Table of Contents
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Volume 6 Issue 2, Feb 2021

Review Article
NAD+ metabolism, stemness, the immune response, and cancer
Lola E. Navas &Amancio Carnero  ORCID: orcid.org/0000-0003-4357-3979 
https://doi.org/10.1038/s41392-020-00354-w
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Targeting TGFβ signal transduction for cancer therapy
Sijia Liu,Jiang Ren &Peter ten Dijke 
https://doi.org/10.1038/s41392-020-00436-9
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G protein-coupled receptors: structure- and function-based drug discovery
Dehua Yang,Qingtong Zhou,Viktorija Labroska,Shanshan Qin,Sanaz Darbalaei,Yiran Wu,Elita Yuliantie,Linshan Xie,Houchao Tao,Jianjun Cheng,Qing Liu,Suwen Zhao,Wenqing Shui,Yi Jiang &…Ming-Wei Wang  ORCID: orcid.org/0000-0001-6550-9017 
https://doi.org/10.1038/s41392-020-00435-w
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Tumor microenvironment: an evil nexus promoting aggressive head and neck squamous cell carcinoma and avenue for targeted therapy
Ajaz A. Bhat,Parvaiz Yousuf  ORCID: orcid.org/0000-0002-6465-9096,Nissar A. Wani,Arshi Rizwan,Shyam S. Chauhan,Mushtaq A. Siddiqi,Davide Bedognetti,Wael El-Rifai,Michael P. Frenneaux,Surinder K. Batra  ORCID: orcid.org/0000-0001-9470-9317,Mohammad Haris &…Muzafar A. Macha  ORCID: orcid.org/0000-0003-4468-4435 
https://doi.org/10.1038/s41392-020-00419-w
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Targeting the signaling in Epstein–Barr virus-associated diseases: mechanism, regulation, and clinical study
Ya Cao,Longlong Xie,Feng Shi,Min Tang,Yueshuo Li,Jianmin Hu,Lin Zhao,Luqing Zhao,Xinfang Yu,Xiangjian Luo,Weihua Liao &…Ann M. Bode 
https://doi.org/10.1038/s41392-020-00376-4
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Targeting ubiquitin signaling for cancer immunotherapy
Xiaofei Zhou  ORCID: orcid.org/0000-0002-9289-2215 &Shao-Cong Sun  ORCID: orcid.org/0000-0001-7353-9400 
https://doi.org/10.1038/s41392-020-00421-2
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The BET family in immunity and disease
Nian Wang,Runliu Wu,Daolin Tang &…Rui Kang 
https://doi.org/10.1038/s41392-020-00384-4
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Interplay between cofactors and transcription factors in hematopoiesis and hematological malignancies
Zi Wang  ORCID: orcid.org/0000-0003-3892-827X,Pan Wang,Yanan Li,Hongling Peng,Yu Zhu,Narla Mohandas &…Jing Liu 
https://doi.org/10.1038/s41392-020-00422-1
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Targeting the ubiquitination/deubiquitination process to regulate immune checkpoint pathways
Jiaxin Liu  ORCID: orcid.org/0000-0002-7048-1992,Yicheng Cheng,Ming Zheng,Bingxiao Yuan,Zimu Wang,Xinying Li,Jie Yin,Mingxiang Ye &…Yong Song 
https://doi.org/10.1038/s41392-020-00418-x
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Regulation of cardiomyocyte fate plasticity: a key strategy for cardiac regeneration
Rui Gong,Zuke Jiang,Naufal Zagidullin,Tianyi Liu &…Benzhi Cai 
https://doi.org/10.1038/s41392-020-00413-2
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Letter
A mouse model for SARS-CoV-2-induced acute respiratory distress syndrome
Weiqi Hong,Jingyun Yang,Zhenfei Bi,Cai He,Hong Lei,Wenhai Yu,Yun Yang,Changfa Fan,Shuaiyao Lu,Xiaozhong Peng  ORCID: orcid.org/0000-0002-8564-0247 &…Xiawei Wei  ORCID: orcid.org/0000-0002-6513-6422 
https://doi.org/10.1038/s41392-020-00451-w
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IFN-γ surmounts PD-L1/PD1 inhibition to CAR-T cell therapy by upregulating ICAM-1 on tumor cells
E Dong,Xiao-zhu Yue,Lin Shui,Bin-rui Liu,Qi-qi Li,Yun Yang,Hui Luo,Wei Wang  ORCID: orcid.org/0000-0001-7788-1895 &…Han-shuo Yang 
https://doi.org/10.1038/s41392-020-00357-7
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Pathological features of COVID-19-associated liver injury—a preliminary proteomics report based on clinical samples
Ling Leng,Ruiyuan Cao,Jie Ma,Luye Lv,Wei Li,Yunping Zhu,Zhihong Wu,Manli Wang  ORCID: orcid.org/0000-0001-8701-3530,Yiwu Zhou &…Wu Zhong  ORCID: orcid.org/0000-0002-0536-620X 
https://doi.org/10.1038/s41392-020-00406-1
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IL-24 armored CAR19-T cells show enhanced antitumor activity and persistence
Qian Hu,Yuxuan Zhang,Peiyun Wang,Miaojin Zhou,Zhiqing Hu,Cong Liu,Mujun Liu,Lingqian Wu,Xionghao Liu &…Desheng Liang 
https://doi.org/10.1038/s41392-020-00380-8
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Lysophosphatidic acid mediates the pathogenesis of psoriasis by activating keratinocytes through LPAR5
Li Lei,Bei Yan,Panpan Liu,Jie Li,Chao Chen,Wu Zhu,Yehong Kuang,Xiang Chen  ORCID: orcid.org/0000-0001-8187-636X &…Cong Peng 
https://doi.org/10.1038/s41392-020-00379-1
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A disease-relevant mutation of SPOP highlights functional significance of ATM-mediated DNA damage response
Mingming Xiao,Joshua S. Fried,Jinlu Ma,Yang Su,Rebecca J. Boohaker,Qinghua Zeng,Yaqi Mo,Fanbiao Meng,Rong Xiang  ORCID: orcid.org/0000-0003-3487-7348 &…Bo Xu 
https://doi.org/10.1038/s41392-020-00381-7
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Identification and construction of a novel biomimetic delivery system of paclitaxel and its targeting therapy for cancer
Xue Wang,Wanwei Zheng,Qing Shen,Yahua Wang,Yujen Tseng,Zhongguang Luo,Xiaoyou Wang,Lei Shi,Chong Li &…Jie Liu 
https://doi.org/10.1038/s41392-020-00390-6
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cFUT8 promotes liver cancer progression by miR-548c/FUT8 axis
Chong Li,Zhuoyuan Xin,Luyun He,Jing Ning,Kaisu Lin,Jiahui Pan,Jagannatha Rao  ORCID: orcid.org/0000-0002-4801-3535,Guoqing Wang  ORCID: orcid.org/0000-0001-9326-3755 &…Hong Zhu 
https://doi.org/10.1038/s41392-020-00393-3
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Hepatic microRNA-126 deficiency restrains liver regeneration through p53 pathway in mice
Lingling Zhang,Yugang Qiu,Fan Yang,Jiyuan Yao,Ying Wang,Yang Qin,Hanchuan Mou,Qing Jing,Leiming Liu &…Zhenyu Ju 
https://doi.org/10.1038/s41392-020-00395-1
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SHP2-mediated mitophagy boosted by lovastatin in neuronal cells alleviates parkinsonism in mice
Wen Liu,Meijing Wang,Lihong Shen,Yuyu Zhu,Hongyue Ma,Bo Liu,Liang Ouyang  ORCID: orcid.org/0000-0001-5537-8834,Wenjie Guo  ORCID: orcid.org/0000-0001-8506-3905,Qiang Xu &…Yang Sun  ORCID: orcid.org/0000-0003-1425-0089 
https://doi.org/10.1038/s41392-021-00474-x
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Characterization of SARS-CoV-2-specific antibodies in COVID-19 patients reveals highly potent neutralizing IgA
Weihong Zeng  ORCID: orcid.org/0000-0003-3853-3630,Huan Ma,Chengchao Ding,Yunru Yang,Yong Sun,Xiaoxue Huang,Weihuang He,Yan Xiang,Yong Gao &…Tengchuan Jin  ORCID: orcid.org/0000-0002-1395-188X 
https://doi.org/10.1038/s41392-021-00478-7
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Perspective
A new precision medicine initiative at the dawn of exascale computing
Ruth Nussinov,Hyunbum Jang,Guy Nir  ORCID: orcid.org/0000-0001-9268-6596,Chung-Jung Tsai &…Feixiong Cheng 
https://doi.org/10.1038/s41392-020-00420-3
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Article
Reprogramming immunosuppressive myeloid cells by activated T cells promotes the response to anti-PD-1 therapy in colorectal cancer
Jing Chen,Hong-Wei Sun  ORCID: orcid.org/0000-0001-6236-2064,Yan-Yan Yang,Hai-Tian Chen,Xing-Juan Yu,Wen-Chao Wu,Yi-Tuo Xu,Li-Lian Jin,Xiao-Jun Wu,Jing Xu &…Limin Zheng 
https://doi.org/10.1038/s41392-020-00377-3
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Loss of FOXC1 contributes to the corneal epithelial fate switch and pathogenesis
Mingsen Li,Liqiong Zhu,Jiafeng Liu,Huaxing Huang,Huizhen Guo,Li Wang,Lingyu Li,Sijie Gu,Jieying Tan,Jing Zhong,Bowen Wang,Zhen Mao,Yong Fan,Chunqiao Liu,Jin Yuan &…Hong Ouyang  ORCID: orcid.org/0000-0002-7622-7733 
https://doi.org/10.1038/s41392-020-00378-2
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Molecular characteristics of primary pulmonary lymphoepithelioma-like carcinoma based on integrated genomic analyses
Bojiang Chen,Yu Zhang,Sisi Dai,Ping Zhou,Wenxin Luo,Zhoufeng Wang,Xuping Chen,Peng Cheng,Guoya Zheng,Jing Ren,Xiaodong Yang &…Weimin Li 
https://doi.org/10.1038/s41392-020-00382-6
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CREBBP/EP300 mutations promoted tumor progression in diffuse large B-cell lymphoma through altering tumor-associated macrophage polarization via FBXW7-NOTCH-CCL2/CSF1 axis
Yao-Hui Huang,Kun Cai,Peng-Peng Xu,Li Wang,Chuan-Xin Huang,Ying Fang,Shu Cheng,Xiao-Jian Sun  ORCID: orcid.org/0000-0001-8826-4614,Feng Liu,Jin-Yan Huang  ORCID: orcid.org/0000-0002-8053-0209,Meng-Meng Ji &…Wei-Li Zhao 
https://doi.org/10.1038/s41392-020-00437-8
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Novel therapeutic evaluation biomarkers of lipid metabolism targets in uncomplicated pulmonary tuberculosis patients
Jia-Xi Chen,Yu-Shuai Han,Shan-Qiang Zhang,Zhi-Bin Li,Jing Chen,Wen-Jing Yi,Huai Huang,Ting-Ting Jiang &…Ji-Cheng Li 
https://doi.org/10.1038/s41392-020-00427-w
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AHA1 upregulates IDH1 and metabolic activity to promote growth and metastasis and predicts prognosis in osteosarcoma
Diwei Zheng,Weihai Liu,Wenlin Xie,Guanyu Huang,Qiwei Jiang,Yang Yang,Jiarong Huang,Zihao Xing,Mengling Yuan,Mengning Wei,Yao Li,Junqiang Yin  ORCID: orcid.org/0000-0001-8366-3480,Jingnan Shen &…Zhi Shi 
https://doi.org/10.1038/s41392-020-00387-1
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Personalized neoantigen pulsed dendritic cell vaccine for advanced lung cancer
Zhenyu Ding,Qing Li,Rui Zhang,Li Xie,Yang Shu,Song Gao,Peipei Wang,Xiaoqing Su,Yun Qin,Yuelan Wang,Juemin Fang,Zhongzheng Zhu,Xuyang Xia,Guochao Wei,Hui Wang,Hong Qian,Xianling Guo,Zhibo Gao,Yu Wang,Yuquan Wei,Qing Xu,Heng Xu  ORCID: orcid.org/0000-0002-7748-2621 &…Li Yang 
https://doi.org/10.1038/s41392-020-00448-5
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Targeting Notch and EGFR signaling in human mucoepidermoid carcinoma
Wei Ni  ORCID: orcid.org/0000-0002-5729-827X,Zirong Chen,Xin Zhou,Rongqiang Yang,Mu Yu,Jianrong Lu,Frederic J. Kaye &…Lizi Wu  ORCID: orcid.org/0000-0002-0076-2617 
https://doi.org/10.1038/s41392-020-00388-0
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Targeting TRPV1-mediated autophagy attenuates nitrogen mustard-induced dermal toxicity
Mingliang Chen,Xunhu Dong,Haoyue Deng,Feng Ye,Yuanpeng Zhao,Jin Cheng,Guorong Dan,Jiqing Zhao,Yan Sai,Xiuwu Bian &…Zhongmin Zou 
https://doi.org/10.1038/s41392-020-00389-z
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Research Highlight
Connections between biomechanics and higher infectivity: a tale of the D614G mutation in the SARS-CoV-2 spike protein
Anshumali Mittal &Vikash Verma  ORCID: orcid.org/0000-0003-2371-4164 
https://doi.org/10.1038/s41392-020-00439-6
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Identification of MSA-2: An oral antitumor non-nucleotide STING agonist
Jianhua Liu,Xu Huang  ORCID: orcid.org/0000-0002-9197-0808 &Jianxun Ding  ORCID: orcid.org/0000-0002-5232-8863 
https://doi.org/10.1038/s41392-020-00459-2
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Efficient HIV-1 in vitro reverse transcription: optimal capsid stability is required
Ryan C. Burdick &Vinay K. Pathak 
https://doi.org/10.1038/s41392-020-00458-3
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Not only ACE2—the quest for additional host cell mediators of SARS-CoV-2 infection: Neuropilin-1 (NRP1) as a novel SARS-CoV-2 host cell entry mediator implicated in COVID-19
Ioannis Kyrou,Harpal S. Randeva,Demetrios A. Spandidos &…Emmanouil Karteris 
https://doi.org/10.1038/s41392-020-00460-9
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Metabolic regulation of pyroptotic cell death expands the therapeutic landscape for treating inflammatory disease
David E. Place  ORCID: orcid.org/0000-0002-1904-4164 &Thirumala-Devi Kanneganti 
https://doi.org/10.1038/s41392-021-00467-w
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Constrained surfaces: promising therapeutic targets for COVID-19 determined by systematically mutational analysis
Manni Wang,Tianxia Lan &Wei Wang  ORCID: orcid.org/0000-0001-7788-1895 
https://doi.org/10.1038/s41392-021-00469-8
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Cell-type-specific memory consolidation driven by translational control
Qing Zhang,Isabel Bestard-Lorigados &Weihong Song  ORCID: orcid.org/0000-0001-9928-889X 
https://doi.org/10.1038/s41392-021-00471-0
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Missing for partnership: understanding nucleosomal de novo DNA cytosine methylation by a spliced DNMT3 complex
Min Zhang &Haitao Li  ORCID: orcid.org/0000-0002-6686-1677 
https://doi.org/10.1038/s41392-021-00461-2
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Engaging the spikes: heparan sulfate facilitates SARS-CoV-2 spike protein binding to ACE2 and potentiates viral infection
Rajkumar Singh Kalra &Ramesh Kandimalla 
https://doi.org/10.1038/s41392-021-00470-1
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Cancer Environment Immunotherapy: targeting TGF-β finds its way towards tissue healing and vasculature remodeling
Ke Jin  ORCID: orcid.org/0000-0001-5371-3440,Fangfang Zhou  ORCID: orcid.org/0000-0003-1870-7584 &Long Zhang  ORCID: orcid.org/0000-0001-8139-0474 
https://doi.org/10.1038/s41392-021-00472-z
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