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Volume 1 Issue 4, Dec 2016

Article
Peptide-substituted oligonucleotide synthesis and non-toxic, passive cell delivery
Shiying Shang,Luca Monfregola &Marvin H Caruthers 
https://doi.org/10.1038/sigtrans.2016.19
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USP21 deubiquitylates Nanog to regulate protein stability and stem cell pluripotency
Xingyu Liu,Yuying Yao,Huiguo Ding,Chuanchun Han,Yuhan Chen,Yuan Zhang,Chanjuan Wang,Xin Zhang,Yiling Zhang,Yun Zhai,Ping Wang,Wenyi Wei,Jing Zhang &…Lingqiang Zhang 
https://doi.org/10.1038/sigtrans.2016.24
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A novel cancer vaccine with the ability to simultaneously produce anti-PD-1 antibody and GM-CSF in cancer cells and enhance Th1-biased antitumor immunity
Hongwei Tian,Gang Shi,Qin Wang,Yiming Li,Qianmei Yang,Chunlei Li,Guoyou Yang,Min Wu,Qian Xie,Shuang Zhang,Yang Yang,Rong Xiang,Dechao Yu,Yuquan Wei &…Hongxin Deng 
https://doi.org/10.1038/sigtrans.2016.25
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Seeing is believing: anti-PD-1/PD-L1 monoclonal antibodies in action for checkpoint blockade tumor immunotherapy
Shuguang Tan,Catherine W-H Zhang &George F Gao 
https://doi.org/10.1038/sigtrans.2016.29
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The competing mini-dumbbell mechanism: new insights into CCTG repeat expansion
Pei Guo &Sik Lok Lam 
https://doi.org/10.1038/sigtrans.2016.28
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Lyn prevents aberrant inflammatory responses to Pseudomonas infection in mammalian systems by repressing a SHIP-1-associated signaling cluster
Rongpeng Li,Lizhu Fang,Qinqin Pu,Ping Lin,Austin Hoggarth,Huang Huang,Xuefeng Li,Guoping Li &…Min Wu 
https://doi.org/10.1038/sigtrans.2016.32
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Tumor cell-intrinsic PD-L1 promotes tumor-initiating cell generation and functions in melanoma and ovarian cancer
Harshita B Gupta,Curtis A Clark,Bin Yuan,Gangadhara Sareddy,Srilakshmi Pandeswara,Alvaro S Padron,Vincent Hurez,José Conejo-Garcia,Ratna Vadlamudi,Rong Li &…Tyler J Curiel 
https://doi.org/10.1038/sigtrans.2016.30
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