Mei Feng,You-Chun Wang  ORCID: orcid.org/0000-0001-9769-5141 &…Jin-Kui Yang  ORCID: orcid.org/0000-0002-5430-2149 
https://doi.org/10.1038/s41392-021-00558-8
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PUMA facilitates EMI1-promoted cytoplasmic Rad51 ubiquitination and inhibits DNA repair in stem and progenitor cells
Jin Wook Kang,Zhiyan Zhan,Guangzhen Ji,Youzhou Sang  ORCID: orcid.org/0000-0003-2081-4258,Daohong Zhou,Yanxin Li,Haizhong Feng  ORCID: orcid.org/0000-0003-3552-6865 &…Tao Cheng  ORCID: orcid.org/0000-0003-4395-1095 
https://doi.org/10.1038/s41392-021-00510-w
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Gender associates with both susceptibility to infection and pathogenesis of SARS-CoV-2 in Syrian hamster
Lunzhi Yuan,Huachen Zhu,Ming Zhou,Jian Ma,Rirong Chen,Yao Chen,Liqiang Chen,Kun Wu,Minping Cai,Junping Hong,Lifeng Li,Che Liu,Huan Yu,Yali Zhang,Jia Wang,Tianying Zhang,Shengxiang Ge,Jun Zhang,Quan Yuan  ORCID: orcid.org/0000-0001-5487-561X,Yixin Chen,Qiyi Tang  ORCID: orcid.org/0000-0002-6487-2356,Honglin Chen,Tong Cheng,Yi Guan &…Ningshao Xia  ORCID: orcid.org/0000-0003-0179-5266 
https://doi.org/10.1038/s41392-021-00552-0
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Review Article
The key roles of cancer stem cell-derived extracellular vesicles
Chaoyue Su,Jianye Zhang  ORCID: orcid.org/0000-0001-5242-3687,Yosef Yarden &…Liwu Fu 
https://doi.org/10.1038/s41392-021-00499-2
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COVID-19 in early 2021: current status and looking forward
Chengdi Wang,Zhoufeng Wang,Guangyu Wang  ORCID: orcid.org/0000-0003-1312-884X,Johnson Yiu-Nam Lau,Kang Zhang &…Weimin Li 
https://doi.org/10.1038/s41392-021-00527-1
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Alternative approaches to target Myc for cancer treatment
Chen Wang,Jiawei Zhang,Jie Yin,Yichao Gan,Senlin Xu,Ying Gu &…Wendong Huang 
https://doi.org/10.1038/s41392-021-00500-y
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Bioactive potential of natural biomaterials: identification, retention and assessment of biological properties
Kieran Joyce,Georgina Targa Fabra,Yagmur Bozkurt &…Abhay Pandit  ORCID: orcid.org/0000-0002-6292-4933 
https://doi.org/10.1038/s41392-021-00512-8
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The adaptive transition of glioblastoma stem cells and its implications on treatments
Zeyu Wang,Hao Zhang,Shengchao Xu,Zhixiong Liu &…Quan Cheng  ORCID: orcid.org/0000-0003-2401-5349 
https://doi.org/10.1038/s41392-021-00491-w
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Targeting macrophages in cancer immunotherapy
Zhaojun Duan &Yunping Luo 
https://doi.org/10.1038/s41392-021-00506-6
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Pyroptosis: mechanisms and diseases
Pian Yu,Xu Zhang,Nian Liu,Ling Tang,Cong Peng &…Xiang Chen  ORCID: orcid.org/0000-0001-8187-636X 
https://doi.org/10.1038/s41392-021-00507-5
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